Effects of Medium-chain Triglyceride (MCT) application to SHR on cardiac function, hypertrophy and expression of endothelin-1 mRNA and other genes

Journal of Cardiovascular Pharmacology

Volumn 44, Issue SUPPL. 1, 2004, Pages

  Shimojo, Nobutake ^a   Miyauchi, Takashi ^a   Iemitsu, Motoyuki ^a   Irukayama tomobe, Yoko ^a   Maeda, Seiji ^a   Ohkubo, Takeshi ^b   Tanaka, Yukihisa ^b   Goto, Katsutoshi ^a   Yamaguchi, Iwao ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b NOF Corporation   (Japan)

Author keywords

Cardiac function; Hypertrophy; Medium chain triglyceride; Spontaneously hypertensive rats

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; DIPEPTIDYL CARBOXYPEPTIDASE; ENDOTHELIN 1; FATTY ACID; MEDIUM CHAIN TRIACYLGLYCEROL; MESSENGER RNA; MOLECULAR MARKER;

ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; FATTY ACID METABOLISM; GENE EXPRESSION; HEART FUNCTION; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART VENTRICLE HYPERTROPHY; HEMODYNAMICS; HYPERTENSION; MALE; MEASUREMENT; MECHANICAL STRESS; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; UPREGULATION;

3-HYDROXYACYL COA DEHYDROGENASES; ACTINS; ANIMALS; BLOOD PRESSURE; CARDIOMEGALY; DISEASE MODELS, ANIMAL; ENDOTHELIN-1; ENERGY METABOLISM; HEART RATE; HYPERTENSION; MALE; MYOCARDIUM; NATRIURETIC PEPTIDE, BRAIN; PEPTIDYL-DIPEPTIDASE A; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RNA, MESSENGER; TIME FACTORS; TRIGLYCERIDES; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 11144320830     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.fjc.0000166263.19852.fc     Document Type: Conference Paper

References (18)

1. Pfeffer MA, Pfeffer JM, Frohlich ED. Pumping ability of the hypertrophying left ventricle of the spontaneously hypertensive rat. Circ Res. 1976;38:423-429.
2. Aitman TJ, Glazier AM, Wallace CA, et al. Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat Genet. 1999;21:76-83.
3. Luiken JJ, Willems I, van der Vusse, et al. Electrostimulation enhances FAT/CD36-mediated long-chain fatty acid uptake by isolated rat cardiac myocytes. Am J Physiol Endocrinol Metab. 2001;281:E704-E712.
4. Coburn CT, Knapp FF Jr, Febbraio M, et al. Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice. J Biol Chem. 2000;275:32523-32529.
5. Grynberg A, Demaison L. Fatty acid oxidation in the heart. J Cardiovasc Pharmacol. 1996;28:S11-S17.
6. Christe ME, Rodgers RL. Altered glucose and fatty acid oxidation in hearts of the spontaneously hypertensive rat. J Mol Cell Cardiol. 1994; 26:1371-1375.
7. Iemitsu M, Miyauchi T, Maeda S, et al. Cardiac hypertrophy by hypertension and exercise training exhibits different gene expression of enzyme in energy metabolism. Hypertens Res. 2003;26:829-837.
8. Rupp H, Schulze W, Vatter R. Dietary medium-chain triglycerides can prevent changes in myosin and SR due to CPT-1 inhibition by etomoxir. Am J Physiol. 1995;269:R630-R640.
9. Luyken J, Hannan RD, Cheung JY, et al. Regulation of rDNA transcription during endothelin-1-induced hypertrophy of neonatal cardiomyocytes. Hyperphosphorylation of upstream binding factor, an rDNA transcription factor. Circ Res. 1996;78:354-361.
10. Komuro I, Yazaki Y. Control of cardiac gene expression by mechanical stress. Annu Rev Physiol. 1993;55:55-75.
11. Hewett TE, Grupp IL, Grupp G, et al. Alpha-skeletal actin is associated with increased contractility in the mouse heart. Circ Res. 1994;74:740-746.
12. Miyauchi T, Yorikane R, Sakai S, et al. Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced pulmonary hypertension. Circ Res. 1993;73:887-897.
13. Sakai S, Miyauchi T, Yamaguchi I. Long-term endothelin receptor antagonist administration improves alterations in expression of various cardiac genes in failing myocardium of rats with heart failure. Circulation. 2000;101:2849-2853.
14. Sakurai T, Yanagisawa M, Inoue A, et al. cDNA cloning, sequence analysis and tissue distribution of rat preproendothelin-1 mRNA. Biochem Biophys Res Commun. 1991;175:44-47.
15. Hu MC, Sharp SB, Davidson N. The complete sequence of the mouse skeletal alpha-actin gene reveals several conserved and inverted repeat sequences outside of the protein-coding region. Mol Cell Biol. 1986;6:15-25.
16. Koike G, Krieger JE, Jacob HJ, et al. Angiotensin converting enzyme and genetic hypertension: cloning of rat cDNAs and characterization of the enzyme. Biochem Biophys Res Commun. 1994;198:380-386.
17. Kojima M, Minamino N, Kangawa K, et al. Cloning and sequence analysis of cDNA encoding a precursor for rat brain natriuretic peptide. Biochem Biophys Res Commun. 1989;159:1420-1426.
18. Nudel U, Zakut R, Shani M, et al. The nucleotide sequence of the rat cytoplasmic beta-actin gene. Nucleic Acids Res. 1983;11:1759-1771.