Ellagic acid promotes Aβ42 fibrillization and inhibits Aβ42-induced neurotoxicity

Biochemical and Biophysical Research Communications

Volumn 390, Issue 4, 2009, Pages 1250-1254

  Feng, Ying ^a,b   Yang, Shi gao ^b   Du, Xue ting ^b   Zhang, Xi ^b   Sun, Xiao xia ^b   Zhao, Min ^b   Sun, Gui yuan ^a   Liu, Rui tian ^b  

^a CHINA MEDICAL UNIVERSITY   (China)

^b Tsinghua University   (China)

Author keywords

Amyloid; Aggregation; Alzheimer's disease; Ellagic acid; Neurotoxicity

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; AMYLOID BETA PROTEIN[1-42]; ELLAGIC ACID; OLIGOMER; POLYPHENOL;

ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; FIBER; HUMAN; HUMAN CELL; IN VITRO STUDY; INCUBATION TIME; NEUROPROTECTION; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN AGGREGATION; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; CELL LINE; ELLAGIC ACID; HUMANS; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, SECONDARY;

EID: 70549096064     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.10.130     Document Type: Article

References (38)

1. Martin J.B. Molecular basis of the neurodegenerative disorders. N. Engl. J. Med. 340 (1999) 1970-1980
2. Lambert M.P., Barlow A.K., Chromy B.A., Edwards C., Freed R., Liosatos M., Morgan T.E., Rozovsky I., Trommer B., Viola K.L., Wals P., Zhang C., Finch C.E., Krafft G.A., and Klein W.L. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc. Natl. Acad. Sci. USA 95 (1998) 6448-6453
3. Walsh D.M., Klyubin I., Fadeeva J.V., Cullen W.K., Anwyl R., Wolfe M.S., Rowan M.J., and Selkoe D.J. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416 (2002) 535-539
4. Necula M., Breydo L., Milton S., Kayed R., van der Veer W.E., Tone P., and Glabe C.G. Methylene blue inhibits amyloid Abeta oligomerization by promoting fibrillization. Biochemistry 46 (2007) 8850-8860
5. Jakob-Roetne R., and Jacobsen H. Alzheimer's disease: from pathology to therapeutic approaches. Angew. Chem. Int. Ed. Engl. 48 (2009) 3030-3059
6. Ono K., Hasegawa K., Naiki H., and Yamada M. Anti-amyloidogenic activity of tannic acid and its activity to destabilize Alzheimer's beta-amyloid fibrils in vitro. Biochim. Biophys. Acta 1690 (2004) 193-202
7. Ono K., Hasegawa K., Naiki H., and Yamada M. Preformed beta-amyloid fibrils are destabilized by coenzyme Q10 in vitro. Biochem. Biophys. Res. Commun. 330 (2005) 111-116
8. Riviere C., Richard T., Quentin L., Krisa S., Merillon J.M., and Monti J.P. Inhibitory activity of stilbenes on Alzheimer's beta-amyloid fibrils in vitro. Bioorg. Med. Chem. 15 (2007) 1160-1167
9. Riviere C., Richard T., Vitrac X., Merillon J.M., Valls J., and Monti J.P. New polyphenols active on beta-amyloid aggregation. Bioorg. Med. Chem. Lett. 18 (2008) 828-831
10. Wang Y.J., Thomas P., Zhong J.H., Bi F.F., Kosaraju S., Pollard A., Fenech M., and Zhou X.F. Consumption of grape seed extract prevents amyloid-beta deposition and attenuates inflammation in brain of an Alzheimer's disease mouse. Neurotox. Res. 15 (2009) 3-14
11. Priyadarsini K.I., Khopde S.M., Kumar S.S., and Mohan H. Free radical studies of ellagic acid, a natural phenolic antioxidant. J. Agric. Food Chem. 50 (2002) 2200-2206
12. Kaur S., Grover I.S., and Kumar S. Antimutagenic potential of ellagic acid isolated from Terminalia arjuna. Indian J. Exp. Biol. 35 (1997) 478-482
13. Makena P.S., and Chung K.T. Effects of various plant polyphenols on bladder carcinogen benzidine-induced mutagenicity. Food Chem. Toxicol. 45 (2007) 1899-1909
14. Cozzi R., Ricordy R., Bartolini F., Ramadori L., Perticone P., and De Salvia R. Taurine and ellagic acid: two differently-acting natural antioxidants. Environ. Mol. Mutagen. 26 (1995) 248-254
15. Rogerio A.P., Fontanari C., Melo M.C., Ambrosio S.R., de Souza G.E., Pereira P.S., Franca S.C., da Costa F.B., Albuquerque D.A., and Faccioli L.H. Anti-inflammatory analgesic and anti-oedematous effects of Lafoensia pacari extract and ellagic acid. J. Pharm. Pharmacol. 58 (2006) 1265-1273
16. Papoutsi Z., Kassi E., Chinou I., Halabalaki M., Skaltsounis L.A., and Moutsatsou P. Walnut extract (Juglans regia L.) and its component ellagic acid exhibit anti-inflammatory activity in human aorta endothelial cells and osteoblastic activity in the cell line KS483. Br. J. Nutr. 99 (2008) 715-722
17. Kim S., Gaber M.W., Zawaski J.A., Zhang F., Richardson M., Zhang X.A., and Yang Y. The inhibition of glioma growth in vitro and in vivo by a chitosan/ellagic acid composite biomaterial. Biomaterials 30 (2009) 4743-4751
18. Yang C.S., Tzou B.C., Liu Y.P., Tsai M.J., Shyue S.K., and Tzeng S.F. Inhibition of cadmium-induced oxidative injury in rat primary astrocytes by the addition of antioxidants and the reduction of intracellular calcium. J. Cell. Biochem. 103 (2008) 825-834
19. Kwak H.M., Jeon S.Y., Sohng B.H., Kim J.G., Lee J.M., Lee K.B., Jeong H.H., Hur J.M., Kang Y.H., and Song K.S. Beta-secretase (BACE1) inhibitors from pomegranate (Punica granatum) husk. Arch. Pharm. Res. 28 (2005) 1328-1332
20. Hartman R.E., Shah A., Fagan A.M., Schwetye K.E., Parsadanian M., Schulman R.N., Finn M.B., and Holtzman D.M. Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease. Neurobiol. Dis. 24 (2006) 506-515
21. Ono K., Condron M.M., Ho L., Wang J., Zhao W., Pasinetti G.M., and Teplow D.B. Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity. J. Biol. Chem. 283 (2008) 32176-32187
22. Wang X.P., Zhang J.H., Wang Y.J., Feng Y., Zhang X., Sun X.X., Li J.L., Du X.T., Lambert M.P., Yang S.G., Zhao M., Klein W.L., and Liu R.T. Conformation-dependent single-chain variable fragment antibodies specifically recognize beta-amyloid oligomers. FEBS Lett. 583 (2009) 579-584
23. Bartolini M., Bertucci C., Bolognesi M.L., Cavalli A., Melchiorre C., and Andrisano V. Insight into the kinetic of amyloid beta (1-42) peptide self-aggregation: elucidation of inhibitors' mechanism of action. Chembiochem 8 (2007) 2152-2161
24. Pollack S.J., Sadler I.I., Hawtin S.R., Tailor V.J., and Shearman M.S. Sulfated glycosaminoglycans and dyes attenuate the neurotoxic effects of beta-amyloid in rat PC12 cells. Neurosci. Lett. 184 (1995) 113-116
25. Fezoui Y., and Teplow D.B. Kinetic studies of amyloid beta-protein fibril assembly. Differential effects of alpha-helix stabilization. J. Biol. Chem. 277 (2002) 36948-36954
26. Fjaeraa C., and Nanberg E. Effect of ellagic acid on proliferation, cell adhesion and apoptosis in SH-SY5Y human neuroblastoma cells. Biomed. Pharmacother. 63 (2009) 254-261
27. Porat Y., Abramowitz A., and Gazit E. Inhibition of amyloid fibril formation by polyphenols: structural similarity and aromatic interactions as a common inhibition mechanism. Chem. Biol. Drug. Des. 67 (2006) 27-37
28. Convertino M., Pellarin R., Catto M., Carotti A., and Caflisch A. 9,10-Anthraquinone hinders beta-aggregation: how does a small molecule interfere with Abeta-peptide amyloid fibrillation?. Protein Sci. 18 (2009) 792-800
29. Gsponer J., Haberthur U., and Caflisch A. The role of side-chain interactions in the early steps of aggregation: molecular dynamics simulations of an amyloid-forming peptide from the yeast prion Sup35. Proc. Natl. Acad. Sci. USA 100 (2003) 5154-5159
30. Klimov D.K., and Thirumalai D. Dissecting the assembly of Abeta16-22 amyloid peptides into antiparallel beta sheets. Structure 11 (2003) 295-307
31. Hills Jr. R.D., and Brooks III C.L. Hydrophobic cooperativity as a mechanism for amyloid nucleation. J. Mol. Biol. 368 (2007) 894-901
32. Porat Y., Mazor Y., Efrat S., and Gazit E. Inhibition of islet amyloid polypeptide fibril formation: a potential role for heteroaromatic interactions. Biochemistry 43 (2004) 14454-14462
33. Powers E.T., and Powers D.L. The kinetics of nucleated polymerizations at high concentrations: amyloid fibril formation near and above the "supercritical concentration". Biophys. J. 91 (2006) 122-132
34. Necula M., Kayed R., Milton S., and Glabe C.G. Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct. J. Biol. Chem. 282 (2007) 10311-10324
35. Dickson D.W., Crystal H.A., Bevona C., Honer W., Vincent I., and Davies P. Correlations of synaptic and pathological markers with cognition of the elderly. Neurobiol. Aging 16 (1995) 285-304
36. McLean C.A., Cherny R.A., Fraser F.W., Fuller S.J., Smith M.J., Beyreuther K., Bush A.I., and Masters C.L. Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann. Neurol. 46 (1999) 860-866
37. Y. Feng, X.P. Wang, S.G. Yang, Y.J. Wang, X. Zhang, X.T. Du, X.X. Sun, M. Zhao, L. Huang, R.T. Liu, Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation, Neurotoxicology, in press.
38. Haass C., and Selkoe D.J. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat. Rev. Mol. Cell Biol. 8 (2007) 101-112