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Volumn 28, Issue 2, 1996, Pages 341-350

Ranolazine increases active pyruvate dehydrogenase in perfused normoxic rat hearts: Evidence for an indirect mechanism

Author keywords

Acetyl CoA; Beta oxidation; Metabolic modulation; Mitochondria; Pyruvate dehydrogenase; Pyruvate dehydrogenase kinase; Pyruvate dehydrogenase phosphate phosphatase; Ranolazine

Indexed keywords

ACETYL COENZYME A; ALBUMIN; CORONARY VASODILATING AGENT; DICHLOROACETIC ACID; GLUCOSE; PALMITIC ACID; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE PHOSPHATASE; RANOLAZINE;

EID: 0029996458     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.1996.0032     Document Type: Article
Times cited : (143)

References (35)
  • 1
    • 4244133563 scopus 로고
    • The effects of the novel antianginal agent ranolazine (i.d.) in a canine model of transient myocardial ischaemia
    • ALLELY MC, ALPS BJ, 1988. The effects of the novel antianginal agent ranolazine (i.d.) in a canine model of transient myocardial ischaemia. (Abstract). Br J Pharmacol 93: 246P.
    • (1988) Br J Pharmacol , vol.93
    • Allely, M.C.1    Alps, B.J.2
  • 2
    • 0025134189 scopus 로고
    • Prevention of myocardial enzyme release by ranolazine in a primate model of ischaemia with reperfusion
    • ALLELY MC, ALPS BJ, 1990. Prevention of myocardial enzyme release by ranolazine in a primate model of ischaemia with reperfusion. Br J Pharmacol 96: 5-6.
    • (1990) Br J Pharmacol , vol.96 , pp. 5-6
    • Allely, M.C.1    Alps, B.J.2
  • 5
    • 0342858278 scopus 로고
    • Improvement in exercise tolerance and left ventricular filling dynamics in patients with angina pectoris with the novel metabolic modulator, ranolazine
    • BOUVY T, ROUSSEAU MF, COCCO G, CHERON P, WILLIAM GJ, DETRY JMR, 1993. Improvement in exercise tolerance and left ventricular filling dynamics in patients with angina pectoris with the novel metabolic modulator, ranolazine. Acta Cardiol 48: 98-99.
    • (1993) Acta Cardiol , vol.48 , pp. 98-99
    • Bouvy, T.1    Rousseau, M.F.2    Cocco, G.3    Cheron, P.4    William, G.J.5    Detry, J.M.R.6
  • 6
    • 0027463073 scopus 로고
    • Beneficial effect of carnitine on mechanical recovery of rat hearts reperfused after a transient period of ischemia is accompanied by a stimulation of glucose oxidation
    • BRODERICK TL, QUINNEY HA, BARKER CC, LOPASCHUK GD, 1993. Beneficial effect of carnitine on mechanical recovery of rat hearts reperfused after a transient period of ischemia is accompanied by a stimulation of glucose oxidation. Circulation 87: 972-981.
    • (1993) Circulation , vol.87 , pp. 972-981
    • Broderick, T.L.1    Quinney, H.A.2    Barker, C.C.3    Lopaschuk, G.D.4
  • 8
    • 0027241659 scopus 로고
    • Protective effects of ranolazine in guinea-pig hearts during low-flow ischaemia and their association with increases in active pyruvate dehydrogenase
    • CLARKE B, SPEDDING M, PATMORE L, MCCORMACK JG, 1993. Protective effects of ranolazine in guinea-pig hearts during low-flow ischaemia and their association with increases in active pyruvate dehydrogenase. Br J Pharmacol 109: 748-750.
    • (1993) Br J Pharmacol , vol.109 , pp. 748-750
    • Clarke, B.1    Spedding, M.2    Patmore, L.3    McCormack, J.G.4
  • 9
    • 0343293256 scopus 로고
    • Ranolazine increases active pyruvate dehydrogenase (PDH) in perfused normoxic rat hearts
    • CLARKE B, WYATT KM, MCCORMACK JG, 1994. Ranolazine increases active pyruvate dehydrogenase (PDH) in perfused normoxic rat hearts. (Abstract). J Mol Cell Cardiol 26: CLXXIV.
    • (1994) J Mol Cell Cardiol , vol.26
    • Clarke, B.1    Wyatt, K.M.2    McCormack, J.G.3
  • 10
    • 0026680239 scopus 로고
    • Effects of a new metabolic modulator, ranolazine, on exercise tolerance in Angina Pectoris patients treated with beta-blocker or diltiazem
    • COCCO G, ROUSSEAU MF, BOUVY T, CHERON P, WILLIAMS G, DETRY JM, POULEUR H, 1992. Effects of a new metabolic modulator, Ranolazine, on exercise tolerance in Angina Pectoris patients treated with beta-blocker or diltiazem. J Cardiovasc Pharmocol 20: 131-138.
    • (1992) J Cardiovasc Pharmocol , vol.20 , pp. 131-138
    • Cocco, G.1    Rousseau, M.F.2    Bouvy, T.3    Cheron, P.4    Williams, G.5    Detry, J.M.6    Pouleur, H.7
  • 11
    • 0024239561 scopus 로고
    • Analysis of acyl-coenzyme A esters in biological samples
    • CORKEY BE, 1988. Analysis of acyl-Coenzyme A esters in biological samples. Meth Enzymol 166: 55-70.
    • (1988) Meth Enzymol , vol.166 , pp. 55-70
    • Corkey, B.E.1
  • 12
    • 0026061030 scopus 로고
    • Amphipathic lipid metabolites and their relation to arrhythmogenesis in the ischemic heart
    • DATORRE SD, CREER MH, POGWIZD SM, CORR PB, 1991. Amphipathic lipid metabolites and their relation to arrhythmogenesis in the ischemic heart. J Mol Cell Cardiol 23 [Suppl. I]: 11-22.
    • (1991) J Mol Cell Cardiol , vol.23 , Issue.1 SUPPL. , pp. 11-22
    • Datorre, S.D.1    Creer, M.H.2    Pogwizd, S.M.3    Corr, P.B.4
  • 13
    • 0006822311 scopus 로고
    • Protective effects of the novel anti-ischaemic agent ranolazine (RS-43285) in the reperfused rat heart
    • FERRANDON P, PASCAL J-C, ARMSTRONG JM, 1988. Protective effects of the novel anti-ischaemic agent ranolazine (RS-43285) in the reperfused rat heart. (Abstract) Br J Pharmacol 93: 247P.
    • (1988) Br J Pharmacol , vol.93
    • Ferrandon, P.1    Pascal, J.-C.2    Armstrong, J.M.3
  • 15
    • 0842341728 scopus 로고
    • Effects of fatty acid oxidation on efficiency of energy production in rat heart
    • HUTTER JF, PIPER HM, SPIECKERMANN PG, 1985. Effects of fatty acid oxidation on efficiency of energy production in rat heart. Am J Physiol 249: H723-H728.
    • (1985) Am J Physiol , vol.249
    • Hutter, J.F.1    Piper, H.M.2    Spieckermann, P.G.3
  • 16
    • 0343728782 scopus 로고
    • Defects of fatty acid oxidation
    • Darley-Usmar V and Shapira A, eds. Portland Press: London
    • JACKSON S, TURNBULL DM, 1994. Defects of fatty acid oxidation. In: Darley-Usmar V and Shapira A, eds. Mitochondria: DNA, Proteins and Disease. Portland Press: London, 201-220.
    • (1994) Mitochondria: DNA, Proteins and Disease , pp. 201-220
    • Jackson, S.1    Turnbull, D.M.2
  • 17
    • 0020617994 scopus 로고
    • Effects of ischaemia and reperfusion on pyruvate dehydrogenase activity in isolated rat hearts
    • KOBAYASHI K, NEELY JR, 1983. Effects of ischaemia and reperfusion on pyruvate dehydrogenase activity in isolated rat hearts. J Mol Cell Cardiol 15: 359-367.
    • (1983) J Mol Cell Cardiol , vol.15 , pp. 359-367
    • Kobayashi, K.1    Neely, J.R.2
  • 18
    • 0027372106 scopus 로고
    • An imbalance between glycolysis and glucose oxidation is a possible explanation for the detrimental effects of high levels of fatty acids during aerobic reperfusion of ischemic hearts
    • LOPASCHUK GD, WAMBOLT RB, BARR RL, 1993. An imbalance between glycolysis and glucose oxidation is a possible explanation for the detrimental effects of high levels of fatty acids during aerobic reperfusion of ischemic hearts. J Pharmacol Exp Therap 264: 135-144.
    • (1993) J Pharmacol Exp Therap , vol.264 , pp. 135-144
    • Lopaschuk, G.D.1    Wambolt, R.B.2    Barr, R.L.3
  • 20
    • 0023856860 scopus 로고
    • Quantitation of the effect of L-carnitine on the levels of acid-soluble short-chain acyl-CoA and CoASH in rat heart and liver mitochondria
    • LYSIAK W, LILLY K, DILISA F, TOTH P, BIEBER LL, 1988. Quantitation of the effect of L-carnitine on the levels of acid-soluble short-chain acyl-CoA and CoASH in rat heart and liver mitochondria. J Biol Chem 263: 1151-1156.
    • (1988) J Biol Chem , vol.263 , pp. 1151-1156
    • Lysiak, W.1    Lilly, K.2    Dilisa, F.3    Toth, P.4    Bieber, L.L.5
  • 21
    • 0021289002 scopus 로고
    • 2+ ions in the regulation of in tramitochondrial metabolism in the heart
    • 2+ ions in the regulation of in tramitochondrial metabolism in the heart. Biochem J 218: 235-247.
    • (1984) Biochem J , vol.218 , pp. 235-247
    • McCormack, J.G.1    Denton, R.M.2
  • 22
    • 0024834330 scopus 로고
    • Influence of calcium ions on mammalian intramitochondrial dehydrogenases
    • MCCORMACK JG, DENTON RM, 1989. Influence of calcium ions on mammalian intramitochondrial dehydrogenases. Meth Enzymol 174: 95-118.
    • (1989) Meth Enzymol , vol.174 , pp. 95-118
    • McCormack, J.G.1    Denton, R.M.2
  • 23
    • 0020004609 scopus 로고
    • 2+ and pyruvate in the regulation of rat heart pyruvate dehydrogenase activity
    • 2+ and pyruvate in the regulation of rat heart pyruvate dehydrogenase activity. Biochem J 202:419-427.
    • (1982) Biochem J , vol.202 , pp. 419-427
    • McCormack, J.G.1    Edgell, N.J.2    Denton, R.M.3
  • 24
    • 0025319665 scopus 로고
    • Role of calcium ions in regulation of mammalian intramitochondrial metabolism
    • MCCORMACK JG, HALESTRAP AP, DENTON RM, 1990. Role of calcium ions in regulation of mammalian intramitochondrial metabolism. Physiol Rev 70: 391-425.
    • (1990) Physiol Rev , vol.70 , pp. 391-425
    • McCormack, J.G.1    Halestrap, A.P.2    Denton, R.M.3
  • 25
  • 26
    • 0025169628 scopus 로고
    • Dichloroacetate stimulation of glucose oxidation improves recovery of ischemic hearts
    • MCVEIGH JJ, LOPASCHUK GD, 1990. Dichloroacetate stimulation of glucose oxidation improves recovery of ischemiC hearts. Am J Physiol 259: H1079-H1085.
    • (1990) Am J Physiol , vol.259
    • McVeigh, J.J.1    Lopaschuk, G.D.2
  • 27
    • 0003082107 scopus 로고
    • Fuels: Carbohydrates and lipids
    • Opie LH, ed. Raven Press: New York
    • OPIE LH, 1991. Fuels: carbohydrates and lipids. In: Opie LH, ed. The Heart: Physiology and Metabolism. Raven Press: New York, 208-246.
    • (1991) The Heart: Physiology and Metabolism , pp. 208-246
    • Opie, L.H.1
  • 28
    • 0345509701 scopus 로고
    • Metabolic pathways modulation: A new approach to treat myocardial ischemia
    • POULEUR H, HUE L, HARLOW BJ, ROUSSEAU MF, 1989. Metabolic pathways modulation: a new approach to treat myocardial ischemia. (Abstract). Circulation 80 [Suppl. II]: 11-52.
    • (1989) Circulation , vol.80 , Issue.2 SUPPL. , pp. 11-52
    • Pouleur, H.1    Hue, L.2    Harlow, B.J.3    Rousseau, M.F.4
  • 29
    • 0018787079 scopus 로고
    • a kinase and synergistic inhibition by pyruvate and ADP
    • a kinase and synergistic inhibition by pyruvate and ADP. J Biol Chem 254: 7191-7196.
    • (1979) J Biol Chem , vol.254 , pp. 7191-7196
    • Pratt, M.L.1    Roche, T.E.2
  • 30
    • 0022802645 scopus 로고
    • Fuel selection in animals
    • RANDLE PJ, 1986. Fuel selection in animals. Biochem Soc Trans 14: 799-806.
    • (1986) Biochem Soc Trans , vol.14 , pp. 799-806
    • Randle, P.J.1
  • 32
    • 0027453493 scopus 로고
    • Acetyl CoA carboxylase regulation of fatty acid oxidation in the heart
    • SADDIK M, GAMBLE J, WITTERS LA, LOPASCHUK GD, 1993. Acetyl CoA carboxylase regulation of fatty acid oxidation in the heart. J Biol Chem 268: 25836-25845.
    • (1993) J Biol Chem , vol.268 , pp. 25836-25845
    • Saddik, M.1    Gamble, J.2    Witters, L.A.3    Lopaschuk, G.D.4
  • 34
    • 0028841015 scopus 로고
    • The anti-anginal agent ranolazine is a weak inhibitor of the respiratory complex I, but with greater potency in broken or uncoupled than in coupled mitochondria
    • in press
    • WYATT KM, SKENE C, VEITCH K, HUE L, MCCORMACK JG, 1995. The anti-anginal agent ranolazine is a weak inhibitor of the respiratory Complex I, but with greater potency in broken or uncoupled than in coupled mitochondria. Biochem Pharmacol, in press.
    • (1995) Biochem Pharmacol
    • Wyatt, K.M.1    Skene, C.2    Veitch, K.3    Hue, L.4    McCormack, J.G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.