Insulin-like growth factor I receptor signaling in transformation by src oncogenes

Molecular and Cellular Biology

Volumn 17, Issue 7, 1997, Pages 3744-3754

  Valentinis, Barbara ^a   Morrione, Andrea ^a   Taylor, Stephen J ^b   Baserga, Renato ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOCAL ADHESION KINASE; SOMATOMEDIN C RECEPTOR; STAT1 PROTEIN;

ANIMAL CELL; ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; FIBROBLAST; MOUSE; NONHUMAN; ONCOGENE SRC; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0030952501     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.7.3744     Document Type: Article

References (84)

1. Altschuler, D., K. Yamamoto, and E. G. Lapetina. 1994. Insulin-like growth factor I-mediated association of p85 phosphatidylinositol 3′ kinase with pp185: requirement of SH domain for in vivo interaction. Mol. Endocrinol. 8:1139-1146.
2. Anderson, S. M., P. M. Carroll, and F. D. Lee. 1990. Abrogation of IL-3 dependent growth requires a functional v-src gene product: evidence for an autocrine growth cycle. Oncogenc 5:317-325.
3. Arteaga, C. L. 1992. Interference of the IGF system as a strategy to inhibit breast cancer growth. Breast Cancer Res. Treat. 22:101-106.
4. Backer, J. M., M. G. Myers, Jr., X. J. Sun, D. J. Chin, S. E. Shoelson, M. Miralpeix, and M. F. White. 1993. Association of IRS-1 with the insulin receptor and the phosphatidylinositol 3′ kinase. J. Biol. Chem. 268:8204-8212.
5. Baker, J., J.-P. Liu, E. J. Robrtson, and A. Efstratiadis. 1993 Role of insulin-like growth factors in embryonic and postnatal growth. Cell 73:73-82.
6. Barone, M. V., and S. A. Courtneidge. 1995. Myc but not Fos rescue of PDGF signaling block caused by kinase-inactive src. Nature 378:509-512.
7. Baserga, R. 1985. The biology of cell reproduction. Harvard University Press, Cambridge, Mass.
8. Baserga, R. 1994. Oncogenes and the strategy of growth factors. Cell 79: 927-930.
9. Baserga, R. 1995. The insulin-like growth factor 1 receptor: a key to tumor growth? Cancer Res. 55:249-252.
10. Baserga, R. 1996. Controlling IGF-I receptor function: a possible strategy for tumor therapy. Trends Biotechnol. 14:150-152.
11. Baserga, R., M. Resnicoff, C. D'Ambrosio, and B. Valentinis. 1997. The role of the IGF-I receptor in apoptosis. Vitam. Horm. 53:65-98.
12. Broome, M. A., and T. Hunter. 1996. Requirement for c-src527 catalytic activity and the SH3 domain in platelet-derived growth factor BB and epidermal growth factor mitogcnic signaling. J. Biol. Chem. 271:16798-16806.
13. Burgaud, J. L., M. Resnicoff, and R. Baserga. 1995. Mutant IGF-I receptors as dominant negatives for growth and transformation. Biochem. Biophys. Res. Commun. 214:475-481.
14. Cao, K., A. Tay, G. R. Guy, and Y. H. Tan. 1996. Activation and association of Stat3 with Src in v-Src-transformed cell lines. Mol. Cell. Biol. 16:1595-1603.
15. Christophen, G., P. Naik, and D. Hanahan. 1994. A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis. Nature 369:414-418.
16. Coppola, D., A. Ferber, M. Miura, C. Sell, C. D'Ambrosio, R. Rubin, and R. Baserga. 1994. A functional IGF-I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor. Mol. Cell. Biol. 14:4588-4595.
17. Craparo, A., T. J. O'Neill, and T. A. Gustafson. 1995. Non-SH2 domains with insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor 1 receptor. J. Biol. Chem. 270:15639-15643.
18. FAK during c-myc-induced apoptosis is suppressed by integrin signalling. Oncogene 12:2689-2696.
19. D'Ambrosio, C., A. Ferber, M. Resnicoff, and R. Baserga. 1996. A soluble insulin-like growth factor 1 receptor that induces apoptosis of tumor cells in vivo and inhibits tumorigenesis. Cancer Res. 56:4013-4020.
20. D'Ambrosio, C., S. R. Keller, A. Morrione, G. E. Lienhard, R, Baserga, and E. Surmacz. 1995. Transforming potential of the insulin receptor substrate 1. Cell Growth Differ. 6:557-562.
21. DeAngelis, T., A. Ferber, and R. Baserga. 1995. Insulin-like growth faclor I receptor is required for the mitogenic and transforming activities of the platelet-derived growth factor receptor. J. Cell. Physiol. 164:214-221.
22. FAK. Mol. Cell. Biol. 15:2819-2827.
23. Erpel, T., G. Alonso, S. Roche, and S. Courtneidge. 1996. The src SH3 domain is required for DNA synthesis induced by platelet-derived growth factor and epidermal growth factor. J. Biol. Chem. 271:16807-16812.
24. Fincham, V. J., J. A. Wyke, and M. C. Frame. 1995. v-src-induced degradation of focal adhesion kinase during morphological transformation of chicken embryo fibroblasts. Oncogene 10:2247-2252.
25. Gritz, L., and J. Davies. 1983. Plasimd-encoded hygromycin B resistance: the sequence of hygromycin phosphotransferase and its expression in Escherichia coli and Saccharomyces cerevisiae. Gene 25:179-188.
26. Haefner, B., R. Baxter, V. J. Fincham, C. P. Downer, and M. C. Frame. 1995. Cooperation of src homology domains in the regulated binding of phospha-tidylinositol 3-kinase. J. Biol. Chem. 270:7937-7943.
27. Hongo, A., C. D'Ambrosio, M. Miura, A. Morrione, and R. Baserga. 1996. Mutational analysis of the mitogenic and transforming activities of the insu-lin-like growth factor I receptor. Oncogene 12:1231-1238.
28. Ihle, J. N. 1994. Cytokine receptors. Nature 377:591-594.
29. c-src can induce focus formation without complete transformation of NIH 3T3 cells. Mol. Cell. Biol. 5:1073-1083.
30. Kalebic, T., M. Tsokos, and L. J. Helman. 1994. In vivo treatment with antibody against the IGF-I receptor suppresses growth of human rhabdo-myosarcoma and down regulates p34/cdc2. Cancer Res. 54:5531-5534.
31. Kaleko, M., W. G. Rutter, and A. D. Miller. 1990. Overexpression of the human insulin-like growth factor 1 receptor promotes ligand-dependent neoplastic transformation. Mol. Cell. Biol. 10:464-173.
32. c-src527 transforming ability by mutation of its primary sites of tyrosine phosphorylation. Cell 49:65-73.
33. Kozma, L. M., and M. J. Weber. 1990. Constitutive phosphorylation of the receptor for insulinlike growth factor I in cells transformed by the src oncogene. Mol. Cell. Biol. 10:3626-3634.
34. Kruger, A., and S. M. Anderson. 1990. The v-src oncogcne blocks the differentiation of a murinc myeloid progenitor cell line and induces a tumorigenic phenotype. Oncogcne 6:245-256.
35. Lee, C. T., S. Wu, D. Gabrilovich, H. Chen, S. Nadaf-Rahrov, I. F. Ciernick, and D. P. Carbone. 1996. Antitumor effect of an adenovirus expressing antiscnsc insulin-like growth factor I receptor on human lung cancer cell lines. Cancer Res. 56:3038-3041.
36. Li, S., A. Ferber, M. Miura, and R. Baserga. 1994. Mitogenicity and transforming activity of the insulin-like growth factor I receptor with mutations in the tyrosine kinase domain. J. Biol. Chem. 269:32558-32564.
37. Liu, D., C. Zong, and L. H. Wang. 1993. Distinctive effects of the carboxylterminal sequence of the insulin-like growth factor I receptor on its signaling functions. J. Virol. 67:6835-6840.
38. Liu, J. P., J. Baker, A. S. Perkins, E. J. Robertson, and A. Efstratiadis. 1993. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igflr). Cell 75:59-72.
39. McCubrey, J. A., L. S. Stillman, M. W. Mayhew, P. A. Algate, R. A. Dellow, and M. Kaleko. 1991. Growth promoting effects of insulin-like growth factor 1 IGF-1 on hematopoictic cells Overexpression of introduced IGF-I receptor abrogates interleukin-3 dependency of murine factor dependent cells by ligand dependent mechanism. Blood 78:921-929.
40. McGlade, J., A. Cheng, G. Pelicci, P. G. Pelicci, and T. Pawson. 1992. Shc proteins are phosphorylated and regulated by v-src and v-Fps protein-tyrosine kinases. Proc. Natl. Acad. Sci. USA 89:8869-8873.
41. Miura, M., E. Surmacz, J. L. Burgaud, and R. Baserga. 1995. Different effects of mitogenesis and transformation of a mutation at tyrosine 1251 of the insulin-like growth factor I receptor. J. Biol. Chem. 270:22639-22644.
42. Morrione, A., T. DeAngelis, and R. Baserga. 1995. Failure of the bovine papillomavirus to transform mouse embryo fibroblasts with a targeted disruption of the insulin-like growth factor I receptor genes. J. Virol. 69:5300-5303.
43. Myers, M. J., X. J. Sun, B. Cheatham, B. R. Jachna, E. M. Glasheen, J. M. Backer, and M. F. White. 1993. IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3′-kinase. Endocrinology 132:1421-1430.
44. Neuenschwander, S., C. T. Roberts, Jr., and D. LeRoith. 1995. Growth inhibition of MCF-7 breast cancer cells by stable expression of an insulin-like growth factor 1 receptor antisense ribonucleic acid. Endocrinology 136: 4298-4303.
45. Parsons, J. T., and M. J. Weber. 1989. Genetics of src: structural and functional organization of a protein tyrosine kinase. Curr. Top. Microbiol. Immunol. 147:80-118.
46. Pass, H. I., D. J. W. Mew, M. Carbone, W. A. Matthews, J. S. Donington, R. Baserga, C. L. Walker, M. Resnicoff, and S. M. Steinberg. 1996. Inhibition of hamster mesothelioma tumorigenesis by an antisense expression plasmid to the insulin-like growth factor I receptor. Cancer Res. 56:4044-4048.
47. Pelicci, G., L. Lanfrancone, F. Grignani, J. McGlade, F. Cavallo, G. Forni, I. Nicoletti, F. Grignani, T. Pawson, and P. G. Pelicci. 1992. A novel transforming protein (SHC) with a SH2 domain is implicated in mitogcnic signal transduction. Cell 70:93-104.
48. Peterson, J. E., T. Jelinek, M. Kaleko, K. Siddle, and M. J. Weber. 1994. Phosphorylalion and activation of the IGF-I receptor in src-transformed cells. J. Biol. Chem. 269:27315-27321.
49. Peterson, J. E., G. Kulik, T. Jelinek, C. W. M. Reuter, J. A. Shannon, and M. J. Weber. 1996. Src phosphorylates the insulin-like growth factor I receptor on the autophosphorylation sites. J. Biol. Chem. 271:31562-31571.
50. Pietrzkowski, Z., R. Lammers, G. Carpenter, A. M. Soderquist, M. Limardo, P. D. Phillips, A. Ullrich, and R. Baserga. 1992. Constitutive expression of IGF-1 and IGF-1 receptor abrogates all requirements for exogenous growth factors. Cell Growth Differ. 3:199-205.
51. Ponten, J. 1971. Spontaneous and virus induced transformation in cell culture. Springer-Verlag, New York, N.Y.
52. Prager, D., H. L. Li, S. Asa, and S. Melmed. 1994. Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor-I receptor mutant. Proc. Natl. Acad. Sci. USA 91:2181-2185.
53. Prisco, M., A. Hongo, M. G. Rizzo, A. Sacchi, and R. Baserga. 1997. The insulin-like growth factor I receptor as a physiologically relevant target of p53 in apoptosis caused by interleukin-3 withdrawal. Mol. Cell. Biol. 17: 1084-1092.
54. Rankin, S., R. Hooshmand-Rad, L. Claesson-Welsh, and E. Rozengurt. 1996. Requirement for phosphatidylinositol 3′-kinase activity in platelet-derived growth factor-stimulated tyrosine phosphorylation of p125 focal adhesion kinase and paxillin. J. Biol. Chem. 271:7829-7834.
55. Resnicoff, M., J. L. Burgaud, H. L. Rotman, D. Abraham, and R. Baserga. 1995. Correlation between apoptosis, tumorigencsis, and levels of insulin-like growth factor I receptors. Cancer Res. 55:3739-3741.
56. Resnicoff, M., D. Coppola, C. Sell, R. Rubin, S. Ferrone, and R. Baserga. 1994. Growth inhibition of human melanoma cells in nude mice by antisense strategies to the type 1 insulin-like growth factor receptor. Cancer Res. 54:4848-4850.
57. Resnicoff, M., C. Sell, M. Rubini, D. Coppola, C. D'Ambrose, R. Baserga, and R. Rubin. 1994. Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor I (IGF-I) receptor are non-tumorigenic and induce regression of wild-type tumors. Cancer Res. 54:2218-2222.
58. Rogler, C. E., D. Yang, L. Rossetti, J. Donohoe, E. Alt, C. J. Chang, R. Rosenfeld, K. Neely, and R. Hintz. 1994. Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor II transgenic mice. J. Biol. Chem. 269:13779-13784.
59. Rose, D. W., A. R. Saltiel, M. Majumdar, S. J. Decker, and J. M. Olefsky. 1994. Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction. Proc. Natl. Acad. Sci. USA 91:797-801.
60. Rubini, M., A. Hongo, C. D'Ambrosio, and R. Baserga. 1997. The IGF-I receptor in mitogenesis and transformation of mouse embryo cells: role of receptor number. Exp. Cell Res. 230:284-292.
61. Sasaoka, T., B. Draznin, J. W. Leitner, W. J. Langlois, and J. M. Olefsky. 1994. She is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21/ras GTP formation. J. Biol. Chem. 269:10734-10738.
62. Sasaoka, T., D. W. Rose, B. H. Jhun, A. R. Saltiel, B. Draznin, and J. M. Olefsky. 1994. Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor I and epidermal growth faclor. J. Biol. Chem. 269:13689-13694.
63. Schaller, M. D. 1996. The focal adhesion kinasc. J. Endocrinol. 150:1-7.
64. cas, and Nck adaptor proteins. Mol. Cell. Biol. 17:1702-1713.
65. Sell, C., G. Dumenil, C. Deveaud, M. Miura, D. Coppola, T. DeAngelis, R. Rubin, A. Efstratiadis, and R. Baserga. 1994. Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts. Mol. Cell. Biol. 14:3604-3612.
66. Sell, C., M. Rubini, R. Rubin, J. P. Liu, A. Efstratiadis, and R. Baserga. 1993. Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type-1 IGF receptor. Proc. Natl. Acad. Sci. USA 90:11217-11221.
67. Shapiro, D. N., B. G. Jones, L. H. Shapiro, P. Dias, and P. J. Houghton. 1994. Antisense-mediated reduction in insulin-like growth factor I receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma. J. Clin. Invest. 94:1235-1242.
68. Steller, M. A., C. H. Delgado, and Z. Zou. 1995. Insulin-like growth factor II mediates epidermal growth factor-induced mitogenesis in cervical cancer cells. Proc. Natl. Acad. Sci. USA 92:11970-11974.
69. Steller, M. A., Z. Zou, J. T. Schiller, and R. Baserga. 1996. Transformation by human papilloma virus 16 E6 and E7: role of the insulin-like growth factor I receptor. Cancer Res. 56:5087-5091.
70. Sun, X. J., M. Miralpeix, M. G. Myers, E. M. Glasheen, J. M. Backer, C. R. Kahn, and M. F. White. 1992. Expression and function of IRS-1 in insulin signal transmission. J. Biol. Chem. 267:22662-22672.
71. Sung, C. K., V. Sanchez-Margalet, and I. D. Gnldfine. 1994. Role of p85 subunit of phosphatidylinositol-3-kinasc as an adaptor molecule linking the insulin receptor, p62, and GTPase activating protein. J. Biol. Chem. 269: 12503-12507.
72. Surmacz, E., C. Sell, J. Swantek, H. Kato, C. T. Roberts, Jr., D. LeRoith, and R. Baserga. 1995. Dissociation of mitogenesis and transforming activity by C-terminal truncation of the insulin-like growth factor I receptor. Exp. Cell Res. 218:370-380.
73. Tartare-Deckert, S., D. Sawka-Verhelle, J. Murdaca, and E. Van Obberghen. 1995. Evidence for a differential interaction of Shc and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor I (IGF-I) receptor in the yeast two-hybrid system. J. Biol. Chem. 270:23456-23460.
74. Trojan, J., T. R. Johnson, S. D. Rudin, J. Ilan, M. L. Tykocinski, and I. Ilan. 1993. Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin-like growth factor I RNA. Science 256:94-97.
75. cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases. Mol. Cell. Biol. 16:2606-2613.
76. Wang, L. M., M. G. Myers, Jr., X. J. Sun, S. A. Saronson, M. White, and J. Pierce. 1993. IRS-1: essential for insulin and IL-4-stimulated mitogenesis in hemopoietic cells. Science 261:1591-1594.
77. Werner, H., E. Karnieli, F. J. Rauscher III, and D. LeRoith. 1996. Wild type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene. Proc. Natl. Acad. Sci. USA 93:8318-8323.
78. Werner, H., Z. Shen-Orr, F. J. Rauscher, J. F. Morris, C. T. Roberts, Jr., and D. LeRoith. 1995. Inhibition of cellular proliferation by the Wilms' tumor suppressor WT1 is associated with suppression of insulin-like growth factor I receptor gene expression. Mol. Cell. Biol. 15:3516-3522.
79. White, M. F., and C. R. Kahn. 1994. The insulin signaling system. J. Biol. Chem. 269:1-4.
80. Xing, Z., H. C. Chen, J. K. Nowlen, S. J. Taylor, D. Shalloway, and J. L. Guan. 1994. Direct interaction of v-src with the focal adhesion kinase mediated by the src SH2 domain. Mol. Biol. Cell 5:413-421.
81. Yamauchi, K., and J. E. Pessin. 1994. Enhancement or inhibition of insulin signaling by insulin receptor substrate-1 is cell context dependent. Mol. Cell. Biol. 14:4427-4434.
82. Yenush, L., K. J. Makati, J. Smith-Hall, O. Ishibashi, M. G. Myers, Jr., and M. F. White. 1996. The pleckstrin homology domain is the principal link between the insulin receptor and IRS-1. J. Biol. Chem. 271:24300-24306.
83. Zachary, Y., J. Sinnett-Smith, and E. Rozengurt. 1992. Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. J. Biol. Chem. 267:19031-19034.
84. Zhou-Li, F., C. D'Ambrosio, S. Li, E. Surmacz, and R. Baserga, 1995. Association of insulin receptor substrate 1 with simian virus 40 large T antigen. Mol. Cell. Biol. 15:4232-4239.