Simvastatin promotes neurite outgrowth in the presence of inhibitory molecules found in central nervous system injury

Journal of Neurotrauma

Volumn 23, Issue 9, 2006, Pages 1366-1378

  Holmberg, Eric ^a,b   Nordstrom, Tuija ^a   Gross, Mica ^a   Kluge, Bridget ^a   Zhang, Shu Xin ^a   Doolen, Suzanne ^a,c  

^a Spinal Cord Society Research Center   (United States)

^b UNIVERSITY OF ALASKA ANCHORAGE   (United States)

^c SCS Research Center   (United States)

Author keywords

HMG CoA reductase inhibitor; Isoprenoids; Myelin stripe assay; Regenerative failure; Rho GTPase; Spinal cord injury; Traumatic brain injury

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; CHOLESTEROL; ENZYME INHIBITOR; GGTI 286; GLYCOPROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LAMININ; MEVALONIC ACID; MYELIN; MYELIN ASSOCIATED GLYCOPROTEIN; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; OLIGODENDROCYTE MYELIN GLYCOPROTEIN; PROTEIN NOGO; PROTEOCHONDROITIN SULFATE; SIMVASTATIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN INJURY; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; EMBRYO; EXPLANT; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MEMBRANE FILTER; NERVE FIBER GROWTH; NERVOUS SYSTEM INJURY; NEUROPROTECTION; NEWBORN; NONHUMAN; RAT; SIGNAL TRANSDUCTION; SPINAL CORD INJURY; ANIMAL; CULTURE TECHNIQUE; GROWTH, DEVELOPMENT AND AGING; MYELIN SHEATH; NEURITE; PATHOLOGY; PHYSIOLOGY; PRENATAL DEVELOPMENT; SPINAL CORD;

ANIMALS; CELL CULTURE TECHNIQUES; CEREBRAL CORTEX; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LAMININ; MYELIN SHEATH; NEURITES; RATS; SIMVASTATIN; SPINAL CORD;

EID: 33947684873     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2006.23.1366     Document Type: Article

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