Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands

Journal of Biological Chemistry

Volumn 284, Issue 44, 2009, Pages 30508-30517

  Lee, Erinna F ^a   Czabotar, Peter E ^a   Yang, Hong ^a   Sleebs, Brad E ^a   Lessene, Guillaume ^a   Colman, Peter M ^a   Smith, Brian J ^a   Fairlie, W Douglas ^a  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CELL DEATH; PEPTIDES; STRUCTURAL PROPERTIES;

BINDING AFFINITIES; CANCER THERAPEUTICS; CONFORMATIONAL CHANGE; HELICAL SEGMENTS; LIGAND-BINDING SITES; PROTEIN TARGETS; SMALL MOLECULES; STRUCTURAL TRANSITIONS;

LIGANDS;

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; BH3 PROTEIN; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN TARGETING; STRUCTURE ANALYSIS;

EID: 71049128694     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.040725     Document Type: Article

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