-
1
-
-
0037475148
-
In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-(1-[6-[(2-[(18)F]fluoroethyl) (methyl)amino]-2-naphthyl]ethylidene) malononitrile
-
Agdeppa E.D., Kepe V., Petric A., Satyamurthy N., Liu J., Huang S.C., Small G.W., Cole G.M., and Barrio J.R. In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-(1-[6-[(2-[(18)F]fluoroethyl) (methyl)amino]-2-naphthyl]ethylidene) malononitrile. Neuroscience 117 (2003) 723-730
-
(2003)
Neuroscience
, vol.117
, pp. 723-730
-
-
Agdeppa, E.D.1
Kepe, V.2
Petric, A.3
Satyamurthy, N.4
Liu, J.5
Huang, S.C.6
Small, G.W.7
Cole, G.M.8
Barrio, J.R.9
-
2
-
-
85047691727
-
NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo
-
Eriksin J.L., Sagi S.A., Smith T.E., Weggen S., Das P., McLendon D.C., Ozols V.V., Jessing K.W., Zavitz K.H., Koo E.H., and Golde T.E. NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo. J. Clin. Invest. 112 (2003) 440-449
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 440-449
-
-
Eriksin, J.L.1
Sagi, S.A.2
Smith, T.E.3
Weggen, S.4
Das, P.5
McLendon, D.C.6
Ozols, V.V.7
Jessing, K.W.8
Zavitz, K.H.9
Koo, E.H.10
Golde, T.E.11
-
4
-
-
24044519616
-
Testing the amyloid toxicity hypothesis of Alzheimer's disease in transgenic Caenorhabditis elegans model
-
Gutierrez-Zepeda A., and Luo Y. Testing the amyloid toxicity hypothesis of Alzheimer's disease in transgenic Caenorhabditis elegans model. Front. Biosci. 9 (2004) 3333-3338
-
(2004)
Front. Biosci.
, vol.9
, pp. 3333-3338
-
-
Gutierrez-Zepeda, A.1
Luo, Y.2
-
5
-
-
0011704476
-
Conventional genetics
-
Hope I.A. (Ed), Oxford University Press, New York
-
Hodgkin J. Conventional genetics. In: Hope I.A. (Ed). C. elegans: a practical approach (1999), Oxford University Press, New York 245-270
-
(1999)
C. elegans: a practical approach
, pp. 245-270
-
-
Hodgkin, J.1
-
6
-
-
27144513779
-
Non-steroidal anti-inflammatory drugs have anti-amyloidogenic effects for Alzheimer's β-amyloid fibrils in vitro
-
Hirohata M., Ono K., Naiki H., and Yamada M. Non-steroidal anti-inflammatory drugs have anti-amyloidogenic effects for Alzheimer's β-amyloid fibrils in vitro. Neuropharmacol. 49 (2005) 1088-1099
-
(2005)
Neuropharmacol.
, vol.49
, pp. 1088-1099
-
-
Hirohata, M.1
Ono, K.2
Naiki, H.3
Yamada, M.4
-
7
-
-
0035936004
-
Nonsteroidal anti-inflammatory drugs and the risk of Alzheimer's disease
-
In't Veld B.A., Ruitenberg A., Hofman A., Launer L.J., van Duijn C.M., Stijnen T., Breteler M.M.B., and Stricker B.H.C. Nonsteroidal anti-inflammatory drugs and the risk of Alzheimer's disease. New Engl. Med. 345 (2001) 1515-1521
-
(2001)
New Engl. Med.
, vol.345
, pp. 1515-1521
-
-
In't Veld, B.A.1
Ruitenberg, A.2
Hofman, A.3
Launer, L.J.4
van Duijn, C.M.5
Stijnen, T.6
Breteler, M.M.B.7
Stricker, B.H.C.8
-
9
-
-
0031013395
-
Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs
-
Lehmann J.M., Lenhard J.M., Oliver B.B., Ringold G.M., and Kliewer S.A. Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J. Biol. Chem. 272 (1997) 3406-3410
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 3406-3410
-
-
Lehmann, J.M.1
Lenhard, J.M.2
Oliver, B.B.3
Ringold, G.M.4
Kliewer, S.A.5
-
10
-
-
0034254924
-
Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease
-
Lim G.P., Yang F., Chu T., Chen T., Beech W., Teter B., Tran T., Ubeda O., Hsiao-Ashe K., Frautschy S.A., and Cole G.M. Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. J. Neurosci. 20 (2000) 5709-5714
-
(2000)
J. Neurosci.
, vol.20
, pp. 5709-5714
-
-
Lim, G.P.1
Yang, F.2
Chu, T.3
Chen, T.4
Beech, W.5
Teter, B.6
Tran, T.7
Ubeda, O.8
Hsiao-Ashe, K.9
Frautschy, S.A.10
Cole, G.M.11
-
11
-
-
0035691115
-
Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice
-
Lim G.P., Yang F., Chu T., Gahtan E., Ubeda O., Beech W., Overmier J.B., Hsiao-Ashe K., Frautschy S.A., and Cole G.M. Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice. Neurobiol. Aging 22 (2001) 982-991
-
(2001)
Neurobiol. Aging
, vol.22
, pp. 982-991
-
-
Lim, G.P.1
Yang, F.2
Chu, T.3
Gahtan, E.4
Ubeda, O.5
Beech, W.6
Overmier, J.B.7
Hsiao-Ashe, K.8
Frautschy, S.A.9
Cole, G.M.10
-
12
-
-
0028981288
-
Expression of human β-amyloid peptide in transgenic Caenorhabditis elegans
-
Link C.D. Expression of human β-amyloid peptide in transgenic Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 9368-9372
-
(1995)
Proc. Natl. Acad. Sci. U.S.A.
, vol.92
, pp. 9368-9372
-
-
Link, C.D.1
-
13
-
-
0032146978
-
The importance of inflammatory mechanisms in Alzheimer disease
-
McGeer E.G., and McGeer P.L. The importance of inflammatory mechanisms in Alzheimer disease. Exp. Gerontol. 33 (1998) 371-378
-
(1998)
Exp. Gerontol.
, vol.33
, pp. 371-378
-
-
McGeer, E.G.1
McGeer, P.L.2
-
14
-
-
0033927533
-
Cyclo-oxygenase-2 inhibitors: rationale and therapeutic potential for Alzheimer's disease
-
McGeer P.L. Cyclo-oxygenase-2 inhibitors: rationale and therapeutic potential for Alzheimer's disease. Drugs Aging 17 (2000) 1-11
-
(2000)
Drugs Aging
, vol.17
, pp. 1-11
-
-
McGeer, P.L.1
-
15
-
-
0025942107
-
Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences
-
Mello C.C., Kramer J.M., Stinchcomb D., and Ambros V. Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J. 10 (1991) 3959-3970
-
(1991)
EMBO J.
, vol.10
, pp. 3959-3970
-
-
Mello, C.C.1
Kramer, J.M.2
Stinchcomb, D.3
Ambros, V.4
-
16
-
-
0036826903
-
Selective inhibition of Aβ42 production by NSAID R-enantiomers
-
Morihara T., Chu T., Ubeda O., Beech W., and Cole G.M. Selective inhibition of Aβ42 production by NSAID R-enantiomers. J. Neurochem. 83 (2002) 1009-1012
-
(2002)
J. Neurochem.
, vol.83
, pp. 1009-1012
-
-
Morihara, T.1
Chu, T.2
Ubeda, O.3
Beech, W.4
Cole, G.M.5
-
17
-
-
0036678146
-
The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans
-
Morley J.F., Brignull H.R., Weyers J.J., and Morimoto R.I. The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 10417-10422
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 10417-10422
-
-
Morley, J.F.1
Brignull, H.R.2
Weyers, J.J.3
Morimoto, R.I.4
-
18
-
-
38949181536
-
Flurbiprofen derivatives in Alzheimer's disease: synthesis, pharmacokinetic and biological assessment of lipoamino acid prodrugs
-
Pignatello R., Pantò V., Salmaso S., Bersani S., Pistarà V., Kepe V., Barrio J.R., and Puglisi G. Flurbiprofen derivatives in Alzheimer's disease: synthesis, pharmacokinetic and biological assessment of lipoamino acid prodrugs. Bioconjugate Chem. 19 (2008) 349-357
-
(2008)
Bioconjugate Chem.
, vol.19
, pp. 349-357
-
-
Pignatello, R.1
Pantò, V.2
Salmaso, S.3
Bersani, S.4
Pistarà, V.5
Kepe, V.6
Barrio, J.R.7
Puglisi, G.8
-
19
-
-
0032211830
-
The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease
-
Selkoe D.J. The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease. Trends Cell Biol. 8 (1998) 447-453
-
(1998)
Trends Cell Biol.
, vol.8
, pp. 447-453
-
-
Selkoe, D.J.1
-
20
-
-
0028265912
-
Secondary structure of amyloid β peptide correlates with neurotoxic activity in vitro
-
Simmons L.K., Patrick C.M., Tomaselli K.J., Rydel R.E., Fuson K.S., Brigham E.F., Wright S., Lieberburg I., Becker G.W., Brems D.N., and Li W.Y. Secondary structure of amyloid β peptide correlates with neurotoxic activity in vitro. Mol. Pharm. 45 (1994) 373-379
-
(1994)
Mol. Pharm.
, vol.45
, pp. 373-379
-
-
Simmons, L.K.1
Patrick, C.M.2
Tomaselli, K.J.3
Rydel, R.E.4
Fuson, K.S.5
Brigham, E.F.6
Wright, S.7
Lieberburg, I.8
Becker, G.W.9
Brems, D.N.10
Li, W.Y.11
-
21
-
-
0030897133
-
Risk of Alzheimer's disease and duration of NSAID use
-
Stewart W.F., Kawas C., Corrada M., and Metter E.J. Risk of Alzheimer's disease and duration of NSAID use. Neurology 48 (1997) 626-632
-
(1997)
Neurology
, vol.48
, pp. 626-632
-
-
Stewart, W.F.1
Kawas, C.2
Corrada, M.3
Metter, E.J.4
-
22
-
-
11244334168
-
Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-κ activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation
-
Takada Y., Bhardwaj A., Potdar P., and Aggarwal B.B. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-κ activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 23 (2004) 9247-9258
-
(2004)
Oncogene
, vol.23
, pp. 9247-9258
-
-
Takada, Y.1
Bhardwaj, A.2
Potdar, P.3
Aggarwal, B.B.4
-
23
-
-
0038719688
-
Sulindacsulfide is a noncompetitive γ-secretase inhibitor that preferentially reduces Aβ42 generation
-
Takahashi Y., Hayashi I., Tominari Y., Rikumaru K., Morohashi Y., Kan T., Natsugari H., Fukuyama T., Tomita T., and Iwatsubo T. Sulindacsulfide is a noncompetitive γ-secretase inhibitor that preferentially reduces Aβ42 generation. J. Biol. Chem. 278 (2003) 18664-18670
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 18664-18670
-
-
Takahashi, Y.1
Hayashi, I.2
Tominari, Y.3
Rikumaru, K.4
Morohashi, Y.5
Kan, T.6
Natsugari, H.7
Fukuyama, T.8
Tomita, T.9
Iwatsubo, T.10
-
24
-
-
0035829592
-
A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
-
Weggen S., Eriksen J.L., Das P., Sagi S.A., Wang R., Pietrzik C.U., Findlay K.A., Smith T.E., Murphy M.P., Bulter T., Kang D.E., Marquez-Sterling N., Golde T.E., and Koo E.H. A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity. Nature 414 (2001) 212-216
-
(2001)
Nature
, vol.414
, pp. 212-216
-
-
Weggen, S.1
Eriksen, J.L.2
Das, P.3
Sagi, S.A.4
Wang, R.5
Pietrzik, C.U.6
Findlay, K.A.7
Smith, T.E.8
Murphy, M.P.9
Bulter, T.10
Kang, D.E.11
Marquez-Sterling, N.12
Golde, T.E.13
Koo, E.H.14
-
25
-
-
33845613251
-
Amyloid-β-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and Ginkgolides in transgenic Caenorhabditis elegans
-
Wu Y., Wu Z., Butko P., Christen Y., Lambert M.P., Klein W.L., Link C.D., and Luo Y. Amyloid-β-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and Ginkgolides in transgenic Caenorhabditis elegans. J. Neurosci. 26 (2006) 13102-13113
-
(2006)
J. Neurosci.
, vol.26
, pp. 13102-13113
-
-
Wu, Y.1
Wu, Z.2
Butko, P.3
Christen, Y.4
Lambert, M.P.5
Klein, W.L.6
Link, C.D.7
Luo, Y.8
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