Transfer of a two-tiered keratinocyte assay: IL-18 production by NCTC2544 to determine the skin sensitizing capacity and epidermal equivalent assay to determine sensitizer potency

Toxicology in Vitro

Volumn 27, Issue 3, 2013, Pages 1135-1150

  Teunis, Marc ^a   Corsini, Emanuela ^b   Smits, Mieke ^a   Madsen, Charlotte Bernhard ^c   Eltze, Tobias ^d   Ezendam, Janine ^e   Galbiati, Valentina ^b   Gremmer, Eric ^e   Krul, Cyrille ^a,f   Landin, Annette ^c   Landsiedel, Robert ^d   Pieters, Raymond ^a,i   Rasmussen, Tina Frid ^c   Reinders, Judith ^g   Roggen, Erwin ^h   Spiekstra, Sander ^g   Gibbs, Susan ^g  

^a UNIVERSITY OF APPLIED SCIENCES UTRECHT   (Netherlands)

^b UNIVERSITY OF MILAN   (Italy)

^c TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^d BASF SE   (Germany)

^e NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^f TNO   (Netherlands)

^g VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^h NOVOZYMES A S   (Denmark)

ⁱ UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Alternatives to animal use; Epidermal equivalent; Keratinocytes; Prevalidation; Ring study; Skin sensitization; Tiered test

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; CONTACT ALLERGEN; INTERLEUKIN 1ALPHA; INTERLEUKIN 8; LACTIC ACID; RESORCINOL; TUBERCULIN;

ARTICLE; CELL ASSAY; CELL DENSITY; CELL EXPOSURE; CELL LINE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOTOXICITY; EPIDERMAL EQUIVALENT ASSAY; EXPOSURE; HUMAN; HUMAN CELL; INTERMETHOD COMPARISON; KERATINOCYTE; NCTC2544 CELL LINE; PROTEIN CONTENT; PROTEIN EXPRESSION; REPRODUCIBILITY; SKIN SENSITIZATION; VALIDATION STUDY;

ANIMALIA;

EID: 84875378611     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2012.06.004     Document Type: Article

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