Differential roles of PI3-Kinase, MAPKs and NF-κB on the manipulation of dendritic cell Th1/Th2 cytokine/chemokine polarizing profile

Molecular Immunology

Volumn 46, Issue 13, 2009, Pages 2481-2492

  Neves, Bruno Miguel ^a,b   Cruz, Maria Teresa ^a,b   Francisco, Vera ^a,b   Garcia Rodriguez, Cármen ^c   Silvestre, Ricardo ^d   Cordeiro da Silva, Anabela ^d   Dinis, Augusto M ^a   Batista, Maria Teresa ^a   Duarte, Carlos B ^b   Lopes, Maria Celeste ^a,b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF VALLADOLID   (Spain)

^d UNIVERSITY OF PORTO   (Portugal)

Author keywords

Chemokines; Cytokines; Dendritic cells; Signal transduction pathways; T cell polarization

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; CXCL2 CHEMOKINE; GRANULOCYTE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; RANTES;

ANIMAL CELL; ARTICLE; CELL MATURATION; CELL STRUCTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; ENZYME ACTIVATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TH1 CELL; TH2 CELL; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIGENS, CD80; ANTIGENS, CD86; BLOTTING, FAR-WESTERN; CELL LINE; CHEMOKINES; CYTOKINES; DENDRITIC CELLS; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HISTOCOMPATIBILITY ANTIGENS; LIPOPOLYSACCHARIDES; MICE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TH1 CELLS; TH2 CELLS;

EID: 67650397827     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2009.05.021     Document Type: Article

References (75)

1. Aiba S. Maturation of dendritic cells induced by cytokines and haptens. Tohoku J. Exp. Med. 184 (1998) 159-172
2. Aiba S., and Tagami H. Dendritic cell activation induced by various stimuli, e.g. exposure to microorganisms, their products, cytokines, and simple chemicals as well as adhesion to extracellular matrix. J. Dermatol. Sci. 20 (1998) 1-13
3. Ajuebor M.N., Hogaboam C.M., Kunkel S.L., Proudfoot A.E., and Wallace J.L. The chemokine RANTES is a crucial mediator of the progression from acute to chronic colitis in the rat. J. Immunol. 166 (2001) 552-558
4. An H., Yu Y., Zhang M., Xu H., Qi R., Yan X., Liu S., Wang W., Guo Z., Guo J., Qin Z., and Cao X. Involvement of ERK, p38 and NF-kappaB signal transduction in regulation of TLR2, TLR4 and TLR9 gene expression induced by lipopolysaccharide in mouse dendritic cells. Immunology 106 (2002) 38-45
5. Arrighi J.F., Rebsamen M., Rousset F., Kindler V., and Hauser C. A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-alpha, and contact sensitizers. J. Immunol. 166 (2001) 3837-3845
6. Azenshtein E., Luboshits G., Shina S., Neumark E., Shahbazian D., Weil M., Wigler N., Keydar I., and Ben-Baruch A. The CC chemokine RANTES in breast carcinoma progression: regulation of expression and potential mechanisms of promalignant activity. Cancer Res. 62 (2002) 1093-1102
7. Banchereau J., Briere F., Caux C., Davoust J., Lebecque S., Liu Y.J., Pulendran B., and Palucka K. Immunobiology of dendritic cells. Annu. Rev. Immunol. 18 (2000) 767-811
8. Banchereau J., and Palucka A.K. Dendritic cells as therapeutic vaccines against cancer. Nat. Rev. Immunol. 5 (2005) 296-306
9. Banchereau J., and Steinman R.M. Dendritic cells and the control of immunity. Nature 392 (1998) 245-252
10. Barnes D.A., Tse J., Kaufhold M., Owen M., Hesselgesser J., Strieter R., Horuk R., and Perez H.D. Polyclonal antibody directed against human RANTES ameliorates disease in the Lewis rat adjuvant-induced arthritis model. J. Clin. Invest. 101 (1998) 2910-2919
11. Blanco P., Palucka A.K., Pascual V., and Banchereau J. Dendritic cells and cytokines in human inflammatory and autoimmune diseases. Cytokine Growth Factor Rev. 19 (2008) 41-52
12. Bober L.A., Grace M.J., Pugliese-Sivo C., Rojas-Triana A., Sullivan L.M., and Narula S.K. The effects of colony stimulating factors on human monocyte cell function. Int. J. Immunopharmacol. 17 (1995) 385-392
13. Cella M., Salio M., Sakakibara Y., Langen H., Julkunen I., and Lanzavecchia A. Maturation, activation, and protection of dendritic cells induced by double-stranded RNA. J. Exp. Med. 189 (1999) 821-829
14. Cella M., Scheidegger D., Palmer-Lehmann K., Lane P., Lanzavecchia A., and Alber G. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184 (1996) 747-752
15. Cruz M.T., Duarte C.B., Goncalo M., Carvalho A.P., and Lopes M.C. LPS induction of I kappa B-alpha degradation and iNOS expression in a skin dendritic cell line is prevented by the janus kinase 2 inhibitor, Tyrphostin b42. Nitric Oxide 5 (2001) 53-61
16. De Smedt T., Pajak B., Muraille E., Lespagnard L., Heinen E., De Baetselier P., Urbain J., Leo O., and Moser M. Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo. J. Exp. Med. 184 (1996) 1413-1424
17. Diehl S., and Rincon M. The two faces of IL-6 on Th1/Th2 differentiation. Mol. Immunol. 39 (2002) 531-536
18. Dinis, A.M., Cruz, M.T., Lopes, M.C., Batista, M.T., 2009. A light, scanning electron and transmission electron microscopic study of a fetal mouse skin dendritic cell line (FSDC). Microsc. Microanal. in press.
19. Dowling D., Hamilton C.M., and O'Neill S.M. A comparative analysis of cytokine responses, cell surface marker expression and MAPKs in DCs matured with LPS compared with a panel of TLR ligands. Cytokine 41 (2008) 254-262
20. Girolomoni G., Lutz M.B., Pastore S., Assmann C.U., Cavani A., and Ricciardi-Castagnoli P. Establishment of a cell line with features of early dendritic cell precursors from fetal mouse skin. Eur. J. Immunol. 25 (1995) 2163-2169
21. Goede V., Brogelli L., Ziche M., and Augustin H.G. Induction of inflammatory angiogenesis by monocyte chemoattractant protein-1. Int. J. Cancer 82 (1999) 765-770
22. Gu L., Tseng S., Horner R.M., Tam C., Loda M., and Rollins B.J. Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1. Nature 404 (2000) 407-411
23. Guha M., and Mackman N. The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J. Biol. Chem. 277 (2002) 32124-32132
24. Hacker H., Mischak H., Miethke T., Liptay S., Schmid R., Sparwasser T., Heeg K., Lipford G.B., and Wagner H. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J. 17 (1998) 6230-6240
25. Hartmann G., Weiner G.J., and Krieg A.M. CpG DNA: a potent signal for growth, activation, and maturation of human dendritic cells. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 9305-9310
26. Hazeki K., Kinoshita S., Matsumura T., Nigorikawa K., Kubo H., and Hazeki O. Opposite effects of wortmannin and 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride on toll-like receptor-mediated nitric oxide production: negative regulation of nuclear factor-{kappa}B by phosphoinositide 3-kinase. Mol. Pharmacol. 69 (2006) 1717-1724
27. Horng T., Barton G.M., and Medzhitov R. TIRAP: an adapter molecule in the Toll signaling pathway. Nat. Immunol. 2 (2001) 835-841
28. Hoshino K., Takeuchi O., Kawai T., Sanjo H., Ogawa T., Takeda Y., Takeda K., and Akira S. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162 (1999) 3749-3752
29. Huang A.Y., Golumbek P., Ahmadzadeh M., Jaffee E., Pardoll D., and Levitsky H. Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens. Science 264 (1994) 961-965
30. Ichim T.E., Zhong R., and Min W.P. Prevention of allograft rejection by in vitro generated tolerogenic dendritic cells. Transpl. Immunol. 11 (2003) 295-306
31. Jonuleit H., Kuhn U., Muller G., Steinbrink K., Paragnik L., Schmitt E., Knop J., and Enk A.H. Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur. J. Immunol. 27 (1997) 3135-3142
32. Kaisho T., Takeuchi O., Kawai T., Hoshino K., and Akira S. Endotoxin-induced maturation of MyD88-deficient dendritic cells. J. Immunol. 166 (2001) 5688-5694
33. Kared H., Masson A., Adle-Biassette H., Bach J.F., Chatenoud L., and Zavala F. Treatment with granulocyte colony-stimulating factor prevents diabetes in NOD mice by recruiting plasmacytoid dendritic cells and functional CD4(+)CD25(+) regulatory T-cells. Diabetes 54 (2005) 78-84
34. Karpus W.J., Lukacs N.W., Kennedy K.J., Smith W.S., Hurst S.D., and Barrett T.A. Differential CC chemokine-induced enhancement of T helper cell cytokine production. J. Immunol. 158 (1997) 4129-4136
35. Kawai T., Takeuchi O., Fujita T., Inoue J., Muhlradt P.F., Sato S., Hoshino K., and Akira S. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J. Immunol. 167 (2001) 5887-5894
36. Kim Y.H., Choi K.H., Park J.W., and Kwon T.K. LY294002 inhibits LPS-induced NO production through a inhibition of NF-kappaB activation: independent mechanism of phosphatidylinositol 3-kinase. Immunol. Lett. 99 (2005) 45-50
37. Korn T., Mitsdoerffer M., Croxford A.L., Awasthi A., Dardalhon V.A., Galileos G., Vollmar P., Stritesky G.L., Kaplan M.H., Waisman A., Kuchroo V.K., and Oukka M. IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc. Natl. Acad. Sci. U.S.A. 105 (2008) 18460-18465
38. Lieschke G.J., Grail D., Hodgson G., Metcalf D., Stanley E., Cheers C., Fowler K.J., Basu S., Zhan Y.F., and Dunn A.R. Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization. Blood 84 (1994) 1737-1746
39. Lu B., Rutledge B.J., Gu L., Fiorillo J., Lukacs N.W., Kunkel S.L., North R., Gerard C., and Rollins B.J. Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J. Exp. Med. 187 (1998) 601-608
40. Luther S.A., and Cyster J.G. Chemokines as regulators of T cell differentiation. Nat. Immunol. 2 (2001) 102-107
41. Makino Y., Cook D.N., Smithies O., Hwang O.Y., Neilson E.G., Turka L.A., Sato H., Wells A.D., and Danoff T.M. Impaired T cell function in RANTES-deficient mice. Clin. Immunol. 102 (2002) 302-309
42. McColl S.R. Chemokines and dendritic cells: a crucial alliance. Immunol. Cell Biol. 80 (2002) 489-496
43. Mellman I., and Steinman R.M. Dendritic cells: specialized and regulated antigen processing machines. Cell 106 (2001) 255-258
44. Miller S.I., Ernst R.K., and Bader M.W. LPS, TLR4 and infectious disease diversity. Nat. Rev. Microbiol. 3 (2005) 36-46
45. Moore K.W., de Waal Malefyt R., Coffman R.L., and O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19 (2001) 683-765
46. Mrowietz U., Schwenk U., Maune S., Bartels J., Kupper M., Fichtner I., Schroder J.M., and Schadendorf D. The chemokine RANTES is secreted by human melanoma cells and is associated with enhanced tumour formation in nude mice. Br. J. Cancer 79 (1999) 1025-1031
47. Musial A., and Eissa N.T. Inducible nitric-oxide synthase is regulated by the proteasome degradation pathway. J. Biol. Chem. 276 (2001) 24268-24273
48. Muthuswamy R., Urban J., Lee J.J., Reinhart T.A., Bartlett D., and Kalinski P. Ability of mature dendritic cells to interact with regulatory T cells is imprinted during maturation. Cancer Res. 68 (2008) 5972-5978
49. Nachbaur D., and Kircher B. Dendritic cells in allogeneic hematopoietic stem cell transplantation. Leuk. Lymphoma 46 (2005) 1387-1396
50. Nakahara T., Moroi Y., Uchi H., and Furue M. Differential role of MAPK signaling in human dendritic cell maturation and Th1/Th2 engagement. J. Dermatol. Sci. 42 (2006) 1-11
51. Nakahara T., Uchi H., Urabe K., Chen Q., Furue M., and Moroi Y. Role of c-Jun N-terminal kinase on lipopolysaccharide induced maturation of human monocyte-derived dendritic cells. Int. Immunol. 16 (2004) 1701-1709
52. Neves B.M., Cruz M.T., Francisco V., Goncalo M., Figueiredo A., Duarte C.B., and Lopes M.C. Differential modulation of CXCR4 and CD40 protein levels by skin sensitizers and irritants in the FSDC cell line. Toxicol. Lett. 177 (2008) 74-82
53. Nouri-Shirazi M., Banchereau J., Fay J., and Palucka K. Dendritic cell based tumor vaccines. Immunol. Lett. 74 (2000) 5-10
54. Pan L., Delmonte Jr. J., Jalonen C.K., and Ferrara J.L. Pretreatment of donor mice with granulocyte colony-stimulating factor polarizes donor T lymphocytes toward type-2 cytokine production and reduces severity of experimental graft-versus-host disease. Blood 86 (1995) 4422-4429
55. Patel T.R., and Corbett S.A. Simvastatin suppresses LPS-induced Akt phosphorylation in the human monocyte cell line THP-1. J. Surg. Res. 116 (2004) 116-120
56. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29 (2001) e45
57. Poltorak A., He X., Smirnova I., Liu M.Y., Van Huffel C., Du X., Birdwell D., Alejos E., Silva M., Galanos C., Freudenberg M., Ricciardi-Castagnoli P., Layton B., and Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282 (1998) 2085-2088
58. Rescigno M., Granucci F., Citterio S., Foti M., and Ricciardi-Castagnoli P. Coordinated events during bacteria-induced DC maturation. Immunol. Today 20 (1999) 200-203
59. Rescigno M., Martino M., Sutherland C.L., Gold M.R., and Ricciardi-Castagnoli P. Dendritic cell survival and maturation are regulated by different signaling pathways. J. Exp. Med. 188 (1998) 2175-2180
60. Roake J.A., Rao A.S., Morris P.J., Larsen C.P., Hankins D.F., and Austyn J.M. Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1. J. Exp. Med. 181 (1995) 2237-2247
61. Sallusto F., Schaerli P., Loetscher P., Schaniel C., Lenig D., Mackay C.R., Qin S., and Lanzavecchia A. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation. Eur. J. Immunol. 28 (1998) 2760-2769
62. Sato K., Yamashita N., Baba M., and Matsuyama T. Modified myeloid dendritic cells act as regulatory dendritic cells to induce anergic and regulatory T cells. Blood 101 (2003) 3581-3589
63. Schrum S., Probst P., Fleischer B., and Zipfel P.F. Synthesis of the CC-chemokines MIP-1alpha, MIP-1beta, and RANTES is associated with a type 1 immune response. J. Immunol. 157 (1996) 3598-3604
64. Shen H., Tesar B.M., Walker W.E., and Goldstein D.R. Dual signaling of MyD88 and TRIF is critical for maximal TLR4-induced dendritic cell maturation. J. Immunol. 181 (2008) 1849-1858
65. Shen Z., Reznikoff G., Dranoff G., and Rock K.L. Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules. J. Immunol. 158 (1997) 2723-2730
66. Sigal L.J., Crotty S., Andino R., and Rock K.L. Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen. Nature 398 (1999) 77-80
67. Siveke J.T., and Hamann A. T helper 1 and T helper 2 cells respond differentially to chemokines. J. Immunol. 160 (1998) 550-554
68. Sloand E.M., Kim S., Maciejewski J.P., Van Rhee F., Chaudhuri A., Barrett J., and Young N.S. Pharmacologic doses of granulocyte colony-stimulating factor affect cytokine production by lymphocytes in vitro and in vivo. Blood 95 (2000) 2269-2274
69. Steinman R.M., and Banchereau J. Taking dendritic cells into medicine. Nature 449 (2007) 419-426
70. Verhasselt V., Buelens C., Willems F., De Groote D., Haeffner-Cavaillon N., and Goldman M. Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells: evidence for a soluble CD14-dependent pathway. J. Immunol. 158 (1997) 2919-2925
71. Vicari A.P., and Caux C. Chemokines in cancer. Cytokine Growth Factor Rev. 13 (2002) 143-154
72. Viola A., Molon B., and Contento R.L. Chemokines: coded messages for T-cell missions. Front. Biosci. 13 (2008) 6341-6353
73. Waldner H. The role of innate immune responses in autoimmune disease development. Autoimmun. Rev. 8 (2009) 400-404
74. Winzler C., Rovere P., Rescigno M., Granucci F., Penna G., Adorini L., Zimmermann V.S., Davoust J., and Ricciardi-Castagnoli P. Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures. J. Exp. Med. 185 (1997) 317-328
75. Xu L., Duan L., Cao K., Yuan G., Peng Y., Huang X., Xiang P., and Li S. Predominant immature CD8alpha+ dendritic cells prevent graft-vs.-host disease but do not increase the risk of leukemia recurrence. Eur. J. Haematol. 78 (2007) 235-245