-
1
-
-
79959936188
-
National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: Systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants
-
21705069 1:CAS:528:DC%2BC3MXotlyltbo%3D 10.1016/S0140-6736(11)60679-X
-
Danaei G, Finucane MM, Lu Y, et al. National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet. 2011;378:31-40.
-
(2011)
Lancet
, vol.378
, pp. 31-40
-
-
Danaei, G.1
Finucane, M.M.2
Lu, Y.3
-
2
-
-
64649104158
-
From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus
-
19336687 1:CAS:528:DC%2BD1MXktleitbw%3D 10.2337/db09-9028
-
DeFronzo RA. From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus. Diabetes. 2009;58:773-95.
-
(2009)
Diabetes
, vol.58
, pp. 773-795
-
-
Defronzo, R.A.1
-
3
-
-
78349297565
-
Oxidative stress and diabetic complications
-
21030723 1:CAS:528:DC%2BC3cXhtlGjsrrP 10.1161/CIRCRESAHA.110.223545
-
Giacco F, Brownlee M. Oxidative stress and diabetic complications. Circ Res. 2010;107:1058-70.
-
(2010)
Circ Res
, vol.107
, pp. 1058-1070
-
-
Giacco, F.1
Brownlee, M.2
-
4
-
-
2642572617
-
Impaired microvascular function in obesity: Implications for obesity-associated microangiopathy, hypertension, and insulin resistance
-
DOI 10.1161/01.CIR.0000129772.26647.6F
-
de Jongh RT, Serne EH, IJzerman RG, De Vries G, Stehouwer CD. Impaired microvascular function in obesity: implications for obesity-associated microangiopathy, hypertension, and insulin resistance. Circulation. 2004;109:2529-35. (Pubitemid 38720552)
-
(2004)
Circulation
, vol.109
, Issue.21
, pp. 2529-2535
-
-
De Jongh, R.T.1
Serne, E.H.2
Ijzerman, R.G.3
De Vries, G.4
Stehouwer, C.D.A.5
-
5
-
-
7044269441
-
Free fatty acid levels modulate microvascular function: Relevance for obesity-associated insulin resistance, hypertension, and microangiopathy
-
DOI 10.2337/diabetes.53.11.2873
-
de Jongh RT, Serne EH, IJzerman RG, de Vries G, Stehouwer CDA. Free fatty acid levels modulate microvascular function: Relevance for obesity-associated insulin resistance, hypertension, and microangiopathy. Diabetes. 2004;53:2873-82. (Pubitemid 39425913)
-
(2004)
Diabetes
, vol.53
, Issue.11
, pp. 2873-2882
-
-
De Jongh, R.T.1
Serne, E.H.2
Ijzerman, R.G.3
De Vries, G.4
Stehouwer, C.D.A.5
-
6
-
-
0034681949
-
Endothelial dysfunction is detectable in young normotensive first-degree relatives of subjects with type 2 diabetes in association with insulin resistance
-
Balletshofer BM, Rittig K, Enderle MD, et al. Endothelial dysfunction is detectable in young normotensive first-degree relatives of subjects with type 2 diabetes in association with insulin resistance. Circulation. 2000;101:1780-4. (Pubitemid 30213098)
-
(2000)
Circulation
, vol.101
, Issue.15
, pp. 1780-1784
-
-
Balletshofer, B.M.1
Rittig, K.2
Enderle, M.D.3
Volk, A.4
Maerker, E.5
Jacob, S.6
Matthaei, S.7
Rett, K.8
Haring, H.U.9
-
7
-
-
0032878326
-
Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes
-
DOI 10.2337/diabetes.48.9.1856
-
Caballero AE, Arora S, Saouaf R, et al. Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes. Diabetes. 1999;48:1856-62. (Pubitemid 29415208)
-
(1999)
Diabetes
, vol.48
, Issue.9
, pp. 1856-1862
-
-
Caballero, A.E.1
Arora, S.2
Saouaf, R.3
Lim, S.C.4
Smakowski, P.5
Park, J.Y.6
King, G.L.7
LoGerfo, F.W.8
Horton, E.S.9
Veves, A.10
-
8
-
-
19744362790
-
"Vasocrine" signalling from perivascular fat: A mechanism linking insulin resistance to vascular disease
-
DOI 10.1016/S0140-6736(05)66585-3, PII S0140673605665853
-
Yudkin JS, Eringa E, Stehouwer CD. "Vasocrine" signalling from perivascular fat: a mechanism linking insulin resistance to vascular disease. Lancet. 2005;365:1817-20. (Pubitemid 40744663)
-
(2005)
Lancet
, vol.365
, Issue.9473
, pp. 1817-1820
-
-
Yudkin, J.S.1
Eringa, E.2
Stehouwer, C.D.A.3
-
9
-
-
0032943709
-
C-reactive protein in healthy subjects: Associations with obesity, insulin resistance, and endothelial dysfunction: A potential role for cytokines originating from adipose tissue?
-
Yudkin JS, Stehouwer CDA, Emeis JJ, Coppack SW. C-reactive protein in healthy subjects: Associations with obesity, insulin resistance, and endothelial dysfunction: A potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol. 1999;19:972-8. (Pubitemid 29177345)
-
(1999)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.19
, Issue.4
, pp. 972-978
-
-
Yudkin, J.S.1
Stehouwer, C.D.A.2
Emeis, J.J.3
Coppack, S.W.4
-
10
-
-
23644439439
-
Compromised arterial function in human type 2 diabetic patients
-
DOI 10.2337/diabetes.54.8.2415
-
Okon EB, Chung AWY, Rauniyar P, et al. Compromised arterial function in human type 2 diabetic patients. Diabetes. 2005;54:2415-23. (Pubitemid 41134270)
-
(2005)
Diabetes
, vol.54
, Issue.8
, pp. 2415-2423
-
-
Okon, E.B.1
Chung, A.W.Y.2
Rauniyar, P.3
Padilla, E.4
Tejerina, T.5
McManus, B.M.6
Luo, H.7
Van Breemen, C.8
-
11
-
-
0036789361
-
Increased activity of endogenous endothelin in patients with type II diabetes mellitus
-
12356630 1:CAS:528:DC%2BD38Xnt1GnsLc%3D 10.1161/01.CIR.0000032260.01569. 64
-
Cardillo C, Campia U, Bryant MB, Panza JA. Increased activity of endogenous endothelin in patients with type II diabetes mellitus. Circulation. 2002;106:1783-7.
-
(2002)
Circulation
, vol.106
, pp. 1783-1787
-
-
Cardillo, C.1
Campia, U.2
Bryant, M.B.3
Panza, J.A.4
-
12
-
-
0033600542
-
Insulin stimulates both endothelin and nitric oxide activity in the human forearm
-
Cardillo C, Nambi SS, Kilcoyne CM, et al. Insulin stimulates both endothelin and nitric oxide activity in the human forearm. Circulation. 1999;100:820-5. (Pubitemid 29398879)
-
(1999)
Circulation
, vol.100
, Issue.8
, pp. 820-825
-
-
Cardillo, C.1
Nambi, S.S.2
Kilcoyne, C.M.3
Choucair, W.K.4
Katz, A.5
Quon, M.J.6
Panza, J.A.7
-
13
-
-
84255167154
-
Coronary microvascular dysfunction in a porcine model of early atherosclerosis and diabetes
-
21984550 10.1152/ajpheart.00311.2011 1:CAS:528:DC%2BC38XitVentLk%3D
-
Van den Heuvel M, Sorop O, Koopmans SJ, et al. Coronary microvascular dysfunction in a porcine model of early atherosclerosis and diabetes. Am J Physiol Heart Circ Physiol. 2012;302:H85-94.
-
(2012)
Am J Physiol Heart Circ Physiol
, vol.302
, pp. 85-94
-
-
Van Den Heuvel, M.1
Sorop, O.2
Koopmans, S.J.3
-
14
-
-
52249116805
-
Preglomerular and postglomerular basal diameter changes and reactivity to angiotensin II in obese rats
-
18093213 1:STN:280:DC%2BD1cnjslSksw%3D%3D 10.1111/j.1463-1326.2007.00827. x
-
Roos MH, Eringa EC, van Rodijnen WF, van Lambalgen TA, ter Wee PM, Tangelder GJ. Preglomerular and postglomerular basal diameter changes and reactivity to angiotensin II in obese rats. Diabetes Obes Metab. 2008;10:898-905.
-
(2008)
Diabetes Obes Metab
, vol.10
, pp. 898-905
-
-
Roos, M.H.1
Eringa, E.C.2
Van Rodijnen, W.F.3
Van Lambalgen, T.A.4
Ter Wee, P.M.5
Tangelder, G.J.6
-
15
-
-
36148981792
-
Selective resistance to vasoactive effects of insulin in muscle resistance arteries of obese Zucker (fa/fa) rats
-
DOI 10.1152/ajpendo.00516.2006
-
Eringa EC, Stehouwer CDA, Roos MH, Westerhof N, Sipkema P. Selective resistance to vasoactive effects of insulin in muscle resistance arteries of obese Zucker (fa/fa) rats. Am J Physiol Endocrinol Metab. 2007;293:E1134-9. (Pubitemid 350106578)
-
(2007)
American Journal of Physiology - Endocrinology and Metabolism
, vol.293
, Issue.5
-
-
Eringa, E.C.1
Stehouwer, C.D.A.2
Roos, M.H.3
Westerhof, N.4
Sipkema, P.5
-
16
-
-
84864740588
-
Insulin-induced microvascular recruitment in skin and muscle are related and both are associated with whole body glucose uptake
-
Meijer RI, de Boer MP, Groen MR et al. (2012) Insulin-induced microvascular recruitment in skin and muscle are related and both are associated with whole body glucose uptake. Microcirculation
-
(2012)
Microcirculation
-
-
Meijer, R.I.1
De Boer, M.P.2
Groen, M.R.3
-
17
-
-
77953148019
-
Glucose intolerance and impaired insulin secretion in pancreas-specific signal transducer and activator of transcription-3 knockout mice are associated with microvascular alterations in the pancreas
-
20215569 1:CAS:528:DC%2BC3cXlsFKgsrw%3D 10.1210/en.2009-1199
-
Kostromina E, Gustavsson N, Wang X, et al. Glucose intolerance and impaired insulin secretion in pancreas-specific signal transducer and activator of transcription-3 knockout mice are associated with microvascular alterations in the pancreas. Endocrinology. 2010;151:2050-9.
-
(2010)
Endocrinology
, vol.151
, pp. 2050-2059
-
-
Kostromina, E.1
Gustavsson, N.2
Wang, X.3
-
18
-
-
84859844406
-
Endothelial insulin receptor expression in human atherosclerotic plaques: Linking micro- and macrovascular disease in diabetes?
-
22341865 1:CAS:528:DC%2BC38XjtVyitbY%3D 10.1016/j.atherosclerosis.2012. 01.035
-
Rensing KL, von der Thusen JH, Weijers EM, et al. Endothelial insulin receptor expression in human atherosclerotic plaques: linking micro- and macrovascular disease in diabetes? Atherosclerosis. 2012;222:208-15.
-
(2012)
Atherosclerosis
, vol.222
, pp. 208-215
-
-
Rensing, K.L.1
Von Der Thusen, J.H.2
Weijers, E.M.3
-
19
-
-
33745324596
-
Clustering of insulin resistance with vascular dysfunction and low-grade inflammation in type 2 diabetes
-
DOI 10.2337/diabetes.55.04.06.db05-1076
-
Natali A, Toschi E, Baldeweg S, et al. Clustering of insulin resistance with vascular dysfunction and low-grade inflammation in type 2 diabetes. Diabetes. 2006;55:1133-40. (Pubitemid 44100192)
-
(2006)
Diabetes
, vol.55
, Issue.4
, pp. 1133-1140
-
-
Natali, A.1
Toschi, E.2
Baldeweg, S.3
Ciociaro, D.4
Favilla, S.5
Sacca, L.6
Ferrannini, E.7
-
20
-
-
37349118333
-
Impaired angiogenesis after hindlimb ischemia in type 2 diabetes mellitus: Differential regulation of vascular endothelial growth factor receptor 1 and soluble vascular endothelial growth factor receptor 1
-
DOI 10.1161/CIRCRESAHA.107.160630
-
Hazarika S, Dokun AO, Li Y, Popel AS, Kontos CD, Annex BH. Impaired angiogenesis after hindlimb ischemia in type 2 diabetes mellitus: differential regulation of vascular endothelial growth factor receptor 1 and soluble vascular endothelial growth factor receptor 1. Circ Res. 2007;101:948-56. (Pubitemid 350287182)
-
(2007)
Circulation Research
, vol.101
, Issue.9
, pp. 948-956
-
-
Hazarika, S.1
Dokun, A.O.2
Li, Y.3
Popel, A.S.4
Kontos, C.D.5
Annex, B.H.6
-
21
-
-
84861843350
-
Enhanced cerebral but not peripheral angiogenesis in the Goto-Kakizaki model of type 2 diabetes involves VEGF and peroxynitrite signaling
-
22403298 1:CAS:528:DC%2BC38XotlGqu70%3D 10.2337/db11-1528
-
Prakash R, Somanath PR, El-Remessy AB, et al. Enhanced cerebral but not peripheral angiogenesis in the Goto-Kakizaki model of type 2 diabetes involves VEGF and peroxynitrite signaling. Diabetes. 2012;61:1533-42.
-
(2012)
Diabetes
, vol.61
, pp. 1533-1542
-
-
Prakash, R.1
Somanath, P.R.2
El-Remessy, A.B.3
-
22
-
-
0025292440
-
Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance
-
Laakso M, Edelman SV, Brechtel G, Baron AD. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance. J Clin Invest. 1990;85:1844-52. (Pubitemid 20192958)
-
(1990)
Journal of Clinical Investigation
, vol.85
, Issue.6
, pp. 1844-1852
-
-
Laakso, M.1
Edelman, S.V.2
Brechtel, G.3
Baron, A.D.4
-
23
-
-
0029789432
-
Insulin-stimulated production of nitric oxide is inhibited by Wortmannin: Direct measurement in vascular endothelial cells
-
Zeng G, Quon MJ. Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells. J Clin Invest. 1996;98:894-8. (Pubitemid 26293305)
-
(1996)
Journal of Clinical Investigation
, vol.98
, Issue.4
, pp. 894-898
-
-
Zeng, G.1
Quon, M.J.2
-
24
-
-
0036889823
-
Physiological concentrations of insulin induce endothelin-mediated vasoconstriction during inhibition of NOS or PI3-kinase in skeletal muscle arterioles
-
DOI 10.1016/S0008-6363(02)00593-X, PII S000863630200593X
-
Eringa EC, Stehouwer CD, Merlijn T, Westerhof N, Sipkema P. Physiological concentrations of insulin induce endothelin-mediated vasoconstriction during inhibition of NOS or PI3-kinase in skeletal muscle arterioles. Cardiovasc Res. 2002;56:464-71. (Pubitemid 35351568)
-
(2002)
Cardiovascular Research
, vol.56
, Issue.3
, pp. 464-471
-
-
Eringa, E.C.1
Stehouwer, C.D.A.2
Merlijn, T.3
Westerhof, N.4
Sipkema, P.5
-
25
-
-
0029119084
-
Insulin-mediated skeletal muscle vasodilation contributes to both insulin sensitivity and responsiveness in lean humans
-
7635973 1:CAS:528:DyaK2MXnsVagur0%3D 10.1172/JCI118124
-
Baron AD, Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G. Insulin-mediated skeletal muscle vasodilation contributes to both insulin sensitivity and responsiveness in lean humans. J Clin Invest. 1995;96:786-92.
-
(1995)
J Clin Invest
, vol.96
, pp. 786-792
-
-
Baron, A.D.1
Steinberg, H.O.2
Chaker, H.3
Leaming, R.4
Johnson, A.5
Brechtel, G.6
-
26
-
-
0033542476
-
Activation of nitric oxide synthase in endothelial cells by Akt- dependent phosphorylation
-
DOI 10.1038/21224
-
Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM. Activation of nitric oxide synthase in endothelial cells by Akt- dependent phosphorylation. Nature. 1999;399:601-5. (Pubitemid 29279182)
-
(1999)
Nature
, vol.399
, Issue.6736
, pp. 601-605
-
-
Dimmeler, S.1
Fleming, I.2
Fisslthaler, B.3
Hermann, C.4
Busse, R.5
Zeiher, A.M.6
-
27
-
-
7244219694
-
Vasoconstrictor effects of insulin in skeletal muscle arterioles are mediated by ERK1/2 activation in endothelium
-
DOI 10.1152/ajpheart.00067.2004
-
Eringa EC, Stehouwer CDA, Nieuw Amerongen GP, Ouwehand L, Westerhof N, Sipkema P. Vasoconstrictor effects of insulin in skeletal muscle arterioles are mediated by ERK1/2 activation in endothelium. Am J Physiol Heart Circ Physiol. 2004;287:H2043-8. (Pubitemid 39430742)
-
(2004)
American Journal of Physiology - Heart and Circulatory Physiology
, vol.287
, Issue.5
-
-
Eringa, E.C.1
Stehouwer, C.D.A.2
Van Nieuw Amerongen, G.P.3
Ouwehand, L.4
Westerhof, N.5
Sipkema, P.6
-
28
-
-
23744511665
-
Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production
-
DOI 10.1152/ajpheart.00092.2005
-
Potenza MA, Marasciulo FL, Chieppa DM, et al. Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production. Am J Physiol Heart Circ Physiol. 2005;289:H813-22. (Pubitemid 41129399)
-
(2005)
American Journal of Physiology - Heart and Circulatory Physiology
, vol.289
, Issue.2
-
-
Potenza, M.A.1
Marasciulo, F.L.2
Chieppa, D.M.3
Brigiani, G.S.4
Formoso, G.5
Quon, M.J.6
Montagnani, M.7
-
29
-
-
3142677991
-
Physiological hyperinsulinaemia increases intramuscular microvascular reactive hyperaemia and vasomotion in healthy volunteers
-
de Jongh RT, Clark AD, IJzerman RG, Serne EH, De Vries G, Stehouwer CD (2004) Physiological hyperinsulinaemia increases intramuscular microvascular reactive hyperaemia and vasomotion in healthy volunteers. Diabetologia
-
(2004)
Diabetologia
-
-
De Jongh, R.T.1
Clark, A.D.2
Ijzerman, R.G.3
Serne, E.H.4
De Vries, G.5
Stehouwer, C.D.6
-
30
-
-
0034603858
-
Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells
-
Zeng G, Nystrom FH, Ravichandran LV, et al. Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells. Circulation. 2000;101:1539-45. (Pubitemid 30180890)
-
(2000)
Circulation
, vol.101
, Issue.13
, pp. 1539-1545
-
-
Zeng, G.1
Nystrom, F.H.2
Ravichandran, L.V.3
Cong, L.-N.4
Kirby, M.5
Mostowski, H.6
Quon, M.J.7
-
31
-
-
0036020513
-
Insulin receptor substrate-1 and phosphoinositide-dependent kinase-1 are required for insulin-stimulated production of nitric oxide in endothelial cells
-
DOI 10.1210/me.2002-0074
-
Montagnani M, Ravichandran LV, Chen H, Esposito DL, Quon MJ. Insulin receptor substrate-1 and phosphoinositide-dependent kinase-1 are required for insulin-stimulated production of nitric oxide in endothelial cells. Mol Endocrinol. 2002;16:1931-42. (Pubitemid 34828099)
-
(2002)
Molecular Endocrinology
, vol.16
, Issue.8
, pp. 1931-1942
-
-
Montagnani, M.1
Ravichandran, L.V.2
Chen, H.3
Esposito, D.L.4
Quon, M.J.5
-
32
-
-
79952142784
-
Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle
-
21356519 1:CAS:528:DC%2BC3MXisFGrsro%3D 10.1016/j.cmet.2011.01.018
-
Kubota T, Kubota N, Kumagai H, et al. Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle. Cell Metabolism. 2011;13:294-307.
-
(2011)
Cell Metabolism
, vol.13
, pp. 294-307
-
-
Kubota, T.1
Kubota, N.2
Kumagai, H.3
-
33
-
-
80755168862
-
APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice
-
21926268 1:CAS:528:DC%2BC3MXhsVyis7%2FL 10.2337/db11-0666
-
Wang Y, Cheng KK, Lam KS, et al. APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice. Diabetes. 2011;60:3044-54.
-
(2011)
Diabetes
, vol.60
, pp. 3044-3054
-
-
Wang, Y.1
Cheng, K.K.2
Lam, K.S.3
-
34
-
-
1042303593
-
The vasodilatory actions of insulin on resistance and terminal arterioles and their impact on muscle glucose uptake
-
DOI 10.1002/dmrr.414
-
Clerk LH, Vincent MA, Lindner JR, Clark MG, Rattigan S, Barrett EJ. The vasodilatory actions of insulin on resistance and terminal arterioles and their impact on muscle glucose uptake. Diabetes Metab Res Rev. 2004;20:3-12. (Pubitemid 38196244)
-
(2004)
Diabetes/Metabolism Research and Reviews
, vol.20
, Issue.1
, pp. 3-12
-
-
Clerk, L.H.1
Vincent, M.A.2
Lindner, J.R.3
Clark, M.G.4
Rattigan, S.5
Barrett, E.J.6
-
35
-
-
55449100538
-
Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance
-
18772497 1:CAS:528:DC%2BD1cXht1Ggtb3K 10.1161/ATVBAHA.108.169722
-
Kim F, Pham M, Maloney E, et al. Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance. Arterioscler Thromb Vasc Biol. 2008;28:1982-8.
-
(2008)
Arterioscler Thromb Vasc Biol
, vol.28
, pp. 1982-1988
-
-
Kim, F.1
Pham, M.2
Maloney, E.3
-
36
-
-
0032719024
-
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats
-
Jiang ZY, Lin YW, Clemont A, et al. Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J Clin Invest. 1999;104:447-57. (Pubitemid 29534329)
-
(1999)
Journal of Clinical Investigation
, vol.104
, Issue.4
, pp. 447-457
-
-
Jiang, Z.Y.1
Lin, Y.-W.2
Clemont, A.3
Feener, E.P.4
Hein, K.D.5
Igarashi, M.6
Yamauchi, T.7
White, M.F.8
King, G.L.9
-
37
-
-
0029933363
-
Insulin increases forearm vascular resistance in obese, insulin-resistant hypertensives
-
Gudbjornsdottir S, Elam M, Sellgren J, Anderson EA. Insulin increases forearm vascular resistance in obese, insulin-resistant hypertensives. J Hypertens. 1996;14:91-7. (Pubitemid 26099522)
-
(1996)
Journal of Hypertension
, vol.14
, Issue.1
, pp. 91-97
-
-
Gudbjornsdottir, S.1
Elam, M.2
Sellgren, J.3
Anderson, E.A.4
-
38
-
-
0028899668
-
Circulating endothelin-1 levels increase during euglycemic hyperinsulinemic clamp in lean NIDDM men
-
7729302 1:STN:280:DyaK2M3ks1GqtQ%3D%3D 10.2337/diacare.18.2.226
-
Ferri C, Carlomagno A, Coassin S, et al. Circulating endothelin-1 levels increase during euglycemic hyperinsulinemic clamp in lean NIDDM men. Diabetes Care. 1995;18:226-33.
-
(1995)
Diabetes Care
, vol.18
, pp. 226-233
-
-
Ferri, C.1
Carlomagno, A.2
Coassin, S.3
-
39
-
-
0037662849
-
Lack of insulin receptor substrate-2 causes progressive neointima formation in response to vessel injury
-
DOI 10.1161/01.CIR.0000070937.52035.25
-
Kubota T, Kubota N, Moroi M, et al. Lack of insulin receptor substrate-2 causes progressive neointima formation in response to vessel injury. Circulation. 2003;107:3073. (Pubitemid 36758982)
-
(2003)
Circulation
, vol.107
, Issue.24
, pp. 3073-3080
-
-
Kubota, T.1
Kubota, N.2
Moroi, M.3
Terauchi, Y.4
Kobayashi, T.5
Kamata, K.6
Suzuki, R.7
Tobe, K.8
Namiki, A.9
Aizawa, S.10
Nagai, R.11
Kadowaki, T.12
Yamaguchi, T.13
-
40
-
-
0032523085
-
Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1
-
Abe H, Yamada N, Kamata K, et al. Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1. J Clin Invest. 1998;101:1784-8. (Pubitemid 28198509)
-
(1998)
Journal of Clinical Investigation
, vol.101
, Issue.8
, pp. 1784-1788
-
-
Abe, H.1
Yamada, N.2
Kamata, K.3
Kuwaki, T.4
Shimada, M.5
Osuga, J.6
Shionoiri, F.7
Yahagi, N.8
Kadowaki, T.9
Tamemoto, H.10
Ishibashi, S.11
Yazaki, Y.12
Makuuchi, M.13
-
41
-
-
80052860823
-
The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium
-
21677284 1:CAS:528:DC%2BC3MXhtValurfE 10.2337/db11-0197
-
Abbas A, Imrie H, Viswambharan H, et al. The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium. Diabetes. 2011;60:2169-78.
-
(2011)
Diabetes
, vol.60
, pp. 2169-2178
-
-
Abbas, A.1
Imrie, H.2
Viswambharan, H.3
-
42
-
-
26844548397
-
Insulin at physiological concentrations selectively activates insulin but not insulin-like growth factor I (IGF-I) or insulin/IGF-I hybrid receptors in endothelial cells
-
DOI 10.1210/en.2005-0505
-
Li G, Barrett EJ, Wang H, Chai W, Liu Z. Insulin at physiological concentrations selectively activates insulin but not insulin-like growth factor I (IGF-I) or insulin/IGF-I hybrid receptors in endothelial cells. Endocrinology. 2005;146:4690-6. (Pubitemid 41446606)
-
(2005)
Endocrinology
, vol.146
, Issue.11
, pp. 4690-4696
-
-
Li, G.1
Barrett, E.J.2
Wang, H.3
Chai, W.4
Liu, Z.5
-
43
-
-
33644857995
-
Physiological concentrations of insulin induce endothelin-dependent vasoconstriction of skeletal muscle resistance arteries in the presence of tumor necrosis factor-α dependence on c-Jun N-terminal kinase
-
DOI 10.1161/01.ATV.0000198248.19391.3e, PII 0004360520060200000012
-
Eringa EC, Stehouwer CDA, Walburg K, et al. Physiological concentrations of insulin induce endothelin-dependent vasoconstriction of skeletal muscle resistance arteries in the presence of tumor necrosis factor-alpha: Dependence on c-Jun N-terminal kinase. Arterioscler Thromb Vasc Biol. 2006;26:274-80. (Pubitemid 43732187)
-
(2006)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.26
, Issue.2
, pp. 274-280
-
-
Eringa, E.C.1
Stehouwer, C.D.A.2
Walburg, K.3
Clark, A.D.4
Van Nieuw Amerongen, G.P.5
Westerhof, N.6
Sipkema, P.7
-
44
-
-
40949129628
-
Protein kinase C theta activation induces insulin-mediated constriction of muscle resistance arteries
-
18086904 1:CAS:528:DC%2BD1cXjt1Chur4%3D 10.2337/db07-0792
-
Bakker W, Sipkema P, Stehouwer CDA, et al. Protein kinase C theta activation induces insulin-mediated constriction of muscle resistance arteries. Diabetes. 2008;57:706-13.
-
(2008)
Diabetes
, vol.57
, pp. 706-713
-
-
Bakker, W.1
Sipkema, P.2
Stehouwer, C.D.A.3
-
45
-
-
59049100254
-
Protein kinase C theta (PKC{theta})-dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance
-
19047061 1:CAS:528:DC%2BD1MXlvFakug%3D%3D 10.1074/jbc.M806336200
-
Wang C, Liu M, Riojas RA, et al. Protein kinase C theta (PKC{theta})-dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance. J Biol Chem. 2009;284:2038-44.
-
(2009)
J Biol Chem
, vol.284
, pp. 2038-2044
-
-
Wang, C.1
Liu, M.2
Riojas, R.A.3
-
46
-
-
8544233570
-
1101
-
DOI 10.1074/jbc.C400186200
-
Li Y, Soos TJ, Li X, et al. Protein kinase C theta inhibits insulin signaling by phosphorylating IRS1 at Ser1101. J Biol Chem. 2004;279:45304-7. (Pubitemid 39491511)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.44
, pp. 45304-45307
-
-
Li, Y.1
Soos, T.J.2
Li, X.3
Wu, J.4
DeGennaro, M.5
Sun, X.6
Littman, D.R.7
Birnbaum, M.J.8
Polakiewicz, R.D.9
-
47
-
-
34347261705
-
Tumor necrosis factor-α induces insulin resistance in endothelial cells via a p38 mitogen-activated protein kinase-dependent pathway
-
DOI 10.1210/en.2006-1441
-
Li G, Barrett EJ, Barrett MO, Cao W, Liu Z. Tumor necrosis factor-alpha induces insulin resistance in endothelial cells via a p38 mitogen-activated protein kinase-dependent pathway. Endocrinology. 2007;148:3356-63. (Pubitemid 46996990)
-
(2007)
Endocrinology
, vol.148
, Issue.7
, pp. 3356-3363
-
-
Li, G.1
Barrett, E.J.2
Barrett, M.O.3
Cao, W.4
Liu, Z.5
-
48
-
-
20944436777
-
Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKβ
-
DOI 10.1161/01.ATV.0000160549.60980.a8
-
Kim F, Tysseling KA, Rice J, et al. Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKK{beta}. Arterioscler Thromb Vasc Biol. 2005;25:989-94. (Pubitemid 40627844)
-
(2005)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.25
, Issue.5
, pp. 989-994
-
-
Kim, F.1
Tysseling, K.A.2
Rice, J.3
Pham, M.4
Haji, L.5
Gallis, B.M.6
Baas, A.S.7
Paramsothy, P.8
Giachelli, C.M.9
Corson, M.A.10
Raines, E.W.11
-
49
-
-
0037059330
-
307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action
-
DOI 10.1074/jbc.M101521200
-
Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem. 2002;277:1531-7. (Pubitemid 34968910)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.2
, pp. 1531-1537
-
-
Aguirre, V.1
Werner, E.D.2
Giraud, J.3
Lee, Y.H.4
Shoelson, S.E.5
White, M.F.6
-
50
-
-
13344293711
-
Amelioration of vascular dysfunctions in diabetic rats by an oral PKC β inhibitor
-
Ishii H, Jirousek MR, Koya D, et al. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science. 1996;272:728-31. (Pubitemid 26000279)
-
(1996)
Science
, vol.272
, Issue.5262
, pp. 728-731
-
-
Ishii, H.1
Jirousek, M.R.2
Koya, D.3
Takagi, C.4
Xia, P.5
Clermont, A.6
Bursell, S.-E.7
Kern, T.S.8
Ballas, L.M.9
Heath, W.F.10
Stramm, L.E.11
Feener, E.P.12
King, G.L.13
-
51
-
-
84874663823
-
Protein kinase-C beta contributes to impaired endothelial insulin signaling in humans with diabetes mellitus
-
Tabit CE, Shenouda SM, Holbrook M et al (2012) Protein kinase-C beta contributes to impaired endothelial insulin signaling in humans with diabetes mellitus. Circulation
-
(2012)
Circulation
-
-
Tabit, C.E.1
Shenouda, S.M.2
Al Et, H.M.3
-
52
-
-
79955920129
-
Perivascular adipose tissue and its role in type 2 diabetes and cardiovascular disease
-
Meijer R, Serne E, Smulders Y, van Hinsbergh V, Yudkin J, Eringa E (2011) Perivascular adipose tissue and its role in type 2 diabetes and cardiovascular disease. Current Diabetes Reports 1-7
-
(2011)
Current Diabetes Reports
, pp. 1-7
-
-
Meijer, R.1
Serne, E.2
Smulders, Y.3
Van Hinsbergh, V.4
Yudkin, J.5
Eringa, E.6
-
53
-
-
78751494530
-
The portal theory supported by Venous DrainageΓÇô Selective fat transplantation
-
20956499 1:CAS:528:DC%2BC3MXosVWiuw%3D%3D 10.2337/db10-0697
-
Rytka JM, Wueest S, Schoenle EJ, Konrad D. The portal theory supported by Venous DrainageΓÇôSelective fat transplantation. Diabetes. 2011;60:56-63.
-
(2011)
Diabetes
, vol.60
, pp. 56-63
-
-
Rytka, J.M.1
Wueest, S.2
Schoenle, E.J.3
Konrad, D.4
-
54
-
-
79956318109
-
Adipose inflammation initiates recruitment of leukocytes to mouse femoral artery: Role of adipo-vascular axis in chronic inflammation
-
21625491 1:CAS:528:DC%2BC3MXms1KmsbY%3D 10.1371/journal.pone.0019871
-
Hagita S, Osaka M, Shimokado K, Yoshida M. Adipose inflammation initiates recruitment of leukocytes to mouse femoral artery: role of adipo-vascular axis in chronic inflammation. PLoS One. 2011;6:e19871.
-
(2011)
PLoS One
, vol.6
, pp. 19871
-
-
Hagita, S.1
Osaka, M.2
Shimokado, K.3
Yoshida, M.4
-
55
-
-
84873046305
-
Perivascular adipose tissue control of insulin-induced vasoreactivity in muscle is impaired in db/db mice
-
23048187 1:CAS:528:DC%2BC3sXhvFOnsL8%3D 10.2337/db11-1603
-
Meijer RI, Bakker W, Alta CAF, et al. Perivascular adipose tissue control of insulin-induced vasoreactivity in muscle is impaired in db/db mice. Diabetes. 2013;62:590-8.
-
(2013)
Diabetes
, vol.62
, pp. 590-598
-
-
Meijer, R.I.1
Bakker, W.2
Alta, C.A.F.3
-
56
-
-
0142053963
-
Tumor Necrosis Factor-α Inhibits Insulin's Stimulating Effect on Glucose Uptake and Endothelium-Dependent Vasodilation in Humans
-
DOI 10.1161/01.CIR.0000091406.72832.11
-
Rask-Madsen C, Dominguez H, Ihlemann N, Hermann T, Kober L, Torp-Pedersen C. Tumor necrosis factor-{alpha} inhibits insulin's stimulating effect on glucose uptake and endothelium-dependent vasodilation in humans. Circulation. 2003;108:1815-21. (Pubitemid 37296090)
-
(2003)
Circulation
, vol.108
, Issue.15
, pp. 1815-1821
-
-
Rask-Madsen, C.1
Dominguez, H.2
Ihlemann, N.3
Hermann, T.4
Kober, L.5
Torp-Pedersen, C.6
-
57
-
-
84862258763
-
Perivascular fat and the microcirculation: Relevance to insulin resistance, diabetes, and cardiovascular disease
-
22247785 10.1007/s12170-011-0214-0
-
Houben AJ, Eringa EC, Jonk AM, Serne EH, Smulders YM, Stehouwer CD. Perivascular fat and the microcirculation: relevance to insulin resistance, diabetes, and cardiovascular disease. Curr Cardiovasc Risk Rep. 2012;6:80-90.
-
(2012)
Curr Cardiovasc Risk Rep
, vol.6
, pp. 80-90
-
-
Houben, A.J.1
Eringa, E.C.2
Jonk, A.M.3
Serne, E.H.4
Smulders, Y.M.5
Stehouwer, C.D.6
-
58
-
-
79151484704
-
Adipokines in inflammation and metabolic disease
-
21252989 1:CAS:528:DC%2BC3MXotlSgsg%3D%3D 10.1038/nri2921
-
Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol. 2011;11:85-97.
-
(2011)
Nat Rev Immunol
, vol.11
, pp. 85-97
-
-
Ouchi, N.1
Parker, J.L.2
Lugus, J.J.3
Walsh, K.4
-
59
-
-
79960018147
-
Adiponectin is required for PPARgamma-mediated improvement of endothelial function in diabetic mice
-
21723508 1:CAS:528:DC%2BC3MXosFeitLo%3D 10.1016/j.cmet.2011.05.009
-
Wong WT, Tian XY, Xu A, et al. Adiponectin is required for PPARgamma-mediated improvement of endothelial function in diabetic mice. Cell Metab. 2011;14:104-15.
-
(2011)
Cell Metab
, vol.14
, pp. 104-115
-
-
Wong, W.T.1
Tian, X.Y.2
Xu, A.3
-
60
-
-
62349141949
-
Associations of serum adiponectin with skeletal muscle morphology and insulin sensitivity
-
19106268 1:CAS:528:DC%2BD1MXjt1Wmt7s%3D 10.1210/jc.2008-1772
-
Ingelsson E, Arnlov J, Zethelius B, et al. Associations of serum adiponectin with skeletal muscle morphology and insulin sensitivity. J Clin Endocrinol Metab. 2009;94:953-7.
-
(2009)
J Clin Endocrinol Metab
, vol.94
, pp. 953-957
-
-
Ingelsson, E.1
Arnlov, J.2
Zethelius, B.3
-
61
-
-
65249102725
-
Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients
-
19289637 1:CAS:528:DC%2BD1MXjsVKrtLw%3D 10.1161/CIRCULATIONAHA.108.821181
-
Greenstein AS, Khavandi K, Withers SB, et al. Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients. Circulation. 2009;119:1661-70.
-
(2009)
Circulation
, vol.119
, pp. 1661-1670
-
-
Greenstein, A.S.1
Khavandi, K.2
Withers, S.B.3
-
62
-
-
0042767516
-
Cooperation between insulin and leptin in the modulation of vascular tone
-
DOI 10.1161/01.HYP.0000082806.73530.68
-
Vecchione C, Aretini A, Maffei A, et al. Cooperation between insulin and leptin in the modulation of vascular tone. Hypertension. 2003;42:166-70. (Pubitemid 36944591)
-
(2003)
Hypertension
, vol.42
, Issue.2
, pp. 166-170
-
-
Vecchione, C.1
Aretini, A.2
Maffei, A.3
Marino, G.4
Selvetella, G.5
Poulet, R.6
Trimarco, V.7
Frati, G.8
Lembo, G.9
-
63
-
-
78650412827
-
Effect of early particulate air pollution exposure on obesity in mice: Role of p47phox
-
20864666 1:CAS:528:DC%2BC3cXhsVCksb3N 10.1161/ATVBAHA.110.215350
-
Xu X, Yavar Z, Verdin M, et al. Effect of early particulate air pollution exposure on obesity in mice: Role of p47phox. Arterioscler Thromb Vasc Biol. 2010;30:2518-27.
-
(2010)
Arterioscler Thromb Vasc Biol
, vol.30
, pp. 2518-2527
-
-
Xu, X.1
Yavar, Z.2
Verdin, M.3
-
64
-
-
34948825774
-
Role of the T cell in the genesis of angiotensin II-induced hypertension and vascular dysfunction
-
DOI 10.1084/jem.20070657
-
Guzik TJ, Hoch NE, Brown KA, et al. Role of the T cell in the genesis of angiotensin II - induced hypertension and vascular dysfunction. J Exp Med. 2007;204:2449-60. (Pubitemid 47529329)
-
(2007)
Journal of Experimental Medicine
, vol.204
, Issue.10
, pp. 2449-2460
-
-
Guzik, T.J.1
Hoch, N.E.2
Brown, K.A.3
McCann, L.A.4
Rahman, A.5
Dikalov, S.6
Goronzy, J.7
Weyand, C.8
Harrison, D.G.9
-
65
-
-
0037046214
-
Mechanisms of increased vascular superoxide production in human diabetes mellitus: Role of NAD(P)H oxidase and endothelial nitric oxide synthase
-
DOI 10.1161/01.CIR.0000012748.58444.08
-
Guzik TJ, Mussa S, Gastaldi D, et al. Mechanisms of increased vascular superoxide production in human diabetes mellitus: Role of NAD(P)H oxidase and endothelial nitric oxide synthase. Circulation. 2002;105:1656-62. (Pubitemid 34298608)
-
(2002)
Circulation
, vol.105
, Issue.14
, pp. 1656-1662
-
-
Guzik, T.J.1
Mussa, S.2
Gastaldi, D.3
Sadowski, J.4
Ratnatunga, C.5
Pillai, R.6
Channon, K.M.7
-
66
-
-
73349097268
-
Endothelial nitric oxide synthase uncoupling and perivascular adipose oxidative stress and inflammation contribute to vascular dysfunction in a rodent model of metabolic syndrome
-
19822799 1:CAS:528:DC%2BD1MXhtl2qur3E 10.1161/HYPERTENSIONAHA.109.138305
-
Marchesi C, Ebrahimian T, Angulo O, Paradis P, Schiffrin EL. Endothelial nitric oxide synthase uncoupling and perivascular adipose oxidative stress and inflammation contribute to vascular dysfunction in a rodent model of metabolic syndrome. Hypertension. 2009;54:1384-92.
-
(2009)
Hypertension
, vol.54
, pp. 1384-1392
-
-
Marchesi, C.1
Ebrahimian, T.2
Angulo, O.3
Paradis, P.4
Schiffrin, E.L.5
-
67
-
-
61949318555
-
Proinflammatory phenotype of perivascular adipocytes: Influence of high-fat feeding
-
19122178 1:CAS:528:DC%2BD1MXhvFejtL4%3D 10.1161/CIRCRESAHA.108.182998
-
Chatterjee TK, Stoll LL, Denning GM, et al. Proinflammatory phenotype of perivascular adipocytes: Influence of high-fat feeding. Circ Res. 2009;104:541-9.
-
(2009)
Circ Res
, vol.104
, pp. 541-549
-
-
Chatterjee, T.K.1
Stoll, L.L.2
Denning, G.M.3
-
68
-
-
33644796221
-
Production of chemokines by perivascular adipose tissue: A role in the pathogenesis of atherosclerosis?
-
DOI 10.1161/01.ATV.0000188508.40052.35, PII 0004360520051200000024
-
Henrichot E, Juge-Aubry CE, Pernin A, et al. Production of chemokines by perivascular adipose tissue: A role in the pathogenesis of atherosclerosis? Arterioscler Thromb Vasc Biol. 2005;25:2594-9. (Pubitemid 43732284)
-
(2005)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.25
, Issue.12
, pp. 2594-2599
-
-
Henrichot, E.1
Juge-Aubry, C.E.2
Pernin, A.3
Pache, J.-C.4
Velebit, V.5
Dayer, J.-M.6
Meda, P.7
Chizzolini, C.8
Meier, C.A.9
-
69
-
-
79953731321
-
Macrophage activation is responsible for loss of anticontractile function in inflamed perivascular fat
-
21273560 1:CAS:528:DC%2BC3MXjt1Gms74%3D 10.1161/ATVBAHA.110.221705
-
Withers SB, gabiti-Rosei C, Livingstone DM, et al. Macrophage activation is responsible for loss of anticontractile function in inflamed perivascular fat. Arterioscler Thromb Vasc Biol. 2011;31:908-13.
-
(2011)
Arterioscler Thromb Vasc Biol
, vol.31
, pp. 908-913
-
-
Withers, S.B.1
Gabiti-Rosei, C.2
Livingstone, D.M.3
-
70
-
-
84874657584
-
Perivascular adipose tissue control of insulin-induced vasoreactivity in muscle is impaired in db/db Mice
-
(In press)
-
Meijer RI, Bakker W, Alta CAF et al. (2012) Perivascular adipose tissue control of insulin-induced vasoreactivity in muscle is impaired in db/db Mice. Diabetes (In press)
-
(2012)
Diabetes
-
-
Meijer, R.I.1
Bakker, W.2
Alta, C.A.F.3
-
71
-
-
85047694430
-
Abundant progenitor cells in the adventitia contribute to atheroscleroses of vein grafts in ApoE-deficient mice
-
DOI 10.1172/JCI200419628
-
Hu Y, Zhang Z, Torsney E, et al. Abundant progenitor cells in the adventitia contribute to atherosclerosis of vein grafts in ApoE-deficient mice. J Clin Invest. 2004;113:1258-65. (Pubitemid 39069924)
-
(2004)
Journal of Clinical Investigation
, vol.113
, Issue.9
, pp. 1258-1265
-
-
Hu, Y.1
Zhang, Z.2
Torsney, E.3
Afzal, A.R.4
Davison, F.5
Metzler, B.6
Xu, Q.7
-
72
-
-
0018672096
-
Ultrastructural features of mast cells in human omental veins
-
Thureson-Klein A, Stijarne L. Ultrastructural features of mast cells in human omental veins. Blood Vessels. 1979;16:311-9. (Pubitemid 10212284)
-
(1979)
Blood Vessels
, vol.16
, Issue.6
, pp. 311-319
-
-
Thureson-Klein, A.1
Stijarne, L.2
-
73
-
-
77955171656
-
Endovascular injury induces rapid phenotypic changes in perivascular adipose tissue
-
20489168 1:CAS:528:DC%2BC3cXovFegu7s%3D 10.1161/ATVBAHA.110.207175
-
Takaoka M, Suzuki H, Shioda S, et al. Endovascular injury induces rapid phenotypic changes in perivascular adipose tissue. Arterioscler Thromb Vasc Biol. 2010;30:1576-82.
-
(2010)
Arterioscler Thromb Vasc Biol
, vol.30
, pp. 1576-1582
-
-
Takaoka, M.1
Suzuki, H.2
Shioda, S.3
-
74
-
-
0344442670
-
Echocardiographic Epicardial Adipose Tissue Is Related to Anthropometric and Clinical Parameters of Metabolic Syndrome: A New Indicator of Cardiovascular Risk
-
DOI 10.1210/jc.2003-030698
-
Iacobellis G, Ribaudo MC, Assael F, et al. Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk. J Clin Endocrinol Metab. 2003;88:5163-8. (Pubitemid 37452712)
-
(2003)
Journal of Clinical Endocrinology and Metabolism
, vol.88
, Issue.11
, pp. 5163-5168
-
-
Iacobellis, G.1
Ribaudo, M.C.2
Assael, F.3
Vecci, E.4
Tiberti, C.5
Zappaterreno, A.6
Di Mario, U.7
Leonetti, F.8
-
75
-
-
53549086389
-
Perivascular fatty tissue at the brachial artery is linked to insulin resistance but not to local endothelial dysfunction
-
%20
-
Rittig K, Staib K, Machann J et al. (2008) Perivascular fatty tissue at the brachial artery is linked to insulin resistance but not to local endothelial dysfunction. Diabetologia. %20
-
(2008)
Diabetologia
-
-
Rittig, K.1
Staib, K.2
Et Al., M.J.3
-
76
-
-
33745774804
-
Rosiglitazone modifies the adipogenic potential of human muscle satellite cells
-
DOI 10.1007/s00125-006-0304-6
-
De Coppi P, Milan G, Scarda A, et al. Rosiglitazone modifies the adipogenic potential of human muscle satellite cells. Diabetologia. 2006;49:1962-73. (Pubitemid 44025052)
-
(2006)
Diabetologia
, vol.49
, Issue.8
, pp. 1962-1973
-
-
De Coppi, P.1
Milan, G.2
Scarda, A.3
Boldrin, L.4
Centobene, C.5
Piccoli, M.6
Pozzobon, M.7
Pilon, C.8
Pagano, C.9
Gamba, P.10
Vettor, R.11
-
77
-
-
0036318227
-
Mice lacking paternally expressed Pref-1/Dlk1 display growth retardation and accelerated adiposity
-
DOI 10.1128/MCB.22.15.5585-5592.2002
-
Moon YS, Smas CM, Lee K, et al. Mice lacking paternally expressed Pref-1/Dlk1 display growth retardation and accelerated adiposity. Mol Cell Biol. 2002;22:5585-92. (Pubitemid 34755767)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.15
, pp. 5585-5592
-
-
Moon, Y.S.1
Smas, C.M.2
Lee, K.3
Villena, J.A.4
Kim, K.-H.5
Yun, E.J.6
Sul, H.S.7
-
78
-
-
70349578367
-
Obesity promotes inflammation in periaortic adipose tissue and angiotensin II-induced abdominal aortic aneurysm formation
-
19608970 1:CAS:528:DC%2BD1MXhtFWhtbfE 10.1161/ATVBAHA.109.192658
-
Police SB, Thatcher SE, Charnigo R, Daugherty A, Cassis LA. Obesity promotes inflammation in periaortic adipose tissue and angiotensin II-induced abdominal aortic aneurysm formation. Arterioscler Thromb Vasc Biol. 2009;29:1458-64.
-
(2009)
Arterioscler Thromb Vasc Biol
, vol.29
, pp. 1458-1464
-
-
Police, S.B.1
Thatcher, S.E.2
Charnigo, R.3
Daugherty, A.4
Cassis, L.A.5
-
79
-
-
34447516158
-
Activated human T lymphocytes express cyclooxygenase-2 and produce proadipogenic prostaglandins that drive human orbital fibroblast differentiation to adipocytes
-
DOI 10.2353/ajpath.2006.060434
-
Feldon SE, O'Loughlin CW, Ray DM, Landskroner-Eiger S, Seweryniak KE, Phipps RP. Activated human T lymphocytes express cyclooxygenase-2 and produce proadipogenic prostaglandins that drive human orbital fibroblast differentiation to adipocytes. Am J Pathol. 2006;169:1183-93. (Pubitemid 351194355)
-
(2006)
American Journal of Pathology
, vol.169
, Issue.4
, pp. 1183-1193
-
-
Feldon, S.E.1
O'Loughlin, C.W.2
Ray, D.M.3
Landskroner-Eiger, S.4
Seweryniak, K.E.5
Phipps, R.P.6
-
80
-
-
44949085653
-
Adventitial mast cells contribute to pathogenesis in the progression of abdominal aortic aneurysm
-
18451339 1:CAS:528:DC%2BD1cXmt1yhtr4%3D 10.1161/CIRCRESAHA.108.173682
-
Tsuruda T, Kato J, Hatakeyama K, et al. Adventitial mast cells contribute to pathogenesis in the progression of abdominal aortic aneurysm. Circ Res. 2008;102:1368-77.
-
(2008)
Circ Res
, vol.102
, pp. 1368-1377
-
-
Tsuruda, T.1
Kato, J.2
Hatakeyama, K.3
-
81
-
-
68349160704
-
Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice
-
19633655 1:CAS:528:DC%2BD1MXovFylsbc%3D 10.1038/nm.1994
-
Liu J, Divoux A, Sun J, et al. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med. 2009;15:940-5.
-
(2009)
Nat Med
, vol.15
, pp. 940-945
-
-
Liu, J.1
Divoux, A.2
Sun, J.3
-
83
-
-
84857914467
-
Blockade of the nuclear factor-kappaB pathway in the endothelium prevents insulin resistance and prolongs life span
-
22302838 1:CAS:528:DC%2BC38Xjt1Gnu7s%3D 10.1161/CIRCULATIONAHA.111.054346
-
Hasegawa Y, Saito T, Ogihara T, et al. Blockade of the nuclear factor-kappaB pathway in the endothelium prevents insulin resistance and prolongs life span. Circulation. 2012;125:1122-33.
-
(2012)
Circulation
, vol.125
, pp. 1122-1133
-
-
Hasegawa, Y.1
Saito, T.2
Ogihara, T.3
-
84
-
-
34047119110
-
Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation
-
DOI 10.2337/db06-0911
-
Hosogai N, Fukuhara A, Oshima K, et al. Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes. 2007;56:901-11. (Pubitemid 46525054)
-
(2007)
Diabetes
, vol.56
, Issue.4
, pp. 901-911
-
-
Hosogai, N.1
Fukuhara, A.2
Oshima, K.3
Miyata, Y.4
Tanaka, S.5
Segawa, K.6
Furukawa, S.7
Tochino, Y.8
Komuro, R.9
Matsuda, M.10
Shimomura, I.11
-
85
-
-
60849121937
-
Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue
-
19066318 1:CAS:528:DC%2BD1MXitVaqsLk%3D 10.1152/ajpendo.90760.2008
-
Yin J, Gao Z, He Q, Zhou D, Guo Z, Ye J. Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue. Am J Physiol Endocrinol Metab. 2009;296:E333-42.
-
(2009)
Am J Physiol Endocrinol Metab
, vol.296
, pp. 333-342
-
-
Yin, J.1
Gao, Z.2
He, Q.3
Zhou, D.4
Guo, Z.5
Ye, J.6
-
86
-
-
0036320410
-
Impaired postprandial adipose tissue blood flow response is related to aspects of insulin sensitivity
-
Karpe F, Fielding BA, Ilic V, Macdonald IA, Summers LKM, Frayn KN. Impaired postprandial adipose tissue blood flow response is related to aspects of insulin sensitivity. Diabetes. 2002;51:2467-73. (Pubitemid 34827395)
-
(2002)
Diabetes
, vol.51
, Issue.8
, pp. 2467-2473
-
-
Karpe, F.1
Fielding, B.A.2
Ilic, V.3
Macdonald, I.A.4
Summers, L.K.M.5
Frayn, K.N.6
-
87
-
-
48449094498
-
AMPK and PPARdelta agonists are exercise mimetics
-
18674809 1:CAS:528:DC%2BD1cXhtVSis77P 10.1016/j.cell.2008.06.051
-
Narkar VA, Downes M, Yu RT, et al. AMPK and PPARdelta agonists are exercise mimetics. Cell. 2008;134:405-15.
-
(2008)
Cell
, vol.134
, pp. 405-415
-
-
Narkar, V.A.1
Downes, M.2
Yu, R.T.3
-
88
-
-
33644747421
-
Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase
-
DOI 10.2337/diabetes.55.02.06.db05-1064
-
Davis BJ, Xie Z, Viollet B, Zou MH. Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase. Diabetes. 2006;55:496-505. (Pubitemid 43343281)
-
(2006)
Diabetes
, vol.55
, Issue.2
, pp. 496-505
-
-
Davis, B.J.1
Xie, Z.2
Viollet, B.3
Zou, M.-H.4
-
89
-
-
73649096734
-
Flow activation of AMP-activated protein kinase in vascular endothelium leads to kruppel-like factor 2 expression
-
19696400 1:CAS:528:DC%2BD1MXht1ymsr7P 10.1161/ATVBAHA.109.193540
-
Young A, Wu W, Sun W, et al. Flow activation of AMP-activated protein kinase in vascular endothelium leads to kruppel-like factor 2 expression. Arterioscler Thromb Vasc Biol. 2009;29:1902-8.
-
(2009)
Arterioscler Thromb Vasc Biol
, vol.29
, pp. 1902-1908
-
-
Young, A.1
Wu, W.2
Sun, W.3
-
90
-
-
77952885895
-
Activation of AMP-activated protein kinase by 5-aminoimidazole-4- carboxamide-1-beta-D-ribofuranoside in the muscle microcirculation increases nitric oxide synthesis and microvascular perfusion
-
20224051 10.1161/ATVBAHA.110.204404 1:CAS:528:DC%2BC3cXmt1altr8%3D
-
Eringa EC, Bradley EA, Stehouwer CDA, et al. Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside in the muscle microcirculation increases nitric oxide synthesis and microvascular perfusion. Arterioscler Thromb Vasc Biol. 2010;30:1137-42.
-
(2010)
Arterioscler Thromb Vasc Biol
, vol.30
, pp. 1137-1142
-
-
Eringa, E.C.1
Bradley, E.A.2
Stehouwer, C.D.A.3
-
91
-
-
0041355355
-
Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells
-
DOI 10.1074/jbc.M212831200
-
Morrow VA, Foufelle F, Connell JM, Petrie JR, Gould GW, Salt IP. Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells. J Biol Chem. 2003;278:31629-39. (Pubitemid 37048341)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.34
, pp. 31629-31639
-
-
Morrow, V.A.1
Foufelle, F.2
Connell, J.M.C.3
Petrie, J.R.4
Gould, G.W.5
Salt, I.P.6
-
92
-
-
0346463030
-
Adiponectin Stimulates Angiogenesis by Promoting Cross-talk between AMP-activated Protein Kinase and Akt Signaling in Endothelial Cells
-
DOI 10.1074/jbc.M310389200
-
Ouchi N, Kobayashi H, Kihara S, et al. Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J Biol Chem. 2004;279:1304-9. (Pubitemid 38082655)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.2
, pp. 1304-1309
-
-
Ouchi, N.1
Kobayashi, H.2
Kihara, S.3
Kumada, M.4
Sato, K.5
Inoue, T.6
Funahashi, T.7
Walsh, K.8
-
93
-
-
77149134285
-
Reduction of AMP-activated protein kinase {alpha}2 increases endoplasmic reticulum stress and atherosclerosis in vivo
-
20124121 1:CAS:528:DC%2BC3cXhvF2rsbY%3D 10.1161/CIRCULATIONAHA.109.900928
-
Dong Y, Zhang M, Liang B, et al. Reduction of AMP-activated protein kinase {alpha}2 increases endoplasmic reticulum stress and atherosclerosis in vivo. Circulation. 2010;121:792-803.
-
(2010)
Circulation
, vol.121
, pp. 792-803
-
-
Dong, Y.1
Zhang, M.2
Liang, B.3
-
94
-
-
61949165795
-
AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633
-
19131647 1:CAS:528:DC%2BD1MXhvFejtLo%3D 10.1161/CIRCRESAHA.108.187567
-
Chen Z, Peng IC, Sun W, et al. AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633. Circ Res. 2009;104:496-505.
-
(2009)
Circ Res
, vol.104
, pp. 496-505
-
-
Chen, Z.1
Peng, I.C.2
Sun, W.3
-
95
-
-
0033036636
-
AMP-activated protein kinase phosphorylation of endothelial NO synthase
-
DOI 10.1016/S0014-5793(98)01705-0, PII S0014579398017050
-
Chen Z, Mitchelhill KI, Michell BJ, et al. AMP-activated protein kinase phosphorylation of endothelial NO synthase. FEBS Lett. 1999;443:285-9. (Pubitemid 29080812)
-
(1999)
FEBS Letters
, vol.443
, Issue.3
, pp. 285-289
-
-
Chen, Z.-P.1
Mitchelhill, K.I.2
Michell, B.J.3
Stapleton, D.4
Rodriguez-Crespo, I.5
Witters, L.A.6
Power, D.A.7
Ortiz De Montellano, P.R.8
Kemp, B.E.9
-
96
-
-
69049120920
-
Intra-arterial AICA-riboside administration induces NO-dependent vasodilation in vivo in human skeletal muscle
-
19602584 1:CAS:528:DC%2BD1MXht1ykurrM 10.1152/ajpendo.00141.2009
-
Bosselaar M, Boon H, van Loon LJC, van den Broek PHH, Smits P, Tack CJ. Intra-arterial AICA-riboside administration induces NO-dependent vasodilation in vivo in human skeletal muscle. Am J Physiol Endocrinol Metab. 2009;297:E759-66.
-
(2009)
Am J Physiol Endocrinol Metab
, vol.297
, pp. 759-766
-
-
Bosselaar, M.1
Boon, H.2
Van Loon, L.J.C.3
Van Den Broek, P.H.H.4
Smits, P.5
Tack, C.J.6
-
97
-
-
34547591785
-
5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men
-
DOI 10.2337/db06-1716
-
Cuthbertson DJ, Babraj JA, Mustard KJW, et al. 5-aminoimidazole-4- carboxamide 1-β-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men. Diabetes. 2007;56:2078-84. (Pubitemid 47195820)
-
(2007)
Diabetes
, vol.56
, Issue.8
, pp. 2078-2084
-
-
Cuthbertson, D.J.1
Babraj, J.A.2
Mustard, K.J.W.3
Towler, M.C.4
Green, K.A.5
Wackerhage, H.6
Leese, G.P.7
Baar, K.8
Thomason-Hughes, M.9
Sutherland, C.10
Hardie, D.G.11
Rennie, M.J.12
-
98
-
-
20044376702
-
The pathobiology of diabetic complications: A unifying mechanism
-
DOI 10.2337/diabetes.54.6.1615
-
Brownlee M. The pathobiology of diabetic complications: A unifying mechanism. Diabetes. 2005;54:1615-25. (Pubitemid 40770750)
-
(2005)
Diabetes
, vol.54
, Issue.6
, pp. 1615-1625
-
-
Brownlee, M.1
-
99
-
-
77952092094
-
Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress
-
20186387 1:CAS:528:DC%2BC3cXktlGgtb0%3D 10.1007/s00125-010-1677-0
-
Brouwers O, Niessen PM, Haenen G, et al. Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress. Diabetologia. 2010;53:989-1000.
-
(2010)
Diabetologia
, vol.53
, pp. 989-1000
-
-
Brouwers, O.1
Niessen, P.M.2
Haenen, G.3
-
100
-
-
44849131121
-
Decreasing intracellular superoxide corrects defective ischemia-induced new vessel formation in diabetic mice
-
18227068 1:CAS:528:DC%2BD1cXksFagur4%3D 10.1074/jbc.M707451200
-
Ceradini DJ, Yao D, Grogan RH, et al. Decreasing intracellular superoxide corrects defective ischemia-induced new vessel formation in diabetic mice. J Biol Chem. 2008;283:10930-8.
-
(2008)
J Biol Chem
, vol.283
, pp. 10930-10938
-
-
Ceradini, D.J.1
Yao, D.2
Grogan, R.H.3
-
101
-
-
0344837347
-
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy
-
DOI 10.1038/nm834
-
Hammes HP, Du X, Edelstein D, et al. Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nat Med. 2003;9:294-9. (Pubitemid 36362784)
-
(2003)
Nature Medicine
, vol.9
, Issue.3
, pp. 294-299
-
-
Hammes, H.-P.1
Du, X.2
Edelstein, D.3
Taguchi, T.4
Matsumura, T.5
Ju, Q.6
Lin, J.7
Bierhaus, A.8
Nawroth, P.9
Hannak, D.10
Neumaier, M.11
Bergfeld, R.12
Giardino, I.13
Brownlee, M.14
-
102
-
-
0032032578
-
Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis
-
Shinohara M, Thornalley PJ, Giardino I, et al. Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis. J Clin Invest. 1998;101:1142-7. (Pubitemid 28125293)
-
(1998)
Journal of Clinical Investigation
, vol.101
, Issue.5
, pp. 1142-1147
-
-
Shinohara, M.1
Thornalley, P.J.2
Giardino, I.3
Beisswenger, P.4
Thorpe, S.R.5
Onorato, J.6
Brownlee, M.7
-
103
-
-
78651410794
-
Overexpression of glyoxalase-I reduces hyperglycemia-induced levels of advanced glycation end products and oxidative stress in diabetic rats
-
21056979 1:CAS:528:DC%2BC3MXjtFehsA%3D%3D 10.1074/jbc.M110.144097
-
Brouwers O, Niessen PM, Ferreira I, et al. Overexpression of glyoxalase-I reduces hyperglycemia-induced levels of advanced glycation end products and oxidative stress in diabetic rats. J Biol Chem. 2011;286:1374-80.
-
(2011)
J Biol Chem
, vol.286
, pp. 1374-1380
-
-
Brouwers, O.1
Niessen, P.M.2
Ferreira, I.3
-
104
-
-
84856729229
-
Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology
-
22143324 1:CAS:528:DC%2BC38Xhsl2gtrg%3D 10.1007/s00125-011-2393-0
-
Berner AK, Brouwers O, Pringle R, et al. Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology. Diabetologia. 2012;55:845-54.
-
(2012)
Diabetologia
, vol.55
, pp. 845-854
-
-
Berner, A.K.1
Brouwers, O.2
Pringle, R.3
-
105
-
-
40949161074
-
Insulin signaling stimulates insulin transport by bovine aortic endothelial cells
-
17977956 1:CAS:528:DC%2BD1cXjt1ChtL0%3D 10.2337/db07-0967
-
Wang H, Wang AX, Liu Z, Barrett EJ. Insulin signaling stimulates insulin transport by bovine aortic endothelial cells. Diabetes. 2008;57:540-7.
-
(2008)
Diabetes
, vol.57
, pp. 540-547
-
-
Wang, H.1
Wang, A.X.2
Liu, Z.3
Barrett, E.J.4
-
106
-
-
64149117276
-
The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action
-
19283361 1:CAS:528:DC%2BD1MXktVOktbY%3D 10.1007/s00125-009-1313-z
-
Barrett EJ, Eggleston EM, Inyard AC, et al. The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action. Diabetologia. 2009;52:752-64.
-
(2009)
Diabetologia
, vol.52
, pp. 752-764
-
-
Barrett, E.J.1
Eggleston, E.M.2
Inyard, A.C.3
-
107
-
-
33745295339
-
Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle
-
DOI 10.2337/db05-1373
-
Clerk LH, Vincent MA, Jahn LA, Liu Z, Lindner JR, Barrett EJ. Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle. Diabetes. 2006;55:1436-42. (Pubitemid 44195384)
-
(2006)
Diabetes
, vol.55
, Issue.5
, pp. 1436-1442
-
-
Clerk, L.H.1
Vincent, M.A.2
Jahn, L.A.3
Liu, Z.4
Lindner, J.R.5
Barrett, E.J.6
-
108
-
-
77950350623
-
Diet-induced obesity prevents interstitial dispersion of insulin in skeletal muscle
-
19959760 1:CAS:528:DC%2BC3cXjslegtb4%3D 10.2337/db09-0839
-
Kolka CM, Harrison LN, Lottati M, Chiu JD, Kirkman EL, Bergman RN. Diet-induced obesity prevents interstitial dispersion of insulin in skeletal muscle. Diabetes. 2010;59:619-26.
-
(2010)
Diabetes
, vol.59
, pp. 619-626
-
-
Kolka, C.M.1
Harrison, L.N.2
Lottati, M.3
Chiu, J.D.4
Kirkman, E.L.5
Bergman, R.N.6
-
109
-
-
42449107752
-
Direct administration of insulin into skeletal muscle reveals that the transport of insulin across the capillary endothelium limits the time course of insulin to activate glucose disposal
-
18223011 1:CAS:528:DC%2BD1cXksVGktb8%3D 10.2337/db07-1444
-
Chiu JD, Richey JM, Harrison LN, et al. Direct administration of insulin into skeletal muscle reveals that the transport of insulin across the capillary endothelium limits the time course of insulin to activate glucose disposal. Diabetes. 2008;57:828-35.
-
(2008)
Diabetes
, vol.57
, pp. 828-835
-
-
Chiu, J.D.1
Richey, J.M.2
Harrison, L.N.3
-
110
-
-
0038665339
-
The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance
-
DOI 10.1172/JCI200315211
-
Vicent D, Ilany J, Kondo T, et al. The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance. J Clin Invest. 2003;111:1373-80. (Pubitemid 36554708)
-
(2003)
Journal of Clinical Investigation
, vol.111
, Issue.9
, pp. 1373-1380
-
-
Vicent, D.1
Ilany, J.2
Kondo, T.3
Naruse, K.4
Fisher, S.J.5
Kisanuki, Y.Y.6
Bursell, S.7
Yanagisawa, M.8
King, G.L.9
Kahn, C.R.10
-
111
-
-
58149328550
-
Effect of endothelium-specific insulin resistance on endothelial function in vivo
-
18835939 1:CAS:528:DC%2BD1MXhsleitrg%3D 10.2337/db07-1111
-
Duncan ER, Crossey PA, Walker S, et al. Effect of endothelium-specific insulin resistance on endothelial function in vivo. Diabetes. 2008;57:3307-14.
-
(2008)
Diabetes
, vol.57
, pp. 3307-3314
-
-
Duncan, E.R.1
Crossey, P.A.2
Walker, S.3
-
112
-
-
0028032895
-
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
-
DOI 10.1038/372186a0
-
Araki E, Lipes MA, Patti ME, et al. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature. 1994;372:186-90. (Pubitemid 24347839)
-
(1994)
Nature
, vol.372
, Issue.6502
, pp. 186-190
-
-
Araki, E.1
Lipes, M.A.2
Patti, M.-E.3
Bruning, J.C.4
Haag III, B.5
Johnson, R.S.6
Kahn, C.R.7
-
113
-
-
0030828823
-
12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways
-
DOI 10.1007/s001250050832
-
Kellerer M, Koch M, Metzinger E, Mushack J, Capp E, Haring H. Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways. Diabetologia. 1997;40:1358-62. (Pubitemid 27469678)
-
(1997)
Diabetologia
, vol.40
, Issue.11
, pp. 1358-1362
-
-
Kellerer, M.1
Koch, M.2
Metzinger, E.3
Mushack, J.4
Capp, E.5
Haring, H.U.6
-
114
-
-
0013054309
-
Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance
-
Shankar RR, Wu Y, Shen H-Q, Zhu J-S, Baron AD (2000) Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance. Diabetes 49
-
(2000)
Diabetes
, pp. 49
-
-
Shankar, R.R.1
Wu, Y.2
Shen, H.-Q.3
Zhu, J.-S.4
Baron, A.D.5
-
115
-
-
80052827107
-
Endothelin-1 reduces glucose uptake in human skeletal muscle in vivo and in vitro
-
21677282 1:CAS:528:DC%2BC3MXhtValurnM 10.2337/db10-1281
-
Shemyakin A, Salehzadeh F, Esteves Duque-Guimaraes D, et al. Endothelin-1 reduces glucose uptake in human skeletal muscle in vivo and in vitro. Diabetes. 2011;60:2061-7.
-
(2011)
Diabetes
, vol.60
, pp. 2061-2067
-
-
Shemyakin, A.1
Salehzadeh, F.2
Esteves Duque-Guimaraes, D.3
-
116
-
-
33847625532
-
Dual endothelin receptor blockade acutely improves insulin sensitivity in obese patients with insulin resistance and coronary artery disease
-
DOI 10.2337/dc06-1978
-
Ahlborg G, Shemyakin A, Bohm F, Gonon A, Pernow J. Dual endothelin receptor blockade acutely improves insulin sensitivity in obese patients with insulin resistance and coronary artery disease. Diabetes Care. 2007;30:591-6. (Pubitemid 46354339)
-
(2007)
Diabetes Care
, vol.30
, Issue.3
, pp. 591-596
-
-
Ahlborg, G.1
Shemyakin, A.2
Bohm, F.3
Gonon, A.4
Pernow, J.5
-
117
-
-
33847404040
-
Endothelin limits insulin action in obese/insulin-resistant humans
-
DOI 10.2337/db06-1406
-
Lteif A, Vaishnava P, Baron AD, Mather KJ. Endothelin limits insulin action in obese/insulin-resistant humans. Diabetes. 2007;56:728-34. (Pubitemid 46348477)
-
(2007)
Diabetes
, vol.56
, Issue.3
, pp. 728-734
-
-
Lteif, A.1
Vaishnava, P.2
Baron, A.D.3
Mather, K.J.4
-
118
-
-
14644427890
-
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
-
DOI 10.1038/nm1166
-
Cai D, Yuan M, Frantz DF, et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-[beta] and NF-[kappa]B. Nat Med. 2005;11:183-90. (Pubitemid 40321354)
-
(2005)
Nature Medicine
, vol.11
, Issue.2
, pp. 183-190
-
-
Cai, D.1
Yuan, M.2
Frantz, D.F.3
Melendez, P.A.4
Hansen, L.5
Lee, J.6
Shoelson, S.E.7
-
119
-
-
77950865464
-
Vascular endothelial growth factor B controls endothelial fatty acid uptake
-
20228789 1:CAS:528:DC%2BC3cXjtFyntbc%3D 10.1038/nature08945
-
Hagberg CE, Falkevall A, Wang X, et al. Vascular endothelial growth factor B controls endothelial fatty acid uptake. Nature. 2010;464:917-21.
-
(2010)
Nature
, vol.464
, pp. 917-921
-
-
Hagberg, C.E.1
Falkevall, A.2
Wang, X.3
-
120
-
-
84867672712
-
Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes
-
23023133 1:CAS:528:DC%2BC38XhsVaqt73E 10.1038/nature11464
-
Hagberg CE, Mehlem A, Falkevall A, et al. Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes. Nature. 2012;490:426-30.
-
(2012)
Nature
, vol.490
, pp. 426-430
-
-
Hagberg, C.E.1
Mehlem, A.2
Falkevall, A.3
-
121
-
-
80054714671
-
Hypercholesterolaemia, signs of islet microangiopathy and altered angiogenesis precede onset of type 2 diabetes in the Goto-Kakizaki (GK) rat
-
21744291 1:CAS:528:DC%2BC3MXpvVKjtrw%3D 10.1007/s00125-011-2223-4
-
Giroix MH, Irminger JC, Lacraz G, et al. Hypercholesterolaemia, signs of islet microangiopathy and altered angiogenesis precede onset of type 2 diabetes in the Goto-Kakizaki (GK) rat. Diabetologia. 2011;54:2451-62.
-
(2011)
Diabetologia
, vol.54
, pp. 2451-2462
-
-
Giroix, M.H.1
Irminger, J.C.2
Lacraz, G.3
-
122
-
-
80052081270
-
Thrombospondin-1: An islet endothelial cell signal of importance for beta-cell function
-
21617177 1:CAS:528:DC%2BC3MXptVChur0%3D 10.2337/db10-0277
-
Olerud J, Mokhtari D, Johansson M, et al. Thrombospondin-1: an islet endothelial cell signal of importance for beta-cell function. Diabetes. 2011;60:1946-54.
-
(2011)
Diabetes
, vol.60
, pp. 1946-1954
-
-
Olerud, J.1
Mokhtari, D.2
Johansson, M.3
-
123
-
-
79960895140
-
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
-
Kilpelainen TO, Zillikens MC, Stancakova A et al. (2011) Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat. Genet
-
(2011)
Nat. Genet
-
-
Kilpelainen, T.O.1
Zillikens, M.C.2
Et Al., S.A.3
-
124
-
-
70349557826
-
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
-
19734900 1:CAS:528:DC%2BD1MXhtV2gsb%2FL 10.1038/ng.443
-
Rung J, Cauchi S, Albrechtsen A, et al. Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet. 2009;41:1110-5.
-
(2009)
Nat Genet
, vol.41
, pp. 1110-1115
-
-
Rung, J.1
Cauchi, S.2
Albrechtsen, A.3
-
125
-
-
34547623750
-
Genomewide association analysis of coronary artery disease
-
DOI 10.1056/NEJMoa072366
-
Samani NJ, Erdmann J, Hall AS, et al. Genomewide association analysis of coronary artery disease. N Engl J Med. 2007;357:443-53. (Pubitemid 47204873)
-
(2007)
New England Journal of Medicine
, vol.357
, Issue.5
, pp. 443-453
-
-
Samani, N.J.1
Erdmann, J.2
Hall, A.S.3
Hengstenberg, C.4
Mangino, M.5
Mayer, B.6
Dixon, R.J.7
Meitinger, T.8
Braund, P.9
Wichmann, H.-E.10
Barrett, J.H.11
Konig, I.R.12
Stevens, S.E.13
Szymczak, S.14
Tregouet, D.-A.15
Iles, M.M.16
Pahlke, F.17
Pollard, H.18
Lieb, W.19
Cambien, F.20
Fischer, M.21
Ouwehand, W.22
Blankenberg, S.23
Balmforth, A.J.24
Baessler, A.25
Ball, S.G.26
Strom, T.M.27
Braenne, I.28
Gieger, C.29
Deloukas, P.30
Tobin, M.D.31
Ziegler, A.32
Thompson, J.R.33
Schunkert, H.34
more..
-
126
-
-
84855245399
-
Intensive diabetes therapy and glomerular filtration rate in type 1 diabetes
-
de Boer I, Sun W, Cleary PA, et al. Intensive diabetes therapy and glomerular filtration rate in type 1 diabetes. N Engl J Med. 2011;365:2366-76
-
(2011)
N Engl J Med.
, vol.365
, pp. 2366-2376
-
-
De Boer, I.1
Sun, W.2
Cleary, P.A.3
-
127
-
-
0037034257
-
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
-
DOI 10.1056/NEJMoa012512
-
Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346:393-403. (Pubitemid 34437694)
-
(2002)
New England Journal of Medicine
, vol.346
, Issue.6
, pp. 393-403
-
-
Knowler, W.C.1
Barrett-Connor, E.2
Fowler, S.E.3
Hamman, R.F.4
Lachin, J.M.5
Walker, E.A.6
Nathan, D.M.7
-
128
-
-
10844255915
-
Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery
-
DOI 10.1056/NEJMoa035622
-
Sjostrom L, Lindroos AK, Peltonen M, et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004;351:2683-93. (Pubitemid 39665322)
-
(2004)
New England Journal of Medicine
, vol.351
, Issue.26
, pp. 2683-2693
-
-
Sjostrom, L.1
Lindroos, A.-K.2
Peltonen, M.3
Torgerson, J.4
Bouchard, C.5
Carlsson, B.6
Dahlgren, S.7
Larsson, B.8
Narbro, K.9
Sjostrom, C.D.10
Sullivan, M.11
Wedel, H.12
-
129
-
-
67149142042
-
A randomized trial of therapies for type 2 diabetes and coronary artery disease
-
19502645 1:CAS:528:DC%2BD1MXntVKqtrw%3D 10.1056/NEJMoa0805796
-
Frye RL, August P, Brooks MM, et al. A randomized trial of therapies for type 2 diabetes and coronary artery disease. N Engl J Med. 2009;360:2503-15.
-
(2009)
N Engl J Med
, vol.360
, pp. 2503-2515
-
-
Frye, R.L.1
August, P.2
Brooks, M.M.3
-
130
-
-
33845493476
-
Prevalence and determinants of insulin resistance among U.S. adolescents: A population-based study
-
DOI 10.2337/dc06-0709
-
Lee JM, Okumura MJ, Davis MM, Herman WH, Gurney JG. Prevalence and determinants of insulin resistance among U.S. adolescents: a population-based study. Diabetes Care. 2006;29:2427-32. (Pubitemid 44912247)
-
(2006)
Diabetes Care
, vol.29
, Issue.11
, pp. 2427-2432
-
-
Lee, J.M.1
Okumura, M.J.2
Davis, M.M.3
Herman, W.H.4
Gurney, J.G.5
-
131
-
-
34047094881
-
Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice
-
DOI 10.2337/db06-0883
-
Ayala JE, Bracy DP, Julien BM, Rottman JN, Fueger PT, Wasserman DH. Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice. Diabetes. 2007;56:1025-33. (Pubitemid 46525081)
-
(2007)
Diabetes
, vol.56
, Issue.4
, pp. 1025-1033
-
-
Ayala, J.E.1
Bracy, D.P.2
Julien, B.M.3
Rottman, J.N.4
Fueger, P.T.5
Wasserman, D.H.6
-
132
-
-
78049238308
-
Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice
-
20876122 1:CAS:528:DC%2BC3cXhtlals73K 10.1073/pnas.1008872107
-
Carlstrom M, Larsen FJ, Nystrom T, et al. Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice. PNAS. 2010;107:17716-20.
-
(2010)
PNAS
, vol.107
, pp. 17716-17720
-
-
Carlstrom, M.1
Larsen, F.J.2
Nystrom, T.3
-
133
-
-
84867743194
-
Overexpression of endothelial nitric oxide synthase prevents diet-induced obesity and regulates adipocyte phenotype
-
Sansbury BE, Cummins TD, Tang Y et al. (2012) Overexpression of endothelial nitric oxide synthase prevents diet-induced obesity and regulates adipocyte phenotype. Circulation Research
-
(2012)
Circulation Research
-
-
Sansbury, B.E.1
Cummins, T.D.2
Et Al., T.Y.3
-
134
-
-
79551595824
-
Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin α2β1 in mice
-
21270253 1:CAS:528:DC%2BC3MXisVOmtbg%3D 10.2337/db10-1116
-
Kang L, Ayala JE, Lee-Young RS, et al. Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin α2β1 in mice. Diabetes. 2011;60:416-26.
-
(2011)
Diabetes
, vol.60
, pp. 416-426
-
-
Kang, L.1
Ayala, J.E.2
Lee-Young, R.S.3
-
135
-
-
84874649611
-
The impact of exercise training compared to caloric restriction on hepatic and peripheral insulin resistance in obesity
-
Coker RH, Williams RH, Yeo SE, et al. The impact of exercise training compared to caloric restriction on hepatic and peripheral insulin resistance in obesity. Endocr Rev. 2009;30:745-a.
-
(2009)
Endocr Rev
, vol.30
-
-
Coker, R.H.1
Williams, R.H.2
Yeo, S.E.3
-
136
-
-
35348957807
-
Endothelin-1-mediated vasoconstriction at rest and during dynamic exercise in healthy humans
-
DOI 10.1152/ajpheart.00867.2007
-
Wray DW, Nishiyama SK, Donato AJ, Sander M, Wagner PD, Richardson RS. Endothelin-1-mediated vasoconstriction at rest and during dynamic exercise in healthy humans. Am J Physiol Heart Circ Physiol. 2007;293:H2550-6. (Pubitemid 47605903)
-
(2007)
American Journal of Physiology - Heart and Circulatory Physiology
, vol.293
, Issue.4
-
-
Wray, D.W.1
Nishiyama, S.K.2
Donato, A.J.3
Sander, M.4
Wagner, P.D.5
Richardson, R.S.6
-
137
-
-
34249678700
-
Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of rapamycin signaling
-
DOI 10.2337/db06-1566
-
Fujita S, Rasmussen BB, Cadenas JG, et al. Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/Mammalian target of rapamycin signaling. Diabetes. 2007;56:1615-22. (Pubitemid 46842620)
-
(2007)
Diabetes
, vol.56
, Issue.6
, pp. 1615-1622
-
-
Fujita, S.1
Rasmussen, B.B.2
Cadenas, J.G.3
Drummond, M.J.4
Glynn, E.L.5
Sattler, F.R.6
Volpi, E.7
-
138
-
-
0036316767
-
Mechanisms of amelioration of glucose-induced endothelial dysfunction following inhibition of protein kinase C in Vivo
-
Booth G, Stalker TJ, Lefer AM, Scalia R. Mechanisms of amelioration of glucose-induced endothelial dysfunction following inhibition of protein kinase C in vivo. Diabetes. 2002;51:1556-64. (Pubitemid 34826625)
-
(2002)
Diabetes
, vol.51
, Issue.5
, pp. 1556-1564
-
-
Booth, G.1
Stalker, T.J.2
Lefer, A.M.3
Scalia, R.4
-
139
-
-
84861918691
-
Protein kinase cbeta phosphorylates occludin regulating tight junction trafficking in vascular endothelial growth factor-induced permeability in vivo
-
22438576 1:CAS:528:DC%2BC38XotlGqu7k%3D 10.2337/db11-1367
-
Murakami T, Frey T, Lin C, Antonetti DA. Protein kinase cbeta phosphorylates occludin regulating tight junction trafficking in vascular endothelial growth factor-induced permeability in vivo. Diabetes. 2012;61:1573-83.
-
(2012)
Diabetes
, vol.61
, pp. 1573-1583
-
-
Murakami, T.1
Frey, T.2
Lin, C.3
Antonetti, D.A.4
-
140
-
-
84870254356
-
The evolutionary benefit of insulin resistance
-
22682085 1:CAS:528:DC%2BC38XosFWitLY%3D 10.1016/j.clnu.2012.05.011
-
Soeters MR, Soeters PB. The evolutionary benefit of insulin resistance. Clin Nutr. 2012;31:1002-7.
-
(2012)
Clin Nutr
, vol.31
, pp. 1002-1007
-
-
Soeters, M.R.1
Soeters, P.B.2
|