-
1
-
-
0038004785
-
Lovastatin and beyond: The history of the HMG-CoA reductase inhibitors
-
Tobert, J.A. 2003. Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat. Rev. 2: 517-526.
-
(2003)
Nat. Rev.
, vol.2
, pp. 517-526
-
-
Tobert, J.A.1
-
2
-
-
0037490080
-
Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: Systematic review andmeta-analysis
-
Law, M.R. et al. 2003. Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review andmeta-analysis. Br.Med. J. 326: 1-7.
-
(2003)
Br.Med. J.
, vol.326
, pp. 1-7
-
-
Law, M.R.1
-
3
-
-
41249085524
-
Statin therapy for stroke prevention
-
Nassief, A. & J.D. Marsh. 2008. Statin therapy for stroke prevention. Stroke 39: 1042-1048.
-
(2008)
Stroke
, vol.39
, pp. 1042-1048
-
-
Nassief, A.1
Marsh, J.D.2
-
4
-
-
42049097650
-
Statin use and the risk of Parkinson disease
-
Wahner, A.D. et al. 2008. Statin use and the risk of Parkinson disease. Neurology 70: 1418-1422.
-
(2008)
Neurology
, vol.70
, pp. 1418-1422
-
-
Wahner, A.D.1
-
5
-
-
22244452701
-
Statins: Drugs for Alzheimer's disease?
-
Eckert, G.P. et al. 2005. Statins: drugs for Alzheimer's disease? J. Neural Transm. 112: 1057-1071.
-
(2005)
J. Neural Transm.
, vol.112
, pp. 1057-1071
-
-
Eckert, G.P.1
-
6
-
-
34248352687
-
Evaluation of atorvastatin and simvastatin for treatment of multiple sclerosis
-
Neuhaus, O. & H.P. Hartung. 2007. Evaluation of atorvastatin and simvastatin for treatment of multiple sclerosis. Expert. Rev. Neurother. 7: 547-556.
-
(2007)
Expert. Rev. Neurother.
, vol.7
, pp. 547-556
-
-
Neuhaus, O.1
Hartung, H.P.2
-
7
-
-
50149118448
-
Effect of rosuvastatin on amnesia and disorientation after traumatic brain injury (NCT003229758)
-
Tapia-Perez, J.H. et al. 2008. Effect of rosuvastatin on amnesia and disorientation after traumatic brain injury (NCT003229758). J. Neurotrauma. 25: 1011-1017.
-
(2008)
J. Neurotrauma.
, vol.25
, pp. 1011-1017
-
-
Tapia-Perez, J.H.1
-
8
-
-
33646167277
-
Neuroprotective properties of statins
-
Stepien, K. et al. 2005. Neuroprotective properties of statins. Pharmacol. Rep. 57: 561-569.
-
(2005)
Pharmacol. Rep.
, vol.57
, pp. 561-569
-
-
Stepien, K.1
-
9
-
-
34547860418
-
Cholesterol-lowering drugs and Alzheimer's disease
-
Eckert, G.P. et al. 2007. Cholesterol-lowering drugs and Alzheimer's disease. Future Lipidol. 2: 423-432.
-
(2007)
Future Lipidol.
, vol.2
, pp. 423-432
-
-
Eckert, G.P.1
-
10
-
-
37349013266
-
Statins and brain protection mechanisms
-
Tapia-Perez, H. et al. 2007. Statins and brain protection mechanisms. Revista de Neurologia 45: 359-364.
-
(2007)
Revista de Neurologia
, vol.45
, pp. 359-364
-
-
Tapia-Perez, H.1
-
11
-
-
36448947190
-
Comparison of biochemical effects of statins and fish oil in brain: The battle of the titans
-
Farooqui, A.A. et al. 2007. Comparison of biochemical effects of statins and fish oil in brain: the battle of the titans. Brain Res. Rev. 56: 443-471.
-
(2007)
Brain Res. Rev.
, vol.56
, pp. 443-471
-
-
Farooqui, A.A.1
-
12
-
-
40749115140
-
Statins in the spectrum of neurologic disease
-
Orr, J.D. 2008. Statins in the spectrum of neurologic disease. Curr. Atheroscler. Rep. 10: 11-18.
-
(2008)
Curr. Atheroscler. Rep.
, vol.10
, pp. 11-18
-
-
Orr, J.D.1
-
13
-
-
0025770041
-
Concentrations of pravastatin and lovastatin in cerebrospinal fluid in healthy subjects
-
Botti, R.E. et al. 1991. Concentrations of pravastatin and lovastatin in cerebrospinal fluid in healthy subjects. Clin. Neuropharmacol. 14: 256-261.
-
(1991)
Clin. Neuropharmacol.
, vol.14
, pp. 256-261
-
-
Botti, R.E.1
-
14
-
-
0035111913
-
A comparison of the effects of 3- hydroxy-3-methylglutaryl-coenzymeA(HMG- CoA) reductase inhibitors on the CYP3A4-dependent oxidation of mexazolam in vitro
-
Ishigami, M. et al. 2001. A comparison of the effects of 3- hydroxy-3-methylglutaryl-coenzymeA(HMG-CoA) reductase inhibitors on the CYP3A4-dependent oxidation of mexazolam in vitro. DrugMetab. Dispos. 29: 282-288.
-
(2001)
DrugMetab. Dispos.
, vol.29
, pp. 282-288
-
-
Ishigami, M.1
-
15
-
-
13444251203
-
Chemical, pharmacokinetic and pharmacodynamic properties of statins: An update
-
Schachter, M. 2004. Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update. Fund Clin. Pharmacol. 19: 117-125.
-
(2004)
Fund Clin. Pharmacol.
, vol.19
, pp. 117-125
-
-
Schachter, M.1
-
16
-
-
0028281788
-
In vivo and in vitro blood-brain barrier transport of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors
-
Saheki, A. et al. 1994. In vivo and in vitro blood-brain barrier transport of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. Pharm. Res. 11: 305-311.
-
(1994)
Pharm. Res.
, vol.11
, pp. 305-311
-
-
Saheki, A.1
-
17
-
-
19944432452
-
Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex
-
Johnson-Anuna, L.N. et al. 2005. Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex. J. Pharmacol. Exp. Ther. 312: 786-793.
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.312
, pp. 786-793
-
-
Johnson-Anuna, L.N.1
-
18
-
-
33644781781
-
Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin
-
Thelen, K.M. et al. 2006. Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin. J. Pharmacol. Exp. Ther. 316: 1146-1152.
-
(2006)
J. Pharmacol. Exp. Ther.
, vol.316
, pp. 1146-1152
-
-
Thelen, K.M.1
-
19
-
-
0038137530
-
Contribution of organic anion transporters to the renal uptake of anionic compounds and nucleoside derivatives
-
Hasegawa,M. et al. 2003. Contribution of organic anion transporters to the renal uptake of anionic compounds and nucleoside derivatives. J. Pharmacol. Exp. Ther. 305: 1087-1097.
-
(2003)
J. Pharmacol. Exp. Ther.
, vol.305
, pp. 1087-1097
-
-
Hasegawa, M.1
-
20
-
-
0347318099
-
Evidence for a role of human organic anion transporters in the muscular side effects of HMG-CoA reductase inhibitors
-
Takeda, M. et al. 2004. Evidence for a role of human organic anion transporters in the muscular side effects of HMG-CoA reductase inhibitors. Eur. J. Pharmacol. 483: 133-138.
-
(2004)
Eur. J. Pharmacol.
, vol.483
, pp. 133-138
-
-
Takeda, M.1
-
21
-
-
0033532065
-
Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain
-
Kusuhara, H. et al. 1999. Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J. Biol. Chem. 274: 13675-13680.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 13675-13680
-
-
Kusuhara, H.1
-
22
-
-
0027723663
-
Transportmechanism of 3-hydroxy- 3-methylglutaryl coenzyme A reductase inhibitors at the blood-brain barrier
-
Tsuji, A. et al. 1993. Transportmechanism of 3-hydroxy- 3-methylglutaryl coenzyme A reductase inhibitors at the blood-brain barrier. J. Pharmacol. Exp. Ther. 267: 1085-1090.
-
(1993)
J. Pharmacol. Exp. Ther.
, vol.267
, pp. 1085-1090
-
-
Tsuji, A.1
-
23
-
-
0033783036
-
Lactonization is the critical first step in the disposition of the 3-hydroxy- 3-methylglutaryl-CoA reductase inhibitor atorvastatin
-
Jacobsen, W. et al. 2000. Lactonization is the critical first step in the disposition of the 3-hydroxy- 3-methylglutaryl-CoA reductase inhibitor atorvastatin. Drug Metab. Dispos. 28: 1369-1378.
-
(2000)
Drug Metab. Dispos.
, vol.28
, pp. 1369-1378
-
-
Jacobsen, W.1
-
24
-
-
0031847115
-
Effect of itraconazole on the pharmacokinetics of atorvastatin
-
Kantola, T. et al. 1998. Effect of itraconazole on the pharmacokinetics of atorvastatin. Clin. Pharmacol. Ther. 64: 58-65.
-
(1998)
Clin. Pharmacol. Ther.
, vol.64
, pp. 58-65
-
-
Kantola, T.1
-
25
-
-
0036045940
-
Differential metabolism of alprazolam by liver and brain c (P4503A) to pharmacologically active metabolite
-
Pai, H.V. et al. 2002. Differential metabolism of alprazolam by liver and brain c (P4503A) to pharmacologically active metabolite. Pharmacogenomics 2: 243-258.
-
(2002)
Pharmacogenomics
, vol.2
, pp. 243-258
-
-
Pai, H.V.1
-
26
-
-
0031158805
-
The physiological function of drugtransportingP- glycoproteins
-
Schinkel, A.H. 1997. The physiological function of drugtransportingP- glycoproteins. Semin. CancerBiol. 8: 161-170.
-
(1997)
Semin. CancerBiol.
, vol.8
, pp. 161-170
-
-
Schinkel, A.H.1
-
27
-
-
0035076611
-
HMG-CoA reductase inhibitors and P-glycoprotein modulation
-
Bogman, K. et al. 2001. HMG-CoA reductase inhibitors and P-glycoprotein modulation. Br. J. Pharmacol. 132: 1183-1192.
-
(2001)
Br. J. Pharmacol.
, vol.132
, pp. 1183-1192
-
-
Bogman, K.1
-
28
-
-
0036325998
-
Expression of mRNAs of multidrug resistance proteins (Mrps) in cultured rat astrocytes, oligodendrocytes, microglial cells and neurons
-
Hirrlinger, J. et al. 2002. Expression of mRNAs of multidrug resistance proteins (Mrps) in cultured rat astrocytes, oligodendrocytes, microglial cells and neurons. J. Neurochem. 82: 716-729.
-
(2002)
J. Neurochem.
, vol.82
, pp. 716-729
-
-
Hirrlinger, J.1
-
29
-
-
0037457803
-
Drug efflux transporters in the CNS
-
Sun, H. et al. 2003. Drug efflux transporters in the CNS. Adv. Drug Deliv. Rev. 55: 83-105.
-
(2003)
Adv. Drug Deliv. Rev.
, vol.55
, pp. 83-105
-
-
Sun, H.1
-
30
-
-
0346749450
-
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity
-
Zacco, A. et al. 2003. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity. J. Neurosci. 23: 11104-11111.
-
(2003)
J. Neurosci.
, vol.23
, pp. 11104-11111
-
-
Zacco, A.1
-
31
-
-
20144385721
-
Neuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neurones
-
Bösel, J. et al. 2005. Neuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neurones. J. Neurochem. 92: 1386-1398.
-
(2005)
J. Neurochem.
, vol.92
, pp. 1386-1398
-
-
Bösel, J.1
-
32
-
-
33947213317
-
Simvastatin protects neurons fromcytotoxicity by up-regulating Bcl-2mRNA and protein
-
Johnson-Anuna, L.N. et al. 2007. Simvastatin protects neurons fromcytotoxicity by up-regulating Bcl-2mRNA and protein. J. Neurochem. 101: 77-86.
-
(2007)
J. Neurochem.
, vol.101
, pp. 77-86
-
-
Johnson-Anuna, L.N.1
-
33
-
-
33644946838
-
Simvastatin prevents oxygen and glucose deprivation/reoxygenation-induced death of cortical neurons by reducing the production and toxicity of 4-hydroxy-2E-nonenal
-
Lim, J.H. et al. 2006. Simvastatin prevents oxygen and glucose deprivation/reoxygenation-induced death of cortical neurons by reducing the production and toxicity of 4-hydroxy-2E-nonenal. J. Neurochem. 97: 140-150.
-
(2006)
J. Neurochem.
, vol.97
, pp. 140-150
-
-
Lim, J.H.1
-
34
-
-
58349121423
-
Rosuvastatin induces delayed preconditioning against oxygen-glucose deprivation in cultured cortical neurons
-
Domoki, F. et al. 2009. Rosuvastatin induces delayed preconditioning against oxygen-glucose deprivation in cultured cortical neurons. Am. J. Physiol. Cell Physiol. 296: C97-C105.
-
(2009)
Am. J. Physiol. Cell Physiol.
, vol.296
-
-
Domoki, F.1
-
35
-
-
33846439745
-
Bcl-2 upregulation and neuroprotection in guinea pig brain following chronic simvastatin treatment
-
Franke, C. et al. 2007. Bcl-2 upregulation and neuroprotection in guinea pig brain following chronic simvastatin treatment. Neurobiol. Dis. 25: 438-445.
-
(2007)
Neurobiol. Dis.
, vol.25
, pp. 438-445
-
-
Franke, C.1
-
36
-
-
40849094518
-
Statins decrease expression of the proinflammatory neuropeptides calcitonin gene-related peptide and substance P in sensory neurons
-
Bucelli, R.C. et al. 2008. Statins decrease expression of the proinflammatory neuropeptides calcitonin gene-related peptide and substance P in sensory neurons. J. Pharmacol. Exp. Ther. 324: 1172-1180.
-
(2008)
J. Pharmacol. Exp. Ther.
, vol.324
, pp. 1172-1180
-
-
Bucelli, R.C.1
-
37
-
-
0032973711
-
Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death
-
Michikawa, M. & K.Yanagisawa. 1999. Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death. J. Neurochem. 72: 2278-2285.
-
(1999)
J. Neurochem.
, vol.72
, pp. 2278-2285
-
-
Michikawa, M.1
Yanagisawa, K.2
-
38
-
-
0034655467
-
Geranylgeranyl-pyrophosphate, an isoprenoid ofmevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl- CoA reductase inhibition
-
Tanaka,T. et al. 2000. Geranylgeranyl-pyrophosphate, an isoprenoid ofmevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl- CoA reductase inhibition. J. Neurosci. 20: 2852-2859.
-
(2000)
J. Neurosci.
, vol.20
, pp. 2852-2859
-
-
Tanaka, T.1
-
39
-
-
1842510494
-
HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis
-
Schulz, J.G. et al. 2004. HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis. J. Neurochem. 89: 24-32.
-
(2004)
J. Neurochem.
, vol.89
, pp. 24-32
-
-
Schulz, J.G.1
-
40
-
-
1842457774
-
Lovastatin-induced up-regulation of the BH3-only protein, Bim, and cell death in glioblastoma cells
-
Jiang, Z. et al. 2004. Lovastatin-induced up-regulation of the BH3-only protein, Bim, and cell death in glioblastoma cells. J. Neurochem. 89: 168-178.
-
(2004)
J. Neurochem.
, vol.89
, pp. 168-178
-
-
Jiang, Z.1
-
41
-
-
33751584846
-
Statins induce differentiation and cell death in neurons and astroglia
-
März, P. et al. 2007. Statins induce differentiation and cell death in neurons and astroglia. Glia 55: 1-12.
-
(2007)
Glia
, vol.55
, pp. 1-12
-
-
März, P.1
-
42
-
-
58149377174
-
Negative impact of statins on oligodendrocytes and myelin formation in vitro and in vivo
-
Klopfleisch, S. et al. 2008. Negative impact of statins on oligodendrocytes and myelin formation in vitro and in vivo. J. Neurosci. 28: 13609-13614.
-
(2008)
J. Neurosci.
, vol.28
, pp. 13609-13614
-
-
Klopfleisch, S.1
-
43
-
-
57449087848
-
Simvastatin induces cells death in a mouse cerebellar slice culture (CSC) model of developmental myelination
-
Xiang, Z. & S.A. Reeves. 2009. Simvastatin induces cells death in a mouse cerebellar slice culture (CSC) model of developmental myelination. Exp. Neurol. 215: 41-47.
-
(2009)
Exp. Neurol.
, vol.215
, pp. 41-47
-
-
Xiang, Z.1
Reeves, S.A.2
-
44
-
-
0034742113
-
Amyloidβ-peptide1-40 increases neuronal membrane fluidity: Role of cholesterol and brain region
-
Chochina, S.V. et al. 2001. Amyloidβ-peptide1-40 increases neuronal membrane fluidity: role of cholesterol and brain region. J. Lipid Res. 42: 1292-1297.
-
(2001)
J. Lipid Res.
, vol.42
, pp. 1292-1297
-
-
Chochina, S.V.1
-
45
-
-
42949170875
-
Do the cholesterol-lowering properties of statins affect cancer risk?
-
Solomon, K.R. & M.R. Freeman. 2008. Do the cholesterol-lowering properties of statins affect cancer risk? Trends Endocrinol. Metab. 19: 113-121.
-
(2008)
Trends Endocrinol. Metab.
, vol.19
, pp. 113-121
-
-
Solomon, K.R.1
Freeman, M.R.2
-
47
-
-
33644858461
-
Anti-cancer therapy: Targeting the mevalonate pathway
-
Swanson, K.M. & R.J. Hohl. 2006. Anti-cancer therapy: targeting the mevalonate pathway. Curr. Cancer Drug Targets 6: 15-37.
-
(2006)
Curr. Cancer Drug Targets
, vol.6
, pp. 15-37
-
-
Swanson, K.M.1
Hohl, R.J.2
-
48
-
-
33646137779
-
Isoprenoids and Alzheimer's disease: A complex relationship
-
Cole, S.L.&R.Vassar. 2006. Isoprenoids and Alzheimer's disease: a complex relationship. Neurobiol. Dis. 22: 209-222.
-
(2006)
Neurobiol. Dis.
, vol.22
, pp. 209-222
-
-
Cole, S.L.1
Vassar, R.2
-
49
-
-
84900915924
-
Cholesterol-a Janus faced molecule in the central nervous system
-
A Lajtha & M.E.A. Reith, Eds. Springer. New York
-
Wood, W.G. et al. 2007. Cholesterol-a Janus faced molecule in the central nervous system. In Handbook of Neurochemistry and Molecular Neurobiology-Neural Membranes and Transport . A Lajtha & M.E.A. Reith, Eds.: 151-170. Springer. New York.
-
(2007)
Handbook of Neurochemistry and Molecular Neurobiology-Neural Membranes and Transport
, pp. 151-170
-
-
Wood, W.G.1
-
50
-
-
30844467746
-
Farnesyl transferase inhibitors
-
Basso, A.D. et al. 2006. Farnesyl transferase inhibitors. J. Lipid Res. 47: 15-31.
-
(2006)
J. Lipid Res.
, vol.47
, pp. 15-31
-
-
Basso, A.D.1
-
51
-
-
32044435884
-
Isoprenylated proteins
-
Mc Taggart, S.J. 2006. Isoprenylated proteins. Cell Mol. Life Sci. 63: 255-267.
-
(2006)
Cell Mol. Life Sci.
, vol.63
, pp. 255-267
-
-
Mc Taggart, S.J.1
-
52
-
-
21444445440
-
Statins cause intracellular accumulation of amyloid precursor protein. β-secretase-cleaved fragments, and amyloidβ-peptide via an isoprenoiddependent mechanism
-
Cole, S.L. 2005. Statins cause intracellular accumulation of amyloid precursor protein.-secretase-cleaved fragments, and amyloid-peptide via an isoprenoiddependent mechanism. J. Biol. Chem. 280: 18755-18770.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 18755-18770
-
-
Cole, S.L.1
-
53
-
-
34848835187
-
Statins reduce amyloid-β production through inhibition of protein isoprenylation
-
Ostrowski, S.M. et al. 2007. Statins reduce amyloid- production through inhibition of protein isoprenylation. J. Biol. Chem. 282: 26832-26844.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 26832-26844
-
-
Ostrowski, S.M.1
-
54
-
-
44649156936
-
Quantitative determination of farnesyl and geranylgeranyl diphosphate levels in mammalian tissue
-
Tong,H. et al. 2008. Quantitative determination of farnesyl and geranylgeranyl diphosphate levels in mammalian tissue. Anal. Biochem. 378: 138-143.
-
(2008)
Anal. Biochem.
, vol.378
, pp. 138-143
-
-
Tongh1
-
55
-
-
52349087722
-
Isoprenoid quantitation in human brain tissue: A validated HPLC-fluorescence detection method for endogenous farnesyl- (FPP) and geranylgeranylpyrophosphate (GGPP)
-
Hooff, G.P. et al. 2008. Isoprenoid quantitation in human brain tissue: a validated HPLC-fluorescence detection method for endogenous farnesyl- (FPP) and geranylgeranylpyrophosphate (GGPP). Anal. Bioanal. Chem. 392: 673-680.
-
(2008)
Anal. Bioanal. Chem.
, vol.392
, pp. 673-680
-
-
Hooff, G.P.1
-
56
-
-
9944233982
-
Simultaneous determination of farnesyl and geranylgeranyl pyrophosphate levels in cultured cells
-
Tong, H. et al. 2005. Simultaneous determination of farnesyl and geranylgeranyl pyrophosphate levels in cultured cells. Anal. Biochem. 336: 51-59.
-
(2005)
Anal. Biochem.
, vol.336
, pp. 51-59
-
-
Tong, H.1
|