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Volumn 125, Issue 3, 2011, Pages 465-472

ROCK inhibition prevents tau hyperphosphorylation and p25/CDK5 increase after global cerebral ischemia

Author keywords

CDK 5; Global cerebral ischemia; Neuroprotection; ROCK inhibitor; Spatial learning and memory; Tau hyperphosphorylation

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CYCLIN DEPENDENT KINASE 5; PROTEIN P25; RHO KINASE; TAU PROTEIN;

EID: 79958725737     PISSN: 07357044     EISSN: 19390084     Source Type: Journal    
DOI: 10.1037/a0023167     Document Type: Article
Times cited : (43)

References (60)
  • 2
    • 1642266407 scopus 로고    scopus 로고
    • Cellular senescence requires CDK5 repression of Rac1 activity
    • Alexander K., Yang H.S., Hinds P.W. Cellular senescence requires CDK5 repression of Rac1 activity. Molecular Cell Biology 2004, 24:2808-2819.
    • (2004) Molecular Cell Biology , vol.24 , pp. 2808-2819
    • Alexander, K.1    Yang, H.S.2    Hinds, P.W.3
  • 4
    • 1642289188 scopus 로고    scopus 로고
    • Role of tau protein in both physiological and pathological conditions
    • Avila J., Lucas J.J., Perez M., Hernandez F. Role of tau protein in both physiological and pathological conditions. Physiological Reviews 2004, 84:361-384.
    • (2004) Physiological Reviews , vol.84 , pp. 361-384
    • Avila, J.1    Lucas, J.J.2    Perez, M.3    Hernandez, F.4
  • 6
    • 0345405447 scopus 로고    scopus 로고
    • Aberrant Cdk5 activation by pp. 25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles
    • Cruz J.C., Tseng H.C., Goldman J.A., Shih H., Tsai L.H. Aberrant Cdk5 activation by pp. 25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron 2003, 40:471-483.
    • (2003) Neuron , vol.40 , pp. 471-483
    • Cruz, J.C.1    Tseng, H.C.2    Goldman, J.A.3    Shih, H.4    Tsai, L.H.5
  • 10
    • 0034329543 scopus 로고    scopus 로고
    • Phosphorylation of human tau protein by microtubule-associated kinases: GSK3beta and cdk5 are key participants
    • Flaherty D.B., Soria J.P., Tomasiewicz H.G., Wood J.G. Phosphorylation of human tau protein by microtubule-associated kinases: GSK3beta and cdk5 are key participants. Journal of Neuroscience Research 2000, 62:463-472.
    • (2000) Journal of Neuroscience Research , vol.62 , pp. 463-472
    • Flaherty, D.B.1    Soria, J.P.2    Tomasiewicz, H.G.3    Wood, J.G.4
  • 11
    • 33845899093 scopus 로고    scopus 로고
    • Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism
    • Fu W.Y., Chen Y., Sahin M., Zhao X.S., Shi L., Bikoff J.B., Ip N.Y. Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nature Neuroscience 2007, 10:67-76.
    • (2007) Nature Neuroscience , vol.10 , pp. 67-76
    • Fu, W.Y.1    Chen, Y.2    Sahin, M.3    Zhao, X.S.4    Shi, L.5    Bikoff, J.B.6    Ip, N.Y.7
  • 13
    • 23444444749 scopus 로고    scopus 로고
    • Role of cyclin-dependent kinase 5 and its activator P35 in local axon and growth cone stabilization
    • Hahn C.M., Kleinholz H., Koester M.P., Grieser S., Thelen K., Pollerberg G.E. Role of cyclin-dependent kinase 5 and its activator P35 in local axon and growth cone stabilization. Neuroscience 2005, 134:449-465.
    • (2005) Neuroscience , vol.134 , pp. 449-465
    • Hahn, C.M.1    Kleinholz, H.2    Koester, M.P.3    Grieser, S.4    Thelen, K.5    Pollerberg, G.E.6
  • 15
    • 46149125926 scopus 로고    scopus 로고
    • Improvement of cognitive deficit and neuronal damage in rats with chronic cerebral ischemia via relative long-term inhibition of rho-kinase
    • Huang L., He Z., Guo L., Wang H. Improvement of cognitive deficit and neuronal damage in rats with chronic cerebral ischemia via relative long-term inhibition of rho-kinase. Cellular and Molecular Neurobiology 2008, 28:757-768.
    • (2008) Cellular and Molecular Neurobiology , vol.28 , pp. 757-768
    • Huang, L.1    He, Z.2    Guo, L.3    Wang, H.4
  • 16
    • 58149230985 scopus 로고    scopus 로고
    • Inhibition of intracellular Ca2+ release by a Rho-kinase inhibitor for the treatment of ischemic damage in primary cultured rat hippocampal neurons
    • Huang L., Li Q., Li H., He Z., Cheng Z., Chen J., Guo L. Inhibition of intracellular Ca2+ release by a Rho-kinase inhibitor for the treatment of ischemic damage in primary cultured rat hippocampal neurons. European Journal of Pharmacology 2009, 602:238-244.
    • (2009) European Journal of Pharmacology , vol.602 , pp. 238-244
    • Huang, L.1    Li, Q.2    Li, H.3    He, Z.4    Cheng, Z.5    Chen, J.6    Guo, L.7
  • 17
    • 0025363198 scopus 로고
    • Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity
    • Johnson D.I., Pringle J.R. Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity. Journal of Cell Biology 1990, 111:143-152.
    • (1990) Journal of Cell Biology , vol.111 , pp. 143-152
    • Johnson, D.I.1    Pringle, J.R.2
  • 18
    • 2342494271 scopus 로고    scopus 로고
    • 35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent Extracellular Signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in neurons
    • Kesavapany S., Amin N., Zheng Y.L., Nijhara R., Jaffe H., Sihag R., Pant H.C. 35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent Extracellular Signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in neurons. Journal of Neuroscience 2004, 24:4421-4431.
    • (2004) Journal of Neuroscience , vol.24 , pp. 4421-4431
    • Kesavapany, S.1    Amin, N.2    Zheng, Y.L.3    Nijhara, R.4    Jaffe, H.5    Sihag, R.6    Pant, H.C.7
  • 19
    • 0033018626 scopus 로고    scopus 로고
    • Activation of RhoA by lysophosphatidic acid and Galpha12/13 subunits in neuronal cells: Induction of neurite retraction
    • Kranenburg O., Poland M., van Horck F.P., Drechsel D., Hall A., Moolenaar W.H. Activation of RhoA by lysophosphatidic acid and Galpha12/13 subunits in neuronal cells: Induction of neurite retraction. Molekuliarnaia Biologiia Cell 1999, 10:1851-1857.
    • (1999) Molekuliarnaia Biologiia Cell , vol.10 , pp. 1851-1857
    • Kranenburg, O.1    Poland, M.2    van Horck, F.P.3    Drechsel, D.4    Hall, A.5    Moolenaar, W.H.6
  • 20
    • 0037079063 scopus 로고    scopus 로고
    • Fear memory formation involves pp. 190 RhoGAP and ROCK proteins through a GRB2-mediated complex
    • Lamprecht R., Farb C.R., LeDoux J.E. Fear memory formation involves pp. 190 RhoGAP and ROCK proteins through a GRB2-mediated complex. Neuron 2002, 36:727-738.
    • (2002) Neuron , vol.36 , pp. 727-738
    • Lamprecht, R.1    Farb, C.R.2    LeDoux, J.E.3
  • 24
    • 0033529620 scopus 로고    scopus 로고
    • Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase
    • Maekawa M., Ishizaki T., Boku S., Watanabe N., Fujita A., Iwamatsu A., Narumiya S. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science 1999, 285:895-898.
    • (1999) Science , vol.285 , pp. 895-898
    • Maekawa, M.1    Ishizaki, T.2    Boku, S.3    Watanabe, N.4    Fujita, A.5    Iwamatsu, A.6    Narumiya, S.7
  • 26
    • 33747446674 scopus 로고    scopus 로고
    • Hippocampal (CA1) activities in Wistar rats from different vendors. Fundamental differences in acute ischemia
    • Marosi M., Rakos G., Robotka H., Nemeth H., Sas K., Kis Z., Toldi J. Hippocampal (CA1) activities in Wistar rats from different vendors. Fundamental differences in acute ischemia. Journal of Neuroscience Methods 2006, 156:231-235.
    • (2006) Journal of Neuroscience Methods , vol.156 , pp. 231-235
    • Marosi, M.1    Rakos, G.2    Robotka, H.3    Nemeth, H.4    Sas, K.5    Kis, Z.6    Toldi, J.7
  • 27
    • 34249092704 scopus 로고    scopus 로고
    • Calcium and neurodegeneration
    • Mattson M.P. Calcium and neurodegeneration. Aging Cell 2007, 6:337-350.
    • (2007) Aging Cell , vol.6 , pp. 337-350
    • Mattson, M.P.1
  • 28
    • 0036892061 scopus 로고    scopus 로고
    • Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells
    • Ming X.F., Viswambharan H., Barandier C., Ruffieux J., Kaibuchi K., Rusconi S., Yang Z. Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells. Molecular Cell Biology 2002, 22:8467-8477.
    • (2002) Molecular Cell Biology , vol.22 , pp. 8467-8477
    • Ming, X.F.1    Viswambharan, H.2    Barandier, C.3    Ruffieux, J.4    Kaibuchi, K.5    Rusconi, S.6    Yang, Z.7
  • 29
    • 0019957779 scopus 로고
    • Place navigation impaired in rats with hippocampal lesions
    • Morris R.G., Garrud P., Rawlins J.N., O'Keefe J. Place navigation impaired in rats with hippocampal lesions. Nature 1982, 297:681-683.
    • (1982) Nature , vol.297 , pp. 681-683
    • Morris, R.G.1    Garrud, P.2    Rawlins, J.N.3    O'Keefe, J.4
  • 30
    • 0032504964 scopus 로고    scopus 로고
    • The pp. 35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity
    • Nikolic M., Chou M.M., Lu W., Mayer B.J., Tsai L.H. The pp. 35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity. Nature 1998, 395:194-198.
    • (1998) Nature , vol.395 , pp. 194-198
    • Nikolic, M.1    Chou, M.M.2    Lu, W.3    Mayer, B.J.4    Tsai, L.H.5
  • 31
    • 0029966469 scopus 로고    scopus 로고
    • The cdk5/pp. 35 kinase is essential for neurite outgrowth during neuronal differentiation
    • Nikolic M., Dudek H., Kwon Y.T., Ramos Y.F., Tsai L.H. The cdk5/pp. 35 kinase is essential for neurite outgrowth during neuronal differentiation. Genes and Development 1996, 10:816-825.
    • (1996) Genes and Development , vol.10 , pp. 816-825
    • Nikolic, M.1    Dudek, H.2    Kwon, Y.T.3    Ramos, Y.F.4    Tsai, L.H.5
  • 33
    • 0034602959 scopus 로고    scopus 로고
    • Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop
    • Ohashi K., Nagata K., Maekawa M., Ishizaki T., Narumiya S., Mizuno K. Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. Journal of Biological Chemistry 2000, 275:3577-3582.
    • (2000) Journal of Biological Chemistry , vol.275 , pp. 3577-3582
    • Ohashi, K.1    Nagata, K.2    Maekawa, M.3    Ishizaki, T.4    Narumiya, S.5    Mizuno, K.6
  • 35
    • 33748752882 scopus 로고    scopus 로고
    • The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation
    • Plattner F., Angelo M., Giese K.P. The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation. Journal of Biological Chemistry 2006, 281:25457-25465.
    • (2006) Journal of Biological Chemistry , vol.281 , pp. 25457-25465
    • Plattner, F.1    Angelo, M.2    Giese, K.P.3
  • 36
    • 0036543312 scopus 로고    scopus 로고
    • Rho proteins, mental retardation and the cellular basis of cognition
    • Ramakers G.J. Rho proteins, mental retardation and the cellular basis of cognition. Trends in Neurosciences 2002, 25:191-199.
    • (2002) Trends in Neurosciences , vol.25 , pp. 191-199
    • Ramakers, G.J.1
  • 37
    • 0035966018 scopus 로고    scopus 로고
    • Phosphorylation of Pak1 by the pp. 35/Cdk5 kinase affects neuronal morphology
    • Rashid T., Banerjee M., Nikolic M. Phosphorylation of Pak1 by the pp. 35/Cdk5 kinase affects neuronal morphology. Journal of Biological Chemistry 2001, 276:49043-49052.
    • (2001) Journal of Biological Chemistry , vol.276 , pp. 49043-49052
    • Rashid, T.1    Banerjee, M.2    Nikolic, M.3
  • 38
    • 0026778133 scopus 로고
    • The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
    • Ridley A.J., Hall A. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 1992, 70:389-399.
    • (1992) Cell , vol.70 , pp. 389-399
    • Ridley, A.J.1    Hall, A.2
  • 39
    • 0026654125 scopus 로고
    • The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
    • Ridley A.J., Paterson H.F., Johnston C.L., Diekmann D., Hall A. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 1992, 70:401-410.
    • (1992) Cell , vol.70 , pp. 401-410
    • Ridley, A.J.1    Paterson, H.F.2    Johnston, C.L.3    Diekmann, D.4    Hall, A.5
  • 40
    • 26444518165 scopus 로고    scopus 로고
    • Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection
    • Rikitake Y., Kim H.H., Huang Z., Seto M., Yano K., Asano T., Liao J.K. Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke 2005, 36:2251-2257.
    • (2005) Stroke , vol.36 , pp. 2251-2257
    • Rikitake, Y.1    Kim, H.H.2    Huang, Z.3    Seto, M.4    Yano, K.5    Asano, T.6    Liao, J.K.7
  • 41
    • 0033215982 scopus 로고    scopus 로고
    • The neuronal architecture of Xenopus retinal ganglion cells is sculpted by rho-family GTPases in vivo
    • Ruchhoeft M.L., Ohnuma S., McNeill L., Holt C.E., Harris W.A. The neuronal architecture of Xenopus retinal ganglion cells is sculpted by rho-family GTPases in vivo. Journal of Neuroscience 1999, 19:8454-8463.
    • (1999) Journal of Neuroscience , vol.19 , pp. 8454-8463
    • Ruchhoeft, M.L.1    Ohnuma, S.2    McNeill, L.3    Holt, C.E.4    Harris, W.A.5
  • 43
    • 0029956924 scopus 로고    scopus 로고
    • Neuroprotective properties of a protein kinase inhibitor against ischaemia-induced neuronal damage in rats and gerbils
    • Satoh S., Ikegaki I., Suzuki Y., Asano T., Shibuya M., Hidaka H. Neuroprotective properties of a protein kinase inhibitor against ischaemia-induced neuronal damage in rats and gerbils. British Journal of Pharmacology 1996, 118:1592-1596.
    • (1996) British Journal of Pharmacology , vol.118 , pp. 1592-1596
    • Satoh, S.1    Ikegaki, I.2    Suzuki, Y.3    Asano, T.4    Shibuya, M.5    Hidaka, H.6
  • 44
    • 39149122495 scopus 로고    scopus 로고
    • Wide therapeutic time window for Rho-kinase inhibition therapy in ischemic brain damage in a rat cerebral thrombosis model
    • Satoh S., Toshima Y., Hitomi A., Ikegaki I., Seto M., Asano T. Wide therapeutic time window for Rho-kinase inhibition therapy in ischemic brain damage in a rat cerebral thrombosis model. Brain Research 2008, 1193:102-108.
    • (2008) Brain Research , vol.1193 , pp. 102-108
    • Satoh, S.1    Toshima, Y.2    Hitomi, A.3    Ikegaki, I.4    Seto, M.5    Asano, T.6
  • 45
    • 0035838950 scopus 로고    scopus 로고
    • Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage
    • Satoh S., Utsunomiya T., Tsurui K., Kobayashi T., Ikegaki I., Sasaki Y., Asano T. Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage. Life Sciences 2001, 69:1441-1453.
    • (2001) Life Sciences , vol.69 , pp. 1441-1453
    • Satoh, S.1    Utsunomiya, T.2    Tsurui, K.3    Kobayashi, T.4    Ikegaki, I.5    Sasaki, Y.6    Asano, T.7
  • 46
    • 33746652117 scopus 로고    scopus 로고
    • Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits
    • Schindowski K., Bretteville A., Leroy K., Begard S., Brion J.P., Hamdane M., Buee L. Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits. American Journal of Pathology 2006, 169:599-616.
    • (2006) American Journal of Pathology , vol.169 , pp. 599-616
    • Schindowski, K.1    Bretteville, A.2    Leroy, K.3    Begard, S.4    Brion, J.P.5    Hamdane, M.6    Buee, L.7
  • 47
    • 0030901162 scopus 로고    scopus 로고
    • Fluoro-Jade: A novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration
    • Schmued L.C., Albertson C., Slikker W. Fluoro-Jade: A novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration. Brain Research 1997, 751:37-46.
    • (1997) Brain Research , vol.751 , pp. 37-46
    • Schmued, L.C.1    Albertson, C.2    Slikker, W.3
  • 49
    • 27644505297 scopus 로고    scopus 로고
    • Effects of fasudil in acute ischemic stroke: Results of a prospective placebo-controlled double-blind trial
    • Shibuya M., Hirai S., Seto M., Satoh S., Ohtomo E. Effects of fasudil in acute ischemic stroke: Results of a prospective placebo-controlled double-blind trial. Journal of Neurology Science 2005, 238:31-39.
    • (2005) Journal of Neurology Science , vol.238 , pp. 31-39
    • Shibuya, M.1    Hirai, S.2    Seto, M.3    Satoh, S.4    Ohtomo, E.5
  • 51
    • 0033807686 scopus 로고    scopus 로고
    • Regulation of dendritic spine morphology by the rho family of small GTPases: Antagonistic roles of Rac and Rho
    • Tashiro A., Minden A., Yuste R. Regulation of dendritic spine morphology by the rho family of small GTPases: Antagonistic roles of Rac and Rho. Cerebral Cortex 2000, 10:927-938.
    • (2000) Cerebral Cortex , vol.10 , pp. 927-938
    • Tashiro, A.1    Minden, A.2    Yuste, R.3
  • 52
    • 3242789407 scopus 로고    scopus 로고
    • Regulation of dendritic spine motility and stability by Rac1 and Rho kinase: Evidence for two forms of spine motility
    • Tashiro A., Yuste R. Regulation of dendritic spine motility and stability by Rac1 and Rho kinase: Evidence for two forms of spine motility. Molecular Cell Neuroscience 2004, 26:429-440.
    • (2004) Molecular Cell Neuroscience , vol.26 , pp. 429-440
    • Tashiro, A.1    Yuste, R.2
  • 53
    • 0033811102 scopus 로고    scopus 로고
    • A new model of cerebral microthrombosis in rats and the neuroprotective effect of a Rho-kinase inhibitor
    • Toshima Y., Satoh S., Ikegaki I., Asano T. A new model of cerebral microthrombosis in rats and the neuroprotective effect of a Rho-kinase inhibitor. Stroke 2000, 31:2245-2250.
    • (2000) Stroke , vol.31 , pp. 2245-2250
    • Toshima, Y.1    Satoh, S.2    Ikegaki, I.3    Asano, T.4
  • 54
    • 0034698841 scopus 로고    scopus 로고
    • Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts
    • Totsukawa G., Yamakita Y., Yamashiro S., Hartshorne D.J., Sasaki Y., Matsumura F. Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts. Journal of Cell Biology 2000, 150:797-806.
    • (2000) Journal of Cell Biology , vol.150 , pp. 797-806
    • Totsukawa, G.1    Yamakita, Y.2    Yamashiro, S.3    Hartshorne, D.J.4    Sasaki, Y.5    Matsumura, F.6
  • 55
    • 2542428253 scopus 로고    scopus 로고
    • Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like tauopathy in female rats
    • Wen Y., Yang S., Liu R., Brun-Zinkernagel A.M., Koulen P., Simpkins J.W. Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like tauopathy in female rats. Journal of Biological Chemistry 2004, 279:22684-22692.
    • (2004) Journal of Biological Chemistry , vol.279 , pp. 22684-22692
    • Wen, Y.1    Yang, S.2    Liu, R.3    Brun-Zinkernagel, A.M.4    Koulen, P.5    Simpkins, J.W.6
  • 56
    • 4444333265 scopus 로고    scopus 로고
    • Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein
    • Wen Y., Yang S., Liu R., Simpkins J.W. Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein. Brain Research 2004, 1022:30-38.
    • (2004) Brain Research , vol.1022 , pp. 30-38
    • Wen, Y.1    Yang, S.2    Liu, R.3    Simpkins, J.W.4
  • 58
    • 34249825465 scopus 로고    scopus 로고
    • Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons
    • Yamashita K., Kotani Y., Nakajima Y., Shimazawa M., Yoshimura S., Nakashima S., Hara H. Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons. Brain Research 2007, 1154:215-224.
    • (2007) Brain Research , vol.1154 , pp. 215-224
    • Yamashita, K.1    Kotani, Y.2    Nakajima, Y.3    Shimazawa, M.4    Yoshimura, S.5    Nakashima, S.6    Hara, H.7
  • 59
    • 50549104382 scopus 로고    scopus 로고
    • Demonstration of elevation and localization of Rho-kinase activity in the brain of a rat model of cerebral infarction
    • Yano K., Kawasaki K., Hattori T., Tawara S., Toshima Y., Ikegaki I., Seto M. Demonstration of elevation and localization of Rho-kinase activity in the brain of a rat model of cerebral infarction. European Journal of Pharmacology 2008, 594:77-83.
    • (2008) European Journal of Pharmacology , vol.594 , pp. 77-83
    • Yano, K.1    Kawasaki, K.2    Hattori, T.3    Tawara, S.4    Toshima, Y.5    Ikegaki, I.6    Seto, M.7


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