Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology

Diabetologia

Volumn 55, Issue 3, 2012, Pages 845-854

  Berner, A K ^a   Brouwers, O ^b   Pringle, R ^a   Klaassen, I ^d   Colhoun, L ^a   McVicar, C ^a   Brockbank, S ^a   Curry, J W ^a   Miyata, T ^c   Brownlee, M ^f   Schlingemann, R O ^d,e   Schalkwijk, C ^b   Stitt, A W ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

^e NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^f ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

AGEs; Diabetic complications; Diabetic retinopathy; Glyoxalase 1; Methylglyoxal; Pathogenesis; Retina

Indexed keywords

6 N CARBOXYMETHYLLYSINE; ADVANCED GLYCATION END PRODUCT; ALKANE DERIVATIVE; DICARBOXYLIC AMINO ACID; GLIAL FIBRILLARY ACIDIC PROTEIN; INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR4.1; LACTOYLGLUTATHIONE LYASE; METHYLGLYOXAL; METHYLGLYOXAL DERIVED HYDROIMIDAZALONE 1; N EPSILON(CARBOXYETHYL)LYSINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DOWN REGULATION; ENZYME LOCALIZATION; ENZYME REGULATION; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MOLECULAR PATHOLOGY; MUELLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; TANDEM MASS SPECTROMETRY; TRANSGENIC RAT; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; UPREGULATION; WILD TYPE;

ANIMALS; DIABETIC RETINOPATHY; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; ISOENZYMES; LACTOYLGLUTATHIONE LYASE; MICROVESSELS; MOLECULAR TARGETED THERAPY; NEUROGLIA; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PYRUVALDEHYDE; RATS; RATS, TRANSGENIC; RECOMBINANT PROTEINS; RETINA; RETINAL VESSELS; TIME FACTORS;

EID: 84856729229     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2393-0     Document Type: Article

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