메뉴 건너뛰기




Volumn 1833, Issue 4, 2013, Pages 857-865

Targeting mitochondrial oxidative metabolism as an approach to treat heart failure

Author keywords

Carnitine palmitoyltransferase 1; Fatty acid oxidation; Glucose oxidation; Glycolysis; Heart failure; Mitochondria

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; MALONYL COENZYME A DECARBOXYLASE; PHOSPHOTRANSFERASE INHIBITOR; PYRUVATE DEHYDROGENASE KINASE;

EID: 84875068490     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2012.08.014     Document Type: Review
Times cited : (116)

References (143)
  • 3
    • 21244492310 scopus 로고    scopus 로고
    • Myocardial substrate metabolism in the normal and failing heart
    • Stanley W.C., Recchia F.A., Lopaschuk G.D. Myocardial substrate metabolism in the normal and failing heart. Physiol. Rev. 2005, 85:1093-1129.
    • (2005) Physiol. Rev. , vol.85 , pp. 1093-1129
    • Stanley, W.C.1    Recchia, F.A.2    Lopaschuk, G.D.3
  • 4
    • 63849177462 scopus 로고    scopus 로고
    • 2009 focused update incorporated into the ACC/AHA 2005 guidelines for the diagnosis and management of heart failure in adults. A report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines developed in collaboration with the International Society for Heart and Lung Transplantation
    • Hunt S.A., Abraham W.T., Chin M.H., Feldman A.M., Francis G.S., Ganiats T.G., Jessup M., Konstam M.A., Mancini D.M., Michl K., Oates J.A., Rahko P.S., Silver M.A., Stevenson L.W., Yancy C.W. 2009 focused update incorporated into the ACC/AHA 2005 guidelines for the diagnosis and management of heart failure in adults. A report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines developed in collaboration with the International Society for Heart and Lung Transplantation. J. Am. Coll. Cardiol. 2009, 53:e1-e90.
    • (2009) J. Am. Coll. Cardiol. , vol.53
    • Hunt, S.A.1    Abraham, W.T.2    Chin, M.H.3    Feldman, A.M.4    Francis, G.S.5    Ganiats, T.G.6    Jessup, M.7    Konstam, M.A.8    Mancini, D.M.9    Michl, K.10    Oates, J.A.11    Rahko, P.S.12    Silver, M.A.13    Stevenson, L.W.14    Yancy, C.W.15
  • 6
    • 1842389677 scopus 로고
    • Relationship between carbohydrate and lipid metabolism and the energy balance of heart muscle
    • Neely J.R., Morgan H.E. Relationship between carbohydrate and lipid metabolism and the energy balance of heart muscle. Annu. Rev. Physiol. 1974, 36:413-459.
    • (1974) Annu. Rev. Physiol. , vol.36 , pp. 413-459
    • Neely, J.R.1    Morgan, H.E.2
  • 7
    • 33947239659 scopus 로고    scopus 로고
    • The failing heart-an engine out of fuel
    • Neubauer S. The failing heart-an engine out of fuel. N. Engl. J. Med. 2007, 356:1140-1151.
    • (2007) N. Engl. J. Med. , vol.356 , pp. 1140-1151
    • Neubauer, S.1
  • 8
    • 0035206455 scopus 로고    scopus 로고
    • The endosomal compartment is an insulin-sensitive recruitment site for GLUT4 and GLUT1 glucose transporters in cardiac myocytes
    • Becker C., Sevilla L., Tomàs E., Palacin M., Zorzano A., Fischer Y. The endosomal compartment is an insulin-sensitive recruitment site for GLUT4 and GLUT1 glucose transporters in cardiac myocytes. Endocrinology 2001, 142:5267-5276.
    • (2001) Endocrinology , vol.142 , pp. 5267-5276
    • Becker, C.1    Sevilla, L.2    Tomàs, E.3    Palacin, M.4    Zorzano, A.5    Fischer, Y.6
  • 10
    • 0026599924 scopus 로고
    • Developmental regulation of GLUT-1 (erythroid/Hep G2) and GLUT-4 (muscle/fat) glucose transporter expression in rat heart, skeletal muscle, and brown adipose tissue
    • Santalucía T., Camps M., Castelló A., Muñoz P., Nuel A., Testar X., Palacin M., Zorzano A. Developmental regulation of GLUT-1 (erythroid/Hep G2) and GLUT-4 (muscle/fat) glucose transporter expression in rat heart, skeletal muscle, and brown adipose tissue. Endocrinology 1992, 130:837-846.
    • (1992) Endocrinology , vol.130 , pp. 837-846
    • Santalucía, T.1    Camps, M.2    Castelló, A.3    Muñoz, P.4    Nuel, A.5    Testar, X.6    Palacin, M.7    Zorzano, A.8
  • 11
    • 0032401577 scopus 로고    scopus 로고
    • Mechanisms of control of heart glycolysis
    • Depré C., Rider M.H., Hue L. Mechanisms of control of heart glycolysis. Eur. J. Biochem. 1998, 258:277-290.
    • (1998) Eur. J. Biochem. , vol.258 , pp. 277-290
    • Depré, C.1    Rider, M.H.2    Hue, L.3
  • 14
    • 64249123194 scopus 로고    scopus 로고
    • Substrate-enzyme competition attenuates upregulated anaplerotic flux through malic enzyme in hypertrophied rat heart and restores triacylglyceride content attenuating upregulated anaplerosis in hypertrophy
    • Pound K.M., Sorokina N., Ballal K., Berkich D.A., Fasano M., LaNoue K.F., Taegtmeyer H., O'Donnell J.M., Lewandowski E.D. Substrate-enzyme competition attenuates upregulated anaplerotic flux through malic enzyme in hypertrophied rat heart and restores triacylglyceride content attenuating upregulated anaplerosis in hypertrophy. Circ. Res. 2009, 104:805-812.
    • (2009) Circ. Res. , vol.104 , pp. 805-812
    • Pound, K.M.1    Sorokina, N.2    Ballal, K.3    Berkich, D.A.4    Fasano, M.5    LaNoue, K.F.6    Taegtmeyer, H.7    O'Donnell, J.M.8    Lewandowski, E.D.9
  • 17
    • 0037404976 scopus 로고    scopus 로고
    • Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs
    • Sugden M.C., Holness M.J. Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs. Am. J. Physiol. Endocrinol. Metab. 2003, 284:E855-E862.
    • (2003) Am. J. Physiol. Endocrinol. Metab. , vol.284
    • Sugden, M.C.1    Holness, M.J.2
  • 18
    • 0035882093 scopus 로고    scopus 로고
    • Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites
    • Kolobova E., Tuganova A., Boulatnikov I., Popov K.M. Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites. Biochem. J. 2001, 358:69.
    • (2001) Biochem. J. , vol.358 , pp. 69
    • Kolobova, E.1    Tuganova, A.2    Boulatnikov, I.3    Popov, K.M.4
  • 19
    • 0035813150 scopus 로고    scopus 로고
    • Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase
    • Korotchkina L.G., Patel M.S. Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase. J. Biol. Chem. 2001, 276:37223-37229.
    • (2001) J. Biol. Chem. , vol.276 , pp. 37223-37229
    • Korotchkina, L.G.1    Patel, M.S.2
  • 20
    • 0346158376 scopus 로고    scopus 로고
    • Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation
    • Holness M.J., Sugden M.C. Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation. Biochem. Soc. Trans. 2003, 31:1143-1151.
    • (2003) Biochem. Soc. Trans. , vol.31 , pp. 1143-1151
    • Holness, M.J.1    Sugden, M.C.2
  • 21
    • 0036220628 scopus 로고    scopus 로고
    • Regulation of pyruvate dehydrogenase (PDH) activity in human skeletal muscle during exercise
    • Spriet L.L., Heigenhauser G.J.F. Regulation of pyruvate dehydrogenase (PDH) activity in human skeletal muscle during exercise. Exerc. Sport Sci. Rev. 2002, 30:91-95.
    • (2002) Exerc. Sport Sci. Rev. , vol.30 , pp. 91-95
    • Spriet, L.L.1    Heigenhauser, G.J.F.2
  • 23
    • 79957937929 scopus 로고    scopus 로고
    • Targeting fatty acid and carbohydrate oxidation - a novel therapeutic intervention in the ischemic and failing heart
    • Jaswal J.S., Keung W., Wang W., Ussher J.R., Lopaschuk G.D. Targeting fatty acid and carbohydrate oxidation - a novel therapeutic intervention in the ischemic and failing heart. Biochim. Biophys. Acta Mol. Cell. Res. 2011, 1813:1333-1350.
    • (2011) Biochim. Biophys. Acta Mol. Cell. Res. , vol.1813 , pp. 1333-1350
    • Jaswal, J.S.1    Keung, W.2    Wang, W.3    Ussher, J.R.4    Lopaschuk, G.D.5
  • 24
    • 0015347784 scopus 로고
    • Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase
    • Denton R.M., Randle P.J., Martin B.R. Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase. Biochem. J. 1972, 128:161-163.
    • (1972) Biochem. J. , vol.128 , pp. 161-163
    • Denton, R.M.1    Randle, P.J.2    Martin, B.R.3
  • 25
    • 63749108094 scopus 로고    scopus 로고
    • Cellular fatty acid uptake: a pathway under construction
    • Su X., Abumrad N.A. Cellular fatty acid uptake: a pathway under construction. Trends Endocrinol. Metab. 2009, 20:72-77.
    • (2009) Trends Endocrinol. Metab. , vol.20 , pp. 72-77
    • Su, X.1    Abumrad, N.A.2
  • 28
    • 0027411821 scopus 로고
    • Binding of sulfosuccinimidyl fatty acids to adipocyte membrane proteins: isolation and amino-terminal sequence of an 88-kD protein implicated in transport of long-chain fatty acids
    • Harmon C.M., Abumrad N.A. Binding of sulfosuccinimidyl fatty acids to adipocyte membrane proteins: isolation and amino-terminal sequence of an 88-kD protein implicated in transport of long-chain fatty acids. J. Membr. Biol. 1993, 133:43-49.
    • (1993) J. Membr. Biol. , vol.133 , pp. 43-49
    • Harmon, C.M.1    Abumrad, N.A.2
  • 30
    • 0032452225 scopus 로고    scopus 로고
    • Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35years
    • Randle P.J. Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35years. Diabetes Metab. Rev. 1998, 14:263-283.
    • (1998) Diabetes Metab. Rev. , vol.14 , pp. 263-283
    • Randle, P.J.1
  • 31
    • 0022972428 scopus 로고
    • Quantitation of the efflux of acylcarnitines from rat heart, brain, and liver mitochondria
    • Lysiak W., Toth P.P., Suelter C.H., Bieber L.L. Quantitation of the efflux of acylcarnitines from rat heart, brain, and liver mitochondria. J. Biol. Chem. 1986, 261:13698-13703.
    • (1986) J. Biol. Chem. , vol.261 , pp. 13698-13703
    • Lysiak, W.1    Toth, P.P.2    Suelter, C.H.3    Bieber, L.L.4
  • 32
    • 19544379673 scopus 로고    scopus 로고
    • Selective versus nonselective B-adrenergic receptor blockade in chronic heart failure: differential effects on myocardial energy substrate utilization
    • Al-Hesayen A., Azevedo E.R., Floras J.S., Hollingshead S., Lopaschuk G.D., Parker J.D. Selective versus nonselective B-adrenergic receptor blockade in chronic heart failure: differential effects on myocardial energy substrate utilization. Eur. J. Heart Fail. 2005, 7:618-623.
    • (2005) Eur. J. Heart Fail. , vol.7 , pp. 618-623
    • Al-Hesayen, A.1    Azevedo, E.R.2    Floras, J.S.3    Hollingshead, S.4    Lopaschuk, G.D.5    Parker, J.D.6
  • 33
    • 0025994345 scopus 로고
    • Protons in ischemia: where do they come from; where do they go to?
    • Dennis S.C., Gevers W., Opie L.H. Protons in ischemia: where do they come from; where do they go to?. J. Mol. Cell. Cardiol. 1991, 23:1077-1086.
    • (1991) J. Mol. Cell. Cardiol. , vol.23 , pp. 1077-1086
    • Dennis, S.C.1    Gevers, W.2    Opie, L.H.3
  • 34
    • 0026721041 scopus 로고
    • Long-chain fatty acids activate calcium channels in ventricular myocytes
    • Huang J.M., Xian H., Bacaner M. Long-chain fatty acids activate calcium channels in ventricular myocytes. Proc. Natl. Acad. Sci. U. S. A. 1992, 89:6452.
    • (1992) Proc. Natl. Acad. Sci. U. S. A. , vol.89 , pp. 6452
    • Huang, J.M.1    Xian, H.2    Bacaner, M.3
  • 37
    • 54449089267 scopus 로고    scopus 로고
    • Essential role for uncoupling protein-3 in mitochondrial adaptation to fasting but not in fatty acid oxidation or fatty acid anion export
    • Seifert E.L., Bézaire V., Estey C., Harper M.-E. Essential role for uncoupling protein-3 in mitochondrial adaptation to fasting but not in fatty acid oxidation or fatty acid anion export. J. Biol. Chem. 2008, 283:25124-25131.
    • (2008) J. Biol. Chem. , vol.283 , pp. 25124-25131
    • Seifert, E.L.1    Bézaire, V.2    Estey, C.3    Harper, M.-E.4
  • 38
    • 33847684672 scopus 로고    scopus 로고
    • Surgical animal models of heart failure related to coronary heart disease
    • Klocke R., Tian W., Kuhlmann M.T., Nikol S. Surgical animal models of heart failure related to coronary heart disease. Cardiovasc. Res. 2007, 74:29-38.
    • (2007) Cardiovasc. Res. , vol.74 , pp. 29-38
    • Klocke, R.1    Tian, W.2    Kuhlmann, M.T.3    Nikol, S.4
  • 39
    • 15944368682 scopus 로고    scopus 로고
    • Animal models of heart failure: what is new?
    • Monnet E., Chachques J.C. Animal models of heart failure: what is new?. Ann. Thorac. Surg. 2005, 79:1445-1453.
    • (2005) Ann. Thorac. Surg. , vol.79 , pp. 1445-1453
    • Monnet, E.1    Chachques, J.C.2
  • 42
    • 0028966882 scopus 로고
    • Enalapril treatment increases cardiac performance and energy reserve via the creatine kinase reaction in myocardium of Syrian myopathic hamsters with advanced heart failure
    • Nascimben L., Friedrich J., Liao R., Pauletto P., Pessina A.C., Ingwall J.S. Enalapril treatment increases cardiac performance and energy reserve via the creatine kinase reaction in myocardium of Syrian myopathic hamsters with advanced heart failure. Circulation 1995, 91:1824-1833.
    • (1995) Circulation , vol.91 , pp. 1824-1833
    • Nascimben, L.1    Friedrich, J.2    Liao, R.3    Pauletto, P.4    Pessina, A.C.5    Ingwall, J.S.6
  • 43
    • 0029897792 scopus 로고    scopus 로고
    • Depletion of energy reserve via the creatine kinase reaction during the evolution of heart failure in cardiomyopathic hamsters
    • Tian R., Nascimben L., Kaddurah-Daouk R., Ingwall J.S. Depletion of energy reserve via the creatine kinase reaction during the evolution of heart failure in cardiomyopathic hamsters. J. Mol. Cell. Cardiol. 1996, 28:755-765.
    • (1996) J. Mol. Cell. Cardiol. , vol.28 , pp. 755-765
    • Tian, R.1    Nascimben, L.2    Kaddurah-Daouk, R.3    Ingwall, J.S.4
  • 48
    • 0037138548 scopus 로고    scopus 로고
    • High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischemic hearts by inhibiting glucose oxidation
    • Liu Q., Docherty J.C., Rendell J.C.T., Clanachan A.S., Lopaschuk G.D. High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischemic hearts by inhibiting glucose oxidation. J. Am. Coll. Cardiol. 2002, 39:718-725.
    • (2002) J. Am. Coll. Cardiol. , vol.39 , pp. 718-725
    • Liu, Q.1    Docherty, J.C.2    Rendell, J.C.T.3    Clanachan, A.S.4    Lopaschuk, G.D.5
  • 49
    • 0346492726 scopus 로고    scopus 로고
    • Metabolic remodelling of the failing heart: the cardiac burn-out syndrome?
    • Van Bilsen M., Smeets P.J.H., Gilde A.J., Vusse G.J. Metabolic remodelling of the failing heart: the cardiac burn-out syndrome?. Cardiovasc. Res. 2004, 61:218-226.
    • (2004) Cardiovasc. Res. , vol.61 , pp. 218-226
    • Van Bilsen, M.1    Smeets, P.J.H.2    Gilde, A.J.3    Vusse, G.J.4
  • 51
    • 0342710352 scopus 로고    scopus 로고
    • Contribution of glycogen and exogenous glucose to glucose metabolism during ischemia in the hypertrophied rat heart
    • Schönekess B.O., Allard M.F., Henning S.L., Wambolt R.B., Lopaschuk G.D. Contribution of glycogen and exogenous glucose to glucose metabolism during ischemia in the hypertrophied rat heart. Circ. Res. 1997, 81:540-549.
    • (1997) Circ. Res. , vol.81 , pp. 540-549
    • Schönekess, B.O.1    Allard, M.F.2    Henning, S.L.3    Wambolt, R.B.4    Lopaschuk, G.D.5
  • 52
    • 0033104660 scopus 로고    scopus 로고
    • Glucose utilization and glycogen turnover are accelerated in hypertrophied rat hearts during severe low-flow ischemia
    • Wambolt R.B., Henning S.L., English D.R., Dyachkova Y., Lopaschuk G.D., Allard M.F. Glucose utilization and glycogen turnover are accelerated in hypertrophied rat hearts during severe low-flow ischemia. J. Mol. Cell. Cardiol. 1999, 31:493-502.
    • (1999) J. Mol. Cell. Cardiol. , vol.31 , pp. 493-502
    • Wambolt, R.B.1    Henning, S.L.2    English, D.R.3    Dyachkova, Y.4    Lopaschuk, G.D.5    Allard, M.F.6
  • 56
    • 0033959905 scopus 로고    scopus 로고
    • Cardiac fatty acid uptake and transport in health and disease
    • Vusse G.J., Van Bilsen M., Glatz J.F.C. Cardiac fatty acid uptake and transport in health and disease. Cardiovasc. Res. 2000, 45:279-293.
    • (2000) Cardiovasc. Res. , vol.45 , pp. 279-293
    • Vusse, G.J.1    Van Bilsen, M.2    Glatz, J.F.C.3
  • 58
    • 0141680787 scopus 로고    scopus 로고
    • Upregulation of GLUT1 expression is necessary for hypertrophy and survival of neonatal rat cardiomyocytes
    • Morissette M.R., Howes A.L., Zhang T., Heller Brown J. Upregulation of GLUT1 expression is necessary for hypertrophy and survival of neonatal rat cardiomyocytes. J. Mol. Cell. Cardiol. 2003, 35:1217-1227.
    • (2003) J. Mol. Cell. Cardiol. , vol.35 , pp. 1217-1227
    • Morissette, M.R.1    Howes, A.L.2    Zhang, T.3    Heller Brown, J.4
  • 61
    • 39149097521 scopus 로고    scopus 로고
    • The absence of endogenous lipid oxidation in early stage heart failure exposes limits in lipid storage and turnover
    • O'Donnell J.M., Fields A.D., Sorokina N., Lewandowski E.D. The absence of endogenous lipid oxidation in early stage heart failure exposes limits in lipid storage and turnover. J. Mol. Cell. Cardiol. 2008, 44:315-322.
    • (2008) J. Mol. Cell. Cardiol. , vol.44 , pp. 315-322
    • O'Donnell, J.M.1    Fields, A.D.2    Sorokina, N.3    Lewandowski, E.D.4
  • 63
    • 77952364346 scopus 로고    scopus 로고
    • Decreased rates of substrate oxidation ex vivo predict the onset of heart failure and contractile dysfunction in rats with pressure overload
    • Doenst T., Pytel G., Schrepper A., Amorim P., Färber G., Shingu Y., Mohr F.W., Schwarzer M. Decreased rates of substrate oxidation ex vivo predict the onset of heart failure and contractile dysfunction in rats with pressure overload. Cardiovasc. Res. 2010, 86:461-470.
    • (2010) Cardiovasc. Res. , vol.86 , pp. 461-470
    • Doenst, T.1    Pytel, G.2    Schrepper, A.3    Amorim, P.4    Färber, G.5    Shingu, Y.6    Mohr, F.W.7    Schwarzer, M.8
  • 68
    • 0031827967 scopus 로고    scopus 로고
    • Beta-receptor blockade decreases carnitine palmitoyl transferase I activity in dogs with heart failure
    • Panchal A.R., Stanley W.C., Kerner J., Sabbah H.N. Beta-receptor blockade decreases carnitine palmitoyl transferase I activity in dogs with heart failure. J. Card. Fail. 1998, 4:121-126.
    • (1998) J. Card. Fail. , vol.4 , pp. 121-126
    • Panchal, A.R.1    Stanley, W.C.2    Kerner, J.3    Sabbah, H.N.4
  • 69
    • 0036932990 scopus 로고    scopus 로고
    • Effect of selective and nonselective β-blockers on resting energy production rate and total body substrate utilization in chronic heart failure
    • Podbregar M., Voga G. Effect of selective and nonselective β-blockers on resting energy production rate and total body substrate utilization in chronic heart failure. J. Card. Fail. 2002, 8:369-378.
    • (2002) J. Card. Fail. , vol.8 , pp. 369-378
    • Podbregar, M.1    Voga, G.2
  • 70
    • 0025071544 scopus 로고
    • Effect of beta-adrenergic blockade on myocardial function and energetics in congestive heart failure improvements in hemodynamic, contractile, and diastolic performance with bucindolol
    • Eichhorn E.J., Bedotto J.B., Malloy C.R., Hatfield B.A., Deitchman D., Brown M., Willard J.E., Grayburn P.A. Effect of beta-adrenergic blockade on myocardial function and energetics in congestive heart failure improvements in hemodynamic, contractile, and diastolic performance with bucindolol. Circulation 1990, 82:473-483.
    • (1990) Circulation , vol.82 , pp. 473-483
    • Eichhorn, E.J.1    Bedotto, J.B.2    Malloy, C.R.3    Hatfield, B.A.4    Deitchman, D.5    Brown, M.6    Willard, J.E.7    Grayburn, P.A.8
  • 71
    • 0028131721 scopus 로고
    • Effect of metoprolol on myocardial function and energetics in patients with nonischemic dilated cardiomyopathy: a randomized, double-blind, placebo-controlled study
    • Eichhorn E.J., Heesch C.M., Barnett J.H., Alvarez L.G., Fass S.M., Grayburn P.A., Hatfield B.A., Marcoux L.G., Malloy C.R. Effect of metoprolol on myocardial function and energetics in patients with nonischemic dilated cardiomyopathy: a randomized, double-blind, placebo-controlled study. J. Am. Coll. Cardiol. 1994, 24:1310-1320.
    • (1994) J. Am. Coll. Cardiol. , vol.24 , pp. 1310-1320
    • Eichhorn, E.J.1    Heesch, C.M.2    Barnett, J.H.3    Alvarez, L.G.4    Fass, S.M.5    Grayburn, P.A.6    Hatfield, B.A.7    Marcoux, L.G.8    Malloy, C.R.9
  • 72
    • 0035933194 scopus 로고    scopus 로고
    • Myocardial free fatty acid and glucose use after carvedilol treatment in patients with congestive heart failure
    • Wallhaus T.R., Taylor M., DeGrado T.R., Russell D.C., Stanko P., Nickles R.J., Stone C.K. Myocardial free fatty acid and glucose use after carvedilol treatment in patients with congestive heart failure. Circulation 2001, 103:2441-2446.
    • (2001) Circulation , vol.103 , pp. 2441-2446
    • Wallhaus, T.R.1    Taylor, M.2    DeGrado, T.R.3    Russell, D.C.4    Stanko, P.5    Nickles, R.J.6    Stone, C.K.7
  • 75
    • 9144262378 scopus 로고    scopus 로고
    • Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy
    • Cheng L., Ding G., Qin Q., Huang Y., Lewis W., He N., Evans R.M., Schneider M.D., Brako F.A., Xiao Y., Chen Y.E., Yang Q. Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. Nat. Med. 2004, 10:1245.
    • (2004) Nat. Med. , vol.10 , pp. 1245
    • Cheng, L.1    Ding, G.2    Qin, Q.3    Huang, Y.4    Lewis, W.5    He, N.6    Evans, R.M.7    Schneider, M.D.8    Brako, F.A.9    Xiao, Y.10    Chen, Y.E.11    Yang, Q.12
  • 76
    • 67449161762 scopus 로고    scopus 로고
    • Angiotensin II downregulates the fatty acid oxidation pathway in adult rat cardiomyocytes via release of tumour necrosis factor-A
    • Pellieux C., Montessuit C., Papageorgiou I., Lerch R. Angiotensin II downregulates the fatty acid oxidation pathway in adult rat cardiomyocytes via release of tumour necrosis factor-A. Cardiovasc. Res. 2009, 82:341-350.
    • (2009) Cardiovasc. Res. , vol.82 , pp. 341-350
    • Pellieux, C.1    Montessuit, C.2    Papageorgiou, I.3    Lerch, R.4
  • 77
    • 20444466460 scopus 로고    scopus 로고
    • Nuclear factor-κB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy
    • Planavila A., Laguna J.C., Vázquez-Carrera M. Nuclear factor-κB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy. J. Biol. Chem. 2005, 280:17464-17471.
    • (2005) J. Biol. Chem. , vol.280 , pp. 17464-17471
    • Planavila, A.1    Laguna, J.C.2    Vázquez-Carrera, M.3
  • 79
    • 0036224012 scopus 로고    scopus 로고
    • Thiazolidinedione treatment normalizes insulin resistance and ischemic injury in the Zucker fatty rat heart
    • Sidell R.J., Cole M.A., Draper N.J., Desrois M., Buckingham R.E., Clarke K. Thiazolidinedione treatment normalizes insulin resistance and ischemic injury in the Zucker fatty rat heart. Diabetes 2002, 51:1110-1117.
    • (2002) Diabetes , vol.51 , pp. 1110-1117
    • Sidell, R.J.1    Cole, M.A.2    Draper, N.J.3    Desrois, M.4    Buckingham, R.E.5    Clarke, K.6
  • 80
    • 0034646419 scopus 로고    scopus 로고
    • Troglitazone improves recovery of left ventricular function after regional ischemia in pigs
    • Zhu P., Lu L., Xu Y., Schwartz G.G. Troglitazone improves recovery of left ventricular function after regional ischemia in pigs. Circulation 2000, 101:1165-1171.
    • (2000) Circulation , vol.101 , pp. 1165-1171
    • Zhu, P.1    Lu, L.2    Xu, Y.3    Schwartz, G.G.4
  • 81
    • 12744268367 scopus 로고    scopus 로고
    • Rosiglitazone treatment in Zucker diabetic fatty rats is associated with ameliorated cardiac insulin resistance and protection from ischemia/reperfusion-induced myocardial injury
    • Yue T.-L., Bao W., Gu J.-L., Cui J., Tao L., Ma X.-L., Ohlstein E.H., Jucker B.M. Rosiglitazone treatment in Zucker diabetic fatty rats is associated with ameliorated cardiac insulin resistance and protection from ischemia/reperfusion-induced myocardial injury. Diabetes 2005, 54:554-562.
    • (2005) Diabetes , vol.54 , pp. 554-562
    • Yue, T.-L.1    Bao, W.2    Gu, J.-L.3    Cui, J.4    Tao, L.5    Ma, X.-L.6    Ohlstein, E.H.7    Jucker, B.M.8
  • 82
    • 34247122261 scopus 로고    scopus 로고
    • Fluid retention with thiazolidinediones: does the mechanism influence the outcome?
    • Lindenfeld J., Masoudi F.A. Fluid retention with thiazolidinediones: does the mechanism influence the outcome?. J. Am. Coll. Cardiol. 2007, 49:1705-1707.
    • (2007) J. Am. Coll. Cardiol. , vol.49 , pp. 1705-1707
    • Lindenfeld, J.1    Masoudi, F.A.2
  • 84
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen S.E., Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N. Engl. J. Med. 2007, 356:2457-2471.
    • (2007) N. Engl. J. Med. , vol.356 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 85
    • 77955285732 scopus 로고    scopus 로고
    • Rosiglitazone revisited: an updated meta-analysis of risk for myocardial infarction and cardiovascular mortality
    • Nissen S.E., Wolski K. Rosiglitazone revisited: an updated meta-analysis of risk for myocardial infarction and cardiovascular mortality. Arch. Intern. Med. 2010, 170:1191-1201.
    • (2010) Arch. Intern. Med. , vol.170 , pp. 1191-1201
    • Nissen, S.E.1    Wolski, K.2
  • 87
    • 0027292101 scopus 로고
    • Acyl-CoA synthetase mRNA expression is controlled by fibric-acid derivatives, feeding and liver proliferation
    • Schoonjans K., Staels B., Grimaldi P., Auwerx J. Acyl-CoA synthetase mRNA expression is controlled by fibric-acid derivatives, feeding and liver proliferation. Eur. J. Biochem. 1993, 216:615-622.
    • (1993) Eur. J. Biochem. , vol.216 , pp. 615-622
    • Schoonjans, K.1    Staels, B.2    Grimaldi, P.3    Auwerx, J.4
  • 90
    • 0033527030 scopus 로고    scopus 로고
    • Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group
    • Rubins H.B., Robins S.J., Collins D., Fye C.L., Anderson J.W., Elam M.B., Faas F.H., Linares E., Schaefer E.J., Schectman G., Wilt T.J., Wittes J. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. N. Engl. J. Med. 1999, 341:410-418.
    • (1999) N. Engl. J. Med. , vol.341 , pp. 410-418
    • Rubins, H.B.1    Robins, S.J.2    Collins, D.3    Fye, C.L.4    Anderson, J.W.5    Elam, M.B.6    Faas, F.H.7    Linares, E.8    Schaefer, E.J.9    Schectman, G.10    Wilt, T.J.11    Wittes, J.12
  • 91
    • 0037049366 scopus 로고    scopus 로고
    • Diabetes, plasma insulin, and cardiovascular disease: subgroup analysis from the Department of Veterans Affairs high-density lipoprotein intervention trial (VA-HIT)
    • Rubins H.B., Robins S.J., Collins D., Nelson D.B., Elam M.B., Schaefer E.J., Faas F.H., Anderson J.W. Diabetes, plasma insulin, and cardiovascular disease: subgroup analysis from the Department of Veterans Affairs high-density lipoprotein intervention trial (VA-HIT). Arch. Intern. Med. 2002, 162:2597-2604.
    • (2002) Arch. Intern. Med. , vol.162 , pp. 2597-2604
    • Rubins, H.B.1    Robins, S.J.2    Collins, D.3    Nelson, D.B.4    Elam, M.B.5    Schaefer, E.J.6    Faas, F.H.7    Anderson, J.W.8
  • 93
    • 0023845559 scopus 로고
    • Additive hypoglycemic effects of drugs that modify free-fatty acid metabolism by different mechanisms in rats with streptozocin-induced diabetes
    • Reaven G.M., Chang H., Hoffman B.B. Additive hypoglycemic effects of drugs that modify free-fatty acid metabolism by different mechanisms in rats with streptozocin-induced diabetes. Diabetes 1988, 37:28-32.
    • (1988) Diabetes , vol.37 , pp. 28-32
    • Reaven, G.M.1    Chang, H.2    Hoffman, B.B.3
  • 95
    • 0024342002 scopus 로고
    • Glucose oxidation rates in fatty acid-perfused isolated working hearts from diabetic rats
    • Wall S.R., Lopaschuk G.D. Glucose oxidation rates in fatty acid-perfused isolated working hearts from diabetic rats. Biochim. Biophys. Acta 1989, 1006:97-103.
    • (1989) Biochim. Biophys. Acta , vol.1006 , pp. 97-103
    • Wall, S.R.1    Lopaschuk, G.D.2
  • 96
    • 0030778603 scopus 로고    scopus 로고
    • Etomoxir improves left ventricular performance of pressure-overloaded rat heart
    • Turcani M., Rupp H. Etomoxir improves left ventricular performance of pressure-overloaded rat heart. Circulation 1997, 96:3681-3686.
    • (1997) Circulation , vol.96 , pp. 3681-3686
    • Turcani, M.1    Rupp, H.2
  • 97
    • 0034527768 scopus 로고    scopus 로고
    • Sarcoplasmic reticulum function and carnitine palmitoyltransferase-1 inhibition during progression of heart failure
    • Rupp H., Vetter R. Sarcoplasmic reticulum function and carnitine palmitoyltransferase-1 inhibition during progression of heart failure. Br. J. Pharmacol. 2000, 131:1748-1756.
    • (2000) Br. J. Pharmacol. , vol.131 , pp. 1748-1756
    • Rupp, H.1    Vetter, R.2
  • 98
    • 0033910352 scopus 로고    scopus 로고
    • First clinical trial with etomoxir in patients with chronic congestive heart failure
    • Schmidt-Schweda S., Holubarsch C. First clinical trial with etomoxir in patients with chronic congestive heart failure. Clin. Sci. 2000, 99:27-35.
    • (2000) Clin. Sci. , vol.99 , pp. 27-35
    • Schmidt-Schweda, S.1    Holubarsch, C.2
  • 99
    • 34547800233 scopus 로고    scopus 로고
    • A double-blind randomized multicentre clinical trial to evaluate the efficacy and safety of two doses of etomoxir in comparison with placebo in patients with moderate congestive heart failure: the ERGO (etomoxir for the recovery of glucose oxidation) study
    • Holubarsch C.J.F., Rohrbach M., Karrasch M., Boehm E., Polonski L., Ponikowski P., Rhein S. A double-blind randomized multicentre clinical trial to evaluate the efficacy and safety of two doses of etomoxir in comparison with placebo in patients with moderate congestive heart failure: the ERGO (etomoxir for the recovery of glucose oxidation) study. Clin. Sci. 2007, 113:205-212.
    • (2007) Clin. Sci. , vol.113 , pp. 205-212
    • Holubarsch, C.J.F.1    Rohrbach, M.2    Karrasch, M.3    Boehm, E.4    Polonski, L.5    Ponikowski, P.6    Rhein, S.7
  • 107
    • 0034678082 scopus 로고    scopus 로고
    • The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase
    • Kantor P.F., Lucien A., Kozak R., Lopaschuk G.D. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ. Res. 2000, 86:580-588.
    • (2000) Circ. Res. , vol.86 , pp. 580-588
    • Kantor, P.F.1    Lucien, A.2    Kozak, R.3    Lopaschuk, G.D.4
  • 108
    • 0141499890 scopus 로고    scopus 로고
    • Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase
    • Lopaschuk G.D., Barr R., Thomas P.D., Dyck J.R.B. Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase. Circ. Res. 2003, 93:e33-e37.
    • (2003) Circ. Res. , vol.93
    • Lopaschuk, G.D.1    Barr, R.2    Thomas, P.D.3    Dyck, J.R.B.4
  • 109
    • 0141723313 scopus 로고    scopus 로고
    • The antianginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolase
    • MacInnes A., Fairman D.A., Binding P., Rhodes J. Ann, Wyatt M.J., Phelan A., Haddock P.S., Karran E.H. The antianginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ. Res. 2003, 93:e26-e32.
    • (2003) Circ. Res. , vol.93
    • MacInnes, A.1    Fairman, D.A.2    Binding, P.3    Rhodes, J.A.4    Wyatt, M.J.5    Phelan, A.6    Haddock, P.S.7    Karran, E.H.8
  • 114
    • 0029746050 scopus 로고    scopus 로고
    • Effects of ranolazine on oxidative substrate preference in epitrochlearis muscle
    • McCormack J.G., Baracos V.E., Barr R., Lopaschuk G.D. Effects of ranolazine on oxidative substrate preference in epitrochlearis muscle. J. Appl. Physiol. 1996, 81:905-910.
    • (1996) J. Appl. Physiol. , vol.81 , pp. 905-910
    • McCormack, J.G.1    Baracos, V.E.2    Barr, R.3    Lopaschuk, G.D.4
  • 115
    • 0030032681 scopus 로고    scopus 로고
    • Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts
    • McCormack J.G., Barr R.L., Wolff A.A., Lopaschuk G.D. Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts. Circulation 1996, 93:135-142.
    • (1996) Circulation , vol.93 , pp. 135-142
    • McCormack, J.G.1    Barr, R.L.2    Wolff, A.A.3    Lopaschuk, G.D.4
  • 116
    • 0027241659 scopus 로고
    • Protective effects of ranolazine in guinea-pig hearts during low-flow ischaemia and their association with increases in active pyruvate dehydrogenase
    • Clarke B., Spedding M., Patmore L., McCormack J.G. Protective effects of ranolazine in guinea-pig hearts during low-flow ischaemia and their association with increases in active pyruvate dehydrogenase. Br. J. Pharmacol. 1993, 109:748-750.
    • (1993) Br. J. Pharmacol. , vol.109 , pp. 748-750
    • Clarke, B.1    Spedding, M.2    Patmore, L.3    McCormack, J.G.4
  • 117
    • 0029996458 scopus 로고    scopus 로고
    • Ranolazine increases active pyruvate dehydrogenase in perfused normoxic rat hearts: evidence for an indirect mechanism
    • Clarke B., Wyatt K.M., McCormack J.G. Ranolazine increases active pyruvate dehydrogenase in perfused normoxic rat hearts: evidence for an indirect mechanism. J. Mol. Cell. Cardiol. 1996, 28:341-350.
    • (1996) J. Mol. Cell. Cardiol. , vol.28 , pp. 341-350
    • Clarke, B.1    Wyatt, K.M.2    McCormack, J.G.3
  • 119
    • 0028841015 scopus 로고
    • The antianginal agent ranolazine is a weak inhibitor of the respiratory complex I, but with greater potency in broken or uncoupled than in coupled mitochondria
    • Wyatt K.M., Skene C., Veitch K., Hue L., McCormack J.G. The antianginal agent ranolazine is a weak inhibitor of the respiratory complex I, but with greater potency in broken or uncoupled than in coupled mitochondria. Biochem. Pharmacol. 1995, 50:1599-1606.
    • (1995) Biochem. Pharmacol. , vol.50 , pp. 1599-1606
    • Wyatt, K.M.1    Skene, C.2    Veitch, K.3    Hue, L.4    McCormack, J.G.5
  • 122
    • 79960430593 scopus 로고    scopus 로고
    • Ranolazine for the treatment of heart failure with preserved ejection fraction: background, aims, and design of the RALI-DHF Study
    • Jacobshagen C., Belardinelli L., Hasenfuss G., Maier L.S. Ranolazine for the treatment of heart failure with preserved ejection fraction: background, aims, and design of the RALI-DHF Study. Clin. Cardiol. 2011, 34:426-432.
    • (2011) Clin. Cardiol. , vol.34 , pp. 426-432
    • Jacobshagen, C.1    Belardinelli, L.2    Hasenfuss, G.3    Maier, L.S.4
  • 123
    • 0029998606 scopus 로고    scopus 로고
    • Cardiac efficiency is improved after ischemia by altering both the source and fate of protons
    • Liu B., Clanachan A.S., Schulz R., Lopaschuk G.D. Cardiac efficiency is improved after ischemia by altering both the source and fate of protons. Circ. Res. 1996, 79:940-948.
    • (1996) Circ. Res. , vol.79 , pp. 940-948
    • Liu, B.1    Clanachan, A.S.2    Schulz, R.3    Lopaschuk, G.D.4
  • 127
    • 42549121281 scopus 로고    scopus 로고
    • Medium-chain fatty acids as metabolic therapy in cardiac disease
    • Labarthe F., Gélinas R., Des Rosiers C. Medium-chain fatty acids as metabolic therapy in cardiac disease. Cardiovasc. Drugs Ther. 2008, 22:97-106.
    • (2008) Cardiovasc. Drugs Ther. , vol.22 , pp. 97-106
    • Labarthe, F.1    Gélinas, R.2    Des Rosiers, C.3
  • 128
    • 0026761747 scopus 로고
    • Triacylglycerol metabolism in hypoxic, glucose-deprived rat cardiomyocytes
    • Myrmel T., Forsdahl K., Larsen T.S. Triacylglycerol metabolism in hypoxic, glucose-deprived rat cardiomyocytes. J. Mol. Cell. Cardiol. 1992, 24:855-868.
    • (1992) J. Mol. Cell. Cardiol. , vol.24 , pp. 855-868
    • Myrmel, T.1    Forsdahl, K.2    Larsen, T.S.3
  • 129
    • 0035968175 scopus 로고    scopus 로고
    • Defective fatty acid uptake in the spontaneously hypertensive rat is a primary determinant of altered glucose metabolism, hyperinsulinemia, and myocardial hypertrophy
    • Hajri T., Ibrahimi A., Coburn C.T., Knapp F.F., Kurtz T., Pravenec M., Abumrad N.A. Defective fatty acid uptake in the spontaneously hypertensive rat is a primary determinant of altered glucose metabolism, hyperinsulinemia, and myocardial hypertrophy. J. Biol. Chem. 2001, 276:23661-23666.
    • (2001) J. Biol. Chem. , vol.276 , pp. 23661-23666
    • Hajri, T.1    Ibrahimi, A.2    Coburn, C.T.3    Knapp, F.F.4    Kurtz, T.5    Pravenec, M.6    Abumrad, N.A.7
  • 131
    • 11144320830 scopus 로고    scopus 로고
    • Effects of medium-chain triglyceride (MCT) application to SHR on cardiac function, hypertrophy and expression of endothelin-1 mRNA and other genes
    • Shimojo N., Miyauchi T., Iemitsu M., Irukayama-Tomobe Y., Maeda S., Ohkubo T., Tanaka Y., Goto K., Yamaguchi I. Effects of medium-chain triglyceride (MCT) application to SHR on cardiac function, hypertrophy and expression of endothelin-1 mRNA and other genes. J. Cardiovasc. Pharmacol. 2004, 44(Suppl. 1):S181-S185.
    • (2004) J. Cardiovasc. Pharmacol. , vol.44 , Issue.SUPPL. 1
    • Shimojo, N.1    Miyauchi, T.2    Iemitsu, M.3    Irukayama-Tomobe, Y.4    Maeda, S.5    Ohkubo, T.6    Tanaka, Y.7    Goto, K.8    Yamaguchi, I.9
  • 133
    • 0037417725 scopus 로고    scopus 로고
    • A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content
    • Finck B.N., Han X., Courtois M., Aimond F., Nerbonne J.M., Kovacs A., Gross R.W., Kelly D.P. A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:1226-1231.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 1226-1231
    • Finck, B.N.1    Han, X.2    Courtois, M.3    Aimond, F.4    Nerbonne, J.M.5    Kovacs, A.6    Gross, R.W.7    Kelly, D.P.8
  • 134
    • 0032898667 scopus 로고    scopus 로고
    • Fatty acids, lipotoxicity and insulin secretion
    • McGarry J.D., Dobbins R.L. Fatty acids, lipotoxicity and insulin secretion. Diabetologia 1999, 42:128-138.
    • (1999) Diabetologia , vol.42 , pp. 128-138
    • McGarry, J.D.1    Dobbins, R.L.2
  • 135
    • 0038509036 scopus 로고    scopus 로고
    • Lipotoxicity: when tissues overeat
    • Schaffer J.E. Lipotoxicity: when tissues overeat. Curr. Opin. Lipidol. 2003, 14:281-287.
    • (2003) Curr. Opin. Lipidol. , vol.14 , pp. 281-287
    • Schaffer, J.E.1
  • 136
    • 0345374579 scopus 로고    scopus 로고
    • Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome
    • Unger R.H. Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome. Endocrinology 2003, 144:5159-5165.
    • (2003) Endocrinology , vol.144 , pp. 5159-5165
    • Unger, R.H.1
  • 138
    • 1042266664 scopus 로고    scopus 로고
    • Apolipoprotein B production reduces lipotoxic cardiomyopathy: studies in heart-specific lipoprotein lipase transgenic mouse
    • Yokoyama M., Yagyu H., Hu Y., Seo T., Hirata K., Homma S., Goldberg I.J. Apolipoprotein B production reduces lipotoxic cardiomyopathy: studies in heart-specific lipoprotein lipase transgenic mouse. J. Biol. Chem. 2004, 279:4204-4211.
    • (2004) J. Biol. Chem. , vol.279 , pp. 4204-4211
    • Yokoyama, M.1    Yagyu, H.2    Hu, Y.3    Seo, T.4    Hirata, K.5    Homma, S.6    Goldberg, I.J.7
  • 140
    • 0027453493 scopus 로고
    • Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart
    • Saddik M., Gamble J., Witters L.A., Lopaschuk G.D. Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart. J. Biol. Chem. 1993, 268:25836-25845.
    • (1993) J. Biol. Chem. , vol.268 , pp. 25836-25845
    • Saddik, M.1    Gamble, J.2    Witters, L.A.3    Lopaschuk, G.D.4
  • 141
    • 68049136011 scopus 로고    scopus 로고
    • Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase
    • Ussher J.R., Koves T.R., Jaswal J.S., Zhang L., Ilkayeva O., Dyck J.R.B., Muoio D.M., Lopaschuk G.D. Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase. Diabetes 2009, 58:1766-1775.
    • (2009) Diabetes , vol.58 , pp. 1766-1775
    • Ussher, J.R.1    Koves, T.R.2    Jaswal, J.S.3    Zhang, L.4    Ilkayeva, O.5    Dyck, J.R.B.6    Muoio, D.M.7    Lopaschuk, G.D.8
  • 143
    • 84875057505 scopus 로고    scopus 로고
    • Cardiac-specific deletion of acetyl CoA carboxylase 2 (ACC2) prevents metabolic remodeling during pressure-overload hypertrophy
    • Kolwicz S.C., Olson D.P., Marney L.C., Garcia-Menendez L., Synovec R.E., Tian R. Cardiac-specific deletion of acetyl CoA carboxylase 2 (ACC2) prevents metabolic remodeling during pressure-overload hypertrophy. Circ. Res. 2012, 366:1279-1289.
    • (2012) Circ. Res. , vol.366 , pp. 1279-1289
    • Kolwicz, S.C.1    Olson, D.P.2    Marney, L.C.3    Garcia-Menendez, L.4    Synovec, R.E.5    Tian, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.