Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis

Journal of Clinical Investigation

Volumn 101, Issue 5, 1998, Pages 1142-1147

  Shinohara, Moritsugu ^a   Thornalley, P J ^b   Giardino, Ida ^a   Beisswenger, Paul ^c   Thorpe, Suzanne R ^d   Onorato, Joelle ^d   Brownlee, Michael ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ESSEX   (United Kingdom)

^c DARTMOUTH MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Advanced glycation endproducts; Cell lines; Endocytosis; Glyoxalase I; Methylglyoxal

Indexed keywords

GENE PRODUCT; GLYOXALASE; GLYOXALASE 1; GLYOXALASE 2; LACTIC ACID; METHYLGLYOXAL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CATTLE; CONTROLLED STUDY; ENDOCYTOSIS; ENDOTHELIUM CELL; ENZYME MECHANISM; FETUS; GLYCATION; HYPERGLYCEMIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REACTION ANALYSIS;

EID: 0032032578     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119885     Document Type: Article

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