HMGA1 protein is a positive regulator of the insulin-like growth factor-I receptor gene

European Journal of Cancer

Volumn 46, Issue 10, 2010, Pages 1919-1926

  Aiello, Aurora ^a   Pandini, Giuseppe ^b   Sarfstein, Rive ^c   Werner, Haim ^c   Manfioletti, Guidalberto ^d   Vigneri, Riccardo ^b   Belfiore, Antonino ^a  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

^c TEL AVIV UNIVERSITY   (Israel)

^d UNIVERSITY OF TRIESTE   (Italy)

Author keywords

HMGA1 protein; IGF IR; IGF IR regulation; Insulin receptor

Indexed keywords

HIGH MOBILITY GROUP A PROTEIN; HIGH MOBILITY GROUP A1 PROTEIN; INSULIN; PROTEIN P53; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; HIGH MOBILITY GROUP A1A PROTEIN; SMALL INTERFERING RNA;

ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL GROWTH; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; UPREGULATION; ADULT; GENETICS; HEPG2 CELL LINE; METABOLISM; MUTATION; PHYSIOLOGY; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING;

ADULT; BLOTTING, WESTERN; GENE SILENCING; GENES, P53; HEP G2 CELLS; HMGA1A PROTEIN; HUMANS; INSULIN; MUTATION; PROMOTER REGIONS, GENETIC; RECEPTOR, IGF TYPE 1; RNA, SMALL INTERFERING; SP1 TRANSCRIPTION FACTOR;

EID: 77953292060     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2010.02.050     Document Type: Article

References (30)

1. Baserga R., Peruzzi F., and Reiss K. The IGF-1 receptor in cancer biology. Int J Cancer 107 6 (2003) 873-877
2. Liu J.P., Baker J., Perkins A.S., Robertson E.J., and Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75 1 (1993) 59-72
3. Sell C., Dumenil G., Deveaud C., et al. Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts. Mol Cell Biol 14 6 (1994) 3604-3612
4. Rubini M., Hongo A., D'Ambrosio C., and Baserga R. The IGF-I receptor in mitogenesis and transformation of mouse embryo cells: role of receptor number. Exp Cell Res 230 2 (1997) 284-292
5. LeRoith D., and Roberts Jr. C.T. The insulin-like growth factor system and cancer. Cancer Lett 195 2 (2003) 127-137
6. Pollak M.N., Schernhammer E.S., and Hankinson S.E. Insulin-like growth factors and neoplasia. Nat Rev Cancer 4 7 (2004) 505-518
7. Hofmann F., and Garcia-Echeverria C. Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer. Drug Discov Today 10 15 (2005) 1041-1047
8. Pandini G., Wurch T., Akla B., et al. Functional responses and in vivo anti-tumour activity of h7C10: a humanised monoclonal antibody with neutralising activity against the insulin-like growth factor-1 (IGF-1) receptor and insulin/IGF-1 hybrid receptors. Eur J Cancer 43 8 (2007) 1318-1327
9. Werner H., and Maor S. The insulin-like growth factor-I receptor gene: a downstream target for oncogene and tumor suppressor action. Trends Endocrinol Metab 17 6 (2006) 236-242
10. Belfiore A., and Frasca F. IGF and insulin receptor signaling in breast cancer. J Mammary Gland Biol Neoplasia 13 4 (2008) 381-406
11. Idelman G., Glaser T., Roberts Jr. C.T., and Werner H. WT1-p53 interactions in insulin-like growth factor-I receptor gene regulation. J Biol Chem 278 5 (2003) 3474-3482
12. Maor S., Yosepovich A., Papa M.Z., et al. Elevated insulin-like growth factor-I receptor (IGF-IR) levels in primary breast tumors associated with BRCA1 mutations. Cancer Lett 257 2 (2007) 236-243
13. Cleynen I., and Van de Ven W.J. The HMGA proteins: a myriad of functions (review). Int J Oncol 32 2 (2008) 289-305
14. Reeves R. Molecular biology of HMGA proteins: hubs of nuclear function. Gene 277 1-2 (2001) 63-81
15. Fusco A., and Fedele M. Roles of HMGA proteins in cancer. Nat Rev Cancer 7 12 (2007) 899-910
16. Reeves R., Edberg D.D., and Li Y. Architectural transcription factor HMGI(Y) promotes tumor progression and mesenchymal transition of human epithelial cells. Mol Cell Biol 21 2 (2001) 575-594
17. Scala S., Portella G., Fedele M., Chiappetta G., and Fusco A. Adenovirus-mediated suppression of HMGI(Y) protein synthesis as potential therapy of human malignant neoplasias. Proc Natl Acad Sci USA 97 8 (2000) 4256-4261
18. Foti D., Iuliano R., Chiefari E., and Brunetti A. A nucleoprotein complex containing Sp1, C/EBP beta, and HMGI-Y controls human insulin receptor gene transcription. Mol Cell Biol 23 8 (2003) 2720-2732
19. Ohlsson C., Kley N., Werner H., and LeRoith D. P53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1. Endocrinology 139 3 (1998) 1101-1107
20. Webster N.J., Resnik J.L., Reichart D.B., et al. Repression of the insulin receptor promoter by the tumor suppressor gene product p53: a possible mechanism for receptor overexpression in breast cancer. Cancer Res 56 12 (1996) 2781-2788
21. Belfiore A., Frasca F., Pandini G., Sciacca L., and Vigneri R. Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. Endocrinol Rev 30 6 (2009) 586-623
22. Chiappetta G., Bandiera A., Berlingieri M.T., et al. The expression of the high mobility group HMGI (Y) proteins correlates with the malignant phenotype of human thyroid neoplasias. Oncogene 10 7 (1995) 1307-1314
23. Sgarra R., Lee J., Tessari M.A., et al. The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6. J Biol Chem 281 7 (2006) 3764-3772
24. Werner H., Bach M.A., Stannard B., Roberts Jr. C.T., and LeRoith D. Structural and functional analysis of the insulin-like growth factor I receptor gene promoter. Mol Endocrinol 6 10 (1992) 1545-1558
25. Pandini G., Vigneri R., Costantino A., et al. Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling. Clin Cancer Res 5 7 (1999) 1935-1944
26. Vella V., Pandini G., Sciacca L., et al. A novel autocrine loop involving IGF-II and the insulin receptor isoform-A stimulates growth of thyroid cancer. J Clin Endocrinol Metab 87 1 (2002) 245-254
27. Frasca F., Rustighi A., Malaguarnera R., et al. HMGA1 inhibits the function of p53 family members in thyroid cancer cells. Cancer Res 66 6 (2006) 2980-2989
28. Pierantoni G.M., Rinaldo C., Esposito F., et al. High Mobility Group A1 (HMGA1) proteins interact with p53 and inhibit its apoptotic activity. Cell Death Differ 13 9 (2006) 1554-1563
29. Ullrich A., Gray A., Tam A.W., et al. Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. Embo J 5 10 (1986) 2503-2512
30. Frasca F., Pandini G., Scalia P., et al. Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Mol Cell Biol 19 5 (1999) 3278-3288