Protein kinase C θ (PKCθ)-dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance

Journal of Biological Chemistry

Volumn 284, Issue 4, 2009, Pages 2038-2044

  Wang, Changhua ^a   Liu, Meilian ^a   Riojas, Ramon A ^b   Xin, Xiaoban ^a   Gao, Zhanguo ^c   Zeng, Rong ^d   Wu, Jiarui ^d   Dong, Lily Q ^a   Liu, Feng ^a,b  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^d INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACID RESISTANCE; AMINO ACIDS; CELL CULTURE; FATTY ACIDS; HORMONES; INSULIN; OPTICAL COMMUNICATION; PHOSPHORYLATION; PLATELETS;

ACTIVATION LOOPS; AKT PHOSPHORYLATIONS; BIOCHEMICAL STUDIES; FREE FATTY ACIDS; HYPERLIPIDEMIA; IN CELLS; IN-VITRO; IN-VIVO; INHIBITORY EFFECTS; INSULIN RESISTANCES; INSULIN SIGNALING; METABOLIC DISEASE; MOLECULAR MECHANISMS; MOUSE EMBRYONIC FIBROBLASTS; MYOTUBES; PHOSPHOINOSITIDE; PLATELET-DERIVED GROWTH FACTORS; PROTEIN KINASE; PROTEIN KINASE C; SERINE PHOSPHORYLATIONS; WILD TYPES;

CHEMICAL REACTIONS;

ALANINE; FATTY ACID; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; PALMITIC ACID; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE B; PROTEIN KINASE C; SERINE; THREONINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FIBROBLAST; HYPERLIPIDEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN RESISTANCE; MOUSE; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; WILD TYPE;

ANIMALS; CELL LINE; CRICETINAE; ENZYME ACTIVATION; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; ISOENZYMES; MICE; MICE, KNOCKOUT; MUTATION; PALMITATES; PHOSPHOSERINE; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 59049100254     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M806336200     Document Type: Article

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