Mass spectroscopy and molecular modeling predict endothelial nitric oxide synthase dimer collapse by hydrogen peroxide through zinc tetrathiolate metal-binding site disruption

DNA and Cell Biology

Volumn 29, Issue 3, 2010, Pages 149-160

  Fonseca, Fabio V ^a   Ravi, Kandasamy ^b   Wiseman, Dean ^a   Tummala, Monorama ^c   Harmon, Cynthia ^d   Ryzhov, Victor ^c   Fineman, Jeffrey R ^d,e   Black, Stephen M ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b Cold Spring Harbor ^*  (United States)

^c NORTHERN ILLINOIS UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; CYSTEIC ACID; DIHYDROBIOPTERIN; DIMER; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDROGEN PEROXIDE; NITRIC OXIDE; RECOMBINANT ENZYME; TETRAHYDROBIOPTERIN; THIOL DERIVATIVE; UNCLASSIFIED DRUG; ZINC; ZINC TETRATHIOLATE;

ARTICLE; BINDING SITE; CHEMICAL MODIFICATION; CONTROLLED STUDY; ENZYME INHIBITION; HYDROGEN BOND; MASS SPECTROMETRY; METAL BINDING; MOLECULAR MODEL; OXIDATION; PRIORITY JOURNAL; PROTEIN QUATERNARY STRUCTURE;

AMINO ACID SEQUENCE; BINDING SITES; BIOPTERIN; CYSTEIC ACID; CYSTEINE; HUMANS; HYDROGEN PEROXIDE; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; ZINC;

OVIS;

EID: 77749234120     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/dna.2009.0858     Document Type: Article

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