Autocrine loop for IGF-I receptor signaling in SLUG-mediated epithelial-mesenchymal transition

International Journal of Oncology

Volumn 34, Issue 2, 2009, Pages 329-338

  Sivakumar, Ramadoss ^a   Koga, Hironori ^a   Selvendiran, Karuppaiyah ^a   Maeyama, Michiko ^a   Ueno, Takato ^a   Sata, Michio ^a  

^a KURUME UNIVERSITY   (Japan)

Author keywords

Akt; EMT; Invasion; RTK; Snail

Indexed keywords

PROTEIN KINASE B; PROTEIN TYROSINE KINASE; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C RECEPTOR; TRANSCRIPTION FACTOR SLUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; CELL STRAIN; CONTROLLED STUDY; ENZYME INACTIVATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; LIVER CELL; MESENCHYME CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALS; CELL LINE; DOGS; EPITHELIAL CELLS; HEPATOCYTES; HUMANS; KIDNEY; MESODERM; OSTEOBLASTS; PHOSPHORYLATION; RECEPTOR, IGF TYPE 1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 64549090709     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000155     Document Type: Article

References (36)

1. Thiery JP and Sleeman JP: Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7: 131-142, 2006.
2. Savagner P, Yamada KM and Thiery JP: The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J Cell Biol 137: 1403-1419, 1997.
3. Nieto MA: The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol 3: 155-166, 2002.
4. Barrallo-Gimeno A and Nieto MA: The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development 132: 3151-3161, 2005.
5. Guarino M, Rubino B and Ballabio G: The role of epithelialmesenchymal transition in cancer pathology. Pathology 39: 305-318, 2007.
6. Larsson O, Girnita A and Girnita L: Role of insulin-like growth factor 1 receptor signalling in cancer. Br J Cancer 92: 2097-2101, 2005.
7. Irie HY, Pearline RV, Grueneberg D, et al: Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelialmesenchymal transition. J Cell Biol 171: 1023-1034, 2005.
8. Kim HJ, Litzenburger BC, Cui X, et al: Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail. Mol Cell Biol 27: 3165-3175, 2007.
9. Gibson SL, Ma A and Shaw LM: Divergent roles for IRS-1 and IRS-2 in breast cancer metastasis. Cell Cycle 6: 631-637, 2007.
10. Guvakova MA and Surmacz E: The activated insulin-like growth factor I receptor induces depolarization in breast epithelial cells characterized by actin filament disassembly and tyrosine dephosphorylation of FAK, Cas, and paxillin. Exp Cell Res 251: 244-255, 1999.
11. Sandhu MS, Dunger DB and Giovannucci EL: Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer. J Natl Cancer Inst 94: 972-980, 2002.
12. Renehan AG, Zwahlen M, Minder C, O'Dwyer ST, Shalet SM and Egger M: Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. Lancet 363: 1346-1353, 2004.
13. Boyer B, Roche S, Denoyelle M and Thiery JP: Src and Ras are involved in separate pathways in epithelial cell scattering. EMBO J 16: 5904-5913, 1997.
14. Avizienyte E, Wyke AW, Jones RJ, et al: Src-induced deregulation of E-cadherin in colon cancer cells requires integrin signalling. Nat Cell Biol 4: 632-638, 2002.
15. Coluccia AM, Benati D, Dekhil H, De Filippo A, Lan C and Gambacorti-Passerini C: SKI-606 decreases growth and motility of colorectal cancer cells by preventing pp60(c-Src)-dependent tyrosine phosphorylation of beta-catenin and its nuclear signaling. Cancer Res 66: 2279-2286, 2006.
16. Nguyen KT, Wang WJ, Chan JL and Wang LH: Differential requirements of the MAP kinase and PI3 kinase signaling pathways in Src- versus insulin and IGF-1 receptors-induced growth and transformation of rat intestinal epithelial cells. Oncogene 19: 5385-5397, 2000.
17. Peterson JE, Kulik G, Jelinek T, Reuter CW, Shannon JA and Weber MJ: Src phosphorylates the insulin-like growth factor type I receptor on the autophosphorylation sites. Requirement for transformation by src. J Biol Chem 271: 31562-31571, 1996.
18. Valentinis B, Morrione A, Taylor SJ and Baserga R: Insulin-like growth factor I receptor signaling in transformation by src oncogenes. Mol Cell Biol 17: 3744-3754, 1997.
19. Sekharam M, Nasir A, Kaiser HE and Coppola D: Insulin-like growth factor 1 receptor activates c-SRC and modifies transformation and motility of colon cancer in vitro. Anticancer Res 23: 1517-1524, 2003.
20. Hakam A, Fang Q, Karl R and Coppola D: Coexpression of IGF-1R and c-Src proteins in human pancreatic ductal adenocarcinoma. Dig Dis Sci 48: 1972-1978, 2003.
21. Kobayashi N, Miyazaki M, Fukaya K, et al: Transplantation of highly differentiated immortalized human hepatocytes to treat acute liver failure. Transplantation 69: 202-207, 2000.
22. Shishido S, Koga H, Harada M, et al: Hydrogen peroxide overproduction in megamitochondria of troglitazone-treated human hepatocytes. Hepatology 37: 136-147, 2003.
23. Shiota M, Izumi H, Onitsuka T, et al: Twist promotes tumor cell growth through YB-1 expression. Cancer Res 68: 98-105, 2008.
24. Maeyama M, Koga H, Selvendiran K, et al: Switching in discoid domain receptor expressions in SLUG-induced epithelial-mesenchymal transition. Cancer (In press).
25. Guo Y, Zi X, Koontz Z, et al: Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells. J Orthop Res 25: 964-971, 2007.
26. Peterson JE, Jelinek T, Kaleko M, Siddle K and Weber MJ: c phosphorylation and activation of the IGF-I receptor in srctransformed cells. J Biol Chem 269: 27315-27321, 1994.
27. Peinado H, Olmeda D and Cano A: Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 7: 415-428, 2007.
28. Hynes NE and Lane HA: ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer 5: 341-354, 2005.
29. Ando Y and Jensen PJ: Epidermal growth factor and insulin-like growth factor I enhance keratinocyte migration. J Invest Dermatol 100: 633-639, 1993.
30. Thomson S, Buck E, Petti F, et al: Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition. Cancer Res 65: 9455-9462, 2005.
31. Jechlinger M, Sommer A, Moriggl R, et al: Autocrine PDGFR signaling promotes mammary cancer metastasis. J Clin Invest 116: 1561-1570, 2006.
32. Del Castillo G, Murillo MM, Alvarez-Barrientos A, et al: Autocrine production of TGF-beta confers resistance to apoptosis after an epithelial-mesenchymal transition process in hepatocytes: role of EGF receptor ligands. Exp Cell Res 312: 2860-2871, 2006.
33. Sakai D, Suzuki T, Osumi N and Wakamatsu Y: Cooperative action of Sox9, Snail2 and PKA signaling in early neural crest development. Development 133: 1323-1333, 2006.
34. Sun H and Baserga R: The role of insulin receptor substrate-1 in transformation by v-src. J Cell Physiol 215: 725-732, 2008.
35. Haluska P, Carboni JM, Loegering DA, et al: In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/ insulin receptor inhibitor, BMS-554417. Cancer Res 66: 362-371, 2006.
36. Hiscox S, Jordan NJ, Smith C, et al: Dual targeting of Src and ER prevents acquired antihormone resistance in breast cancer cells. Breast Cancer Res Treat (In press).