Evaluation of CD86 expression and MHC class II molecule internalization in THP-1 human monocyte cells as predictive endpoints for contact sensitizers

Toxicology in Vitro

Volumn 16, Issue 6, 2002, Pages 711-716

  Ashikaga, T ^a   Hoya, M ^a   Itagaki, H ^a   Katsumura, Y ^a   Aiba, S ^b  

^a Safety Research Labs   (Japan)

^b TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

CD86; Contact sensitizer; In vitro sensitization assay; Moocyte

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; 2 MERCAPTOBENZOTHIAZOLE; AMMONIUM DERIVATIVE; CD86 ANTIGEN; COBALT SULFATE; DIMETHYL SULFOXIDE; DODECYL SULFATE SODIUM; EUGENOL; GAMMA INTERFERON; IRRITANT AGENT; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NICKEL SULFATE; PHENYLENEDIAMINE; SALICYLIC ACID METHYL ESTER; TETRACHLOROPLATINATE AMMONIUM; UNCLASSIFIED DRUG; CD86 PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN;

ARTICLE; CELL CULTURE; CELL LINE; CONCENTRATION RESPONSE; CONTACT SENSITIZATION; CONTROLLED STUDY; DENDRITIC CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERNALIZATION; MOLECULAR MODEL; MONOCYTE; PREDICTION; PROTEIN EXPRESSION; TOXICITY; ANIMAL TESTING ALTERNATIVE; BIOASSAY; BIOSYNTHESIS; CONTACT DERMATITIS; CULTURE TECHNIQUE; DRUG SCREENING; GENE; GENE EXPRESSION REGULATION; IMMUNOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; PREDICTION AND FORECASTING;

ANIMAL TESTING ALTERNATIVES; ANTIGENS, CD; ANTIGENS, CD86; CELL CULTURE TECHNIQUES; DERMATITIS, CONTACT; DRUG EVALUATION, PRECLINICAL; ENDPOINT DETERMINATION; GENE EXPRESSION REGULATION; GENES, MHC CLASS II; HUMANS; IRRITANTS; MEMBRANE GLYCOPROTEINS; MONOCYTES; PHENOTYPE; PREDICTIVE VALUE OF TESTS;

EID: 0036889788     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(02)00060-7     Document Type: Article

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