Angiotensin II downregulates the fatty acid oxidation pathway in adult rat cardiomyocytes via release of tumour necrosis factor-α

Cardiovascular Research

Volumn 82, Issue 2, 2009, Pages 341-350

  Pellieux, Corinne ^a   Montessuit, Christophe ^a   Papageorgiou, Irne ^a   Lerch, René ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Angiotensin; Cell culture; Energy metabolism; Myocytes; Remodelling

Indexed keywords

ANGIOTENSIN II; ANTIBODY; CARNITINE PALMITOYLTRANSFERASE I; CD36 ANTIGEN; FATTY ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MEDIUM CHAIN ACYL COENZYME A DEHYDROGENASE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; REACTIVE OXYGEN METABOLITE; REGULATOR PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT ANIMAL; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FATTY ACID OXIDATION; HEART MUSCLE CELL; MALE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT;

ACYL-COA DEHYDROGENASE; ANGIOTENSIN II; ANIMALS; CARNITINE O-PALMITOYLTRANSFERASE; CELLS, CULTURED; FATTY ACIDS; MALE; MYOCYTES, CARDIAC; NATRIURETIC PEPTIDE, BRAIN; NF-KAPPA B; OXIDATION-REDUCTION; PPAR ALPHA; PPAR DELTA; PPAR GAMMA; PPAR-BETA; RATS; RATS, INBRED STRAINS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 67449161762     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvp004     Document Type: Article

References (41)

1. Rosenblatt-Velin N, Montessuit C, Papageorgiou I, Terrand J, Lerch R. Postinfarction heart failure in rats is associated with upregulation of GLUT-1 and downregulation of genes of fatty acid metabolism. Cardiovasc Res 2001;52:407-416.
2. RemondinoA, Rosenblatt-Velin N, Montessuit C, Tardy I, Papageorgiou I, Dorsaz PA et al. Altered expression of proteins of metabolic regulation during remodeling of the left ventricle after myocardial infarction. J Mol Cell Cardiol 2000;32:2025-2034.
3. Young ME, Laws FA, Goodwin GW, Taegtmeyer H. Reactivation of peroxisome proliferator-activated receptor alpha is associated with contractile dysfunction in hypertrophied rat heart. J Biol Chem 2001; 276: 44390-44395.
4. Allard MF, Schonekess BO, Henning SL, English DR, Lopaschuk GD. Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts. Am J Physiol 1994; 267: H742-H750.
5. el Alaoui-Talibi Z, Landormy S, Loireau A, Moravec J. Fatty acid oxidation and mechanical performance of volume-overloaded rat hearts. Am J Physiol 1992;262:H1068-H1074.
6. Osorio JC, Stanley WC, Linke A, Castellar) M, Diep QN, Panchal AR et al. Impaired myocardial fatty acid oxidation and reduced protein expression of retinoid X receptor-alpha in pacing-induced heart failure. Circulation 2002;106:606-612.
7. Lei B, Lionetti V, Young ME, Chandler MP, d'Agostino C, Kang E et al. Paradoxical downregulation of the glucose oxidation pathway despite enhanced flux in severe heart failure. J Mol Cell Cardiol 2004; 36: 567 576.
8. Chandler MP, Kerner J, Huang H, Vazquez E, Reszko A, Martini WZ et al. Moderate severity heart failure does not involve a downregulation of myocardial fatty acid oxidation. Am J Physiol Heart Circ Physiol 2004; 287:H1538-H1543.
9. Pellieux C, Aasum E, Larsen TS, Montessuit C, Papageorgiou I, Pedrazzini Tet al. Overexpression of angiotensinogen in the myocardium induces downregulation of the fatty acid oxidation pathway. J Mol Cell Cardiol 2006;41:459-466.
10. Stanley WC, Recchia FA, Lopaschuk GD. Myocardial substrate metabolism in the normal and failing heart. Physiol Rev 2005;85:1093-1129.
11. Kusuoka H, Marban E. Mechanism of the diastolic dysfunction induced by glycolytic inhibition. Does adenosine triphosphate derived from glycolysis play a favored role in cellular Ca2 + homeostasis in ferret myocardium? J Clin Invest 1994;93:1216-1223.
12. Lopaschuk GD. Cardiac energy metabolism alterations in angiotensin || induced hypertrophy. J Mol Cell Cardiol 2006;41:418-420.
13. Finck BN, Han X, Courtois M, Aimond F, Nerbonne JM, Kovacs A et al. A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content. Proc Notl Acad Sei USA 2003;100:1226-1231.
14. Sack MN, Rader TA, Park S, Bastin J, McCune SA, Kelly DP. Fatty acid oxidation enzyme gene expression is downregulated in the failing heart. Circulation 1996;94:2837-2842.
15. Lionetti V, Linke A, Chandler MP, Young ME, Penn MS, Gupte S et al. Carnitine palmitoyl transferase-I inhibition prevents ventricular remodeling and delays decompensation in pacing-induced heart failure. Cardiovasc Res 2005;66:454-461.
16. de Brouwer KFJ, Degens H, Aartsen WM, Lindhout M, Bitsch NJJE, Gilde AJ et al. Specific and sustained down-regulation of genes involved in fatty acid metabolism is not a hallmark of progression to cardiac failure in mice. J Mol Cell Cardiol 2006;40:838 845.
17. Barger PM, Brandt JM, Leone TC, Weinheimer CJ, Kelly DP. Deactivation of peroxisome proliferator-activated receptor-alpha during cardiac hypertrophic growth. J Clin Invest 2000;105:1723 1730.
18. Sack MN, Disch DL, Rockman HA, Kelly DP. A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. Proc Natl Acad Sd USA 1997;94:6438-6443.
19. Planavila A, Laguna JC, Vazquez-Carrera M. Nuclear factor-kappaB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy. J Biol Chem 2005;280:17464-17471.
20. Finck BN, Kelly DP. Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease. Circulation 2007; 115:2540 2548.
21. Serneri GG, Boddi M, Cecioni I, Vanni S, Coppo M, Papa ML et al. Cardiac angiotensin || formation in the clinical course of heart failure and its relationship with left ventricular function. Circ Res 2001 ;88: 961-968.
22. Bouzegrhane F, Thibault G. Is angiotensin || a proliferative factor of cardiac fibroblasts? Cardiovasc Res 2002;53:304-312.
23. Mann DL. Angiotensin || as an inflammatory mediator: evolving concepts in the role of the renin angiotensin system in the failing heart. Cardiovasc Drugs Ther 2002;16:7-9.
24. Mazzolai L, Pedrazzini T, Nicoud F, Gabbiani G, Brunner HR, Nussberger J. Increased cardiac angiotensin || levels induce right and left ventricular hypertrophy in normotensive mice. Hypertension 2000;35:985 991.
25. Montessuit C, Rosenblatt-Velin N, Papageorgiou I, Campos L, Pellieux C, Palma T et al. Regulation of glucose transporter expression in cardiac myocytes: p38 MAPK is a strong inducer of GLUT4. Cardiovasc Res 2004;64:94-104.
26. Pellieux C, Montessuit C, Papageorgiou I, Lerch R. Inactivation of peroxisome proliferator-activated receptor isoforms alpha, beta/delta, and gamma mediate distinct facets of hypertrophic transformation of adult cardiac myocytes. Pflugers Arch 2007;455:443-454.
27. Kalra D, Sivasubramanian N, Mann DL. Angiotensin || induces tumor necrosis factor biosynthesis in the adult mammalian heart through a protein kinase C-dependent pathway. Circulation 2002; 105:2198 2205.
28. Mann DL. Inflammatory mediators and the failing heart: past, present, and the foreseeable future. Circ Res 2002;91:988 998.
29. Purcell NH, Tang G, Yu C, Mercurio F, DiDonato JA, Lin A. Activation of NF-kappa B is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes. Proc Natl Acad Sd USA 2001 ;98:6668 6673.
30. Cui R, Tieu B, Recinos A, Tilton RG, Brasier AR. RhoA mediates angiotensin ||-induced phospho-Ser536 nuclear factor kappaB/RelA subunit exchange on the interleukin-6 promoter in VSMCs. Circ Res2006;99: 723-730.
31. Sekiguchi K, Tian Q, lshiyama M, Burchfield J, Gao F, Mann DL et al. Inhibition of PPAR-alpha activity in mice with cardiac-restricted expression of tumor necrosis factor: potential role of TGF-beta/Smad3. Am J Physiol Heart Circ Physiol 2007;292:H1443-H1451.
32. Schaub MC, Hefti MA, Harder BA, Eppenberger HM. Various hypertrophic stimuli induce distinct phenotypes in cardiomyocytes. J Mol Med 1997; 75:901 920.
33. Rosenblatt-Velin N, Lerch R, Papageorgiou I, Montessuit C. Insulin resistance in adult cardiomyocytes undergoing dedifferentiation: role of GLUT4 expression and translocation. FASEB J 2004;18:872-874.
34. Zahrádka P, Werner JP, Buhay S, Litchie B, Helwer G, Thomas S. NF-kappaB activation is essential for angiotensin ||-dependent proliferation and migration of vascular smooth muscle cells. J Mol Cell Cardiol 2002;34:1609-1621.
35. GloireG, Legrand-PoelsS, PietteJ. NF-kappaB activation by reactive oxygen species: fifteen years later. Biochem Pharmacol 2006;72:1493- 1505.
36. Garnier A, Fortin D, Delomenie C, Momken I, Veksler V, Ventura-Clapier R. Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles. J Physiol 2003;551 : 491-501.
37. Li YP, Lecker SH, Chen Y, Waddell ID, Goldberg AL, Reid MB. TNF-alpha increases ubiquitin-conjugating activity in skeletal muscle by up-regulating UbcH2/E220 k. FASEB J 2003;17:1048-1057.
38. Torre-Amione G, Kapadia S, Lee J, Durand JB, Bies RD, Young JB et al. Tumor necrosis factor-alpha and tumor necrosis factor receptors in the failing human heart. Circulation 1996;93:704-711.
39. Planavila A, Rodriguez-Calvo R, Jove M, Michalik L, Wahli W, Laguna JC et al. Peroxisome proliferator-activated receptor beta/delta activation inhibits hypertrophy in neonatal rat cardiomyocytes. Cardiovasc Res 2005;65:832-841.
40. Smeets PJ, Teunissen BE, Willemsen PH, van Nieuwenhoven FA, Brauns AE, Janssen BJ et al. Cardiac hypertrophy is enhanced in PPAR(alpha) - / - mice in response to chronic pressure overload. Cardiovasc Res 2008;78:79 89.
41. Takáno H, Nagai T, Asakawa M, Toyozaki T, Oka T, Komuro | et al. Peroxisome proliferator-activated receptor activators inhibit lipopolysaccharide-induced tumor necrosis factor « expression in neonatal rat cardiac myocytes. Circ Res 2000;87:596 602.