Identification of Intracellular Residues in the Dopamine Transporter Critical for Regulation of Transporter Conformation and Cocaine Binding

Journal of Biological Chemistry

Volumn 279, Issue 5, 2004, Pages 3228-3238

  Loland, Claus Juul ^a   Grånäs, Charlotta ^a   Javitch, Jonathan A ^b   Gether, Ulrik ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Columbia Univ Coll Physic/Surgs ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; CHEMICAL ACTIVATION; CONFORMATIONS; ENZYME INHIBITION; MUTAGENESIS;

MUTANTS;

BIOCHEMISTRY;

ALANINE; CARRIER PROTEIN; COCAINE; DOPAMINE; DOPAMINE BINDING PROTEIN; DOPAMINE TRANSPORTER; DOPAMINE UPTAKE INHIBITOR; DOPAMINE-BINDING PROTEIN; NORADRENALIN; TYROSINE; ZINC;

AMINO ACID SEQUENCE; ANIMAL; ANIMAL CELL; ARTICLE; BIOTINYLATION; CELL MEMBRANE; CELL STRAIN COS1; CHEMISTRY; CONFORMATIONAL TRANSITION; DOPAMINE METABOLISM; DOPAMINE RELEASE; DOPAMINERGIC TRANSMISSION; DRUG RECEPTOR BINDING; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; IC 50; KINETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; NEUROTRANSMITTER RELEASE; NONHUMAN; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTOR AFFINITY; RESIDUE ANALYSIS; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING;

ALANINE; AMINO ACID SEQUENCE; ANIMALS; BIOTINYLATION; BLOTTING, WESTERN; CELL MEMBRANE; COCAINE; COS CELLS; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINE UPTAKE INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; NERVE TISSUE PROTEINS; NOREPINEPHRINE; PROTEIN BINDING; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; TRANSFECTION; TYROSINE; ZINC;

ANIMALIA;

EID: 0942276396     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M304755200     Document Type: Article

References (42)

1. Amara, S. G., and Kuhar, M. J. (1993) Annu. Rev. Neurosci. 16, 73-93
2. Blakely, R. D., and Bauman, A. L. (2000) Curr. Opin. Neurobiol. 10, 328-336
3. Norregaard, L., and Gether, U. (2001) Curr. Opin. Drug Discov. Dev. 4, 591-601
4. Giros, B., Jaber, M., Jones, S. R., Wightman, R. M., and Caron, M. G. (1996) Nature 379, 606-612
5. Gainetdinov, R. R., and Caron, M. G. (2003) Annu. Rev. Pharmacol. Toxicol. 43, 261-284
6. Chen, N., and Reith, M. E. (2000) Eur. J. Pharmacol. 405, 329-339
7. Norregaard, L., Frederiksen, D., Nielsen, E. O., and Gether, U. (1998) EMBO J. 17, 4266-4273
8. Loland, C. J., Norregaard, L., and Gether, U. (1999) J. Biol. Chem. 274, 36928-36934
9. Norregaard, L., Visiers, I., Loland, C. J., Ballesteros, J., Weinstein, H., and Gether, U. (2000) Biochemistry 39, 15836-15846
10. Hastrup, H., Karlin, A., and Javitch, J. A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 10055-10060
11. Kilic, F., and Rudnick, G. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 3106-3111
12. Schmid, J. A., Scholze, P., Kudlacek, O., Freissmuth, M., Singer, E. A., and Sitte, H. H. (2001) J. Biol. Chem. 276, 3805-3810
13. Norgaard-Nielsen, K., Norregaard, L., Hastrup, H., Javitch, J. A., and Gether, U. (2002) FEBS Lett. 524, 87-91
14. Rudnick, G. (1997) in Neurotransmitter Transporters: Structure, Function, and Regulation (Reith, M. E. A., ed) 1st Ed., pp. 73-100, Humana Press, Totowa, NJ
15. Ferrer, J., and Javitch, J. A. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 9238-9243
16. Chen, N., Ferrer, J. V., Javitch, J. A., and Justice, J. B., Jr. (2000) J. Biol. Chem. 275, 1608-1614
17. Chen, J. G., and Rudnick, G. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 1044-1049
18. Androutsellis-Theotokis, A., Ghassemi, F., and Rudnick, G. (2001) J. Biol. Chem. 276, 45933-45938
19. Androutsellis-Theotokis, A., and Rudnick, G. (2002) J. Neurosci. 22, 8370-8378
20. Loland, C. J., Norregaard, L., Litman, T., and Gether, U. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 1683-1688
21. Saunders, C., Ferrer, J. V., Shi, L., Chen, J., Merrill, G., Lamb, M. E., Leeb-Lundberg, L. M., Carvelli, L., Javitch, J. A., and Galli, A. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 6850-6855
22. Goldberg, N. R., Beuming, T., Weinstein, H., and Javitch, J. A. (2003) in Structure and Function of Neurotransmitter Transporters (Brä uner-Osborne, H., and Schousboe, A., eds) pp. 213-234, Humana Press, Totowa, NJ
23. Johansen, T. E., Scholler, M. S., Tolstoy, S., and Schwartz, T. W. (1990) FEBS Lett, 267, 289-294
24. Gether, U., Marray, T., Schwartz, T. W., and Johansen, T. E. (1992) FEBS Lett. 296, 241-244
25. Giros, B., el Mestikawy, S., Godinot, N., Zheng, K., Han, H., Yang-Feng, T., and Caron, M. G. (1992) Mol. Pharmacol. 42, 383-390
26. Granas, C., Ferrer, J., Loland, C. J., Javitch, J. A., and Gether, U. (2003) J. Biol. Chem. 278, 4990-5000
27. Torres, G. E., Carneiro, A., Seamans, K., Fiorentini, C., Sweeney, A., Yao, W. D., and Caron, M. G. (2003) J. Biol. Chem. 278, 2731-2739
28. Karlin, A., and Akabas, M. H. (1998) Methods Enzymol. 293, 123-145
29. Chen, N., Vaughan, R. A., and Reith, M. E. (2001) J. Neurochem. 77, 1116-1127
30. Samama, P., Cotecchia, S., Costa, T., and Lefkowitz, R. J. (1993) J. Biol. Chem. 268, 4625-4636
31. Lefkowitz, R. J., Cotecchia, S., Samama, P., and Costa, T. (1993) Trends Pharmacol. Sci. 14, 303-307
32. Gether, U. (2000) Endocr. Rev. 21, 90-113
33. Reith, M. E., Berfield, J. L., Wang, L. C., Ferrer, J. V., and Javitch, J. A. (2001) J. Biol. Chem. 276, 29012-29018
34. Itokawa, M., Lin, Z., Cai, N. S., Wu, C., Kitayama, S., Wang, J. B., and Uhl, G. R. (2000) Mol. Pharmacol. 57, 1093-1103
35. Lin, Z., Itokawa, M., and Uhl, G. R. (2000) FASEB J. 14, 715-728
36. Lin, Z., and Uhl, G. R. (2002) Mol. Pharmacol. 61, 885-891
37. Wu, X., and Gu, H. H. (2003) Mol. Pharmacol. 63, 653-658
38. Zou, M. F., Kopajtic, T., Katz, J. L., Wirtz, S., Justice, J. B., Jr., and Newman, A. H. (2001) J. Med. Chem. 44, 4453-4461
39. Vaughan, R. A., Gaffaney, J. D., Lever, J. R., Reith, M. E., and Dutta, A. K. (2001) Mol. Pharmacol. 59, 1157-1164
40. Arnis, S., Fahmy, K., Hofmann, K. P., and Sakmar, T. P. (1994) J. Biol. Chem. 269, 23879-23881
41. Ballesteros, J. A., Jensen, A. D., Liapakis, G., Rasmussen, S. G., Shi, L., Gether, U., and Javitch, J. A. (2001) J. Biol. Chem. 276, 29171-29177
42. MacAulay, N., Meinild, A. K., Zeuthen, T., and Gether, U. (2003) J. Biol. Chem. 278, 28771-28777