Mutational Analysis of the High-Affinity Zinc Binding Site Validates a Refined Human Dopamine Transporter Homology Model

PLoS Computational Biology

Volumn 9, Issue 2, 2013, Pages

  Stockner, Thomas ^a   Montgomery, Therese R ^a   Kudlacek, Oliver ^a   Weissensteiner, Rene ^b   Ecker, Gerhard F ^b   Freissmuth, Michael ^a   Sitte, Harald H ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; CRYSTAL STRUCTURE; ENZYME ACTIVITY; NEUROPHYSIOLOGY; SUBSTRATES; ZINC;

AMINO TERMINUS; CARBOXYL TERMINUS; DOPAMINE TRANSPORTERS; EXTRACELLULAR LOOP 2; HIGH AFFINITY; HIGH RESOLUTION CRYSTAL STRUCTURE; HOMOLOGY MODELING; MUTATIONAL ANALYSIS; ZINC BINDING; ZINC-BINDING SITES;

AMINO ACIDS;

CYSTEINE; DOPAMINE TRANSPORTER; LYSINE; ZINC;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MUTATIONAL ANALYSIS; PREDICTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

EID: 84874785148     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002909     Document Type: Article

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