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Volumn 26, Issue 3, 2013, Pages 368-378

Development of an in vitro dendritic cell-based test for skin sensitizer identification

Author keywords

[No Author keywords available]

Indexed keywords

1 FLUORO 2,4 DINITROBENZENE; BENZALKONIUM CHLORIDE; DODECYL SULFATE SODIUM; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NICKEL SULFATE; OXAZOLONE; PHENYLENEDIAMINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; THIOREDOXIN REDUCTASE 1;

EID: 84875168719     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx300472d     Document Type: Article
Times cited : (23)

References (57)
  • 1
    • 35248880520 scopus 로고    scopus 로고
    • The epidemiology of contact allergy in the general population: Prevalence and main findings
    • Thyssen, J. P., Linneberg, A., Menne, T., and Johansen, J. D. (2007) The epidemiology of contact allergy in the general population: Prevalence and main findings Contact Dermatitis 57, 287-299
    • (2007) Contact Dermatitis , vol.57 , pp. 287-299
    • Thyssen, J.P.1    Linneberg, A.2    Menne, T.3    Johansen, J.D.4
  • 2
    • 0024356617 scopus 로고
    • A murine local lymph node assay for the identification of contact allergens. Assay development and results of an initial validation study
    • Kimber, I. and Weisenberger, C. (1989) A murine local lymph node assay for the identification of contact allergens. Assay development and results of an initial validation study Arch. Toxicol. 63, 274-282
    • (1989) Arch. Toxicol. , vol.63 , pp. 274-282
    • Kimber, I.1    Weisenberger, C.2
  • 3
    • 0014480637 scopus 로고
    • The identification of contact allergens by animal assay. The guinea pig maximization test
    • Magnusson, B. and Kligman, A. M. (1969) The identification of contact allergens by animal assay. The guinea pig maximization test J. Invest. Dermatol. 52, 268-276
    • (1969) J. Invest. Dermatol. , vol.52 , pp. 268-276
    • Magnusson, B.1    Kligman, A.M.2
  • 4
    • 0001267196 scopus 로고
    • Delayed contact hypersensitivity in the guinea pig
    • Buehler, E. V. (1965) Delayed Contact Hypersensitivity in the Guinea Pig Arch. Dermatol. 91, 171-177
    • (1965) Arch. Dermatol. , vol.91 , pp. 171-177
    • Buehler, E.V.1
  • 5
    • 0142177156 scopus 로고    scopus 로고
    • EC 2003. 2003/15/EC. Commission Directive of 27 February 2003 amending Council Directive 76/768/EEC on the approximation of laws of the Member States relating to cosmetic products
    • European Commission () - 35
    • European Commission (2003) EC 2003. 2003/15/EC. Commission Directive of 27 February 2003 amending Council Directive 76/768/EEC on the approximation of laws of the Member States relating to cosmetic products Official Journal of the European Union L66, 26-35
    • (2003) Official Journal of the European Union , vol.66 , pp. 26
  • 6
    • 78449295622 scopus 로고    scopus 로고
    • European Regulation, (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products
    • European Commission () - 209
    • European Commission (2009) European Regulation, (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products Official Journal of the European Union L342, 59-209
    • (2009) Official Journal of the European Union , vol.342 , pp. 59
  • 7
    • 84875163117 scopus 로고    scopus 로고
    • Note
    • European Union () - 849
    • European Union (2006) European Regulation, 2006. Regulation (EU) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC Official Journal of the European Union L396, 1-849
    • (2006) Official Journal of the European Union , vol.396 , pp. 1
  • 8
    • 63649098913 scopus 로고    scopus 로고
    • Progress on the development of human in vitro dendritic cell based assays for assessment of the sensitizing potential of a compound
    • dos Santos, G. G., Reinders, J., Ouwehand, K., Rustemeyer, T., Scheper, R. J., and Gibbs, S. (2009) Progress on the development of human in vitro dendritic cell based assays for assessment of the sensitizing potential of a compound Toxicol. Appl. Pharmacol. 236, 372-382
    • (2009) Toxicol. Appl. Pharmacol. , vol.236 , pp. 372-382
    • Dos Santos, G.G.1    Reinders, J.2    Ouwehand, K.3    Rustemeyer, T.4    Scheper, R.J.5    Gibbs, S.6
  • 9
    • 0036889788 scopus 로고    scopus 로고
    • Evaluation of CD86 expression and MHC class II molecule internalization in THP-1 human monocyte cells as predictive endpoints for contact sensitizers
    • Ashikaga, T., Hoya, M., Itagaki, H., Katsumura, Y., and Aiba, S. (2002) Evaluation of CD86 expression and MHC class II molecule internalization in THP-1 human monocyte cells as predictive endpoints for contact sensitizers Toxicol. In Vitro 16, 711-716
    • (2002) Toxicol. in Vitro , vol.16 , pp. 711-716
    • Ashikaga, T.1    Hoya, M.2    Itagaki, H.3    Katsumura, Y.4    Aiba, S.5
  • 10
    • 0036389674 scopus 로고    scopus 로고
    • Elucidating changes in surface marker expression of dendritic cells following chemical allergen treatment
    • Hulette, B. C., Ryan, C. A., and Gerberick, G. F. (2002) Elucidating changes in surface marker expression of dendritic cells following chemical allergen treatment Toxicol. Appl. Pharmacol. 182, 226-233
    • (2002) Toxicol. Appl. Pharmacol. , vol.182 , pp. 226-233
    • Hulette, B.C.1    Ryan, C.A.2    Gerberick, G.F.3
  • 11
    • 59149095125 scopus 로고    scopus 로고
    • HMOX1 and NQO1 genes are upregulated in response to contact sensitizers in dendritic cells and THP-1 cell line: Role of the Keap1/Nrf2 pathway
    • Ade, N., Leon, F., Pallardy, M., Peiffer, J. L., Kerdine-Romer, S., Tissier, M. H., Bonnet, P. A., Fabre, I., and Ourlin, J. C. (2009) HMOX1 and NQO1 genes are upregulated in response to contact sensitizers in dendritic cells and THP-1 cell line: Role of the Keap1/Nrf2 pathway Toxicol. Sci. 107, 451-460
    • (2009) Toxicol. Sci. , vol.107 , pp. 451-460
    • Ade, N.1    Leon, F.2    Pallardy, M.3    Peiffer, J.L.4    Kerdine-Romer, S.5    Tissier, M.H.6    Bonnet, P.A.7    Fabre, I.8    Ourlin, J.C.9
  • 13
    • 33947719856 scopus 로고    scopus 로고
    • Assessment of the U937 cell line for the detection of contact allergens
    • Python, F., Goebel, C., and Aeby, P. (2007) Assessment of the U937 cell line for the detection of contact allergens Toxicol. Appl. Pharmacol. 220, 113-124
    • (2007) Toxicol. Appl. Pharmacol. , vol.220 , pp. 113-124
    • Python, F.1    Goebel, C.2    Aeby, P.3
  • 14
    • 39549123001 scopus 로고    scopus 로고
    • Differential modulation of CXCR4 and CD40 protein levels by skin sensitizers and irritants in the FSDC cell line
    • Neves, B. M., Cruz, M. T., Francisco, V., Goncalo, M., Figueiredo, A., Duarte, C. B., and Lopes, M. C. (2008) Differential modulation of CXCR4 and CD40 protein levels by skin sensitizers and irritants in the FSDC cell line Toxicol. Lett. 177, 74-82
    • (2008) Toxicol. Lett. , vol.177 , pp. 74-82
    • Neves, B.M.1    Cruz, M.T.2    Francisco, V.3    Goncalo, M.4    Figueiredo, A.5    Duarte, C.B.6    Lopes, M.C.7
  • 15
    • 0034616086 scopus 로고    scopus 로고
    • In vitro evaluation of the sensitization potential of weak contact allergens using langerhans-like dendritic cells and autologous T cells
    • Rougier, N., Redziniak, G., Mougin, D., Schmitt, D., and Vincent, C. (2000) In vitro evaluation of the sensitization potential of weak contact allergens using langerhans-like dendritic cells and autologous T cells Toxicology 145, 73-82
    • (2000) Toxicology , vol.145 , pp. 73-82
    • Rougier, N.1    Redziniak, G.2    Mougin, D.3    Schmitt, D.4    Vincent, C.5
  • 17
    • 0036015703 scopus 로고    scopus 로고
    • Phenotypic alterations and IL-1β production in CD34(+) progenitor- and monocyte-derived dendritic cells after exposure to allergens: A comparative analysis
    • De Smedt, A. C., Van Den Heuvel, R. L., Van Tendeloo, V. F., Berneman, Z. N., Schoeters, G. E., Weber, E., and Tuschl, H. (2002) Phenotypic alterations and IL-1β production in CD34(+) progenitor- and monocyte-derived dendritic cells after exposure to allergens: A comparative analysis Arch. Dermatol. Res. 294, 109-116
    • (2002) Arch. Dermatol. Res. , vol.294 , pp. 109-116
    • De Smedt, A.C.1    Van Den Heuvel, R.L.2    Van Tendeloo, V.F.3    Berneman, Z.N.4    Schoeters, G.E.5    Weber, E.6    Tuschl, H.7
  • 19
    • 1942517450 scopus 로고    scopus 로고
    • Gene expression changes in peripheral blood-derived dendritic cells following exposure to a contact allergen
    • Ryan, C. A., Gildea, L. A., Hulette, B. C., Dearman, R. J., Kimber, I., and Gerberick, G. F. (2004) Gene expression changes in peripheral blood-derived dendritic cells following exposure to a contact allergen Toxicol. Lett. 150, 301-316
    • (2004) Toxicol. Lett. , vol.150 , pp. 301-316
    • Ryan, C.A.1    Gildea, L.A.2    Hulette, B.C.3    Dearman, R.J.4    Kimber, I.5    Gerberick, G.F.6
  • 20
    • 33746176069 scopus 로고    scopus 로고
    • Identification of gene expression changes induced by chemical allergens in dendritic cells: Opportunities for skin sensitization testing
    • Gildea, L. A., Ryan, C. A., Foertsch, L. M., Kennedy, J. M., Dearman, R. J., Kimber, I., and Gerberick, G. F. (2006) Identification of gene expression changes induced by chemical allergens in dendritic cells: Opportunities for skin sensitization testing J. Invest. Dermatol. 126, 1813-1822
    • (2006) J. Invest. Dermatol. , vol.126 , pp. 1813-1822
    • Gildea, L.A.1    Ryan, C.A.2    Foertsch, L.M.3    Kennedy, J.M.4    Dearman, R.J.5    Kimber, I.6    Gerberick, G.F.7
  • 23
    • 77957132598 scopus 로고    scopus 로고
    • Prediction of the contact sensitizing potential of chemicals using analysis of gene expression changes in human THP-1 monocytes
    • Arkusz, J., Stepnik, M., Sobala, W., and Dastych, J. (2010) Prediction of the contact sensitizing potential of chemicals using analysis of gene expression changes in human THP-1 monocytes Toxicol. Lett. 199, 51-59
    • (2010) Toxicol. Lett. , vol.199 , pp. 51-59
    • Arkusz, J.1    Stepnik, M.2    Sobala, W.3    Dastych, J.4
  • 24
    • 79961120567 scopus 로고    scopus 로고
    • A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests
    • Johansson, H., Lindstedt, M., Albrekt, A. S., and Borrebaeck, C. A. (2011) A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests BMC Genomics 12, 399
    • (2011) BMC Genomics , vol.12 , pp. 399
    • Johansson, H.1    Lindstedt, M.2    Albrekt, A.S.3    Borrebaeck, C.A.4
  • 25
    • 78650559757 scopus 로고    scopus 로고
    • Signal transduction profile of chemical sensitisers in dendritic cells: An endpoint to be included in a cell-based in vitro alternative approach to hazard identification?
    • Neves, B. M., Goncalo, M., Figueiredo, A., Duarte, C. B., Lopes, M. C., and Cruz, M. T. (2011) Signal transduction profile of chemical sensitisers in dendritic cells: An endpoint to be included in a cell-based in vitro alternative approach to hazard identification? Toxicol. Appl. Pharmacol. 250, 87-95
    • (2011) Toxicol. Appl. Pharmacol. , vol.250 , pp. 87-95
    • Neves, B.M.1    Goncalo, M.2    Figueiredo, A.3    Duarte, C.B.4    Lopes, M.C.5    Cruz, M.T.6
  • 26
    • 75249099695 scopus 로고    scopus 로고
    • The Nrf2-Keap1-ARE toxicity pathway as a cellular sensor for skin sensitizers: Functional relevance and a hypothesis on innate reactions to skin sensitizers
    • Natsch, A. (2010) The Nrf2-Keap1-ARE toxicity pathway as a cellular sensor for skin sensitizers: Functional relevance and a hypothesis on innate reactions to skin sensitizers Toxicol. Sci. 113, 284-292
    • (2010) Toxicol. Sci. , vol.113 , pp. 284-292
    • Natsch, A.1
  • 27
    • 39149086011 scopus 로고    scopus 로고
    • Skin sensitizers induce antioxidant response element dependent genes: Application to the in vitro testing of the sensitization potential of chemicals
    • Natsch, A. and Emter, R. (2008) Skin sensitizers induce antioxidant response element dependent genes: Application to the in vitro testing of the sensitization potential of chemicals Toxicol. Sci. 102, 110-119
    • (2008) Toxicol. Sci. , vol.102 , pp. 110-119
    • Natsch, A.1    Emter, R.2
  • 28
    • 0035869634 scopus 로고    scopus 로고
    • A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-α, and contact sensitizers
    • Arrighi, J. F., Rebsamen, M., Rousset, F., Kindler, V., and Hauser, C. (2001) A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-α, and contact sensitizers J. Immunol. 166, 3837-3845
    • (2001) J. Immunol. , vol.166 , pp. 3837-3845
    • Arrighi, J.F.1    Rebsamen, M.2    Rousset, F.3    Kindler, V.4    Hauser, C.5
  • 29
    • 23044493875 scopus 로고    scopus 로고
    • DNFB activates MAPKs and upregulates CD40 in skin-derived dendritic cells
    • Matos, T. J., Duarte, C. B., Goncalo, M., and Lopes, M. C. (2005) DNFB activates MAPKs and upregulates CD40 in skin-derived dendritic cells J. Dermatol. Sci. 39, 113-123
    • (2005) J. Dermatol. Sci. , vol.39 , pp. 113-123
    • Matos, T.J.1    Duarte, C.B.2    Goncalo, M.3    Lopes, M.C.4
  • 30
    • 77956180476 scopus 로고    scopus 로고
    • Use of IL-8 release and p38 MAPK activation in THP-1 cells to identify allergens and to assess their potency in vitro
    • Mitjans, M., Galbiati, V., Lucchi, L., Viviani, B., Marinovich, M., Galli, C. L., and Corsini, E. (2010) Use of IL-8 release and p38 MAPK activation in THP-1 cells to identify allergens and to assess their potency in vitro Toxicol. In Vitro 24, 1803-1809
    • (2010) Toxicol. in Vitro , vol.24 , pp. 1803-1809
    • Mitjans, M.1    Galbiati, V.2    Lucchi, L.3    Viviani, B.4    Marinovich, M.5    Galli, C.L.6    Corsini, E.7
  • 36
    • 27744606605 scopus 로고    scopus 로고
    • Relationship of CD86 surface marker expression and cytotoxicity on dendritic cells exposed to chemical allergen
    • Hulette, B. C., Ryan, C. A., Gildea, L. A., and Gerberick, G. F. (2005) Relationship of CD86 surface marker expression and cytotoxicity on dendritic cells exposed to chemical allergen Toxicol. Appl. Pharmacol. 209, 159-166
    • (2005) Toxicol. Appl. Pharmacol. , vol.209 , pp. 159-166
    • Hulette, B.C.1    Ryan, C.A.2    Gildea, L.A.3    Gerberick, G.F.4
  • 37
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann, T. (1983) Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays J. Immunol. Methods 65, 55-63
    • (1983) J. Immunol. Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 39
    • 33745450390 scopus 로고    scopus 로고
    • Development of an in vitro skin sensitization test using human cell lines: The human Cell Line Activation Test (h-CLAT). I. Optimization of the h-CLAT protocol
    • Ashikaga, T., Yoshida, Y., Hirota, M., Yoneyama, K., Itagaki, H., Sakaguchi, H., Miyazawa, M., Ito, Y., Suzuki, H., and Toyoda, H. (2006) Development of an in vitro skin sensitization test using human cell lines: The human Cell Line Activation Test (h-CLAT). I. Optimization of the h-CLAT protocol Toxicol. In Vitro 20, 767-773
    • (2006) Toxicol. in Vitro , vol.20 , pp. 767-773
    • Ashikaga, T.1    Yoshida, Y.2    Hirota, M.3    Yoneyama, K.4    Itagaki, H.5    Sakaguchi, H.6    Miyazawa, M.7    Ito, Y.8    Suzuki, H.9    Toyoda, H.10
  • 42
    • 0037336383 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase and extracellular signal-regulated kinases play distinct roles in the activation of dendritic cells by two representative haptens, NiCl2 and 2,4-dinitrochlorobenzene
    • Aiba, S., Manome, H., Nakagawa, S., Mollah, Z. U., Mizuashi, M., Ohtani, T., Yoshino, Y., and Tagami, H. (2003) p38 mitogen-activated protein kinase and extracellular signal-regulated kinases play distinct roles in the activation of dendritic cells by two representative haptens, NiCl2 and 2,4- dinitrochlorobenzene J. Invest. Dermatol. 120, 390-399
    • (2003) J. Invest. Dermatol. , vol.120 , pp. 390-399
    • Aiba, S.1    Manome, H.2    Nakagawa, S.3    Mollah, Z.U.4    Mizuashi, M.5    Ohtani, T.6    Yoshino, Y.7    Tagami, H.8
  • 43
    • 59249105382 scopus 로고    scopus 로고
    • Metallic haptens induce differential phenotype of human dendritic cells through activation of mitogen-activated protein kinase and NF-κB pathways
    • Antonios, D., Ade, N., Kerdine-Romer, S., Assaf-Vandecasteele, H., Larange, A., Azouri, H., and Pallardy, M. (2009) Metallic haptens induce differential phenotype of human dendritic cells through activation of mitogen-activated protein kinase and NF-κB pathways Toxicol. In Vitro 23, 227-234
    • (2009) Toxicol. in Vitro , vol.23 , pp. 227-234
    • Antonios, D.1    Ade, N.2    Kerdine-Romer, S.3    Assaf-Vandecasteele, H.4    Larange, A.5    Azouri, H.6    Pallardy, M.7
  • 44
    • 38549091168 scopus 로고    scopus 로고
    • Role of p38 MAPK in the selective release of IL-8 induced by chemical allergen in naive THp-1 cells
    • Mitjans, M., Viviani, B., Lucchi, L., Galli, C. L., Marinovich, M., and Corsini, E. (2008) Role of p38 MAPK in the selective release of IL-8 induced by chemical allergen in naive THp-1 cells Toxicol. In Vitro 22, 386-395
    • (2008) Toxicol. in Vitro , vol.22 , pp. 386-395
    • Mitjans, M.1    Viviani, B.2    Lucchi, L.3    Galli, C.L.4    Marinovich, M.5    Corsini, E.6
  • 45
    • 46749122589 scopus 로고    scopus 로고
    • Characterization of early events involved in human dendritic cell maturation induced by sensitizers: Cross talk between MAPK signalling pathways
    • Trompezinski, S., Migdal, C., Tailhardat, M., Le Varlet, B., Courtellemont, P., Haftek, M., and Serres, M. (2008) Characterization of early events involved in human dendritic cell maturation induced by sensitizers: Cross talk between MAPK signalling pathways Toxicol. Appl. Pharmacol. 230, 397-406
    • (2008) Toxicol. Appl. Pharmacol. , vol.230 , pp. 397-406
    • Trompezinski, S.1    Migdal, C.2    Tailhardat, M.3    Le Varlet, B.4    Courtellemont, P.5    Haftek, M.6    Serres, M.7
  • 46
    • 10044279431 scopus 로고    scopus 로고
    • Implication of the MAPK pathways in the maturation of human dendritic cells induced by nickel and TNF-α
    • Boisleve, F., Kerdine-Romer, S., and Pallardy, M. (2005) Implication of the MAPK pathways in the maturation of human dendritic cells induced by nickel and TNF-α Toxicology 206, 233-244
    • (2005) Toxicology , vol.206 , pp. 233-244
    • Boisleve, F.1    Kerdine-Romer, S.2    Pallardy, M.3
  • 47
    • 19444384370 scopus 로고    scopus 로고
    • JNK activation limits dendritic cell maturation in response to reactive oxygen species by the induction of apoptosis
    • Handley, M. E., Thakker, M., Pollara, G., Chain, B. M., and Katz, D. R. (2005) JNK activation limits dendritic cell maturation in response to reactive oxygen species by the induction of apoptosis Free Radical Biol. Med. 38, 1637-1652
    • (2005) Free Radical Biol. Med. , vol.38 , pp. 1637-1652
    • Handley, M.E.1    Thakker, M.2    Pollara, G.3    Chain, B.M.4    Katz, D.R.5
  • 48
    • 15044359360 scopus 로고    scopus 로고
    • Redox imbalance induced by contact sensitizers triggers the maturation of dendritic cells
    • Mizuashi, M., Ohtani, T., Nakagawa, S., and Aiba, S. (2005) Redox imbalance induced by contact sensitizers triggers the maturation of dendritic cells J. Invest. Dermatol. 124, 579-586
    • (2005) J. Invest. Dermatol. , vol.124 , pp. 579-586
    • Mizuashi, M.1    Ohtani, T.2    Nakagawa, S.3    Aiba, S.4
  • 50
    • 36148995114 scopus 로고    scopus 로고
    • In vitro differentiation of skin sensitizers by cell signaling pathways
    • Koeper, L. M., Schulz, A., Ahr, H. J., and Vohr, H. W. (2007) In vitro differentiation of skin sensitizers by cell signaling pathways Toxicology 242, 144-152
    • (2007) Toxicology , vol.242 , pp. 144-152
    • Koeper, L.M.1    Schulz, A.2    Ahr, H.J.3    Vohr, H.W.4
  • 51
    • 79751490387 scopus 로고    scopus 로고
    • Characterization of skin sensitizing chemicals: A lesson learnt from nickel allergy
    • Kimber, I., Basketter, D. A., McFadden, J. P., and Dearman, R. J. (2011) Characterization of skin sensitizing chemicals: A lesson learnt from nickel allergy J. Immunotoxicol. 8, 1-2
    • (2011) J. Immunotoxicol. , vol.8 , pp. 1-2
    • Kimber, I.1    Basketter, D.A.2    McFadden, J.P.3    Dearman, R.J.4
  • 52
    • 0026088677 scopus 로고
    • Nickel-sulphate-induced contact dermatitis in the guinea pig maximization test: A dose-response study
    • Rohold, A. E., Nielsen, G. D., and Andersen, K. E. (1991) Nickel-sulphate-induced contact dermatitis in the guinea pig maximization test: A dose-response study Contact Dermatitis 24, 35-39
    • (1991) Contact Dermatitis , vol.24 , pp. 35-39
    • Rohold, A.E.1    Nielsen, G.D.2    Andersen, K.E.3
  • 53
    • 0033864251 scopus 로고    scopus 로고
    • Incidence rates of occupational allergic contact dermatitis caused by metals
    • Kanerva, L., Jolanki, R., Estlander, T., Alanko, K., and Savela, A. (2000) Incidence rates of occupational allergic contact dermatitis caused by metals Dermatitis 11, 155-160
    • (2000) Dermatitis , vol.11 , pp. 155-160
    • Kanerva, L.1    Jolanki, R.2    Estlander, T.3    Alanko, K.4    Savela, A.5
  • 54
    • 63349086579 scopus 로고    scopus 로고
    • Expression of surface markers on the human monocytic leukaemia cell line, THP-1, as indicators for the sensitizing potential of chemicals
    • An, S., Kim, S., Huh, Y., Lee, T. R., Kim, H. K., Park, K. L., and Eun, H. C. (2009) Expression of surface markers on the human monocytic leukaemia cell line, THP-1, as indicators for the sensitizing potential of chemicals Contact Dermatitis 60, 185-192
    • (2009) Contact Dermatitis , vol.60 , pp. 185-192
    • An, S.1    Kim, S.2    Huh, Y.3    Lee, T.R.4    Kim, H.K.5    Park, K.L.6    Eun, H.C.7
  • 56
    • 34447547764 scopus 로고    scopus 로고
    • Quantification of chemical peptide reactivity for screening contact allergens: A classification tree model approach
    • Gerberick, G. F., Vassallo, J. D., Foertsch, L. M., Price, B. B., Chaney, J. G., and Lepoittevin, J. P. (2007) Quantification of chemical peptide reactivity for screening contact allergens: A classification tree model approach Toxicol. Sci. 97, 417-427
    • (2007) Toxicol. Sci. , vol.97 , pp. 417-427
    • Gerberick, G.F.1    Vassallo, J.D.2    Foertsch, L.M.3    Price, B.B.4    Chaney, J.G.5    Lepoittevin, J.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.