Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 13, 2006, Pages 3484-3488

  Cheng, Jie Fei ^a   Mak, Chi Ching ^a   Huang, Yujin ^a   Penuliar, Richard ^a   Nishimoto, Masahiro ^a   Zhang, Lin ^a   Chen, Mi ^a   Wallace, David ^a   Arrhenius, Thomas ^a   Chu, Donald ^a   Yang, Guang ^a   Barbosa, Miguel ^a   Barr, Rick ^b   Dyck, Jason R B ^b   Lopaschuk, Gary D ^b   Nadzan, Alex M ^a  

^a Chaugai Pharma USA   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Acetyl CoA; Fatty acid oxidation; Glucose oxidation; Malonyl CoA; Malonyl CoA decarboxylase; MCD

Indexed keywords

BIS TRIFLUOROMETHYL CARBINOL DERIVATIVE; CARBOXYLYASE; MALONYL COENZYME A DECARBOXYLASE; METHANOL DERIVATIVE; NICOTINIC ACID DERIVATIVE; PYRIDINE DERIVATIVE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; EXPERIMENTAL MODEL; GLUCOSE OXIDATION; HEART; IN VITRO STUDY; POLYMERIZATION; SUBSTITUTION REACTION;

ANIMALS; CARBOXY-LYASES; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; ENZYME INHIBITORS; GLUCOSE; HEART; HETEROCYCLIC COMPOUNDS; METHANOL; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33646849601     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.03.100     Document Type: Article

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