Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice

Journal of Clinical Investigation

Volumn 121, Issue 2, 2011, Pages 628-639

  Khan, Omar M ^a   Ibrahim, Mohamed X ^a   Jonsson, Ing Marie ^a   Karlsson, Christin ^a   Liu, Meng ^a,b   Sjogren, Anna Karin M ^a   Olofsson, Frida J ^a   Brisslert, Mikael ^a   Andersson, Sofia ^a   Ohlsson, Claes ^a   Hultén, Lillemor Mattsson ^a   Bokarewa, Maria ^a   Bergo, Martin O ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHYTOENE SYNTHASE; PHYTOENE SYNTHASE 1; PROTEIN CDC42; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW TRANSPLANTATION; CELL MEMBRANE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME DEFICIENCY; MACROPHAGE ACTIVATION; MACROPHAGE MIGRATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHAGOCYTOSIS; PHYTOENE SYNTHASE 1 DEFICIENCY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RHEUMATOID ARTHRITIS;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ARTHRITIS; CDC42 GTP-BINDING PROTEIN; CYTOKINES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RAC1 GTP-BINDING PROTEIN; RAP1 GTP-BINDING PROTEINS; RHOA GTP-BINDING PROTEIN;

EID: 79551515862     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI43758     Document Type: Article

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