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Volumn 99, Issue 3, 2002, Pages 1683-1688
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Generation of an activating Zn2+ switch in the dopamine transporter: Mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle
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Author keywords
[No Author keywords available]
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Indexed keywords
3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER;
AMPHETAMINE;
CARRIER PROTEIN;
COCAINE;
DOPAMINE;
DOPAMINE TRANSPORTER;
MAZINDOL;
NORADRENALIN;
PROTEIN KINASE C;
SEROTONIN;
VANOXERINE;
ZINC;
AMINO ACID SUBSTITUTION;
ANIMAL CELL;
ARTICLE;
BINDING AFFINITY;
BINDING SITE;
CELL STRAIN COS7;
CONFORMATIONAL TRANSITION;
CONTROLLED STUDY;
DOPAMINE UPTAKE;
GENE MUTATION;
HUMAN;
HUMAN CELL;
HYDROPHOBICITY;
INTERNALIZATION;
ISOMERISM;
NONHUMAN;
PHENOTYPE;
PRIORITY JOURNAL;
PROTEIN CONFORMATION;
PROTEIN DOMAIN;
PROTEIN EXPRESSION;
PROTEIN INTERACTION;
PROTEIN TRANSPORT;
SITE DIRECTED MUTAGENESIS;
SODIUM TRANSPORT;
SYNAPSE;
SYNAPTIC MEMBRANE;
AMINO ACID SEQUENCE;
AMINO ACID SUBSTITUTION;
ANIMALS;
BINDING SITES;
BIOLOGICAL TRANSPORT;
CERCOPITHECUS AETHIOPS;
CONSERVED SEQUENCE;
COS CELLS;
DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS;
HUMANS;
KIDNEY;
KINETICS;
MEMBRANE GLYCOPROTEINS;
MEMBRANE TRANSPORT PROTEINS;
MOLECULAR SEQUENCE DATA;
MUTAGENESIS, SITE-DIRECTED;
NERVE TISSUE PROTEINS;
PROTEIN CONFORMATION;
PROTEIN KINASE C;
PROTEIN STRUCTURE, SECONDARY;
RECOMBINANT PROTEINS;
TRANSFECTION;
TYROSINE;
ZINC;
ANIMALIA;
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EID: 0037022356
PISSN: 00278424
EISSN: None
Source Type: Journal
DOI: 10.1073/pnas.032386299 Document Type: Article |
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Times cited : (118)
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References (34)
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