CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks

Journal of Biological Chemistry

Volumn 287, Issue 25, 2012, Pages 21471-21480

  Wang, Hailong ^a   Shao, Zhengping ^b   Shi, Linda Z ^c   Hwang, Patty Yi Hwa ^a   Truong, Lan N ^a   Berns, Michael W ^c   Chen, David J ^b   Wu, Xiaohua ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEFECTS; DNA; MAMMALS; PROTEINS; REPAIR;

ATAXIA TELANGIECTASIA; BIOLOGICAL SIGNIFICANCE; DNA DAMAGE RESPONSE; HOMOLOGOUS RECOMBINATION; LIVE-CELL IMAGING; MICROHOMOLOGY-MEDIATED END JOINING; MRE11-RAD50-NBS1 COMPLEXES; PROTEIN DIMERIZATION;

DIMERIZATION;

BRCA1 PROTEIN; CHECKPOINT KINASE RAD3; CHYMOTRYPSIN; CTBP INTERACTING PROTEIN; NIBRIN; UNCLASSIFIED DRUG;

ARTICLE; ATAXIA TELANGIECTASIA; CONTROLLED STUDY; DIMERIZATION; DISEASE SEVERITY; DNA DAMAGE; DNA END JOINING REPAIR; DOUBLE STRANDED DNA BREAK; GENE ACTIVATION; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION;

EID: 84862282124     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.355354     Document Type: Article

References (33)

1. Stracker, T. H., and Petrini, J. H. (2011) The MRE11 complex. Starting from the ends. Nat. Rev. Mol. Cell Biol. 12, 90-103
2. Paull, T. T., and Lee, J. H. (2005) The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM. Cell Cycle 4, 737-740 (Pubitemid 41353819)
3. Chinnadurai, G. (2006) CtIP, a candidate tumor susceptibility gene is a team player with luminaries. Biochim. Biophys. Acta 1765, 67-73
4. You, Z., and Bailis, J. M. (2010) DNA damage and decisions. CtIP coordinates DNA repair and cell cycle checkpoints. Trends Cell Biol. 20, 402-409
5. Yu, X., and Chen, J. (2004) DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. Mol. Cell. Biol. 24, 9478-9486 (Pubitemid 39391684)
6. Sartori, A. A., Lukas, C., Coates, J., Mistrik, M., Fu, S., Bartek, J., Baer, R., Lukas, J., and Jackson, S. P. (2007) Human CtIP promotes DNA end resection. Nature 450, 509-514 (Pubitemid 350190253)
7. You, Z., Shi, L. Z., Zhu, Q., Wu, P., Zhang, Y. W., Basilio, A., Tonnu, N., Verma, I. M., Berns, M. W., and Hunter, T. (2009) CtIP links DNA double-strand break sensing to resection. Mol. Cell 36, 954-969
8. Greenberg, R. A., Sobhian, B., Pathania, S., Cantor, S. B., Nakatani, Y., and Livingston, D. M. (2006) Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes. Genes Dev. 20, 34-46 (Pubitemid 43042666)
9. Chen, L., Nievera, C. J., Lee, A. Y., and Wu, X. (2008) Cell cycle-dependent complex formation of BRCA1·CtIP·MRN is important for DNA double-strand break repair. J. Biol. Chem. 283, 7713-7720
10. Yun, M. H., and Hiom, K. (2009) CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle. Nature 459, 460-463
11. Huertas, P., and Jackson, S. P. (2009) Human CtIP mediates cell cycle control of DNA end resection and double strand break repair. J. Biol. Chem. 284, 9558-9565
12. Limbo, O., Chahwan, C., Yamada, Y., de Bruin, R. A., Wittenberg, C., and Russell, P. (2007) Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination. Mol. Cell 28, 134-146 (Pubitemid 47531975)
13. Paull, T. T. (2010) Making the best of the loose ends. Mre11/Rad50 complexes and Sae2 promote DNA double-strand break resection. DNA Repair 9, 1283-1291
14. Takeda, S., Nakamura, K., Taniguchi, Y., and Paull, T. T. (2007) Ctp1/CtIP and the MRN complex collaborate in the initial steps of homologous recombination. Mol. Cell 28, 351-352 (Pubitemid 350030570)
15. Huertas, P., Cortés-Ledesma, F., Sartori, A. A., Aguilera, A., and Jackson, S. P. (2008) CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature 455, 689-692
16. Kim, H. S., Vijayakumar, S., Reger, M., Harrison, J. C., Haber, J. E., Weil, C., and Petrini, J. H. (2008) Functional interactions between Sae2 and the Mre11 complex. Genetics 178, 711-723 (Pubitemid 351398786)
17. Dubin, M. J., Stokes, P. H., Sum, E. Y., Williams, R. S., Valova, V. A., Robinson, P. J., Lindeman, G. J., Glover, J. N., Visvader, J. E., and Matthews, J. M. (2004) Dimerization of CtIP, a BRCA1- and CtBP-interacting protein, is mediated by an N-terminal coiled-coil motif. J. Biol. Chem. 279, 26932-26938 (Pubitemid 38812528)
18. Wilson, I. A., Haft, D. H., Getzoff, E. D., Tainer, J. A., Lerner, R. A., and Brenner, S. (1985) Identical short peptide sequences in unrelated proteins can have different conformations. A testing ground for theories of immune recognition. Proc. Natl. Acad. Sci. U.S.A. 82, 5255-5259 (Pubitemid 15012085)
19. Olson, E., Nievera, C. J., Liu, E., Lee, A. Y., Chen, L., and Wu, X. (2007) The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A. Mol. Cell. Biol. 27, 6053-6067 (Pubitemid 47326694)
20. Jackson, R. J., Howell, M. T., and Kaminski, A. (1990) The novel mechanism of initiation of picornavirus RNA translation. Trends Biochem. Sci. 15, 477-483
21. Jang, S. K., Kräusslich, H. G., Nicklin, M. J., Duke, G. M., Palmenberg, A. C., and Wimmer, E. (1988) A segment of the 5′ nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation. J. Virol. 62, 2636-2643
22. Pelletier, J., and Sonenberg, N. (1988) Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature 334, 320-325
23. Uematsu, N., Weterings, E., Yano, K., Morotomi-Yano, K., Jakob, B., Taucher-Scholz, G., Mari, P. O., van Gent, D. C., Chen, B. P., and Chen, D. J. (2007) Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks. J. Cell Biol. 177, 219-229 (Pubitemid 46658634)
24. Botvinick, E. L., and Berns, M. W. (2005) Internet-based robotic laser scissors and tweezers microscopy. Microsc. Res. Tech. 68, 65-74 (Pubitemid 41566388)
25. Li, S., Ting, N. S., Zheng, L., Chen, P. L., Ziv, Y., Shiloh, Y., Lee, E. Y., and Lee, W. H. (2000) Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature 406, 210-215 (Pubitemid 30469007)
26. McVey, M., and Lee, S. E. (2008) MMEJ repair of double-strand breaks (director's cut). Deleted sequences and alternative endings. Trends Genet 24, 529-538
27. Xie, A., Kwok, A., and Scully, R. (2009) Role of mammalian Mre11 in classical and alternative nonhomologous end joining. Nat. Struct. Mol. Biol. 16, 814-818
28. Bennardo, N., Cheng, A., Huang, N., and Stark, J. M. (2008) Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair. PLoS Genet. 4, e1000110
29. Rass, E., Grabarz, A., Plo, I., Gautier, J., Bertrand, P., and Lopez, B. S. (2009) Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells. Nat. Struct. Mol. Biol. 16, 819-824
30. Dinkelmann, M., Spehalski, E., Stoneham, T., Buis, J., Wu, Y., Sekiguchi, J. M., and Ferguson, D. O. (2009) Multiple functions of MRN in endjoining pathways during isotype class switching. Nat. Struct. Mol. Biol. 16, 808-813
31. Somanathan, S., Suchyna, T. M., Siegel, A. J., and Berezney, R. (2001) Targeting of PCNA to sites of DNA replication in the mammalian cell nucleus. J. Cell. Biochem. 81, 56-67
32. O'Shea, E. K., Klemm, J. D., Kim, P. S., and Alber, T. (1991) X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil. Science 254, 539-544 (Pubitemid 21917367)
33. Zgheib, O., Pataky, K., Brugger, J., and Halazonetis, T. D. (2009) An oligomerized 53BP1 tudor domain suffices for recognition of DNA double-strand breaks. Mol. Cell. Biol. 29, 1050-1058