Atorvastatin requires geranylgeranyl transferase-I and Rac1 activation to exert neuronal protection and induce plasticity

Neurochemistry International

Volumn 62, Issue 4, 2013, Pages 433-445

  Posada Duque, Rafael Andrés ^a   Velasquez Carvajal, David ^a   Eckert, Gunter P ^b   Cardona Gomez, Gloria Patricia ^a  

^a UNIVERSIDAD DE ANTIOQUIA   (Colombia)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

N catenin; Atorvastatin; Excitotoxicity; GGTase I ; Neuronal plasticity; Neuroprotection; Rac1

Indexed keywords

ALPHA CATENIN; ALPHA N CATENIN; ATORVASTATIN; FARNESYL DIPHOSPHATE; GERANYLGERANYL PYROPHOSPHATE; GERANYLGERANYLTRANSFERASE 1; GERANYLGERANYLTRANSFERASE 1BETA; GERANYLTRANSFERASE; GGTI 286; GLUTAMIC ACID; ISOPRENOID; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAC PROTEIN; RAC1 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SHORT HAIRPIN RNA; TRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN CELL; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYTOTOXICITY; DENDRITE; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVATION; EXCITOTOXICITY; FARNESYLATION; NERVE CELL CULTURE; NERVE CELL PLASTICITY; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PRENYLATION; RAT; RECEPTOR DOWN REGULATION;

ALKYL AND ARYL TRANSFERASES; ANIMALS; BASE SEQUENCE; DNA PRIMERS; HEPTANOIC ACIDS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; NEURONAL PLASTICITY; NEURONS; PYRROLES; RAC1 GTP-BINDING PROTEIN; RATS; RATS, WISTAR;

AMBYSTOMA TIGRINUM STEBBENSI VIRUS;

EID: 84874605527     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2013.01.026     Document Type: Article

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