Dominant negative farnesyltransferase α-subunit inhibits insulin mitogenic effects

Biochemical and Biophysical Research Communications

Volumn 285, Issue 2, 2001, Pages 161-166

  Solomon, Curtis Scott ^a   Goalstone, Marc Lee ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; DNA; FARNESYL TRANS TRANSFERASE; INSULIN; PROTEIN P21; RAS PROTEIN;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL MIGRATION; CONTROLLED STUDY; DNA SYNTHESIS; DOWN REGULATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME SUBUNIT; HYPERINSULINEMIA; MITOGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTO ONCOGENE; VASCULAR SMOOTH MUSCLE;

EID: 0034811763     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.5142     Document Type: Article

References (25)

1. p21 ras is modified by a farnesyl isoprenoid
2. Identification oand preliminary characterization of protein-cystein farnesyltransferase
3. Polyisoprenylation of ras in vivo by a farnesyl-protein transferase
4. Protein prenylation: Molecular mechanisms and functional consequences
5. Characterization of recombinant human farnesyl-protein transferase: Cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases
6. Insulin stimulates the phosphorylation and activity of farnesyl-transferase via the Ras-mitogen-activated protein kinase pathway
7. Photoaffinity-labeling peptide substrates for farnesyl-protein transferase and the intersubunit location of the active site
8. The p21 ras C-terminus is required for transformation and membrane association
9. Relation between the insulin receptor number in cells, autophosphorylation and insulin-stimulated Ras-GTP formation
10. Insulin activates p21Ras and guanine nucleotide releasing factor in cells expressing wild type and mutant insulin receptors
11. Effect of insulin on farnesyltransferase: Specificity of insulin action and potentiation of nuclear effects of insulin-like growth factor-1, epidermal growth factor, and platelet-derived growth factor
12. Effect of insulin on farnesyltransferase activity in 3T3-L1 adipocytes
13. Insulin signals to prenyltransferases via the Shc branch of intracellular signaling
14. Insulin potentiates platelet-derived growth factor action in vascular smooth muscle cells
15. Increased amounts of farnesylated p21Ras in tissues of hyperinsulinemic animals
16. Effects of insulin on prenylation as a mechanism of potentially detrimental influence of hyperinsulinemia
17. Hyperinsulinemia potentiates activation of p21Ras by growth factors
18. Platelet-derived growth factor-BB, insulin-like growth factor-I, and phorbol ester activate different signaling pathways for stimulation of vascular smooth muscle cell migration
19. GTP loading of farnesylated p21Ras by insulin at the plasma membrane
20. A role for activated p21 ras in inhibition/regulation of platelet-derived growth factor (PDGF) type-beta receptor activation
21. Insulin and insulin-like growth factor-I signal transduction requires p21Ras
22. Interaction of the transforming growth factor-beta type I receptor with farnesyl-protein transferase-alpha
23. Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides of p21Ras
24. Prenylation of Ras proteins is required for efficient hSOS1-promoted guanine nucleotide exchange
25. Potentiation of Rho-A-mediated lysophophatidic acid activity by hyperinsulinemia