Cadherin regulates dendritic spine morphogenesis

Neuron

Volumn 35, Issue 1, 2002, Pages 77-89

  Togashi, Hideru ^a   Abe, Kentaro ^a   Mizoguchi, Akira ^a   Takaoka, Kanna ^a   Chisaka, Osamu ^a   Takeichi, Masatoshi ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b RIKEN   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN; NERVE PROTEIN; SYNAPSIN;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CELL ADHESION; CELL MATURATION; CELL SIZE; CELL STRUCTURE; CONTROLLED STUDY; DENDRITIC SPINE; EMBRYO; FILOPODIUM; HIPPOCAMPUS; MORPHOGENESIS; NERVE CELL CULTURE; NERVE FIBER; NONHUMAN; POSTSYNAPTIC MEMBRANE; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; REGULATORY MECHANISM; SYNAPSE VESICLE; SYNAPTOGENESIS; TISSUE DIFFERENTIATION;

EID: 0037014446     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(02)00748-1     Document Type: Article

References (71)

1. Postsynaptic scaffolds of excitatory and inhibitory synapses in hippocampal neurons: Maintenance of core components independent of actin filaments and microtubules
2. P120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells
3. N-cadherin redistribution during synaptogenesis in hippocampal neurons
4. Increasing numbers of synaptic puncta during late-phase LTP: N-cadherin is synthesized, recruited to synaptic sites, and required for potentiation
5. Lateral dimerization is required for the homophilic binding activity of C-cadherin
6. Cadherin-mediated adhesion at the interneuronal synapse
7. Contributions of dendritic spines and perforated synapses to synaptic plasticity
8. Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits
9. GABAergic innervation organizes synaptic and extrasynaptic GABAA receptor clustering in cultured hippocampal neurons
10. PSD-95 involvement in maturation of excitatory synapses
11. Dendritic spine changes associated with hippocampal long-term synaptic plasticity
12. A model for central synaptic junctional complex formation based on the differential adhesive specificities of the cadherins
13. Rapid actin-based plasticity in dendritic spines
14. Disruption of epithelial cell-cell adhesion by exogenous expression of a mutated nonfunctional N-cadherin
15. Rat hippocampal neurons in low-density culture
16. Identification of a neural α-catenin as a key regulator of cadherin function and multicellular organization
17. Blockade of cadherin-6B activity perturbs the distribution of PSD-95 family proteins in retinal neurones
18. Adhesive subdivisions intrinsic to the epithelial somites
19. Repeated confocal imaging of individual dendritic spines in the living hippocampal slice: Evidence for changes in length and orientation associated with chemically induced LTP
20. Neural (N)-cadherin at developing thalamocortical synapses provides an adhesion mechanism for the formation of somatopically organized connections
21. Cadherin-6 in the developing mouse brain: Expression along restricted connection systems and synaptic localization suggest a potential role in neuronal circuitry
22. DN-Cadherin is required for spatial arrangement of axon terminals and their targets, and ultrastructural organization of synapses in the Drosophila visual system
23. αT-catenin: A novel tissue-specific β-catenin-binding protein mediating strong cell-cell adhesion
24. Filopodia, spines, and the generation of synaptic diversity
25. Activity-dependent regulation of synaptic clustering in a hippocampal culture system
26. Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain
27. Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex
28. Cadherin-directed actin assembly. E-cadherin physically associates with the arp 2/3 complex to direct actin assembly in nascent adhesive contacts
29. Development of neuron-neuron synapses
30. Experience-dependent plasticity of dendritic spines in the developing rat barrel cortex in vivo
31. Rapid dendritic morphogenesis in CA1 hippocampal dendrites induced by synaptic activity
32. Loss of cadherin-11 adhesion receptor enhances plastic changes in hippocampal synapses and modifies behavioral responses
33. PSA-NCAM is required for activity-induced synaptic plasticity
34. Spine changes associated with long-term potentiation
35. Cell binding function of E-cadherin is regulated by the cytoplasmic domain
36. Neural crest emigration from the neural tube depends on regulated cadherin expression
37. Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites
38. Small GTPases Rac and Rho in the maintenance of dendritic spines and branches in hippocampal pyramidal neurons
39. Abnormal development of dendritic spines in FMR1 knock-out mice
40. Cadherin engagement regulates Rho family GTPases
41. P120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity
42. Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule
43. Regulation of dendritic spine morphology by SPAR, a PSD-95-associated rap GAP
44. α-Catenin binds directly to spectrin and facilitates spectrin- membrane assembly in vivo
45. Heterogeneity in the molecular composition of excitatory postsynaptic sites during development of hippocampal neurons in culture
46. αE-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex
47. A mutation in α-catenin disrupts adhesion in clone A cells without perturbing its actin and β-catenin binding activity
48. Reduction in spine density associated with long-term potentiation in the dentate gyrus suggests a spine fusion-and-branching model of potentiation
49. Regulation of dendritic spine morphology and synaptic function by shank and homer
50. Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons
51. Synaptic and extrasynaptic γ-aminobutyric acid type A receptor clusters in rat hippocampal cultures during development
52. Cadherin dysfunction in a human cancer cell line: Possible involvement of loss of alpha-catenin expression in reduced cell-cell adhesiveness
53. Three-dimensional analysis of dendritic spines. II. Spine apparatus and other cytoplasmic components
54. Three-dimensional organization of cell adhesion junctions at synapses and dendritic spines in area CA1 of the rat hippocampus
55. Neuronal circuits are subdivided by differential expression of type-II classic cadherins in postnatal mouse brains
56. Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20
57. Cadherin cell adhesion receptors as a morphogenetic regulator
58. Molecular modification of N-cadherin in response to synaptic activity
59. A role for the cadherin family of cell adhesion molecules in hippocampal long-term potentiation
60. Cadherins in embryonic and neural morphogenesis
61. Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion
62. LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
63. Mouse αN-catenin: Two isoforms, specific expression in the nervous system, and chromosomal localization of the gene
64. The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones
65. α-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells
66. Lamina-specific expression of adhesion molecules in developing chick optic tectum
67. Arcadlin is a neural activity-regulated cadherin involved in long term potentiation
68. Morphologial changes in dendritic spines associated with long-term synaptic plasticity
69. Assembling the presynaptic active zone: A characterization of an active one precursor vesicle
70. Stages of synapse development defined by dependence on F-actin
71. Evidence for a role of dendritic filopodia in synaptogenesis and spine formation