Inverse solvent isotope effects arising from substrate triggering in the factor inhibiting hypoxia inducible factor

Biochemistry

Volumn 52, Issue 9, 2013, Pages 1594-1602

  Hangasky, John A ^a   Saban, Evren ^a   Knapp, Michael J ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS; CELL METABOLISM; CHEMICAL MECHANISM; COFACTORS; COORDINATION CHANGE; COORDINATION GEOMETRY; DIOXYGENASES; EXPERIMENTAL EVIDENCE; HYPOXIA-INDUCIBLE FACTORS; KETOGLUTARATE; MECHANISTIC PROBES; MECHANISTIC STUDIES; OXYGENASES; SATURATING CONCENTRATION; SOLVENT ISOTOPE EFFECTS; STEADY STATE; STEADY-STATE RATE CONSTANTS; TIGHT COUPLING; TRANSACTIVATION DOMAIN;

ISOTOPES; METAL IONS; OXYGEN; PHYSIOLOGY; PORPHYRINS; RATE CONSTANTS; SOLVENTS;

CARRIER MOBILITY;

2 OXOGLUTARIC ACID; ASPARAGINE; C TERMINAL TRANSACTIVATION DOMAIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IRON; ISOTOPE; PROTEIN; SOLVENT; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; GEOMETRY; HYDROGEN BOND; HYDROXYLATION; PRIORITY JOURNAL; STEADY STATE; VISCOSITY;

AMINO ACID SEQUENCE; DEUTERIUM OXIDE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KETOGLUTARIC ACIDS; KINETICS; MIXED FUNCTION OXYGENASES; MOLECULAR SEQUENCE DATA; OXYGEN; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; SUBSTRATE SPECIFICITY;

EID: 84874600046     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi3015482     Document Type: Article

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