Coordination changes and auto-hydroxylation of FIH-1: Uncoupled O2-activation in a human hypoxia sensor

Journal of Inorganic Biochemistry

Volumn 102, Issue 12, 2008, Pages 2120-2129

  Chen, Yuan Han ^a   Comeaux, Lindsay M ^a   Herbst, Robert W ^a   Saban, Evren ^a   Kennedy, David C ^a   Maroney, Michael J ^a   Knapp, Michael J ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Ketoglutarate; Asparaginyl hydroxylase; Factor inhibiting HIF; HIF; Hypoxia; Non heme iron; Protein oxidation

Indexed keywords

2 OXOGLUTARIC ACID; FACTOR INHIBITING HIF 1; FERRIC ION; GLYCEROL; HYPOXIA INDUCIBLE FACTOR 1; IRON; METHIONINE; OXYGEN; PROTEIN; SUCCINIC ACID; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; AUTOOXIDATION; CHEMICAL ANALYSIS; CHROMATOPHORE; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; ENZYME METABOLISM; HYDROXYLATION; HYPOXIA; LOW TEMPERATURE; OXIDATION KINETICS; OXYGENATION;

ANAEROBIOSIS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CATALYTIC DOMAIN; FERROUS COMPOUNDS; HUMANS; HYDROXYLATION; IRON; OXYGEN; RECOMBINANT PROTEINS; REPRESSOR PROTEINS;

EID: 55349091988     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2008.07.018     Document Type: Article

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