Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains

FEBS Journal

Volumn 278, Issue 7, 2011, Pages 1086-1097

  Yang, Ming ^a   Chowdhury, Rasheduzzaman ^a   Ge, Wei ^a,b   Hamed, Refaat B ^a   McDonough, Michael A ^a   Claridge, Timothy D W ^a   Kessler, Benedikt M ^c   Cockman, Matthew E ^c   Ratcliffe, Peter J ^c   Schofield, Christopher J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b Assiut University   (Egypt)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

2 oxoglutarate dependent dioxygenase; ankyrin repeat domain; factor inhibiting HIF; histidinyl hydroxylation; post translational hydroxylation

Indexed keywords

2 OXOGLUTARIC ACID; ANKYRIN; HISTIDINE; HYPOXIA INDUCIBLE FACTOR; PEPTIDE FRAGMENT; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; SYNTHETIC PEPTIDE; TANKYRASE; TANKYRASE 2; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTALLOGRAPHY; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROXYLATION; IN VITRO STUDY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROCESSING;

AMINO ACID SEQUENCE; ANKYRIN REPEAT; HEK293 CELLS; HISTIDINE; HUMANS; HYDROXYLATION; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; SEQUENCE ALIGNMENT; TANKYRASES;

EID: 79952858715     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2011.08022.x     Document Type: Article

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