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Volumn 27, Issue 3, 2013, Pages 523-533

Polycomb-group proteins in hematopoietic stem cell regulation and hematopoietic neoplasms

Author keywords

hematopoiesis; lymphoma; Polycomb group genes; stem cells

Indexed keywords

BMI1 PROTEIN; HISTONE H3; HISTONE METHYLTRANSFERASE; POLYCOMB REPRESSIVE COMPLEX 2;

EID: 84875217558     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2012.368     Document Type: Review
Times cited : (46)

References (146)
  • 1
    • 0018240421 scopus 로고
    • A gene complex controlling segmentation in Drosophila
    • Lewis EB. A gene complex controlling segmentation in Drosophila. Nature 1978; 276: 565-570.
    • (1978) Nature , vol.276 , pp. 565-570
    • Lewis, E.B.1
  • 2
    • 0036340237 scopus 로고    scopus 로고
    • The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans
    • Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P, Kingston RE. The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. Mol Cell Biol 2002; 22: 6070-6078.
    • (2002) Mol Cell Biol , vol.22 , pp. 6070-6078
    • Levine, S.S.1    Weiss, A.2    Erdjument-Bromage, H.3    Shao, Z.4    Tempst, P.5    Kingston, R.E.6
  • 3
    • 70349469565 scopus 로고    scopus 로고
    • Mechanisms of polycomb gene silencing: Knowns and unknowns
    • Simon JA, Kingston RE. Mechanisms of polycomb gene silencing: knowns and unknowns. Nat Rev Mol Cell Biol 2009; 10: 697-708.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 697-708
    • Simon, J.A.1    Kingston, R.E.2
  • 4
    • 77954758157 scopus 로고    scopus 로고
    • Polycomb group protein-mediated repression of transcription
    • Morey L, Helin K. Polycomb group protein-mediated repression of transcription. Trends Biochem Sci 2010; 35: 323-332.
    • (2010) Trends Biochem Sci , vol.35 , pp. 323-332
    • Morey, L.1    Helin, K.2
  • 5
    • 0036830642 scopus 로고    scopus 로고
    • Role of histone H3 lysine 27 methylation in Polycomb-group silencing
    • Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P et al. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 2002; 298: 1039-1043.
    • (2002) Science , vol.298 , pp. 1039-1043
    • Cao, R.1    Wang, L.2    Wang, H.3    Xia, L.4    Erdjument-Bromage, H.5    Tempst, P.6
  • 6
    • 0037131523 scopus 로고    scopus 로고
    • Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites
    • Czermin B, Melfi R, McCabe D, Seitz V, Imhof A, Pirrotta V. Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell 2002; 111: 185-196.
    • (2002) Cell , vol.111 , pp. 185-196
    • Czermin, B.1    Melfi, R.2    McCabe, D.3    Seitz, V.4    Imhof, A.5    Pirrotta, V.6
  • 7
    • 0037111831 scopus 로고    scopus 로고
    • Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein
    • Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev 2002; 16: 2893-2905.
    • (2002) Genes Dev , vol.16 , pp. 2893-2905
    • Kuzmichev, A.1    Nishioka, K.2    Erdjument-Bromage, H.3    Tempst, P.4    Reinberg, D.5
  • 8
    • 1942502862 scopus 로고    scopus 로고
    • Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3
    • Kuzmichev A, Jenuwein T, Tempst P, Reinberg D. Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol Cell 2004; 14: 183-193.
    • (2004) Mol Cell , vol.14 , pp. 183-193
    • Kuzmichev, A.1    Jenuwein, T.2    Tempst, P.3    Reinberg, D.4
  • 9
    • 17644410781 scopus 로고    scopus 로고
    • Nucleosome binding and histone methyltransferase activity of Drosophila PRC2
    • Nekrasov M, Wild B, Muller J. Nucleosome binding and histone methyltransferase activity of Drosophila PRC2. EMBO Rep 2005; 6: 348-353.
    • (2005) EMBO Rep , vol.6 , pp. 348-353
    • Nekrasov, M.1    Wild, B.2    Muller, J.3
  • 10
    • 3042781030 scopus 로고    scopus 로고
    • Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27
    • Kirmizis A, Bartley SM, Kuzmichev A, Margueron R, Reinberg D, Green R et al. Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27. Genes Dev 2004; 18: 1592-1605.
    • (2004) Genes Dev , vol.18 , pp. 1592-1605
    • Kirmizis, A.1    Bartley, S.M.2    Kuzmichev, A.3    Margueron, R.4    Reinberg, D.5    Green, R.6
  • 11
    • 55949132133 scopus 로고    scopus 로고
    • Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms
    • Margueron R, Li G, Sarma K, Blais A, Zavadil J, Woodcock CL et al. Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell 2008; 32: 503-518.
    • (2008) Mol Cell , vol.32 , pp. 503-518
    • Margueron, R.1    Li, G.2    Sarma, K.3    Blais, A.4    Zavadil, J.5    Woodcock, C.L.6
  • 12
    • 70349952171 scopus 로고    scopus 로고
    • Role of the polycomb protein EED in the propagation of repressive histone marks
    • Margueron R, Justin N, Ohno K, Sharpe ML, Son J, Drury 3rd WJ et al. Role of the polycomb protein EED in the propagation of repressive histone marks. Nature 2009; 461: 762-767.
    • (2009) Nature , vol.461 , pp. 762-767
    • Margueron, R.1    Justin, N.2    Ohno, K.3    Sharpe, M.L.4    Son, J.5    Drury III, W.J.6
  • 13
    • 3042801308 scopus 로고    scopus 로고
    • SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex
    • Cao R, Zhang Y. SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Mol Cell 2004; 15: 57-67.
    • (2004) Mol Cell , vol.15 , pp. 57-67
    • Cao, R.1    Zhang, Y.2
  • 14
    • 34648834735 scopus 로고    scopus 로고
    • Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes
    • Nekrasov M, Klymenko T, Fraterman S, Papp B, Oktaba K, Kocher T et al. Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes. EMBO J 2007; 26: 4078-4088.
    • (2007) EMBO J , vol.26 , pp. 4078-4088
    • Nekrasov, M.1    Klymenko, T.2    Fraterman, S.3    Papp, B.4    Oktaba, K.5    Kocher, T.6
  • 15
    • 42149149895 scopus 로고    scopus 로고
    • Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo
    • Sarma K, Margueron R, Ivanov A, Pirrotta V, Reinberg D. Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo. Mol Cell Biol 2008; 28: 2718-2731.
    • (2008) Mol Cell Biol , vol.28 , pp. 2718-2731
    • Sarma, K.1    Margueron, R.2    Ivanov, A.3    Pirrotta, V.4    Reinberg, D.5
  • 16
    • 42149149344 scopus 로고    scopus 로고
    • Recruitment of Drosophila Polycomb-group proteins by Polycomblike, a component of a novel protein complex in larvae
    • Savla U, Benes J, Zhang J, Jones RS. Recruitment of Drosophila Polycomb-group proteins by Polycomblike, a component of a novel protein complex in larvae. Development 2008; 135: 813-817.
    • (2008) Development , vol.135 , pp. 813-817
    • Savla, U.1    Benes, J.2    Zhang, J.3    Jones, R.S.4
  • 17
    • 66249121737 scopus 로고    scopus 로고
    • AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2
    • Kim H, Kang K, Kim J. AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2. Nucleic Acids Res 2009; 37: 2940-2950.
    • (2009) Nucleic Acids Res , vol.37 , pp. 2940-2950
    • Kim, H.1    Kang, K.2    Kim, J.3
  • 19
    • 84859258692 scopus 로고    scopus 로고
    • Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal
    • Hunkapiller J, Shen Y, Diaz A, Cagney G, McCleary D, Ramalho-Santos M et al. Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal. PLoS Genet 2012; 8: e1002576.
    • (2012) PLoS Genet , vol.8
    • Hunkapiller, J.1    Shen, Y.2    Diaz, A.3    Cagney, G.4    McCleary, D.5    Ramalho-Santos, M.6
  • 21
    • 79953311668 scopus 로고    scopus 로고
    • Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells
    • Vandamme J, Volkel P, Rosnoblet C, Le Faou P, Angrand PO. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. Mol Cell Proteomics 2011; 10: 002642.
    • (2011) Mol Cell Proteomics , vol.10 , pp. 002642
    • Vandamme, J.1    Volkel, P.2    Rosnoblet, C.3    Le Faou, P.4    Angrand, P.O.5
  • 23
    • 33645231102 scopus 로고    scopus 로고
    • Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin
    • Bernstein E, Duncan EM, Masui O, Gil J, Heard E, Allis CD. Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin. Mol Cell Biol 2006; 26: 2560-2569.
    • (2006) Mol Cell Biol , vol.26 , pp. 2560-2569
    • Bernstein, E.1    Duncan, E.M.2    Masui, O.3    Gil, J.4    Heard, E.5    Allis, C.D.6
  • 24
    • 29144487990 scopus 로고    scopus 로고
    • Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing
    • Cao R, Tsukada Y, Zhang Y. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol Cell 2005; 20: 845-854.
    • (2005) Mol Cell , vol.20 , pp. 845-854
    • Cao, R.1    Tsukada, Y.2    Zhang, Y.3
  • 25
    • 0035833726 scopus 로고    scopus 로고
    • General transcription factors bind promoters repressed by Polycomb group proteins
    • Breiling A, Turner BM, Bianchi ME, Orlando V. General transcription factors bind promoters repressed by Polycomb group proteins. Nature 2001; 412: 651-655.
    • (2001) Nature , vol.412 , pp. 651-655
    • Breiling, A.1    Turner, B.M.2    Bianchi, M.E.3    Orlando, V.4
  • 26
    • 36749089980 scopus 로고    scopus 로고
    • Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells
    • Stock JK, Giadrossi S, Casanova M, Brookes E, Vidal M, Koseki H et al. Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells. Nat Cell Biol 2007; 9: 1428-1435.
    • (2007) Nat Cell Biol , vol.9 , pp. 1428-1435
    • Stock, J.K.1    Giadrossi, S.2    Casanova, M.3    Brookes, E.4    Vidal, M.5    Koseki, H.6
  • 27
    • 38149098408 scopus 로고    scopus 로고
    • Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation
    • Zhou W, Zhu P, Wang J, Pascual G, Ohgi KA, Lozach J et al. Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation. Mol Cell 2008; 29: 69-80.
    • (2008) Mol Cell , vol.29 , pp. 69-80
    • Zhou, W.1    Zhu, P.2    Wang, J.3    Pascual, G.4    Ohgi, K.A.5    Lozach, J.6
  • 29
    • 74049150799 scopus 로고    scopus 로고
    • Novel motifs distinguish multiple homologues of Polycomb in vertebrates: Expansion and diversification of the epigenetic toolkit
    • Senthilkumar R, Mishra RK. Novel motifs distinguish multiple homologues of Polycomb in vertebrates: expansion and diversification of the epigenetic toolkit. BMC Genomics 2009; 10: 549.
    • (2009) BMC Genomics , vol.10 , pp. 549
    • Senthilkumar, R.1    Mishra, R.K.2
  • 30
    • 84860570324 scopus 로고    scopus 로고
    • A human Polycomb isoform lacking the Pc box does not participate to PRC1 complexes but forms protein assemblies and represses transcription
    • Volkel P, Le Faou P, Vandamme J, Pira D, Angrand PO. A human Polycomb isoform lacking the Pc box does not participate to PRC1 complexes but forms protein assemblies and represses transcription. Epigenetics 2012; 7: 482-491.
    • (2012) Epigenetics , vol.7 , pp. 482-491
    • Volkel, P.1    Le Faou, P.2    Vandamme, J.3    Pira, D.4    Angrand, P.O.5
  • 31
    • 77954676296 scopus 로고    scopus 로고
    • Origin of the polycomb repressive complex 2 and gene silencing by an E(z) homolog in the unicellular alga Chlamydomonas
    • Shaver S, Casas-Mollano JA, Cerny RL, Cerutti H. Origin of the polycomb repressive complex 2 and gene silencing by an E(z) homolog in the unicellular alga Chlamydomonas. Epigenetics 2010; 5: 301-312.
    • (2010) Epigenetics , vol.5 , pp. 301-312
    • Shaver, S.1    Casas-Mollano, J.A.2    Cerny, R.L.3    Cerutti, H.4
  • 32
    • 69449097106 scopus 로고    scopus 로고
    • Diversity of Polycomb group complexes in plants: Same rules different players?
    • Hennig L, Derkacheva M. Diversity of Polycomb group complexes in plants: same rules, different players? Trends Genet 2009; 25: 414-423.
    • (2009) Trends Genet , vol.25 , pp. 414-423
    • Hennig, L.1    Derkacheva, M.2
  • 33
    • 79961210109 scopus 로고    scopus 로고
    • Polycomb-group mediated epigenetic mechanisms through plant evolution
    • Butenko Y, Ohad N. Polycomb-group mediated epigenetic mechanisms through plant evolution. Biochim Biophys Acta 2011; 1809: 395-406.
    • (2011) Biochim Biophys Acta , vol.1809 , pp. 395-406
    • Butenko, Y.1    Ohad, N.2
  • 34
    • 78751662908 scopus 로고    scopus 로고
    • The Polycomb complex PRC2 and its mark in life
    • Margueron R, Reinberg D. The Polycomb complex PRC2 and its mark in life. Nature 2011; 469: 343-349.
    • (2011) Nature , vol.469 , pp. 343-349
    • Margueron, R.1    Reinberg, D.2
  • 35
    • 79952007418 scopus 로고    scopus 로고
    • The zebrafish genes encoding the Polycomb repressive complex (PRC) 1
    • Le Faou P, Volkel P, Angrand PO. The zebrafish genes encoding the Polycomb repressive complex (PRC) 1. Gene 2011; 475: 10-21.
    • (2011) Gene , vol.475 , pp. 10-21
    • Le Faou, P.1    Volkel, P.2    Angrand, P.O.3
  • 36
    • 84855516244 scopus 로고    scopus 로고
    • Nonoverlapping functions of the Polycomb group Cbx family of proteins in embryonic stem cells
    • Morey L, Pascual G, Cozzuto L, Roma G, Wutz A, Benitah SA et al. Nonoverlapping functions of the Polycomb group Cbx family of proteins in embryonic stem cells. Cell Stem Cell 2012; 10: 47-62.
    • (2012) Cell Stem Cell , vol.10 , pp. 47-62
    • Morey, L.1    Pascual, G.2    Cozzuto, L.3    Roma, G.4    Wutz, A.5    Benitah, S.A.6
  • 38
    • 84863011309 scopus 로고    scopus 로고
    • PCGF homologs CBX proteins, and RYBP define functionally distinct PRC1 family complexes
    • Gao Z, Zhang J, Bonasio R, Strino F, Sawai A, Parisi F et al. PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. Mol Cell 2012; 45: 344-356.
    • (2012) Mol Cell , vol.45 , pp. 344-356
    • Gao, Z.1    Zhang, J.2    Bonasio, R.3    Strino, F.4    Sawai, A.5    Parisi, F.6
  • 39
    • 0025727771 scopus 로고
    • Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in e mu-myc transgenic mice
    • Haupt Y, Alexander WS, Barri G, Klinken SP, Adams JM. Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice. Cell 1991; 65: 753-763.
    • (1991) Cell , vol.65 , pp. 753-763
    • Haupt, Y.1    Alexander, W.S.2    Barri, G.3    Klinken, S.P.4    Adams, J.M.5
  • 40
    • 0033552813 scopus 로고    scopus 로고
    • The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
    • Jacobs JJ, Kieboom K, Marino S, DePinho RA, Van Lohuizen M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 1999; 397: 164-168.
    • (1999) Nature , vol.397 , pp. 164-168
    • Jacobs, J.J.1    Kieboom, K.2    Marino, S.3    Depinho, R.A.4    Van Lohuizen, M.5
  • 41
    • 0032191954 scopus 로고    scopus 로고
    • Mel-18 negatively regulates cell cycle progression upon B cell antigen receptor stimulation through a cascade leading to c-myc/cdc25
    • Tetsu O, Ishihara H, Kanno R, Kamiyasu M, Inoue H, Tokuhisa T et al. mel-18 negatively regulates cell cycle progression upon B cell antigen receptor stimulation through a cascade leading to c-myc/cdc25. Immunity 1998; 9: 439-448.
    • (1998) Immunity , vol.9 , pp. 439-448
    • Tetsu, O.1    Ishihara, H.2    Kanno, R.3    Kamiyasu, M.4    Inoue, H.5    Tokuhisa, T.6
  • 42
    • 33846850149 scopus 로고    scopus 로고
    • Mel-18 a Polycomb Group Protein, Regulates Cell Proliferation and Senescence via Transcriptional Repression of Bmi-1 and c-Myc Oncoproteins
    • Guo W-J, Datta S, Band V, Dimri GP. Mel-18 a Polycomb Group Protein, Regulates Cell Proliferation and Senescence via Transcriptional Repression of Bmi-1 and c-Myc Oncoproteins. Mol Biol Cell 2007; 18: 536-546.
    • (2007) Mol Biol Cell , vol.18 , pp. 536-546
    • Guo, W.-J.1    Datta, S.2    Band, V.3    Dimri, G.P.4
  • 43
    • 34347233480 scopus 로고    scopus 로고
    • Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells
    • Guo WJ, Zeng MS, Yadav A, Song LB, Guo BH, Band V et al. Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells. Cancer Res 2007; 67: 5083-5089.
    • (2007) Cancer Res , Issue.67 , pp. 5083-5089
    • Guo, W.J.1    Zeng, M.S.2    Yadav, A.3    Song, L.B.4    Guo, B.H.5    Band, V.6
  • 44
    • 55949121452 scopus 로고    scopus 로고
    • Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences
    • Vincenz C, Kerppola TK. Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences. Proc Natl Acad Sci USA 2008; 105: 16572-16577.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 16572-16577
    • Vincenz, C.1    Kerppola, T.K.2
  • 45
    • 84856237597 scopus 로고    scopus 로고
    • Polycomb protein Ezh1 promotes RNA polymerase II elongation
    • Mousavi K, Zare H, Wang AH, Sartorelli V. Polycomb protein Ezh1 promotes RNA polymerase II elongation. Mol Cell 2012; 45: 255-262.
    • (2012) Mol Cell , vol.45 , pp. 255-262
    • Mousavi, K.1    Zare, H.2    Wang, A.H.3    Sartorelli, V.4
  • 46
    • 84857367297 scopus 로고    scopus 로고
    • RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3
    • Tavares L, Dimitrova E, Oxley D, Webster J, Poot R, Demmers J et al. RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3. Cell 2012; 148: 664-678.
    • (2012) Cell , vol.148 , pp. 664-678
    • Tavares, L.1    Dimitrova, E.2    Oxley, D.3    Webster, J.4    Poot, R.5    Demmers, J.6
  • 47
    • 55949124844 scopus 로고    scopus 로고
    • EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency
    • Shen X, Liu Y, Hsu YJ, Fujiwara Y, Kim J, Mao X et al. EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell 2008; 32: 491-502.
    • (2008) Mol Cell , vol.32 , pp. 491-502
    • Shen, X.1    Liu, Y.2    Hsu, Y.J.3    Fujiwara, Y.4    Kim, J.5    Mao, X.6
  • 48
    • 79952220410 scopus 로고    scopus 로고
    • EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair
    • Ezhkova E, Lien W-H, Stokes N, Pasolli HA, Silva JM, Fuchs E. EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair. Genes Dev 2011; 25: 485-498.
    • (2011) Genes Dev , vol.25 , pp. 485-498
    • Ezhkova, E.1    Lien, W.-H.2    Stokes, N.3    Pasolli, H.A.4    Silva, J.M.5    Fuchs, E.6
  • 49
    • 84055218931 scopus 로고    scopus 로고
    • Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells
    • Mochizuki-Kashio M, Mishima Y, Miyagi S, Negishi M, Saraya A, Konuma T et al. Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells. Blood 2011; 118: 6553-6561.
    • (2011) Blood , vol.118 , pp. 6553-6561
    • Mochizuki-Kashio, M.1    Mishima, Y.2    Miyagi, S.3    Negishi, M.4    Saraya, A.5    Konuma, T.6
  • 50
    • 33646870495 scopus 로고    scopus 로고
    • Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
    • Bracken AP, Dietrich N, Pasini D, Hansen KH, Helin K. Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev 2006; 20: 1123-1136.
    • (2006) Genes Dev , vol.20 , pp. 1123-1136
    • Bracken, A.P.1    Dietrich, N.2    Pasini, D.3    Hansen, K.H.4    Helin, K.5
  • 51
  • 52
    • 33746407708 scopus 로고    scopus 로고
    • Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing
    • Schoeftner S, Sengupta AK, Kubicek S, Mechtler K, Spahn L, Koseki H et al. Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing. EMBO J 2006; 25: 3110-3122.
    • (2006) EMBO J , vol.25 , pp. 3110-3122
    • Schoeftner, S.1    Sengupta, A.K.2    Kubicek, S.3    Mechtler, K.4    Spahn, L.5    Koseki, H.6
  • 53
    • 33845898866 scopus 로고    scopus 로고
    • Polycomb recruitment to DNA in vivo by the YY1 REPO domain
    • Wilkinson FH, Park K, Atchison ML. Polycomb recruitment to DNA in vivo by the YY1 REPO domain. Proc Natl Acad Sci USA 2006; 103: 19296-19301.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 19296-19301
    • Wilkinson, F.H.1    Park, K.2    Atchison, M.L.3
  • 54
    • 33745151459 scopus 로고    scopus 로고
    • A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities
    • Klymenko T, Papp B, Fischle W, Kocher T, Schelder M, Fritsch C et al. A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities. Genes Dev 2006; 20: 1110-1122.
    • (2006) Genes Dev , vol.20 , pp. 1110-1122
    • Klymenko, T.1    Papp, B.2    Fischle, W.3    Kocher, T.4    Schelder, M.5    Fritsch, C.6
  • 55
    • 73149111929 scopus 로고    scopus 로고
    • A region of the human HOXD cluster that confers polycomb-group responsiveness
    • Woo CJ, Kharchenko PV, Daheron L, Park PJ, Kingston RE. A region of the human HOXD cluster that confers polycomb-group responsiveness. Cell 2010; 140: 99-110.
    • (2010) Cell , vol.140 , pp. 99-110
    • Woo, C.J.1    Kharchenko, P.V.2    Daheron, L.3    Park, P.J.4    Kingston, R.E.5
  • 56
    • 34250364559 scopus 로고    scopus 로고
    • Analysis of overrepresented motifs in human core promoters reveals dual regulatory roles of YY1
    • Xi H, Yu Y, Fu Y, Foley J, Halees A, Weng Z. Analysis of overrepresented motifs in human core promoters reveals dual regulatory roles of YY1. Genome Res 2007; 17: 798-806.
    • (2007) Genome Res , vol.17 , pp. 798-806
    • Xi, H.1    Yu, Y.2    Fu, Y.3    Foley, J.4    Halees, A.5    Weng, Z.6
  • 57
    • 79952274283 scopus 로고    scopus 로고
    • Yin 1 Yang A multifaceted protein beyond a transcription factor
    • Deng Z, Cao P, Wan M, Sui G, Yin 1 Yang. A multifaceted protein beyond a transcription factor. Transcription 2010; 1: 81-84.
    • (2010) Transcription , vol.1 , pp. 81-84
    • Deng, Z.1    Cao, P.2    Wan, M.3    Sui, G.4
  • 58
    • 84866359488 scopus 로고    scopus 로고
    • GATA-1 utilizes Ikaros and the Polycomb Repressive Complex 2 to suppress Hes1 and to promote erythropoiesis
    • Ross J, Mavoungou L, Bresnick EH, Milot E. GATA-1 utilizes Ikaros and the Polycomb Repressive Complex 2 to suppress Hes1 and to promote erythropoiesis. Mol Cell Biol 2012; 32: 3624-3638.
    • (2012) Mol Cell Biol , vol.32 , pp. 3624-3638
    • Ross, J.1    Mavoungou, L.2    Bresnick, E.H.3    Milot, E.4
  • 59
    • 84858969865 scopus 로고    scopus 로고
    • Hypermethylated in cancer 1 (HIC1) recruits polycomb repressive complex 2 (PRC2) to a subset of its target genes through interaction with human polycomb-like (hPCL) proteins
    • Boulay G, Dubuissez M, Van Rechem C, Forget A, Helin K, Ayrault O et al. Hypermethylated in cancer 1 (HIC1) recruits polycomb repressive complex 2 (PRC2) to a subset of its target genes through interaction with human polycomb-like (hPCL) proteins. J Biol Chem 2012; 1: 10509-10524.
    • (2012) J Biol Chem , vol.1 , pp. 10509-10524
    • Boulay, G.1    Dubuissez, M.2    Van Rechem, C.3    Forget, A.4    Helin, K.5    Ayrault, O.6
  • 61
    • 84863012512 scopus 로고    scopus 로고
    • Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors
    • Yu M, Mazor T, Huang H, Huang H-T, Kathrein KL, Woo AJ et al. Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors. Mol Cell 2012; 45: 330-343.
    • (2012) Mol Cell , vol.45 , pp. 330-343
    • Yu, M.1    Mazor, T.2    Huang, H.3    Huang, H.-T.4    Kathrein, K.L.5    Woo, A.J.6
  • 62
    • 0344223442 scopus 로고    scopus 로고
    • RYBP a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1
    • Garca E, Marcos-Gutie rrez C, Del Mar Lorente M, Moreno JC, Vidal M. RYBP a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1. EMBO J 1999; 18: 3404-3418.
    • (1999) EMBO J , vol.18 , pp. 3404-3418
    • Garca, E.1    Marcos-Gutie Rrez, C.2    Del Mar Lorente, M.3    Moreno, J.C.4    Vidal, M.5
  • 63
    • 10344258563 scopus 로고    scopus 로고
    • Enhanced selfrenewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1
    • Iwama A, Oguro H, Negishi M, Kato Y, Morita Y, Tsukui H et al. Enhanced selfrenewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1. Immunity 2004; 21: 843-851.
    • (2004) Immunity , vol.21 , pp. 843-851
    • Iwama, A.1    Oguro, H.2    Negishi, M.3    Kato, Y.4    Morita, Y.5    Tsukui, H.6
  • 64
    • 0038349957 scopus 로고    scopus 로고
    • Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    • Park IK, Qian D, Kiel M, Becker MW, Pihalja M, Weissman IL et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 2003; 423: 302-305.
    • (2003) Nature , vol.423 , pp. 302-305
    • Park, I.K.1    Qian, D.2    Kiel, M.3    Becker, M.W.4    Pihalja, M.5    Weissman, I.L.6
  • 65
    • 0028201742 scopus 로고
    • Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene
    • van der Lugt NM, Domen J, Linders K, van Roon M, Robanus-Maandag E, te Riele H et al. Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev 1994; 8: 757-769.
    • (1994) Genes Dev , vol.8 , pp. 757-769
    • Van Der Lugt, N.M.1    Domen, J.2    Linders, K.3    Van Roon, M.4    Robanus-Maandag, E.5    Te Riele, H.6
  • 66
    • 70349563368 scopus 로고    scopus 로고
    • Repression of BMI1 in normal and leukemic human CD34(\+) cells impairs self-renewal and induces apoptosis
    • Rizo A, Olthof S, Han L, Vellenga E, de Haan G, Schuringa JJ. Repression of BMI1 in normal and leukemic human CD34(\+) cells impairs self-renewal and induces apoptosis. Blood 2009; 114: 1498-1505.
    • (2009) Blood , vol.114 , pp. 1498-1505
    • Rizo, A.1    Olthof, S.2    Han, L.3    Vellenga, E.4    De Haan, G.5    Schuringa, J.J.6
  • 67
    • 0030849638 scopus 로고    scopus 로고
    • The role of mel-18, a mammalian Polycomb group gene, during IL-7-dependent proliferation of lymphocyte precursors
    • Akasaka T, Tsuji K, Kawahira H, Kanno M, Harigaya K, Hu L et al. The role of mel-18, a mammalian Polycomb group gene, during IL-7-dependent proliferation of lymphocyte precursors. Immunity 1997; 7: 135-146.
    • (1997) Immunity , vol.7 , pp. 135-146
    • Akasaka, T.1    Tsuji, K.2    Kawahira, H.3    Kanno, M.4    Harigaya, K.5    Hu, L.6
  • 68
    • 2942618531 scopus 로고    scopus 로고
    • Polycomb group gene mel-18 modulates the self-renewal activity and cell cycle status of hematopoietic stem cells
    • Kajiume T, Ninomiya Y, Ishihara H, Kanno R, Kanno M. Polycomb group gene mel-18 modulates the self-renewal activity and cell cycle status of hematopoietic stem cells. Exp Hematol 2004; 32: 571-578.
    • (2004) Exp Hematol , vol.32 , pp. 571-578
    • Kajiume, T.1    Ninomiya, Y.2    Ishihara, H.3    Kanno, R.4    Kanno, M.5
  • 69
    • 0032519809 scopus 로고    scopus 로고
    • Stage-specific expression of polycomb group genes in human bone marrow cells
    • Lessard J, Baban S, Sauvageau G. Stage-specific expression of polycomb group genes in human bone marrow cells. Blood 1998; 91: 1216-1224.
    • (1998) Blood , vol.91 , pp. 1216-1224
    • Lessard, J.1    Baban, S.2    Sauvageau, G.3
  • 70
    • 33750030758 scopus 로고    scopus 로고
    • The regulation of INK4/ARF in cancer and aging
    • Kim WY, Sharpless NE. The regulation of INK4/ARF in cancer and aging. Cell 2006; 127: 265-275.
    • (2006) Cell , vol.127 , pp. 265-275
    • Kim, W.Y.1    Sharpless, N.E.2
  • 71
    • 77449159608 scopus 로고    scopus 로고
    • Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1
    • Oguro H, Yuan J, Ichikawa H, Ikawa T, Yamazaki S, Kawamoto H et al. Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1. Cell Stem Cell 2010; 6: 279-286.
    • (2010) Cell Stem Cell , vol.6 , pp. 279-286
    • Oguro, H.1    Yuan, J.2    Ichikawa, H.3    Ikawa, T.4    Yamazaki, S.5    Kawamoto, H.6
  • 72
    • 33749350639 scopus 로고    scopus 로고
    • Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice
    • Oguro H, Iwama A, Morita Y, Kamijo T, van Lohuizen M, Nakauchi H. Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice. J Exp Med 2006; 203: 2247-2253.
    • (2006) J Exp Med , vol.203 , pp. 2247-2253
    • Oguro, H.1    Iwama, A.2    Morita, Y.3    Kamijo, T.4    Van Lohuizen, M.5    Nakauchi, H.6
  • 73
    • 67349156082 scopus 로고    scopus 로고
    • Bmi1 regulates mitochondrial function and the DNA damage response pathway
    • Liu J, Cao L, Chen J, Song S, Lee IH, Quijano C et al. Bmi1 regulates mitochondrial function and the DNA damage response pathway. Nature 2009; 459: 387-392.
    • (2009) Nature , vol.459 , pp. 387-392
    • Liu, J.1    Cao, L.2    Chen, J.3    Song, S.4    Lee, I.H.5    Quijano, C.6
  • 74
    • 77957748289 scopus 로고    scopus 로고
    • BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair
    • Ismail IH, Andrin C, McDonald D, Hendzel MJ. BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair. J Cell Biol 2010; 191: 45-60.
    • (2010) J Cell Biol , vol.191 , pp. 45-60
    • Ismail, I.H.1    Andrin, C.2    McDonald, D.3    Hendzel, M.J.4
  • 75
    • 77955381770 scopus 로고    scopus 로고
    • BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery
    • Facchino S, Abdouh M, Chatoo W, Bernier G. BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery. J Neurosci 2010; 30: 10096-10111.
    • (2010) J Neurosci , vol.30 , pp. 10096-10111
    • Facchino, S.1    Abdouh, M.2    Chatoo, W.3    Bernier, G.4
  • 76
    • 79952633107 scopus 로고    scopus 로고
    • Polycomb group proteins in the DNA damage response: A link between radiation resistance and 'stemness'
    • Gieni RS, Ismail IH, Campbell S, Hendzel MJ. Polycomb group proteins in the DNA damage response: a link between radiation resistance and 'stemness'. Cell Cycle 2011; 10: 883-894.
    • (2011) Cell Cycle , vol.10 , pp. 883-894
    • Gieni, R.S.1    Ismail, I.H.2    Campbell, S.3    Hendzel, M.J.4
  • 77
    • 0031049215 scopus 로고    scopus 로고
    • Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice
    • Core N, Bel S, Gaunt SJ, Aurrand-Lions M, Pearce J, Fisher A et al. Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice. Development 1997; 124: 721-729.
    • (1997) Development , vol.124 , pp. 721-729
    • Core, N.1    Bel, S.2    Gaunt, S.J.3    Aurrand-Lions, M.4    Pearce, J.5    Fisher, A.6
  • 78
    • 0035655540 scopus 로고    scopus 로고
    • Polycomb-group genes as regulators of mammalian lymphopoiesis
    • Raaphorst FM, Otte AP, Meijer CJ. Polycomb-group genes as regulators of mammalian lymphopoiesis. Trends Immunol 2001; 22: 682-690.
    • (2001) Trends Immunol , vol.22 , pp. 682-690
    • Raaphorst, F.M.1    Otte, A.P.2    Meijer, C.J.3
  • 79
    • 33847622174 scopus 로고    scopus 로고
    • Unique composition of polycomb repressive complex 1 in hematopoietic stem cells
    • Kato Y, Koseki H, Vidal M, Nakauchi H, Iwama A. Unique composition of polycomb repressive complex 1 in hematopoietic stem cells. Int J Hematol 2007; 85: 179-181.
    • (2007) Int J Hematol , vol.85 , pp. 179-181
    • Kato, Y.1    Koseki, H.2    Vidal, M.3    Nakauchi, H.4    Iwama, A.5
  • 82
    • 0030729636 scopus 로고    scopus 로고
    • Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects
    • Takihara Y, Tomotsune D, Shirai M, Katoh-Fukui Y, Nishii K, Motaleb MA et al. Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects. Development 1997; 124: 3673-3682.
    • (1997) Development , vol.124 , pp. 3673-3682
    • Takihara, Y.1    Tomotsune, D.2    Shirai, M.3    Katoh-Fukui, Y.4    Nishii, K.5    Motaleb, M.A.6
  • 83
    • 0035172279 scopus 로고    scopus 로고
    • Lack of the Polycomb-group gene rae28 causes maturation arrest at the early B-cell developmental stage
    • Tokimasa S, Ohta H, Sawada A, Matsuda Y, Kim JY, Nishiguchi S et al. Lack of the Polycomb-group gene rae28 causes maturation arrest at the early B-cell developmental stage. Exp Hematol 2001; 29: 93-103.
    • (2001) Exp Hematol , vol.29 , pp. 93-103
    • Tokimasa, S.1    Ohta, H.2    Sawada, A.3    Matsuda, Y.4    Kim, J.Y.5    Nishiguchi, S.6
  • 84
    • 0037128662 scopus 로고    scopus 로고
    • Polycomb group gene rae28 is required for sustaining activity of hematopoietic stem cells
    • Ohta H, Sawada A, Kim JY, Tokimasa S, Nishiguchi S, Humphries RK et al. Polycomb group gene rae28 is required for sustaining activity of hematopoietic stem cells. J Exp Med 2002; 195: 759-770.
    • (2002) J Exp Med , vol.195 , pp. 759-770
    • Ohta, H.1    Sawada, A.2    Kim, J.Y.3    Tokimasa, S.4    Nishiguchi, S.5    Humphries, R.K.6
  • 85
    • 3242759042 scopus 로고    scopus 로고
    • Defective long-term repopulating ability in hematopoietic stem cells lacking the Polycomb-group gene rae28
    • Kim JY, Sawada A, Tokimasa S, Endo H, Ozono K, Hara J et al. Defective long-term repopulating ability in hematopoietic stem cells lacking the Polycomb-group gene rae28. Eur J Haematol 2004; 73: 75-84.
    • (2004) Eur J Haematol , vol.73 , pp. 75-84
    • Kim, J.Y.1    Sawada, A.2    Tokimasa, S.3    Endo, H.4    Ozono, K.5    Hara, J.6
  • 86
    • 38549106607 scopus 로고    scopus 로고
    • Inactivation of the polycomb group protein Ring1B unveils an antiproliferative role in hematopoietic cell expansion and cooperation with tumorigenesis associated with Ink4a deletion
    • Cales C, Roman-Trufero M, Pavon L, Serrano I, Melgar T, Endoh M et al. Inactivation of the polycomb group protein Ring1B unveils an antiproliferative role in hematopoietic cell expansion and cooperation with tumorigenesis associated with Ink4a deletion. Mol Cell Biol 2008; 28: 1018-1028.
    • (2008) Mol Cell Biol , vol.28 , pp. 1018-1028
    • Cales, C.1    Roman-Trufero, M.2    Pavon, L.3    Serrano, I.4    Melgar, T.5    Endoh, M.6
  • 87
    • 77956282774 scopus 로고    scopus 로고
    • Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells
    • Majewski IJ, Ritchie ME, Phipson B, Corbin J, Pakusch M, Ebert A et al. Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells. Blood 2010; 116: 731-739.
    • (2010) Blood , vol.116 , pp. 731-739
    • Majewski, I.J.1    Ritchie, M.E.2    Phipson, B.3    Corbin, J.4    Pakusch, M.5    Ebert, A.6
  • 88
    • 84856118147 scopus 로고    scopus 로고
    • Increased expression of PcG protein YY1 negatively regulates B cell development while allowing accumulation of myeloid cells and LT-HSC cells
    • Pan X, Jones M, Jiang J, Zaprazna K, Yu D, Pear W et al. Increased expression of PcG protein YY1 negatively regulates B cell development while allowing accumulation of myeloid cells and LT-HSC cells. PLoS ONE 2012; 7: e30656.
    • (2012) PLoS ONE , vol.7
    • Pan, X.1    Jones, M.2    Jiang, J.3    Zaprazna, K.4    Yu, D.5    Pear, W.6
  • 89
    • 34548392803 scopus 로고    scopus 로고
    • Epigenetic control of hematopoietic stem cell aging the case of Ezh2
    • De Haan G, Gerrits A. Epigenetic control of hematopoietic stem cell aging the case of Ezh2. Ann NY Acad Sci 2007; 1106: 233-239.
    • (2007) Ann NY Acad Sci , vol.1106 , pp. 233-239
    • De Haan, G.1    Gerrits, A.2
  • 90
  • 91
    • 84856746717 scopus 로고    scopus 로고
    • Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease
    • Herrera-Merchan A, Arranz L, Ligos JM, de Molina A, Dominguez O, Gonzalez S. Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease. Nat Commun 2012; 3: 623.
    • (2012) Nat Commun , vol.3 , pp. 623
    • Herrera-Merchan, A.1    Arranz, L.2    Ligos, J.M.3    De Molina, A.4    Dominguez, O.5    Gonzalez, S.6
  • 93
  • 96
    • 0033569429 scopus 로고    scopus 로고
    • Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF
    • Jacobs JJ, Scheijen B, Voncken JW, Kieboom K, Berns A, van Lohuizen M. Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF. Genes Dev 1999; 13: 2678-2690.
    • (1999) Genes Dev , vol.13 , pp. 2678-2690
    • Jacobs, J.J.1    Scheijen, B.2    Voncken, J.W.3    Kieboom, K.4    Berns, A.5    Van Lohuizen, M.6
  • 97
    • 84860364648 scopus 로고    scopus 로고
    • Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes
    • Oguro H, Yuan J, Tanaka S, Miyagi S, Mochizuki-Kashio M, Ichikawa H et al. Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes. J Exp Med 2012; 209: 445-454.
    • (2012) J Exp Med , vol.209 , pp. 445-454
    • Oguro, H.1    Yuan, J.2    Tanaka, S.3    Miyagi, S.4    Mochizuki-Kashio, M.5    Ichikawa, H.6
  • 98
    • 78650495421 scopus 로고    scopus 로고
    • Polycomb proteins in hematologic malignancies
    • Martin-Perez D, Piris MA, Sanchez-Beato M. Polycomb proteins in hematologic malignancies. Blood 2010; 116: 5465-5475.
    • (2010) Blood , vol.116 , pp. 5465-5475
    • Martin-Perez, D.1    Piris, M.A.2    Sanchez-Beato, M.3
  • 99
    • 77956222562 scopus 로고    scopus 로고
    • Polycomb group proteins: Multi-faceted regulators of somatic stem cells and cancer
    • Sauvageau M, Sauvageau G. Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer. Cell Stem Cell 2010; 7: 299-313.
    • (2010) Cell Stem Cell , vol.7 , pp. 299-313
    • Sauvageau, M.1    Sauvageau, G.2
  • 101
    • 30144443995 scopus 로고    scopus 로고
    • Bmi-1 is useful as a novel molecular marker for predicting progression of myelodysplastic syndrome and patient prognosis
    • Mihara K, Chowdhury M, Nakaju N, Hidani S, Ihara A, Hyodo H et al. Bmi-1 is useful as a novel molecular marker for predicting progression of myelodysplastic syndrome and patient prognosis. Blood 2006; 107: 305-308.
    • (2006) Blood , vol.107 , pp. 305-308
    • Mihara, K.1    Chowdhury, M.2    Nakaju, N.3    Hidani, S.4    Ihara, A.5    Hyodo, H.6
  • 102
    • 79956145260 scopus 로고    scopus 로고
    • Overexpression of the EZH2 RING1 and BMI1 genes is common in myelodysplastic syndromes: Relation to adverse epigenetic alteration and poor prognostic scoring
    • Xu F, Li X, Wu L, Zhang Q, Yang R, Yang Y et al. Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: relation to adverse epigenetic alteration and poor prognostic scoring. Ann Hematol 2011; 90: 643-653.
    • (2011) Ann Hematol , vol.90 , pp. 643-653
    • Xu, F.1    Li, X.2    Wu, L.3    Zhang, Q.4    Yang, R.5    Yang, Y.6
  • 103
    • 34247560765 scopus 로고    scopus 로고
    • Expression of Polycomb-group (PcG) protein BMI-1 predicts prognosis in patients with acute myeloid leukemia
    • Chowdhury M, Mihara K, Yasunaga S, Ohtaki M, Takihara Y, Kimura A. Expression of Polycomb-group (PcG) protein BMI-1 predicts prognosis in patients with acute myeloid leukemia. Leukemia 2007; 21: 1116-1122.
    • (2007) Leukemia , vol.21 , pp. 1116-1122
    • Chowdhury, M.1    Mihara, K.2    Yasunaga, S.3    Ohtaki, M.4    Takihara, Y.5    Kimura, A.6
  • 104
    • 34249692139 scopus 로고    scopus 로고
    • The polycomb group BMI1 gene is a molecular marker for predicting prognosis of chronic myeloid leukemia
    • Mohty M, Yong AS, Szydlo RM, Apperley JF, Melo JV. The polycomb group BMI1 gene is a molecular marker for predicting prognosis of chronic myeloid leukemia. Blood 2007; 110: 380-383.
    • (2007) Blood , vol.110 , pp. 380-383
    • Mohty, M.1    Yong, A.S.2    Szydlo, R.M.3    Apperley, J.F.4    Melo, J.V.5
  • 105
    • 79954443802 scopus 로고    scopus 로고
    • Improved outcome following allogeneic stem cell transplantation in chronic myeloid leukemia is associated with higher expression of BMI-1 and immune responses to BMI-1 protein
    • Yong AS, Stephens N, Weber G, Li Y, Savani BN, Eniafe R et al. Improved outcome following allogeneic stem cell transplantation in chronic myeloid leukemia is associated with higher expression of BMI-1 and immune responses to BMI-1 protein. Leukemia 2011; 25: 629-637.
    • (2011) Leukemia , vol.25 , pp. 629-637
    • Yong, A.S.1    Stephens, N.2    Weber, G.3    Li, Y.4    Savani, B.N.5    Eniafe, R.6
  • 106
  • 107
    • 0035877978 scopus 로고    scopus 로고
    • Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma
    • van Kemenade FJ, Raaphorst FM, Blokzijl T, Fieret E, Hamer KM, Satijn DP et al. Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma. Blood 2001; 97: 3896-3901.
    • (2001) Blood , vol.97 , pp. 3896-3901
    • Van Kemenade, F.J.1    Raaphorst, F.M.2    Blokzijl, T.3    Fieret, E.4    Hamer, K.M.5    Satijn, D.P.6
  • 108
    • 33749185394 scopus 로고    scopus 로고
    • SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice
    • Ma Y, Cui W, Yang J, Qu J, Di C, Amin HM et al. SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice. Blood 2006; 108: 2726-2735.
    • (2006) Blood , vol.108 , pp. 2726-2735
    • Ma, Y.1    Cui, W.2    Yang, J.3    Qu, J.4    Di Amin C, H.M.5
  • 110
    • 0032126633 scopus 로고    scopus 로고
    • Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b
    • Kroon E, Krosl J, Thorsteinsdottir U, Baban S, Buchberg AM, Sauvageau G. Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b. EMBO J 1998; 17: 3714-3725.
    • (1998) EMBO J , vol.17 , pp. 3714-3725
    • Kroon, E.1    Krosl, J.2    Thorsteinsdottir, U.3    Baban, S.4    Buchberg, A.M.5    Sauvageau, G.6
  • 111
    • 0037673984 scopus 로고    scopus 로고
    • Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
    • Lessard J, Sauvageau G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 2003; 423: 255-260.
    • (2003) Nature , vol.423 , pp. 255-260
    • Lessard, J.1    Sauvageau, G.2
  • 112
    • 80051794055 scopus 로고    scopus 로고
    • Bmi1 is essential for leukemic reprogramming of myeloid progenitor cells
    • Yuan J, Takeuchi M, Negishi M, Oguro H, Ichikawa H, Iwama A. Bmi1 is essential for leukemic reprogramming of myeloid progenitor cells. Leukemia 2011; 25: 1335-1343.
    • (2011) Leukemia , vol.25 , pp. 1335-1343
    • Yuan, J.1    Takeuchi, M.2    Negishi, M.3    Oguro, H.4    Ichikawa, H.5    Iwama, A.6
  • 113
    • 33746498580 scopus 로고    scopus 로고
    • Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9
    • Krivtsov AV, Twomey D, Feng Z, Stubbs MC, Wang Y, Faber J et al. Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature 2006; 442: 818-822.
    • (2006) Nature , vol.442 , pp. 818-822
    • Krivtsov, A.V.1    Twomey, D.2    Feng, Z.3    Stubbs, M.C.4    Wang, Y.5    Faber, J.6
  • 114
    • 0025117392 scopus 로고
    • Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome
    • Daley GQ, Van Etten RA, Baltimore D. Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science 1990; 247: 824-830.
    • (1990) Science , vol.247 , pp. 824-830
    • Daley, G.Q.1    Van Etten, R.A.2    Baltimore, D.3
  • 115
    • 78649478552 scopus 로고    scopus 로고
    • BMI1 collaborates with BCR-ABL in leukemic transformation of human CD34\+ cells
    • Rizo A, Horton SJ, Olthof S, Dontje B, Ausema A, van Os R et al. BMI1 collaborates with BCR-ABL in leukemic transformation of human CD34\+ cells. Blood 2010; 116: 4621-4630.
    • (2010) Blood , vol.116 , pp. 4621-4630
    • Rizo, A.1    Horton, S.J.2    Olthof, S.3    Dontje, B.4    Ausema, A.5    Van Os, R.6
  • 116
    • 84855846941 scopus 로고    scopus 로고
    • Bmi1 reprograms CML B-lymphoid progenitors to become B-ALL-initiating cells
    • Sengupta A, Ficker AM, Dunn SK, Madhu M, Cancelas JA. Bmi1 reprograms CML B-lymphoid progenitors to become B-ALL-initiating cells. Blood 2012; 119: 494-502.
    • (2012) Blood , vol.119 , pp. 494-502
    • Sengupta, A.1    Ficker, A.M.2    Dunn, S.K.3    Madhu, M.4    Cancelas, J.A.5
  • 117
    • 1242316271 scopus 로고    scopus 로고
    • Unique polycomb gene expression pattern in Hodgkin's lymphoma and Hodgkin's lymphoma-derived cell lines
    • Dukers DF, van Galen JC, Giroth C, Jansen P, Sewalt RG, Otte AP et al. Unique polycomb gene expression pattern in Hodgkin's lymphoma and Hodgkin's lymphoma-derived cell lines. Am J Pathol 2004; 164: 873-881.
    • (2004) Am J Pathol , vol.164 , pp. 873-881
    • Dukers, D.F.1    Van Galen, J.C.2    Giroth, C.3    Jansen, P.4    Sewalt, R.G.5    Otte, A.P.6
  • 118
    • 1542349930 scopus 로고    scopus 로고
    • Sitespecific expression of polycomb-group genes encoding the HPC-HPH/PRC1 complex in clinically defined primary nodal and cutaneous large B-cell lymphomas
    • Raaphorst FM, Vermeer M, Fieret E, Blokzijl T, Dukers D, Sewalt RG et al. Sitespecific expression of polycomb-group genes encoding the HPC-HPH/PRC1 complex in clinically defined primary nodal and cutaneous large B-cell lymphomas. Am J Pathol 2004; 164: 533-542.
    • (2004) Am J Pathol , vol.164 , pp. 533-542
    • Raaphorst, F.M.1    Vermeer, M.2    Fieret, E.3    Blokzijl, T.4    Dukers, D.5    Sewalt, R.G.6
  • 120
    • 81255192170 scopus 로고    scopus 로고
    • CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis
    • Tan J, Jones M, Koseki H, Nakayama M, Muntean AG, Maillard I et al. CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis. Cancer Cell 2011; 20: 563-575.
    • (2011) Cancer Cell , vol.20 , pp. 563-575
    • Tan, J.1    Jones, M.2    Koseki, H.3    Nakayama, M.4    Muntean, A.G.5    Maillard, I.6
  • 121
    • 0035945657 scopus 로고    scopus 로고
    • The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3
    • Garcia-Cuellar MP, Zilles O, Schreiner SA, Birke M, Winkler TH, Slany RK. The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3. Oncogene 2001; 20: 411-419.
    • (2001) Oncogene , vol.20 , pp. 411-419
    • Garcia-Cuellar, M.P.1    Zilles, O.2    Schreiner, S.A.3    Birke, M.4    Winkler, T.H.5    Slany, R.K.6
  • 123
    • 33646161725 scopus 로고    scopus 로고
    • Variability in the expression of polycomb proteins in different normal and tumoral tissues A pilot study using tissue microarrays
    • Sanchez-Beato M, Sanchez E, Gonzalez-Carrero J, Morente M, Diez A, Sanchez-Verde L et al. Variability in the expression of polycomb proteins in different normal and tumoral tissues. A pilot study using tissue microarrays. Mod Pathol 2006; 19: 684-694.
    • (2006) Mod Pathol , vol.19 , pp. 684-694
    • Sanchez-Beato, M.1    Sanchez, E.2    Gonzalez-Carrero, J.3    Morente, M.4    Diez, A.5    Sanchez-Verde, L.6
  • 124
    • 0030661972 scopus 로고    scopus 로고
    • 12p abnormalities and the TEL gene (ETV6) in childhood acute lymphoblastic leukemia
    • Raimondi SC, Shurtleff SA, Downing JR, Rubnitz J, Mathew S, Hancock M et al. 12p abnormalities and the TEL gene (ETV6) in childhood acute lymphoblastic leukemia. Blood 1997; 90: 4559-4566.
    • (1997) Blood , vol.90 , pp. 4559-4566
    • Raimondi, S.C.1    Shurtleff, S.A.2    Downing, J.R.3    Rubnitz, J.4    Mathew, S.5    Hancock, M.6
  • 125
    • 0031453531 scopus 로고    scopus 로고
    • Heterogeneity in the breakpoints in balanced rearrangements involving band 12p13 in hematologic malignancies identified by fluorescence in situ hybridization: TEL (ETV6 ) is involved in only one half
    • Sato Y, Bohlander SK, Kobayashi H, Reshmi S, Suto Y, Davis EM et al. Heterogeneity in the breakpoints in balanced rearrangements involving band 12p13 in hematologic malignancies identified by fluorescence in situ hybridization: TEL (ETV6 ) is involved in only one half. Blood 1997; 90: 4886-4893.
    • (1997) Blood , vol.90 , pp. 4886-4893
    • Sato, Y.1    Bohlander, S.K.2    Kobayashi, H.3    Reshmi, S.4    Suto, Y.5    Davis, E.M.6
  • 126
    • 0032101546 scopus 로고    scopus 로고
    • Clinical significance of cytogenetic abnormalities in adult acute lymphoblastic leukemia
    • Faderl S, Kantarjian HM, Talpaz M, Estrov Z. Clinical significance of cytogenetic abnormalities in adult acute lymphoblastic leukemia. Blood 1998; 91: 3995-4019.
    • (1998) Blood , vol.91 , pp. 3995-4019
    • Faderl, S.1    Kantarjian, H.M.2    Talpaz, M.3    Estrov, Z.4
  • 127
    • 75749124332 scopus 로고    scopus 로고
    • Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
    • Morin RD, Johnson NA, Severson TM, Mungall AJ, An J, Goya R et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat Genet 2010; 42: 181-185.
    • (2010) Nat Genet , vol.42 , pp. 181-185
    • Morin, R.D.1    Johnson, N.A.2    Severson, T.M.3    Mungall, A.J.4    An, J.5    Goya, R.6
  • 129
    • 78650454078 scopus 로고    scopus 로고
    • Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
    • Sneeringer CJ, Scott MP, Kuntz KW, Knutson SK, Pollock RM, Richon VM et al. Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas. Proc Natl Acad Sci USA 2010; 107: 20980-20985.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 20980-20985
    • Sneeringer, C.J.1    Scott, M.P.2    Kuntz, K.W.3    Knutson, S.K.4    Pollock, R.M.5    Richon, V.M.6
  • 130
    • 84870573126 scopus 로고    scopus 로고
    • EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
    • McCabe MT, Ott HM, Ganji G, Korenchuk S, Thompson C, Van Aller GS et al. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. Nature 2012; 492: 108-112.
    • (2012) Nature , vol.492 , pp. 108-112
    • McCabe, M.T.1    Ott, H.M.2    Ganji, G.3    Korenchuk, S.4    Thompson, C.5    Van Aller, G.S.6
  • 132
    • 84862907593 scopus 로고    scopus 로고
    • The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
    • Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D et al. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature 2012; 481: 157-163.
    • (2012) Nature , vol.481 , pp. 157-163
    • Zhang, J.1    Ding, L.2    Holmfeldt, L.3    Wu, G.4    Heatley, S.L.5    Payne-Turner, D.6
  • 133
    • 77955085750 scopus 로고    scopus 로고
    • Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
    • Ernst T, Chase AJ, Score J, Hidalgo-Curtis CE, Bryant C, Jones AV et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet 2010; 42: 722-726.
    • (2010) Nat Genet , vol.42 , pp. 722-726
    • Ernst, T.1    Chase, A.J.2    Score, J.3    Hidalgo-Curtis, C.E.4    Bryant, C.5    Jones, A.V.6
  • 134
  • 136
    • 84856596417 scopus 로고    scopus 로고
    • Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms
    • Score J, Hidalgo-Curtis C, Jones AV, Winkelmann N, Skinner A, Ward D et al. Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms. Blood 2012; 119: 1208-1213.
    • (2012) Blood , vol.119 , pp. 1208-1213
    • Score, J.1    Hidalgo-Curtis, C.2    Jones, A.V.3    Winkelmann, N.4    Skinner, A.5    Ward, D.6
  • 137
    • 84859831338 scopus 로고    scopus 로고
    • A complex Polycomb issue: The two faces of EZH2 in cancer
    • Hock H. A complex Polycomb issue: the two faces of EZH2 in cancer. Genes Dev 2012; 26: 751-755.
    • (2012) Genes Dev , vol.26 , pp. 751-755
    • Hock, H.1
  • 138
    • 84859295400 scopus 로고    scopus 로고
    • A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia
    • Simon C, Chagraoui J, Krosl J, Gendron P, Wilhelm B, Lemieux S et al. A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia. Genes Dev 2012; 26: 651-656.
    • (2012) Genes Dev , vol.26 , pp. 651-656
    • Simon, C.1    Chagraoui, J.2    Krosl, J.3    Gendron, P.4    Wilhelm, B.5    Lemieux, S.6
  • 140
    • 79959674418 scopus 로고    scopus 로고
    • Epigenetics of haematopoietic cell development
    • Cedar H, Bergman Y. Epigenetics of haematopoietic cell development. Nat Rev Immunol 2011; 11: 478-488.
    • (2011) Nat Rev Immunol , vol.11 , pp. 478-488
    • Cedar, H.1    Bergman, Y.2
  • 141
    • 0032880120 scopus 로고    scopus 로고
    • Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality
    • Donohoe ME, Zhang X, McGinnis L, Biggers J, Li E, Shi Y. Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality. Mol Cell Biol 1999; 19: 7237-7244.
    • (1999) Mol Cell Biol , vol.19 , pp. 7237-7244
    • Donohoe, M.E.1    Zhang, X.2    McGinnis, L.3    Biggers, J.4    Li, E.5    Shi, Y.6
  • 142
    • 0028910338 scopus 로고
    • The eed mutation disrupts anterior mesoderm production in mice
    • Faust C, Schumacher A, Holdener B, Magnuson T. The eed mutation disrupts anterior mesoderm production in mice. Development 1995; 121: 273-285.
    • (1995) Development , vol.121 , pp. 273-285
    • Faust, C.1    Schumacher, A.2    Holdener, B.3    Magnuson, T.4
  • 143
    • 8144230178 scopus 로고    scopus 로고
    • Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity
    • Pasini D, Bracken AP, Jensen MR, Lazzerini Denchi E, Helin K. Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J 2004; 23: 4061-4071.
    • (2004) EMBO J , vol.23 , pp. 4061-4071
    • Pasini, D.1    Bracken, A.P.2    Jensen, M.R.3    Lazzerini Denchi, E.4    Helin, K.5
  • 145
    • 0037050254 scopus 로고    scopus 로고
    • The Polycomb-group gene eed regulates thymocyte differentiation and suppresses the development of carcinogen-induced T-cell lymphomas
    • Richie ER, Schumacher A, Angel JM, Holloway M, Rinchik EM, Magnuson T. The Polycomb-group gene eed regulates thymocyte differentiation and suppresses the development of carcinogen-induced T-cell lymphomas. Oncogene 2002; 21: 299-306.
    • (2002) Oncogene , vol.21 , pp. 299-306
    • Richie, E.R.1    Schumacher, A.2    Angel, J.M.3    Holloway, M.4    Rinchik, E.M.5    Magnuson, T.6
  • 146
    • 38349107912 scopus 로고    scopus 로고
    • Quantitative expression profiling guided by common retroviral insertion sites reveals novel and cell type specific cancer genes in leukemia
    • Sauvageau M, Miller M, Lemieux S, Lessard J, Hebert J, Sauvageau G. Quantitative expression profiling guided by common retroviral insertion sites reveals novel and cell type specific cancer genes in leukemia. Blood 2008; 111: 790-799.
    • (2008) Blood , vol.111 , pp. 790-799
    • Sauvageau, M.1    Miller, M.2    Lemieux, S.3    Lessard, J.4    Hebert, J.5    Sauvageau, G.6


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