Substrate-enzyme competition attenuates upregulated anaplerotic flux through malic enzyme in hypertrophied rat heart and restores triacylglyceride content: Attenuating upregulated anaplerosis in hypertrophy

Circulation Research

Volumn 104, Issue 6, 2009, Pages 805-812

  Pound, Kayla M ^a   Sorokina, Natalia ^a   Ballal, Kalpana ^b   Berkich, Deborah A ^c   Fasano, Mathew ^a   Lanoue, Kathryn F ^c   Taegtmeyer, Heinrich ^b   O'donnell, J Michael ^a   Lewandowski, E Douglas ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Anaplerosis; Cardiac hypertrophy; Triglycerides

Indexed keywords

CARBON 13; DICHLOROACETIC ACID; GLUCOSE; MALATE DEHYDROGENASE (DECARBOXYLATING); PALMITIC ACID; PYRUVATE DEHYDROGENASE; TRIACYLGLYCEROL; MALATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; OXIDOREDUCTASE; PYRUVATE DEHYDROGENASE (NADP+); PYRUVIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXYLATION; CATALYSIS; CONTROLLED STUDY; ENZYME SUBSTRATE; FATTY ACID METABOLISM; HEART HYPERTROPHY; HEART MUSCLE CONTRACTILITY; LIPID STORAGE; LIPOGENESIS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION; ANIMAL; CARDIOMEGALY; CITRIC ACID CYCLE; ENZYMOLOGY; HEART MUSCLE; HUMAN; METABOLISM; PERFUSION; SPRAGUE DAWLEY RAT;

ANIMALS; CARDIOMEGALY; CITRIC ACID CYCLE; DICHLOROACETATE; HUMANS; KETONE OXIDOREDUCTASES; MALATE DEHYDROGENASE; MALE; MYOCARDIUM; NADP; PERFUSION; PYRUVIC ACID; RATS; RATS, SPRAGUE-DAWLEY; TRIGLYCERIDES;

EID: 64249123194     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.108.189951     Document Type: Article

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