Inverse solvent isotope effects demonstrate slow aquo release from hypoxia inducible factor-prolyl hydroxylase (PHD2)

Biochemistry

Volumn 51, Issue 33, 2012, Pages 6654-6666

  Flagg, Shannon C ^a   Giri, Nitai ^a   Pektas, Serap ^a   Maroney, Michael J ^a   Knapp, Michael J ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC CONDITIONS; ACTIVE SITE; ANAEROBIC METABOLISM; CIRCULAR DICHROISM SPECTRA; COORDINATION SITES; COORDINATION SPHERE; EXTENDED X-RAY ABSORPTION FINE STRUCTURE ANALYSIS; HYDROXYLASES; KETOGLUTARATE; PROLYL HYDROXYLASE DOMAINS; RATE-LIMITING STEPS; SECONDARY STRUCTURES; SOLVENT ISOTOPE EFFECTS; SPECTROSCOPIC PROBES; UNDERLYING MECHANISM; UV-VISIBLE;

CARRIER MOBILITY; ENZYMES; EXTENDED X RAY ABSORPTION FINE STRUCTURE SPECTROSCOPY; LIGANDS; SOLVENTS; X RAY ABSORPTION SPECTROSCOPY;

ISOTOPES;

HYPOXIA INDUCIBLE FACTOR; IRON; LIGAND; NITROGEN; OXYGEN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLYL HYDROXYLASE DOMAIN 2; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; CHEMICAL PHENOMENA; CIRCULAR DICHROISM; CONTROLLED STUDY; INVERSE SOLVENT ISOTOPE EFFECT; NONHUMAN; PH; PKA; PRIORITY JOURNAL; STEADY STATE; TURNOVER TIME; X RAY ABSORPTION SPECTROSCOPY;

ANOXIA; CATALYTIC DOMAIN; CIRCULAR DICHROISM; DEUTERIUM OXIDE; HUMANS; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IRON; PROCOLLAGEN-PROLINE DIOXYGENASE; SPECTROPHOTOMETRY, ULTRAVIOLET; WATER; X-RAY ABSORPTION SPECTROSCOPY;

EID: 84865437643     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300229y     Document Type: Article

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