Uncoupled O2-activation in the human HIF-asparaginyl hydroxylase, FIH, does not produce reactive oxygen species

Journal of Inorganic Biochemistry

Volumn 105, Issue 5, 2011, Pages 630-636

  Saban, Evren ^a   Flagg, Shannon C ^a   Knapp, Michael J ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

ketoglutarate; Factor inhibiting HIF; HIF; Hypoxia; Non heme iron; Reactive oxygen species

Indexed keywords

ASCORBIC ACID; BACTERIAL ENZYME; DITHIOTHREITOL; FACTOR INHIBITING HYPOXIA INDUCIBLE FACTOR; HYDROGEN PEROXIDE; HYPOXIA INDUCIBLE FACTOR; OXYGEN; OXYGENASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; 2 OXOGLUTARIC ACID; ALKYL SULFATASE; ALPHA-KETOGLUTARIC ACID; DIOXYGENASE; HIF1AN PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; REPRESSOR PROTEIN; SULFATASE;

ARTICLE; ENZYME INACTIVATION; HUMAN; HUMAN CELL; HYDROXYLATION; STEADY STATE; TIME; CHEMISTRY; METABOLISM;

BACTERIA (MICROORGANISMS);

DIOXYGENASES; HUMANS; HYDROGEN PEROXIDE; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KETOGLUTARIC ACIDS; OXYGEN; REACTIVE OXYGEN SPECIES; REPRESSOR PROTEINS; SULFATASES;

EID: 79952989146     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2011.01.007     Document Type: Article

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