-
1
-
-
33644748133
-
Thematic review series: Lipid posttranslational modifications: Structural biology of protein farnesyltransferase and geranylgeranyltransferase type-I
-
Lane, K. T., and L. S. Beese. 2006. Thematic review series: lipid posttranslational modifications: structural biology of protein farnesyltransferase and geranylgeranyltransferase type-I. J. Lipid Res. 47: 681-699.
-
(2006)
J. Lipid Res.
, vol.47
, pp. 681-699
-
-
Lane, K.T.1
Beese, L.S.2
-
2
-
-
30844467746
-
Thematic review series: Lipid posttranslational modifications. Farnesyl transferase inhibitors
-
Basso, A. D., P. Kirschmeier, and W. R. Bishop. 2006. Thematic review series: lipid posttranslational modifications. Farnesyl transferase inhibitors. J. Lipid Res. 47: 15-31.
-
(2006)
J. Lipid Res.
, vol.47
, pp. 15-31
-
-
Basso, A.D.1
Kirschmeier, P.2
Bishop, W.R.3
-
3
-
-
0021170342
-
The p21 ras C-terminus is required for transformation and membrane association
-
Willumsen, B. M., A. Christensen, N. L. Hubbert, A. G. Papageorge, and D. R. Lowy. 1984. The p21 ras C-terminus is required for transformation and membrane association. Nature. 310: 583-586.
-
(1984)
Nature
, vol.310
, pp. 583-586
-
-
Willumsen, B.M.1
Christensen, A.2
Hubbert, N.L.3
Papageorge, A.G.4
Lowy, D.R.5
-
4
-
-
0025183869
-
Evidence for an S-farnesylcysteine methyl ester at the carboxyl terminus of the Saccharomyces cerevisiae RAS2 protein
-
Stimmel, J. B., R. J. Deschenes, C. Volker, J. Stock, and S. Clarke. 1990. Evidence for an S-farnesylcysteine methyl ester at the carboxyl terminus of the Saccharomyces cerevisiae RAS2 protein. Biochemistry. 29: 9651-9659.
-
(1990)
Biochemistry
, vol.29
, pp. 9651-9659
-
-
Stimmel, J.B.1
Deschenes, R.J.2
Volker, C.3
Stock, J.4
Clarke, S.5
-
5
-
-
0000081175
-
Posttranslational modification of the Ha-ras oncogene protein: Evidence for a third class of protein carboxyl methyltransferases
-
Clarke, S., J. P. Vogel, R. J. Deschenes, and J. B. Stock. 1988. Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases. Proc. Natl. Acad. Sci. USA. 85: 4643-4647.
-
(1988)
Proc. Natl. Acad. Sci. USA
, vol.85
, pp. 4643-4647
-
-
Clarke, S.1
Vogel, J.P.2
Deschenes, R.J.3
Stock, J.B.4
-
6
-
-
0022657845
-
Direct identification of palmitic acid as the lipid attached to p21ras
-
Buss, J. E., and B. M. Sefton. 1986. Direct identification of palmitic acid as the lipid attached to p21ras. Mol. Cell. Biol. 6: 116-122.
-
(1986)
Mol. Cell. Biol.
, vol.6
, pp. 116-122
-
-
Buss, J.E.1
Sefton, B.M.2
-
7
-
-
0024406286
-
All ras proteins are polyisoprenylated but only some are palmitoylated
-
Hancock, J. F., A. I. Magee, J. E. Childs, and C. J. Marshall. 1989. All ras proteins are polyisoprenylated but only some are palmitoylated. Cell. 57: 1167-1177.
-
(1989)
Cell
, vol.57
, pp. 1167-1177
-
-
Hancock, J.F.1
Magee, A.I.2
Childs, J.E.3
Marshall, C.J.4
-
8
-
-
0030909336
-
Modulation of Ras and a-factor function by carboxyl-terminal proteolysis
-
Boyartchuk, V. L., M. N. Ashby, and J. Rine. 1997. Modulation of Ras and a-factor function by carboxyl-terminal proteolysis. Science. 275: 1796-1800.
-
(1997)
Science
, vol.275
, pp. 1796-1800
-
-
Boyartchuk, V.L.1
Ashby, M.N.2
Rine, J.3
-
9
-
-
0025764049
-
The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that modulates C-terminal methylation of a-factor and RAS proteins
-
Hrycyna, C. A., S. K. Sapperstein, S. Clarke, and S. Michaelis. 1991. The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that modulates C-terminal methylation of a-factor and RAS proteins. EMBO J. 10: 1699-1709.
-
(1991)
EMBO J.
, vol.10
, pp. 1699-1709
-
-
Hrycyna, C.A.1
Sapperstein, S.K.2
Clarke, S.3
Michaelis, S.4
-
10
-
-
0032511057
-
Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum
-
Dai, Q., E. Choy, V. Chiu, J. Romano, S. Slivka, S. Steitz, S. Michaelis, and M. R. Philips. 1998. Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. J. Biol. Chem. 273: 15030-15034.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 15030-15034
-
-
Dai, Q.1
Choy, E.2
Chiu, V.3
Romano, J.4
Slivka, S.5
Steitz, S.6
Michaelis, S.7
Philips, M.R.8
-
11
-
-
0022388682
-
Methyl-esterified proteins in a mammalian cell line
-
Chelsky, D., B. Ruskin, and D. E. Koshland. 1985. Methyl-esterified proteins in a mammalian cell line. Biochemistry. 24: 6651-6658.
-
(1985)
Biochemistry
, vol.24
, pp. 6651-6658
-
-
Chelsky, D.1
Ruskin, B.2
Koshland, D.E.3
-
12
-
-
0026353346
-
Sequence dependence of protein isoprenylation
-
Moores, S. L., M. D. Schaber, S. D. Mosser, E. Rands, M. B. O'Hara, V. M. Garsky, M. S. Marshall, D. L. Pompliano, and J. B. Gibbs. 1991. Sequence dependence of protein isoprenylation. J. Biol. Chem. 266: 14603-14610.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 14603-14610
-
-
Moores, S.L.1
Schaber, M.D.2
Mosser, S.D.3
Rands, E.4
O'Hara, M.B.5
Garsky, V.M.6
Marshall, M.S.7
Pompliano, D.L.8
Gibbs, J.B.9
-
15
-
-
0037174987
-
Identification of a Ras palmitoyltransferase in Saccharomyces cerevisiae
-
Lobo, S., W. K. Greentree, M. E. Linder, and R. J. Deschenes. 2002. Identification of a Ras palmitoyltransferase in Saccharomyces cerevisiae. J. Biol. Chem. 277: 41268-41273.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 41268-41273
-
-
Lobo, S.1
Greentree, W.K.2
Linder, M.E.3
Deschenes, R.J.4
-
16
-
-
24744466287
-
DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- And N-Ras
-
Swarthout, J. T., S. Lobo, L. Farh, M. R. Croke, W. K. Greentree, R. J. Deschenes, and M. E. Linder. 2005. DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras. J. Biol. Chem. 280: 31141-31148.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 31141-31148
-
-
Swarthout, J.T.1
Lobo, S.2
Farh, L.3
Croke, M.R.4
Greentree, W.K.5
Deschenes, R.J.6
Linder, M.E.7
-
18
-
-
0036732940
-
Membrane trafficking of heterotrimeric G proteins via the endoplasmic reticulum and Golgi
-
Michaelson, D., I. Ahearn, M. Bergo, S. Young, and M. Philips. 2002. Membrane trafficking of heterotrimeric G proteins via the endoplasmic reticulum and Golgi. Mol. Biol. Cell. 13: 3294-3302.
-
(2002)
Mol. Biol. Cell.
, vol.13
, pp. 3294-3302
-
-
Michaelson, D.1
Ahearn, I.2
Bergo, M.3
Young, S.4
Philips, M.5
-
19
-
-
0033621812
-
Interaction with Gbetagamma is required for membrane targeting and palmitoylation of Galpha(s) and Galpha(q)
-
Evanko, D. S., M. M. Thiyagarajan, and P. B. Wedegaertner. 2000. Interaction with Gbetagamma is required for membrane targeting and palmitoylation of Galpha(s) and Galpha(q). J. Biol. Chem. 275: 1327-1336.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 1327-1336
-
-
Evanko, D.S.1
Thiyagarajan, M.M.2
Wedegaertner, P.B.3
-
20
-
-
0031858844
-
The Saccharomyces cerevisiae prenylcysteine carboxyl methyltransferase Ste14p is in the endoplasmic reticulum membrane
-
Romano, J. D., W. K. Schmidt, and S. Michaelis. 1998. The Saccharomyces cerevisiae prenylcysteine carboxyl methyltransferase Ste14p is in the endoplasmic reticulum membrane. Mol. Biol. Cell. 9: 2231-2247.
-
(1998)
Mol. Biol. Cell.
, vol.9
, pp. 2231-2247
-
-
Romano, J.D.1
Schmidt, W.K.2
Michaelis, S.3
-
21
-
-
0032530150
-
Endoplasmic reticulum membrane localization of Rce1p and Ste24p, yeast proteases involved in carboxyl-terminal CAAX protein processing and amino-terminal a-factor cleavage
-
Schmidt, W. K., A. Tam, K. Fujimura-Kamada, and S. Michaelis. 1998. Endoplasmic reticulum membrane localization of Rce1p and Ste24p, yeast proteases involved in carboxyl-terminal CAAX protein processing and amino-terminal a-factor cleavage. Proc. Natl. Acad. Sci. USA. 95: 11175-11180.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 11175-11180
-
-
Schmidt, W.K.1
Tam, A.2
Fujimura-Kamada, K.3
Michaelis, S.4
-
22
-
-
0033538559
-
Endomembrane trafficking of ras: The CAAX motif targets proteins to the ER and Golgi
-
Choy, E., V. K. Chiu, J. Silletti, M. Feoktistov, T. Morimoto, D. Michaelson, I. E. Ivanov, and M. R. Philips. 1999. Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi. Cell. 98: 69-80.
-
(1999)
Cell
, vol.98
, pp. 69-80
-
-
Choy, E.1
Chiu, V.K.2
Silletti, J.3
Feoktistov, M.4
Morimoto, T.5
Michaelson, D.6
Ivanov, I.E.7
Philips, M.R.8
-
23
-
-
0034062812
-
H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway
-
Apolloni, A., I. A. Prior, M. Lindsay, R. G. Parton, and J. F. Hancock. 2000. H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway. Mol. Cell. Biol. 20: 2475-2487.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 2475-2487
-
-
Apolloni, A.1
Prior, I.A.2
Lindsay, M.3
Parton, R.G.4
Hancock, J.F.5
-
24
-
-
0041689887
-
Palmitoylation and plasma membrane localization of Ras2p by a nonclassical trafficking pathway in Saccharomyces cerevisiae
-
Dong, X., D. A. Mitchell, S. Lobo, L. Zhao, D. J. Bartels, and R. J. Deschenes. 2003. Palmitoylation and plasma membrane localization of Ras2p by a nonclassical trafficking pathway in Saccharomyces cerevisiae. Mol. Cell. Biol. 23: 6574-6584.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 6574-6584
-
-
Dong, X.1
Mitchell, D.A.2
Lobo, S.3
Zhao, L.4
Bartels, D.J.5
Deschenes, R.J.6
-
25
-
-
0028196986
-
Fluorimetric evaluation of the affinities of isoprenylated peptides for lipid bilayers
-
Silvius, J. R., and F. l'Heureux. 1994. Fluorimetric evaluation of the affinities of isoprenylated peptides for lipid bilayers. Biochemistry. 33: 3014-3022.
-
(1994)
Biochemistry
, vol.33
, pp. 3014-3022
-
-
Silvius, J.R.1
L'Heureux, F.2
-
26
-
-
16344396081
-
Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases
-
Michaelson, D., W. Ali, V. K. Chiu, M. Bergo, J. Silletti, L. Wright, S. G. Young, and M. Philips. 2005. Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases. Mol. Biol. Cell. 16: 1606-1616.
-
(2005)
Mol. Biol. Cell.
, vol.16
, pp. 1606-1616
-
-
Michaelson, D.1
Ali, W.2
Chiu, V.K.3
Bergo, M.4
Silletti, J.5
Wright, L.6
Young, S.G.7
Philips, M.8
-
27
-
-
0035825193
-
Differential localization of Rho GTPases in live cells. Regulation by hypervariable regions and RhoGDI binding
-
Michaelson, D., J. Silletti, G. Murphy, P. D'Eustachio, M. Rush, and M. R. Philips. 2001. Differential localization of Rho GTPases in live cells. Regulation by hypervariable regions and RhoGDI binding. J. Cell Biol. 152: 111-126.
-
(2001)
J. Cell Biol.
, vol.152
, pp. 111-126
-
-
Michaelson, D.1
Silletti, J.2
Murphy, G.3
D'Eustachio, P.4
Rush, M.5
Philips, M.R.6
-
28
-
-
33646773289
-
Intracellular targeting of Rho family GTPases: Implications of localization on function
-
M. Symon, editor. Kluwer Academic/Plenum Publishers, New York
-
Michaelson, D., M. Rush, and M. R. Philips. 2003. Intracellular targeting of Rho family GTPases: implications of localization on function. In M. Symon, editor. Rho GTPases. Kluwer Academic/Plenum Publishers, New York. 17-31.
-
(2003)
Rho GTPases
, pp. 17-31
-
-
Michaelson, D.1
Rush, M.2
Philips, M.R.3
-
29
-
-
0034603198
-
Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI
-
Hoffman, G. R., N. Nassar, and R. A. Cerione. 2000. Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI. Cell. 100: 345-356.
-
(2000)
Cell
, vol.100
, pp. 345-356
-
-
Hoffman, G.R.1
Nassar, N.2
Cerione, R.A.3
-
30
-
-
0024465343
-
Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxyl-terminal proteolysis
-
Gutierrez, L., A. I. Magee, C. J. Marshall, and J. F. Hancock. 1989. Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxyl-terminal proteolysis. EMBO J. 8: 1093-1098.
-
(1989)
EMBO J.
, vol.8
, pp. 1093-1098
-
-
Gutierrez, L.1
Magee, A.I.2
Marshall, C.J.3
Hancock, J.F.4
-
31
-
-
0037177881
-
The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases
-
Nancy, V., I. Callebaut, A. El Marjou, and J. de Gunzburg. 2002. The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases. J. Biol. Chem. 277: 15076-15084.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 15076-15084
-
-
Nancy, V.1
Callebaut, I.2
El Marjou, A.3
De Gunzburg, J.4
-
32
-
-
0035958898
-
Prenylated Rab acceptor protein is a receptor for prenylated small GTPases
-
Figueroa, C., J. Taylor, and A. B. Vojtek. 2001. Prenylated Rab acceptor protein is a receptor for prenylated small GTPases. J. Biol. Chem. 276: 28219-28225.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 28219-28225
-
-
Figueroa, C.1
Taylor, J.2
Vojtek, A.B.3
-
33
-
-
0035829731
-
Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anhorage and cell transformation
-
Paz, A., R. Haklai, G. Elad-Sfadia, E. Ballan, and Y. Kloog. 2001. Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anhorage and cell transformation. Oncogene. 20: 7486-7493.
-
(2001)
Oncogene
, vol.20
, pp. 7486-7493
-
-
Paz, A.1
Haklai, R.2
Elad-Sfadia, G.3
Ballan, E.4
Kloog, Y.5
-
34
-
-
0037455589
-
Direct visualization of Ras proteins in spatially distinct cell surface microdomains
-
Prior, I. A., C. Muncke, R. G. Parton, and J. F. Hancock. 2003. Direct visualization of Ras proteins in spatially distinct cell surface microdomains. J. Cell Biol. 160: 165-170.
-
(2003)
J. Cell Biol.
, vol.160
, pp. 165-170
-
-
Prior, I.A.1
Muncke, C.2
Parton, R.G.3
Hancock, J.F.4
-
35
-
-
22144479017
-
Ras plasma membrane signalling platforms
-
Hancock, J. F., and R. G. Parton. 2005. Ras plasma membrane signalling platforms. Biochem. J. 389: 1-11.
-
(2005)
Biochem. J.
, vol.389
, pp. 1-11
-
-
Hancock, J.F.1
Parton, R.G.2
-
36
-
-
0035067187
-
GTP-dependent segregation of H-ras from lipid rafts is required for biological activity
-
Prior, I. A., A. Harding, J. Yan, J. Sluimer, R. G. Parton, and J. F. Hancock. 2001. GTP-dependent segregation of H-ras from lipid rafts is required for biological activity. Nat. Cell Biol. 3: 368-375.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 368-375
-
-
Prior, I.A.1
Harding, A.2
Yan, J.3
Sluimer, J.4
Parton, R.G.5
Hancock, J.F.6
-
37
-
-
0023445442
-
Dynamic fatty acylation of p21N-ras
-
Magee, A. I., L. Gutierrez, I. A. McKay, C. J. Marshall, and A. Hall. 1987. Dynamic fatty acylation of p21N-ras. EMBO J. 6: 3353-3357.
-
(1987)
EMBO J.
, vol.6
, pp. 3353-3357
-
-
Magee, A.I.1
Gutierrez, L.2
McKay, I.A.3
Marshall, C.J.4
Hall, A.5
-
38
-
-
0028915903
-
Depalmitoylation of CAAX motif proteins. Protein structural determinants of palmitate turnover rate
-
Lu, J. Y., and S. L. Hofmann. 1995. Depalmitoylation of CAAX motif proteins. Protein structural determinants of palmitate turnover rate. J. Biol. Chem. 270: 7251-7256.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 7251-7256
-
-
Lu, J.Y.1
Hofmann, S.L.2
-
39
-
-
0038143229
-
Distinct rates of palmitate turnover on membrane-bound cellular and oncogenic H-ras
-
Baker, T. L., H. Zheng, J. Walker, J. L. Coloff, and J. E. Buss. 2003. Distinct rates of palmitate turnover on membrane-bound cellular and oncogenic H-ras. J. Biol. Chem. 278: 19292-19300.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 19292-19300
-
-
Baker, T.L.1
Zheng, H.2
Walker, J.3
Coloff, J.L.4
Buss, J.E.5
-
40
-
-
22944460791
-
Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway
-
Goodwin, J. S., K. R. Drake, C. Rogers, L. Wright, J. Lippincott-Schwartz, M. R. Philips, and A. K. Kenworthy. 2005. Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway. J. Cell Biol. 170: 261-272.
-
(2005)
J. Cell Biol.
, vol.170
, pp. 261-272
-
-
Goodwin, J.S.1
Drake, K.R.2
Rogers, C.3
Wright, L.4
Lippincott-Schwartz, J.5
Philips, M.R.6
Kenworthy, A.K.7
-
41
-
-
20144375061
-
An acylation cycle regulates localization and activity of palmitoylated Ras isoforms
-
Rocks, O., A. Peyker, M. Kahms, P. J. Verveer, C. Koerner, M. Lumbierres, J. Kuhlmann, H. Waldmann, A. Wittinghofer, and P. I. Bastiaens. 2005. An acylation cycle regulates localization and activity of palmitoylated Ras isoforms. Science. 307: 1746-1752.
-
(2005)
Science
, vol.307
, pp. 1746-1752
-
-
Rocks, O.1
Peyker, A.2
Kahms, M.3
Verveer, P.J.4
Koerner, C.5
Lumbierres, M.6
Kuhlmann, J.7
Waldmann, H.8
Wittinghofer, A.9
Bastiaens, P.I.10
-
43
-
-
0034790751
-
Calmodulin binds to K-Ras, but not to H- Or N-Ras, and modulates its downstream signaling
-
Villalonga, P., C. Lopez-Alcala, M. Bosch, A. Chiloeches, N. Rocamora, J. Gil, R. Marais, C. J. Marshall, O. Bachs, and N. Agell. 2001. Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling. Mol. Cell. Biol. 21: 7345-7354.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 7345-7354
-
-
Villalonga, P.1
Lopez-Alcala, C.2
Bosch, M.3
Chiloeches, A.4
Rocamora, N.5
Gil, J.6
Marais, R.7
Marshall, C.J.8
Bachs, O.9
Agell, N.10
-
45
-
-
32444441115
-
L on mitochondria and induces apoptosis
-
L on mitochondria and induces apoptosis. Mol. Cell. 21: 481-494.
-
(2006)
Mol. Cell.
, vol.21
, pp. 481-494
-
-
Bivona, T.G.1
Quatela, S.E.2
Bodemann, B.O.3
Ahearn, I.O.4
Soskis, M.J.5
Mor, A.6
Miura, J.7
Wiener, H.H.8
Wright, L.9
Saba, S.G.10
-
46
-
-
0029058605
-
The myristoyl-electrostatic switch: A modulator of reversible protein-membrane interactions
-
McLaughlin, S., and A. Aderem. 1995. The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions. Trends Biochem. Sci. 20: 272-276.
-
(1995)
Trends Biochem. Sci.
, vol.20
, pp. 272-276
-
-
McLaughlin, S.1
Aderem, A.2
-
47
-
-
30044431691
-
K-ras4B and prenylated proteins lacking "second signals" associate dynamically with cellular membranes
-
Silvius, J. R., P. Bhagatji, R. Leventis, and D. Terrone. 2006. K-ras4B and prenylated proteins lacking "second signals" associate dynamically with cellular membranes. Mol. Biol. Cell. 17: 192-202.
-
(2006)
Mol. Biol. Cell.
, vol.17
, pp. 192-202
-
-
Silvius, J.R.1
Bhagatji, P.2
Leventis, R.3
Terrone, D.4
-
48
-
-
0029842109
-
Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP
-
Choi, J., J. Chen, S. L. Schreiber, and J. Clardy. 1996. Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science. 273: 239-242.
-
(1996)
Science.
, vol.273
, pp. 239-242
-
-
Choi, J.1
Chen, J.2
Schreiber, S.L.3
Clardy, J.4
-
49
-
-
0035937112
-
Isoprenylcysteine carboxyl methyltransferase deficiency in mice
-
Bergo, M. O., G. K. Leung, P. Ambroziak, J. C. Otto, P. J. Casey, A. Q. Gomes, M. C. Seabra, and S. G. Young. 2001. Isoprenylcysteine carboxyl methyltransferase deficiency in mice. J. Biol. Chem. 276: 5841-5845.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 5841-5845
-
-
Bergo, M.O.1
Leung, G.K.2
Ambroziak, P.3
Otto, J.C.4
Casey, P.J.5
Gomes, A.Q.6
Seabra, M.C.7
Young, S.G.8
-
50
-
-
0036301339
-
Prenylcysteine carboxylmethyltransferase is essential for the earliest stages of liver development in mice
-
Lin, X., J. Jung, D. Kang, B. Xu, K. S. Zaret, and H. Zoghbi. 2002. Prenylcysteine carboxylmethyltransferase is essential for the earliest stages of liver development in mice. Gastroenterology. 123: 345-351.
-
(2002)
Gastroenterology
, vol.123
, pp. 345-351
-
-
Lin, X.1
Jung, J.2
Kang, D.3
Xu, B.4
Zaret, K.S.5
Zoghbi, H.6
-
51
-
-
0036132907
-
Absence of the CAAX endoprotease Rce1: Effects on cell growth and transformation
-
Bergo, M. O., P. Ambroziak, C. Gregory, A. George, J. C. Otto, E. Kim, H. Nagase, P. J. Casey, A. Balmain, and S. G. Young. 2002. Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation. Mol. Cell. Biol. 22: 171-181.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 171-181
-
-
Bergo, M.O.1
Ambroziak, P.2
Gregory, C.3
George, A.4
Otto, J.C.5
Kim, E.6
Nagase, H.7
Casey, P.J.8
Balmain, A.9
Young, S.G.10
-
52
-
-
0033605596
-
Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells
-
Kim, E., P. Ambroziak, J. C. Otto, B. Taylor, M. Ashby, K. Shannon, P. J. Casey, and S. G. Young. 1999. Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells. J. Biol. Chem. 274: 8383-8390.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 8383-8390
-
-
Kim, E.1
Ambroziak, P.2
Otto, J.C.3
Taylor, B.4
Ashby, M.5
Shannon, K.6
Casey, P.J.7
Young, S.G.8
-
53
-
-
1642326112
-
Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf
-
Bergo, M. O., B. J. Gavino, C. Hong, A. P. Beigneux, M. McMahon, P. J. Casey, and S. G. Young. 2004. Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. J. Clin. Invest. 113: 539-550.
-
(2004)
J. Clin. Invest.
, vol.113
, pp. 539-550
-
-
Bergo, M.O.1
Gavino, B.J.2
Hong, C.3
Beigneux, A.P.4
McMahon, M.5
Casey, P.J.6
Young, S.G.7
-
54
-
-
0027983602
-
Effects of carboxyl methylation of photoreceptor G protein gamma-subunit in visual transduction
-
Fukada, Y., T. Matsuda, K. Kokame, T. Takao, Y. Shimonishi, T. Akino, and T. Yoshizawa. 1994. Effects of carboxyl methylation of photoreceptor G protein gamma-subunit in visual transduction. J. Biol. Chem. 269: 5163-5170.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 5163-5170
-
-
Fukada, Y.1
Matsuda, T.2
Kokame, K.3
Takao, T.4
Shimonishi, Y.5
Akino, T.6
Yoshizawa, T.7
-
55
-
-
0029940468
-
The role of G protein methylation in the function of a geranylgeranylated beta gamma isoform
-
Parish, C. A., A. V. Smrcka, and R. R. Rando. 1996. The role of G protein methylation in the function of a geranylgeranylated beta gamma isoform. Biochemistry. 35: 7499-7505.
-
(1996)
Biochemistry
, vol.35
, pp. 7499-7505
-
-
Parish, C.A.1
Smrcka, A.V.2
Rando, R.R.3
-
56
-
-
0027932723
-
Functional significance of G protein carboxymethylation
-
Parish, C. A., and R. R. Rando. 1994. Functional significance of G protein carboxymethylation. Biochemistry. 33: 9986-9991.
-
(1994)
Biochemistry
, vol.33
, pp. 9986-9991
-
-
Parish, C.A.1
Rando, R.R.2
-
57
-
-
0036091925
-
Ras signalling on the endoplasmic reticulum and the Golgi
-
Chiu, V. K., T. Bivona, A. Hach, J. B. Sajous, J. Silletti, H. Wiener, R. L. Johnson, A. D. Cox, and M. R. Philips. 2002. Ras signalling on the endoplasmic reticulum and the Golgi. Nat. Cell Biol. 4: 343-350.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 343-350
-
-
Chiu, V.K.1
Bivona, T.2
Hach, A.3
Sajous, J.B.4
Silletti, J.5
Wiener, H.6
Johnson, R.L.7
Cox, A.D.8
Philips, M.R.9
-
58
-
-
0041488671
-
Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1
-
Bivona, T. G., I. Perez De Castro, I. M. Ahearn, T. M. Grana, V. K. Chiu, P. J. Lockyer, P. J. Cullen, A. Pellicer, A. D. Cox, and M. R. Philips. 2003. Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1. Nature. 424: 694-698.
-
(2003)
Nature
, vol.424
, pp. 694-698
-
-
Bivona, T.G.1
Perez De Castro, I.2
Ahearn, I.M.3
Grana, T.M.4
Chiu, V.K.5
Lockyer, P.J.6
Cullen, P.J.7
Pellicer, A.8
Cox, A.D.9
Philips, M.R.10
-
59
-
-
1842609782
-
Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi
-
Pérez de Castro, I., T. Bivona, M. Philips, and A. Pellicer. 2004. Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi. Mol. Cell. Biol. 24: 3485-3496.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 3485-3496
-
-
Pérez De Castro, I.1
Bivona, T.2
Philips, M.3
Pellicer, A.4
-
60
-
-
0042858184
-
Exchange factors of the RasGRP family mediate Ras activation in the Golgi
-
Caloca, M. J., J. L. Zugaza, and X. R. Bustelo. 2003. Exchange factors of the RasGRP family mediate Ras activation in the Golgi. J. Biol. Chem. 278: 33465-33473.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 33465-33473
-
-
Caloca, M.J.1
Zugaza, J.L.2
Bustelo, X.R.3
-
61
-
-
0842304220
-
Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors
-
Arozarena, I., D. Matallanas, M. T. Berciano, V. Sanz-Moreno, F. Calvo, M. T. Munoz, G. Egea, M. Lafarga, and P. Crespo. 2004. Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors. Mol. Cell. Biol. 24: 1516-1530.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 1516-1530
-
-
Arozarena, I.1
Matallanas, D.2
Berciano, M.T.3
Sanz-Moreno, V.4
Calvo, F.5
Munoz, M.T.6
Egea, G.7
Lafarga, M.8
Crespo, P.9
-
62
-
-
33644856168
-
Distinct utilization of effectors and biological outcomes resulting from sitespecific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation
-
Matallanas, D., V. Sanz-Moreno, I. Arozarena, F. Calvo, L. Agudo-Ibanez, E. Santos, M. T. Berciano, and P. Crespo. 2006. Distinct utilization of effectors and biological outcomes resulting from sitespecific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation. Mol. Cell. Biol. 26: 100-116.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 100-116
-
-
Matallanas, D.1
Sanz-Moreno, V.2
Arozarena, I.3
Calvo, F.4
Agudo-Ibanez, L.5
Santos, E.6
Berciano, M.T.7
Crespo, P.8
-
63
-
-
0030923192
-
K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors
-
Whyte, D. B., P. Kirschmeier, T. N. Hockenberry, I. Nunez-Oliva, L. James, J. J. Catino, W. R. Bishop, and J. K. Pai. 1997. K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors. J. Biol. Chem. 272: 14459-14464.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 14459-14464
-
-
Whyte, D.B.1
Kirschmeier, P.2
Hockenberry, T.N.3
Nunez-Oliva, I.4
James, L.5
Catino, J.J.6
Bishop, W.R.7
Pai, J.K.8
-
64
-
-
0347320784
-
Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice
-
Sun, J., J. Ohkanda, D. Coppola, H. Yin, M. Kothare, B. Busciglio, A. D. Hamilton, and S. M. Sebti. 2003. Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice. Cancer Res. 63: 8922-8929.
-
(2003)
Cancer Res.
, vol.63
, pp. 8922-8929
-
-
Sun, J.1
Ohkanda, J.2
Coppola, D.3
Yin, H.4
Kothare, M.5
Busciglio, B.6
Hamilton, A.D.7
Sebti, S.M.8
-
65
-
-
18344394166
-
Post-prenylation-processing enzymes as new targets in oncogenesis
-
Winter-Vann,A.M., and P. J.Casey. 2005. Post-prenylation-processing enzymes as new targets in oncogenesis. Nat. Rev. Cancer. 5: 405-412.
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 405-412
-
-
Winter-Vann, A.M.1
Casey, P.J.2
-
66
-
-
0037637529
-
Targeting Ras signaling through inhibition of carboxyl methylation: An unexpected property of methotrexate
-
Winter-Vann, A. M., B. A. Kamen, M. O. Bergo, S. G. Young, S. Melnyk, S. J. James, and P. J. Casey. 2003. Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate. Proc. Natl. Acad. Sci. USA. 100: 6529-6534.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 6529-6534
-
-
Winter-Vann, A.M.1
Kamen, B.A.2
Bergo, M.O.3
Young, S.G.4
Melnyk, S.5
James, S.J.6
Casey, P.J.7
-
67
-
-
20144365360
-
A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells
-
Winter-Vann, A. M., R. A. Baron, W. Wong, J. dela Cruz, J. D. York, D. M. Gooden, M. O. Bergo, S. G. Young, E. J. Toone, and P. J. Casey. 2005. A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells. Proc. Natl. Acad. Sci. USA. 102: 4336-4341.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 4336-4341
-
-
Winter-Vann, A.M.1
Baron, R.A.2
Wong, W.3
Dela Cruz, J.4
York, J.D.5
Gooden, D.M.6
Bergo, M.O.7
Young, S.G.8
Toone, E.J.9
Casey, P.J.10
|