Lipotoxicity contributes to endothelial dysfunction: A focus on the contribution from ceramide

Reviews in Endocrine and Metabolic Disorders

Volumn 14, Issue 1, 2013, Pages 59-68

  Symons, J David ^a   Abel, E Dale ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Adiponectin; Ceramide; Diabetes; Endothelial dysfunction; Glucotoxicity; Inflammation; Insulin resistance; Mitochondria; Nitric oxide; Obesity; Pathways and mechanisms; Reactive oxygen species; Vascular dysfunction

Indexed keywords

ADIPONECTIN; ADIPONECTIN RECEPTOR 1; ADIPONECTIN RECEPTOR 2; BONE MORPHOGENETIC PROTEIN; CERAMIDE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FATTY ACID; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE B; PROTEIN KINASE C BETA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SOMATOMEDIN C RECEPTOR; SPHINGOSINE; TOLL LIKE RECEPTOR 4;

ATHEROSCLEROSIS; BIOAVAILABILITY; CARDIOMYOPATHY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; HUMAN; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN RESISTANCE; KIDNEY DISEASE; LIPID STORAGE; LIPOTOXICITY; MICROVASCULAR ENDOTHELIAL CELL; MITOCHONDRION; MORBIDITY; MORTALITY; NEUROPATHY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OXIDATIVE STRESS; PHENOTYPE; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RETINOPATHY; REVIEW; SIGNAL TRANSDUCTION; VASODILATATION;

ANIMALS; CERAMIDES; ENDOTHELIUM, VASCULAR; HUMANS; INFLAMMATION; INSULIN RESISTANCE; NITRIC OXIDE; OBESITY;

EID: 84874667392     PISSN: 13899155     EISSN: 15732606     Source Type: Journal    
DOI: 10.1007/s11154-012-9235-3     Document Type: Review

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