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Volumn 9, Issue 2, 2013, Pages

The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR-Mediated Double-Strand Break Repair

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; ATR PROTEIN; BRCA1 PROTEIN; CTBP INTERACTING PROTEIN; CYCLIN DEPENDENT KINASE; DEOXYRIBONUCLEOPROTEIN; HISTONE H2AX; NIBRIN; RAD50 PROTEIN; UNCLASSIFIED DRUG;

EID: 84874761014     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003277     Document Type: Article
Times cited : (197)

References (68)
  • 1
    • 33747188326 scopus 로고    scopus 로고
    • Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation
    • Keeney S, Neale MJ, (2006) Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation. Biochem Soc Trans 34: 523-525.
    • (2006) Biochem Soc Trans , vol.34 , pp. 523-525
    • Keeney, S.1    Neale, M.J.2
  • 2
    • 33646181086 scopus 로고    scopus 로고
    • Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus
    • Jung D, Giallourakis C, Mostoslavsky R, Alt FW, (2006) Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu Rev Immunol 24: 541-570.
    • (2006) Annu Rev Immunol , vol.24 , pp. 541-570
    • Jung, D.1    Giallourakis, C.2    Mostoslavsky, R.3    Alt, F.W.4
  • 3
    • 3242881500 scopus 로고    scopus 로고
    • The cellular response to general and programmed DNA double strand breaks
    • Bassing CH, Alt FW, (2004) The cellular response to general and programmed DNA double strand breaks. DNA Repair (Amst) 3: 781-796.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 781-796
    • Bassing, C.H.1    Alt, F.W.2
  • 4
    • 0035093737 scopus 로고    scopus 로고
    • DNA double-strand breaks: signaling, repair and the cancer connection
    • Khanna KK, Jackson SP, (2001) DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet 27: 247-254.
    • (2001) Nat Genet , vol.27 , pp. 247-254
    • Khanna, K.K.1    Jackson, S.P.2
  • 5
    • 17344372572 scopus 로고    scopus 로고
    • Positional cloning of the gene for Nijmegen breakage syndrome
    • Matsuura S, Tauchi H, Nakamura A, Kondo N, Sakamoto S, et al. (1998) Positional cloning of the gene for Nijmegen breakage syndrome. Nat Genet 19: 179-181.
    • (1998) Nat Genet , vol.19 , pp. 179-181
    • Matsuura, S.1    Tauchi, H.2    Nakamura, A.3    Kondo, N.4    Sakamoto, S.5
  • 6
    • 0032076190 scopus 로고    scopus 로고
    • Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome
    • Varon R, Vissinga C, Platzer M, Cerosaletti KM, Chrzanowska KH, et al. (1998) Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. Cell 93: 467-476.
    • (1998) Cell , vol.93 , pp. 467-476
    • Varon, R.1    Vissinga, C.2    Platzer, M.3    Cerosaletti, K.M.4    Chrzanowska, K.H.5
  • 7
    • 0033544724 scopus 로고    scopus 로고
    • The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder
    • Stewart GS, Maser RS, Stankovic T, Bressan DA, Kaplan MI, et al. (1999) The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder. Cell 99: 577-587.
    • (1999) Cell , vol.99 , pp. 577-587
    • Stewart, G.S.1    Maser, R.S.2    Stankovic, T.3    Bressan, D.A.4    Kaplan, M.I.5
  • 8
    • 0029057336 scopus 로고
    • A single ataxia telangiectasia gene with a product similar to PI-3 kinase
    • Savitsky K, Bar-Shira A, Gilad S, Rotman G, Ziv Y, et al. (1995) A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268: 1749-1753.
    • (1995) Science , vol.268 , pp. 1749-1753
    • Savitsky, K.1    Bar-Shira, A.2    Gilad, S.3    Rotman, G.4    Ziv, Y.5
  • 9
    • 0028113345 scopus 로고
    • A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
    • Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, et al. (1994) A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266: 66-71.
    • (1994) Science , vol.266 , pp. 66-71
    • Miki, Y.1    Swensen, J.2    Shattuck-Eidens, D.3    Futreal, P.A.4    Harshman, K.5
  • 10
    • 77953229115 scopus 로고    scopus 로고
    • The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
    • Lieber MR, (2010) The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem 79: 181-211.
    • (2010) Annu Rev Biochem , vol.79 , pp. 181-211
    • Lieber, M.R.1
  • 11
    • 77649131406 scopus 로고    scopus 로고
    • Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis
    • Moynahan ME, Jasin M, (2010) Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat Rev Mol Cell Biol 11: 196-207.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 196-207
    • Moynahan, M.E.1    Jasin, M.2
  • 12
    • 80755187806 scopus 로고    scopus 로고
    • Double-strand break end resection and repair pathway choice
    • Symington LS, Gautier J, (2011) Double-strand break end resection and repair pathway choice. Annu Rev Genet 45: 247-271.
    • (2011) Annu Rev Genet , vol.45 , pp. 247-271
    • Symington, L.S.1    Gautier, J.2
  • 13
    • 0036276388 scopus 로고    scopus 로고
    • The Mre11 complex: at the crossroads of dna repair and checkpoint signalling
    • D'Amours D, Jackson SP, (2002) The Mre11 complex: at the crossroads of dna repair and checkpoint signalling. Nat Rev Mol Cell Biol 3: 317-327.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 317-327
    • D'Amours, D.1    Jackson, S.P.2
  • 14
    • 30344463835 scopus 로고    scopus 로고
    • ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
    • Jazayeri A, Falck J, Lukas C, Bartek J, Smith GC, et al. (2006) ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol 8: 37-45.
    • (2006) Nat Cell Biol , vol.8 , pp. 37-45
    • Jazayeri, A.1    Falck, J.2    Lukas, C.3    Bartek, J.4    Smith, G.C.5
  • 15
    • 52949109260 scopus 로고    scopus 로고
    • Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation
    • Buis J, Wu Y, Deng Y, Leddon J, Westfield G, et al. (2008) Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation. Cell 135: 85-96.
    • (2008) Cell , vol.135 , pp. 85-96
    • Buis, J.1    Wu, Y.2    Deng, Y.3    Leddon, J.4    Westfield, G.5
  • 17
    • 66149114020 scopus 로고    scopus 로고
    • Human CtIP mediates cell cycle control of DNA end resection and double strand break repair
    • Huertas P, Jackson SP, (2009) Human CtIP mediates cell cycle control of DNA end resection and double strand break repair. J Biol Chem 284: 9558-9565.
    • (2009) J Biol Chem , vol.284 , pp. 9558-9565
    • Huertas, P.1    Jackson, S.P.2
  • 18
    • 43149118369 scopus 로고    scopus 로고
    • Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair
    • Chen L, Nievera CJ, Lee AY, Wu X, (2008) Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair. J Biol Chem 283: 7713-7720.
    • (2008) J Biol Chem , vol.283 , pp. 7713-7720
    • Chen, L.1    Nievera, C.J.2    Lee, A.Y.3    Wu, X.4
  • 19
    • 0032566753 scopus 로고    scopus 로고
    • The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression
    • Yu X, Wu LC, Bowcock AM, Aronheim A, Baer R, (1998) The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression. J Biol Chem 273: 25388-25392.
    • (1998) J Biol Chem , vol.273 , pp. 25388-25392
    • Yu, X.1    Wu, L.C.2    Bowcock, A.M.3    Aronheim, A.4    Baer, R.5
  • 20
    • 6344264992 scopus 로고    scopus 로고
    • DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains
    • Yu X, Chen J, (2004) DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. Mol Cell Biol 24: 9478-9486.
    • (2004) Mol Cell Biol , vol.24 , pp. 9478-9486
    • Yu, X.1    Chen, J.2
  • 21
    • 70450242630 scopus 로고    scopus 로고
    • N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair
    • Yuan J, Chen J, (2009) N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair. J Biol Chem 284: 31746-31752.
    • (2009) J Biol Chem , vol.284 , pp. 31746-31752
    • Yuan, J.1    Chen, J.2
  • 22
    • 70349470626 scopus 로고    scopus 로고
    • A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage
    • Lloyd J, Chapman JR, Clapperton JA, Haire LF, Hartsuiker E, et al. (2009) A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage. Cell 139: 100-111.
    • (2009) Cell , vol.139 , pp. 100-111
    • Lloyd, J.1    Chapman, J.R.2    Clapperton, J.A.3    Haire, L.F.4    Hartsuiker, E.5
  • 23
    • 70349472553 scopus 로고    scopus 로고
    • Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair
    • Williams RS, Dodson GE, Limbo O, Yamada Y, Williams JS, et al. (2009) Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair. Cell 139: 87-99.
    • (2009) Cell , vol.139 , pp. 87-99
    • Williams, R.S.1    Dodson, G.E.2    Limbo, O.3    Yamada, Y.4    Williams, J.S.5
  • 24
    • 36248942617 scopus 로고    scopus 로고
    • Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex
    • Lengsfeld BM, Rattray AJ, Bhaskara V, Ghirlando R, Paull TT, (2007) Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex. Mol Cell 28: 638-651.
    • (2007) Mol Cell , vol.28 , pp. 638-651
    • Lengsfeld, B.M.1    Rattray, A.J.2    Bhaskara, V.3    Ghirlando, R.4    Paull, T.T.5
  • 25
    • 34948872046 scopus 로고    scopus 로고
    • Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination
    • Limbo O, Chahwan C, Yamada Y, de Bruin RA, Wittenberg C, et al. (2007) Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination. Mol Cell 28: 134-146.
    • (2007) Mol Cell , vol.28 , pp. 134-146
    • Limbo, O.1    Chahwan, C.2    Yamada, Y.3    de Bruin, R.A.4    Wittenberg, C.5
  • 26
    • 67349246802 scopus 로고    scopus 로고
    • CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle
    • Yun MH, Hiom K, (2009) CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle. Nature 459: 460-463.
    • (2009) Nature , vol.459 , pp. 460-463
    • Yun, M.H.1    Hiom, K.2
  • 27
  • 28
    • 0034644220 scopus 로고    scopus 로고
    • Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response
    • Li S, Ting NS, Zheng L, Chen PL, Ziv Y, et al. (2000) Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature 406: 210-215.
    • (2000) Nature , vol.406 , pp. 210-215
    • Li, S.1    Ting, N.S.2    Zheng, L.3    Chen, P.L.4    Ziv, Y.5
  • 29
    • 72149103012 scopus 로고    scopus 로고
    • CtIP links DNA double-strand break sensing to resection
    • You Z, Shi LZ, Zhu Q, Wu P, Zhang YW, et al. (2009) CtIP links DNA double-strand break sensing to resection. Mol Cell 36: 954-969.
    • (2009) Mol Cell , vol.36 , pp. 954-969
    • You, Z.1    Shi, L.Z.2    Zhu, Q.3    Wu, P.4    Zhang, Y.W.5
  • 30
    • 36949026694 scopus 로고    scopus 로고
    • Activation and regulation of ATM kinase activity in response to DNA double-strand breaks
    • Lee JH, Paull TT, (2007) Activation and regulation of ATM kinase activity in response to DNA double-strand breaks. Oncogene 26: 7741-7748.
    • (2007) Oncogene , vol.26 , pp. 7741-7748
    • Lee, J.H.1    Paull, T.T.2
  • 31
    • 77951879405 scopus 로고    scopus 로고
    • A divalent FHA/BRCT-binding mechanism couples the Mre11-Rad50-Nbs1 complex to damaged chromatin
    • Hari FJ, Spycher C, Jungmichel S, Pavic L, Stucki M, (2010) A divalent FHA/BRCT-binding mechanism couples the Mre11-Rad50-Nbs1 complex to damaged chromatin. EMBO Rep 11: 387-392.
    • (2010) EMBO Rep , vol.11 , pp. 387-392
    • Hari, F.J.1    Spycher, C.2    Jungmichel, S.3    Pavic, L.4    Stucki, M.5
  • 32
    • 0037821657 scopus 로고    scopus 로고
    • Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation
    • Cerosaletti KM, Concannon P, (2003) Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation. J Biol Chem 278: 21944-21951.
    • (2003) J Biol Chem , vol.278 , pp. 21944-21951
    • Cerosaletti, K.M.1    Concannon, P.2
  • 34
    • 0034437354 scopus 로고    scopus 로고
    • The FHA domain, a phosphoamino acid binding domain involved in the DNA damage response pathway
    • Huang M, Elledge SJ, (2000) The FHA domain, a phosphoamino acid binding domain involved in the DNA damage response pathway. Cold Spring Harb Symp Quant Biol 65: 413-421.
    • (2000) Cold Spring Harb Symp Quant Biol , vol.65 , pp. 413-421
    • Huang, M.1    Elledge, S.J.2
  • 35
    • 6344287454 scopus 로고    scopus 로고
    • Interactions between BRCT repeats and phosphoproteins: tangled up in two
    • Glover JN, Williams RS, Lee MS, (2004) Interactions between BRCT repeats and phosphoproteins: tangled up in two. Trends Biochem Sci 29: 579-585.
    • (2004) Trends Biochem Sci , vol.29 , pp. 579-585
    • Glover, J.N.1    Williams, R.S.2    Lee, M.S.3
  • 36
    • 0033197541 scopus 로고    scopus 로고
    • The FHA domain is a modular phosphopeptide recognition motif
    • Durocher D, Henckel J, Fersht AR, Jackson SP, (1999) The FHA domain is a modular phosphopeptide recognition motif. Mol Cell 4: 387-394.
    • (1999) Mol Cell , vol.4 , pp. 387-394
    • Durocher, D.1    Henckel, J.2    Fersht, A.R.3    Jackson, S.P.4
  • 37
    • 68249125947 scopus 로고    scopus 로고
    • 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response
    • Mohammad DH, Yaffe MB, (2009) 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response. DNA Repair (Amst) 8: 1009-1017.
    • (2009) DNA Repair (Amst) , vol.8 , pp. 1009-1017
    • Mohammad, D.H.1    Yaffe, M.B.2
  • 38
    • 78649460650 scopus 로고    scopus 로고
    • DNA end resection by CtIP and Exonuclease 1 prevents genomic instability
    • Eid W, Steger M, El-Shemerly M, Ferretti LP, Pena-Diaz J, et al. (2010) DNA end resection by CtIP and Exonuclease 1 prevents genomic instability. EMBO Rep 11: 962-968.
    • (2010) EMBO Rep , vol.11 , pp. 962-968
    • Eid, W.1    Steger, M.2    El-Shemerly, M.3    Ferretti, L.P.4    Pena-Diaz, J.5
  • 39
    • 53649090109 scopus 로고    scopus 로고
    • DNA helicases Sgs1 and BLM promote DNA double-strand break resection
    • Gravel S, Chapman JR, Magill C, Jackson SP, (2008) DNA helicases Sgs1 and BLM promote DNA double-strand break resection. Genes Dev 22: 2767-2772.
    • (2008) Genes Dev , vol.22 , pp. 2767-2772
    • Gravel, S.1    Chapman, J.R.2    Magill, C.3    Jackson, S.P.4
  • 40
    • 79951688343 scopus 로고    scopus 로고
    • BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair
    • Nimonkar AV, Genschel J, Kinoshita E, Polaczek P, Campbell JL, et al. (2011) BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. Genes Dev 25: 350-362.
    • (2011) Genes Dev , vol.25 , pp. 350-362
    • Nimonkar, A.V.1    Genschel, J.2    Kinoshita, E.3    Polaczek, P.4    Campbell, J.L.5
  • 42
    • 42449086413 scopus 로고    scopus 로고
    • Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of Nbs1 at the DNA damage-modified chromatin
    • Melander F, Bekker-Jensen S, Falck J, Bartek J, Mailand N, et al. (2008) Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of Nbs1 at the DNA damage-modified chromatin. J Cell Biol 181: 213-226.
    • (2008) J Cell Biol , vol.181 , pp. 213-226
    • Melander, F.1    Bekker-Jensen, S.2    Falck, J.3    Bartek, J.4    Mailand, N.5
  • 43
    • 42449115711 scopus 로고    scopus 로고
    • Constitutive phosphorylation of MDC1 physically links the Mre11-Rad50-Nbs1 complex to damaged chromatin
    • Spycher C, Miller ES, Townsend K, Pavic L, Morrice NA, et al. (2008) Constitutive phosphorylation of MDC1 physically links the Mre11-Rad50-Nbs1 complex to damaged chromatin. J Cell Biol 181: 227-240.
    • (2008) J Cell Biol , vol.181 , pp. 227-240
    • Spycher, C.1    Miller, E.S.2    Townsend, K.3    Pavic, L.4    Morrice, N.A.5
  • 44
    • 48649100438 scopus 로고    scopus 로고
    • Phospho-dependent interactions between Nbs1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage
    • Chapman JR, Jackson SP, (2008) Phospho-dependent interactions between Nbs1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage. EMBO Rep 9: 795-801.
    • (2008) EMBO Rep , vol.9 , pp. 795-801
    • Chapman, J.R.1    Jackson, S.P.2
  • 45
    • 49649089537 scopus 로고    scopus 로고
    • MDC1 regulates intra-S-phase checkpoint by targeting Nbs1 to DNA double-strand breaks
    • Wu L, Luo K, Lou Z, Chen J, (2008) MDC1 regulates intra-S-phase checkpoint by targeting Nbs1 to DNA double-strand breaks. Proc Natl Acad Sci U S A 105: 11200-11205.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 11200-11205
    • Wu, L.1    Luo, K.2    Lou, Z.3    Chen, J.4
  • 46
    • 29244434544 scopus 로고    scopus 로고
    • MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
    • Stucki M, Clapperton JA, Mohammad D, Yaffe MB, Smerdon SJ, et al. (2005) MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell 123: 1213-1226.
    • (2005) Cell , vol.123 , pp. 1213-1226
    • Stucki, M.1    Clapperton, J.A.2    Mohammad, D.3    Yaffe, M.B.4    Smerdon, S.J.5
  • 47
    • 54849404458 scopus 로고    scopus 로고
    • MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings
    • McVey M, Lee SE, (2008) MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings. Trends Genet 24: 529-538.
    • (2008) Trends Genet , vol.24 , pp. 529-538
    • McVey, M.1    Lee, S.E.2
  • 48
    • 35348821296 scopus 로고    scopus 로고
    • A backup DNA repair pathway moves to the forefront
    • Nussenzweig A, Nussenzweig MC, (2007) A backup DNA repair pathway moves to the forefront. Cell 131: 223-225.
    • (2007) Cell , vol.131 , pp. 223-225
    • Nussenzweig, A.1    Nussenzweig, M.C.2
  • 49
    • 84862282124 scopus 로고    scopus 로고
    • CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded Breaks
    • Wang H, Shao Z, Shi LZ, Hwang PY, Truong LN, et al. (2012) CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded Breaks. J Biol Chem 287: 21471-21480.
    • (2012) J Biol Chem , vol.287 , pp. 21471-21480
    • Wang, H.1    Shao, Z.2    Shi, L.Z.3    Hwang, P.Y.4    Truong, L.N.5
  • 50
    • 7244220162 scopus 로고    scopus 로고
    • DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1
    • Ira G, Pellicioli A, Balijja A, Wang X, Fiorani S, et al. (2004) DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature 431: 1011-1017.
    • (2004) Nature , vol.431 , pp. 1011-1017
    • Ira, G.1    Pellicioli, A.2    Balijja, A.3    Wang, X.4    Fiorani, S.5
  • 51
    • 44349086462 scopus 로고    scopus 로고
    • Molecular characterization of the role of the Schizosaccharomyces pombe nip1+/ctp1+ gene in DNA double-strand break repair in association with the Mre11-Rad50-Nbs1 complex
    • Akamatsu Y, Murayama Y, Yamada T, Nakazaki T, Tsutsui Y, et al. (2008) Molecular characterization of the role of the Schizosaccharomyces pombe nip1+/ctp1+ gene in DNA double-strand break repair in association with the Mre11-Rad50-Nbs1 complex. Mol Cell Biol 28: 3639-3651.
    • (2008) Mol Cell Biol , vol.28 , pp. 3639-3651
    • Akamatsu, Y.1    Murayama, Y.2    Yamada, T.3    Nakazaki, T.4    Tsutsui, Y.5
  • 52
    • 2942594756 scopus 로고    scopus 로고
    • The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation
    • Baroni E, Viscardi V, Cartagena-Lirola H, Lucchini G, Longhese MP, (2004) The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation. Mol Cell Biol 24: 4151-4165.
    • (2004) Mol Cell Biol , vol.24 , pp. 4151-4165
    • Baroni, E.1    Viscardi, V.2    Cartagena-Lirola, H.3    Lucchini, G.4    Longhese, M.P.5
  • 53
    • 51549095956 scopus 로고    scopus 로고
    • Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends
    • Zhu Z, Chung WH, Shim EY, Lee SE, Ira G, (2008) Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell 134: 981-994.
    • (2008) Cell , vol.134 , pp. 981-994
    • Zhu, Z.1    Chung, W.H.2    Shim, E.Y.3    Lee, S.E.4    Ira, G.5
  • 54
    • 53649104599 scopus 로고    scopus 로고
    • Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
    • Mimitou EP, Symington LS, (2008) Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. Nature 455: 770-774.
    • (2008) Nature , vol.455 , pp. 770-774
    • Mimitou, E.P.1    Symington, L.S.2
  • 55
    • 34548213632 scopus 로고    scopus 로고
    • The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A
    • Olson E, Nievera CJ, Liu E, Lee AY, Chen L, et al. (2007) The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A. Mol Cell Biol 27: 6053-6067.
    • (2007) Mol Cell Biol , vol.27 , pp. 6053-6067
    • Olson, E.1    Nievera, C.J.2    Liu, E.3    Lee, A.Y.4    Chen, L.5
  • 56
    • 84862972549 scopus 로고    scopus 로고
    • Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint
    • Lee AY, Chiba T, Truong LN, Cheng AN, Do J, et al. (2012) Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint. J Biol Chem 287: 2531-2543.
    • (2012) J Biol Chem , vol.287 , pp. 2531-2543
    • Lee, A.Y.1    Chiba, T.2    Truong, L.N.3    Cheng, A.N.4    Do, J.5
  • 57
    • 0034674706 scopus 로고    scopus 로고
    • Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor
    • Yu X, Baer R, (2000) Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor. J Biol Chem 275: 18541-18549.
    • (2000) J Biol Chem , vol.275 , pp. 18541-18549
    • Yu, X.1    Baer, R.2
  • 58
    • 77951251067 scopus 로고    scopus 로고
    • Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
    • Bolderson E, Tomimatsu N, Richard DJ, Boucher D, Kumar R, et al. (2010) Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks. Nucleic Acids Res 38: 1821-1831.
    • (2010) Nucleic Acids Res , vol.38 , pp. 1821-1831
    • Bolderson, E.1    Tomimatsu, N.2    Richard, D.J.3    Boucher, D.4    Kumar, R.5
  • 59
    • 37349090772 scopus 로고    scopus 로고
    • Expression and localization of Werner syndrome protein is modulated by SIRT1 and PML
    • Vaitiekunaite R, Butkiewicz D, Krzesniak M, Przybylek M, Gryc A, et al. (2007) Expression and localization of Werner syndrome protein is modulated by SIRT1 and PML. Mech Ageing Dev 128: 650-661.
    • (2007) Mech Ageing Dev , vol.128 , pp. 650-661
    • Vaitiekunaite, R.1    Butkiewicz, D.2    Krzesniak, M.3    Przybylek, M.4    Gryc, A.5
  • 60
    • 27644495154 scopus 로고    scopus 로고
    • Internet-based robotic laser scissors and tweezers microscopy
    • Botvinick EL, Berns MW, (2005) Internet-based robotic laser scissors and tweezers microscopy. Microsc Res Tech 68: 65-74.
    • (2005) Microsc Res Tech , vol.68 , pp. 65-74
    • Botvinick, E.L.1    Berns, M.W.2
  • 61
    • 34247477667 scopus 로고    scopus 로고
    • Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks
    • Uematsu N, Weterings E, Yano K, Morotomi-Yano K, Jakob B, et al. (2007) Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks. J Cell Biol 177: 219-229.
    • (2007) J Cell Biol , vol.177 , pp. 219-229
    • Uematsu, N.1    Weterings, E.2    Yano, K.3    Morotomi-Yano, K.4    Jakob, B.5
  • 62
    • 18444391517 scopus 로고    scopus 로고
    • Shotgun identification of protein modifications from protein complexes and lens tissue
    • MacCoss MJ, McDonald WH, Saraf A, Sadygov R, Clark JM, et al. (2002) Shotgun identification of protein modifications from protein complexes and lens tissue. Proc Natl Acad Sci U S A 99: 7900-7905.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 7900-7905
    • MacCoss, M.J.1    McDonald, W.H.2    Saraf, A.3    Sadygov, R.4    Clark, J.M.5
  • 63
    • 0037277179 scopus 로고    scopus 로고
    • Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: the yeast proteome
    • Peng J, Elias JE, Thoreen CC, Licklider LJ, Gygi SP, (2003) Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: the yeast proteome. J Proteome Res 2: 43-50.
    • (2003) J Proteome Res , vol.2 , pp. 43-50
    • Peng, J.1    Elias, J.E.2    Thoreen, C.C.3    Licklider, L.J.4    Gygi, S.P.5
  • 64
    • 35648943746 scopus 로고    scopus 로고
    • ProLuCID, a fast and sensitive tandem mass spectra-based protein identification program
    • Xu T, Venable JD, Park SK, Cociorva D, Lu B, et al. (2006) ProLuCID, a fast and sensitive tandem mass spectra-based protein identification program. Molecular & Cellular Proteomics 5: S174-S174.
    • (2006) Molecular & Cellular Proteomics , vol.5
    • Xu, T.1    Venable, J.D.2    Park, S.K.3    Cociorva, D.4    Lu, B.5
  • 65
    • 70349761870 scopus 로고    scopus 로고
    • Shotgun protein identification and quantification by mass spectrometry
    • Lu B, Xu T, Park SK, Yates JR 3rd, (2009) Shotgun protein identification and quantification by mass spectrometry. Methods Mol Biol 564: 261-288.
    • (2009) Methods Mol Biol , vol.564 , pp. 261-288
    • Lu, B.1    Xu, T.2    Park, S.K.3    Yates 3rd, J.R.4
  • 66
    • 0036393898 scopus 로고    scopus 로고
    • DTASelect and Contrast: tools for assembling and comparing protein identifications from shotgun proteomics
    • Tabb DL, McDonald WH, Yates JR 3rd, (2002) DTASelect and Contrast: tools for assembling and comparing protein identifications from shotgun proteomics. J Proteome Res 1: 21-26.
    • (2002) J Proteome Res , vol.1 , pp. 21-26
    • Tabb, D.L.1    McDonald, W.H.2    Yates 3rd, J.R.3
  • 67
    • 0000857494 scopus 로고
    • An approach to correlate tandem mass-spectral data of peptides with amino-acid-sequences in a protein database
    • Eng JK, Mccormack AL, Yates JR, (1994) An approach to correlate tandem mass-spectral data of peptides with amino-acid-sequences in a protein database. Journal of the American Society for Mass Spectrometry 5: 976-989.
    • (1994) Journal of the American Society for Mass Spectrometry , vol.5 , pp. 976-989
    • Eng, J.K.1    Mccormack, A.L.2    Yates, J.R.3
  • 68
    • 0035089657 scopus 로고    scopus 로고
    • Targeting of PCNA to sites of DNA replication in the mammalian cell nucleus
    • Somanathan S, Suchyna TM, Siegel AJ, Berezney R, (2001) Targeting of PCNA to sites of DNA replication in the mammalian cell nucleus. J Cell Biochem 81: 56-67.
    • (2001) J Cell Biochem , vol.81 , pp. 56-67
    • Somanathan, S.1    Suchyna, T.M.2    Siegel, A.J.3    Berezney, R.4


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