Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K)

Journal of Biological Chemistry

Volumn 287, Issue 7, 2012, Pages 4518-4530

  Maeno, Yasuhiro ^a   Li, Qian ^a   Park, Kyoungmin ^a   Rask Madsen, Christian ^a   Gao, Benbo ^a   Matsumoto, Motonobu ^a   Liu, Yingjie ^a   Wu, I Hsien ^a   White, Morris F ^b   Feener, Edward P ^a   King, George L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II; CYTOKINES; DELETION MUTANTS; ENDOTHELIAL DYSFUNCTION; ENDOTHELIAL FUNCTION; ENDOTHELIAL NITRIC-OXIDE SYNTHASE (ENOS); INSULIN RECEPTORS; INSULIN SIGNALING; METABOLIC DISORDERS; PHOSPHATIDYLINOSITOL 3-KINASE; PROTEIN KINASE; PROTEIN KINASE C; TYROSINE PHOSPHORYLATION;

AMINO ACIDS; ENDOTHELIAL CELLS; ENZYMES; INSULIN; PHOSPHORYLATION;

CHEMICAL ACTIVATION;

ANGIOTENSIN II; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C; PROTEIN P85; VASCULOTROPIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; CATTLE; CELLS, CULTURED; CLASS IA PHOSPHATIDYLINOSITOL 3-KINASE; ENDOTHELIAL CELLS; ENZYME ACTIVATION; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; METABOLIC DISEASES; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84863115564     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.286591     Document Type: Article

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