Activation of Peroxisome Proliferator-Activated Receptor-α Protects the Heart from Ischemia/Reperfusion Injury

Circulation

Volumn 108, Issue 19, 2003, Pages 2393-2399

  Yue, Tian Li ^a   Bao, Weike ^b   Jucker, Beat M ^b   Gu, Juan Li ^b   Romanic, Anne M ^b   Brown, Peter J ^b   Cui, Jianqi ^b   Thudium, Douglas T ^b   Boyce, Rogely ^b   Burns Kurtis, Cynthia L ^b   Mirabile, Rosanna C ^b   Aravindhan, Karpagam ^b   Ohlstein, Eliot H ^b  

^a GLAXOSMITHKLINE   (United States)

^b NONE

Author keywords

Ischemia; Myocardial infarction; Receptors; Reperfusion

Indexed keywords

GELATINASE A; GELATINASE B; GW 7647; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY LIGATION; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY; ENZYME ACTIVITY; FATTY ACID OXIDATION; GENE CONTROL; HEART INFARCTION SIZE; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY;

ANIMALS; BUTYRIC ACIDS; CHEMOTAXIS, LEUKOCYTE; CYTOKINES; DOWN-REGULATION; DRUG EVALUATION, PRECLINICAL; FATTY ACIDS; I-KAPPA B PROTEINS; LIGATION; MALE; MATRIX METALLOPROTEINASES; MICE; MICE, KNOCKOUT; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NF-KAPPA B; OXIDATION-REDUCTION; PHENYLUREA COMPOUNDS; PREMEDICATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 0242525729     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000093187.42015.6C     Document Type: Article

References (28)

1. Barger PM, Kelly DP. PPAR signaling in the control of cardiac energy metabolism. Trends Cardiovasc Med. 2001;10:238-245.
2. Delerive P, Fruchart JC, Staels B. Peroxisome proliferator-activated receptors in inflammation control. J Endocrinol. 2001;169:453-459.
3. Watanabe K, Fujii H, Takahashi T, et al. Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor-α associated with age-dependent cardiac toxicity. J Biol Chem. 2000;275:22293-22299.
4. Djouadi F, Weinheimer CJ, Saffitz JE, et al. A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator-activated receptor α-deficient mice. J Clin Invest. 1998;102:1083-1091.
5. Kurtz DM, Rinaldo P, Rhead WJ, et al. Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation. Proc Natl Acad Sci USA. 1998;95:15592-15597.
6. Chiu HC, Kovacs A, Ford DA, et al. A novel mouse model of lipotoxic cardiomyopathy. J Clin Invest. 2001;107:813-822.
7. Kelly DP, Strauss AW. Inherited cardiomyopathies. N Engl J Med. 1994;330:913-919.
8. Young ME, Laws FA, Goodwin GW, et al. Reactivation of peroxisome proliferator-activated receptor α is associated with contractile dysfunction in hypertrophied rat heart. J Biol Chem. 2001;276:44390-44395.
9. Finck BN, Lehman JJ, Leone TC, et al. The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus. J Clin Invest. 2002;109:121-130.
10. Romanic AM, Harrison SM, Bao W, et al. Myocardial protection from ischemia/reperfusion injury by targeted deletion of matria metalloproteinase-9. Cardiovasc Res. 2002;54:549-558.
11. Brown PJ, Stuart W, Hurley KP, et al. Identification of a subtype selective human PPARα agonist through parallel-array synthesis. Bioorg Med Chem Lett. 2001;11:1225-1227.
12. Yue TL, Chen J, Bao W, et al. In vivo myocardial protection from ischemia/reperfusion injury by the peroxisome proliferator-activated receptor-γ agonist rosiglitazone. Circulation. 2001;104:2588-2594.
13. 31P NMR studies on the effects of increased plasma free fatty acids on intramuscular glucose metabolism in the awake rat. J Biol Chem. 1997;272:10464-10473.
14. 13C NMR study. Diabetes. 1999;48:134-140.
15. Fan H, Sun B, Gu Q, et al. Oxygen radicals trigger activation of NF-κB and Ap-1 and upregulation of ICAM-1 in reperfused canine heart. Am J Physiol Heart Circ Physiol. 2002;282:H1778-H1786.
16. Barger PM, Brandt JM, Leone TC, et al. Deactivation of peroxisome proliferator-activated receptor-α during cardiac hypertrophic growth. J Clin Invest. 2000;105:1723-1730.
17. Razeghi P, Young ME, Abbasi S. Hypoxia in vivo decreases peroxisome proliferator-activated receptor-α-regulated gene expression in rat heart. Biochem Biophys Res Commun. 2001;287:5-10.
18. Campbell FM, Kozak R, Wagner A, et al. A role for peroxisome proliferator-activated receptor-α (PPAR-α) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPAR-α are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase. J Biol Chem. 2002;277:4098-4103.
19. Van Der Vusse GJ, Glatz JFC, Stam CG, et al. Fatty acid homeostasis in the normoxic and ischemic heart. Physiol Rev. 1992;72:881-940.
20. Opie LH, Tansey M, Kennely BM. Proposed metabolic vicious circles in patients with large myocardial infarcts and high plasma-free-fatty-acid concentrations. Lancet. 1977;2:890-892.
21. DeVries JE, Vork M, Rowmen THM, et al. Saturated but not monounsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes. J Lipid Res. 1997;38:1384-1394.
22. Cheung PY, Sawichi G, Wozniak M, et al. Matrix metalloproteinase-2 contributes to ischemia-reperfusion injury in the heart. Circulation. 2000;101:1833-1839.
23. D'Acquisto F, May MJ, Ghosh S. Inhibition of nuclear factor κB (NF-κB): an emerging theme in anti-inflammatory therapies. Mol Intervent. 2002;2:22-35.
24. Morishita R, Sugimoto T, Aoki M, et al. In vivo transfection of cis element 'decoy' against nuclear factor-κB binding site prevents myocardial infarction. Nat Med. 1997;3:894-899.
25. Bond M, Chase AJ, Baker AH, et al. Inhibition of transcription factor NF-κB reduces matrix metalloproteinase-1, -3 and -9 production by vascular smooth muscle cells. Cardiovasc Res. 2001;50:556-565.
26. Delerive P, Gervois P, Fruchart J-C, et al. Induction of IκBα expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-α activators. J Biol Chem. 2000;275:36703-36707.
27. 12,14-prostaglandin J2 in activated murine macrophages. Mol Cell Biol. 2000;20:1692-1698.
28. Wayman NS, Hattori Y, McDonald MC, et al. Ligands of the peroxisome proliferator-activated receptors (PPAR-γ and PPAR-α) reduce myocardial infarct size. FASEB J. 2002;16:1027-1040.