Expression of protease-activated receptor-1, -2, -3, and -4 in control and experimentally inflamed mouse bladder

American Journal of Pathology

Volumn 162, Issue 3, 2003, Pages 907-923

  D'Andrea, Michael R ^a   Saban, Marcia R ^b   Nguyen, Ngoc Bich ^b   Andrade Gordon, Patricia ^a   Saban, Ricardo ^b  

^a J/J Pharmaceut Res/Development   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 3; PROTEINASE ACTIVATED RECEPTOR 4; TRYPTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLADDER FUNCTION; CHRONIC INFLAMMATION; CONTROLLED STUDY; CYSTITIS; DETRUSOR MUSCLE; DOWN REGULATION; IMMUNOHISTOCHEMISTRY; MAST CELL; MOUSE; NEUROGENIC INFLAMMATION; NONHUMAN; PERIPHERAL NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; UPREGULATION; UROTHELIUM;

EID: 0345074090     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63886-2     Document Type: Article

References (59)

1. Okragly A, Niles A, Saban R, Schmidt D, Hoffman R, Warner T, Moon T, Uehling D, Haak-Frendscho M: Elevated tryptase, NGF, NT-3, and GDNF levels in the urine of interstitial cystitis and bladder cancer patients. J Urol 1999, 161:434-441
2. Saban M, Nguyen N-B, Hammond T, Saban R: Gene expression profiling of mouse bladder inflammatory responses to LPS, substance P, and antigen-stimulation. Am J Pathol 2002, 160:2095-2110
3. Hollenberg D, Compton S: International Union of Pharmacology. XX-VIII. Proteinase-Activated Receptors. Pharmacol Rev 2002, 54:203-217
4. Vergnolle N, Wallace JL, Bunnett NW, Hollenberg MD: Protease-activated receptors in inflammation, neuronal signaling and pain. Trends Pharmacol Sci 2001, 22:146-152
5. Vergnolle N: Proteinase-activated receptors - novel signals for gastrointestinal pathophysiology. Aliment Pharmacol Ther 2000, 14:257-266
6. Ishihara H, Connolly AJ, Zeng D, Kahn ML, Zheng YW, Timmons C, Tram T, Coughlin SR: Protease-activated receptor 3 is a second thrombin receptor in humans. Nature 1997, 386:502-506
7. Xu WF, Andersen H, Whitmore TE, Presnell SR, Yee DP, Ching A, Gilbert T, Davie EW, Foster DC: Cloning and characterization of human protease-activated receptor 4. Proc Natl Acad Sci USA 1998, 95:6642-6646
8. Asokananthan N, Graham PT, Fink J, Knight DA, Bakker AJ, McWilliam AS, Thompson PJ, Stewart GA: Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells. J Immunol 2002, 168:3577-3585
9. Macfarlane S, Seatter M, Kanke T, Hunter G, Plevin R: Proteinase-activated receptors. Pharmacol Rev 2001, 53:245-282
10. Carr MJ, Schechter NM, Undem BJ: Trypsin-induced, neurokinin-mediated contraction of guinea pig bronchus. Am J Respir Crit Care Med 2000, 162:1662-1667
11. Cunningham MA, Rondeau E, Chen X, Coughlin SR, Holdsworth SR, Tipping PG: Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis. J Exp Med 2000, 191:455-462
12. Kawabata A, Kuroda R, Nagata N, Kawao N, Masuko T, Nishikawa H, Kawai K: In vivo evidence that protease-activated receptors 1 and 2 modulate gastrointestinal transit in the mouse. Br J Pharmacol 2001, 133:1213-1218
13. de Garavilla L, Vergnolle N, Young SH, Ennes H, Steinhoff M, Ossovskaya VS, D'Andrea MR, Mayer EA, Wallace JL, Hollenberg MD, Andrade-Gordon P, Bunnett NW: Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism. Br J Pharmacol 2001, 133:975-987
14. Nystedt S, Emilsson K, Wahlestedt C, Sundelin J: Molecular cloning of a potential proteinase activated receptor. Proc Natl Acad Sci USA 1994, 91:9208-9212
15. Hamilton JR, Frauman AG, Cocks TM: Increased expression of protease-activated receptor-2 (PAR2) and PAR4 in human coronary artery by inflammatory stimuli unveils endothelium-dependent relaxations to PAR2 and PAR4 agonists. Circ Res 2001, 89:92-98
16. Bretschneider E, Kaufmann R, Braun M, Nowak G, Glusa E, Schror K: Evidence for functionally active protease-activated receptor-4 (PAR-4) in human vascular smooth muscle cells. Br J Pharmacol 2001, 132:1441-1446
17. Carney DH, Mann R, Redin WR, Pernia SD, Berry D, Heggers JP, Hayward PG, Robson MC, Christie J, Annable C, Fenton II JW, Glenn KC: Enhancement of incisional wound healing and neovascularization in normal rats by thrombin and synthetic thrombin receptor-activating peptides. J Clin Invest 1992, 89:1469-1477
18. Dabbagh K, Laurent GJ, McAnulty RJ, Chambers RC: Thrombin stimulates smooth muscle cell procollagen synthesis and mRNA levels via a PAR-1 mediated mechanism. Thromb Haemost 1998, 79:405-409
19. Stiernberg J, Redin WR, Warner WS, Carney DH: The role of thrombin and thrombin receptor activating peptide (TRAP-508) in initiation of tissue repair. Thromb Haemost 1993, 70:158-162
20. Chambers RC, Dabbagh K, McAnulty RJ, Gray AJ, Blanc-Brude OP, Laurent GJ: Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1. Biochem J 1998, 333:121-127
21. Chambers RC, Leoni P, Blanc-Brude OP, Wembridge DE, Laurent GJ: Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1. J Biol Chem 2000, 275:35584-35591
22. Vliagoftis H, Schwingshackl A, Milne CD, Duszyk M, Hollenberg MD, Wallace JL, Befus AD, Moqbel R: Proteinase-activated receptor-2-mediated matrix metalloproteinase-9 release from airway epithelial cells. J Allergy Clin Immunol 2000, 106:537-545
23. Corvera CU, Dery O, McConalogue K, Bohm SK, Khitin LM, Caughey GH, Payan DG, Bunnett NW: Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2. J Clin Invest 1997, 100:1383-1393
24. D'Andrea MR, Rogahn CJ, Andrade-Gordon P: Localization of protease-activated receptors-1 and -2 in human mast cells: indications for an ampllfied mast cell degranulation cascade. Biotech Histochem 2000, 75:85-90
25. Haak-Frendscho M, Saban R, Shields RL, Jardieu PM: Anti-immunoglobulin E antibody treatment blocks histamine release and tissue contraction in sensitized mice. Immunology 1998, 94:115-121
26. Saban R, Gerard N, Saban M, Nguyen N-B, DeBoer D, Wershil B: Mast cells mediate substance P-induced bladder inflammation through a neurokinin-1 receptor-independent mechanism. Am J Physiol 2002, 160:F2095-F2110
27. Saban R, Saban M, Nguyen N-B, Lu B, Gerard C, Gerard N, Hammond T: Neurokinin-1 (NK-1) receptor is required in antigen-induced cystitis. Am J Pathol 2000, 156:775-780
28. Saban M, Hellmich H, Nguyen N-B, Winston J, Hammond T, Saban R: Time course of LPS-induced gene-expression in a mouse model of genitourinary inflammation. Physiol Genomics 2001, 5:147-116
29. Saban M, Saban R, Hammond T, Haak-Frendscho M, Steinberg H, Tengowski M, Bjorling D: LPS-sensory peptide communication in experimental cystitis. Am J Physiol 2002, 282:F202-F210
30. Luna L: Histopathologic Methods and Color Atlas of Special Stains and Tissue Artifacts. Gaithersburg, American Histolabs, Inc., Publications Division, 1992, p 311
31. D'Andrea MR, Derian CK, Santulli RJ, Andrade-Gordon P: Differential expression of protease-activated receptors-1 and -2 in stromal fibroblasts of normal, benign, and malignant human tissues. Am J Pathol 2001, 158:2031-2041
32. D'Andrea MR, Derian CK, Leturcq D, Baker SM, Brunmark A, Ling P, Darrow AL, Santulli RJ, Brass LF, Andrade-Gordon P: Characterization of protease-activated receptor-2 immunoreactivity in normal human tissues. J Histochem Cytochem 1998, 46:157-164
33. Lourbakos A, Potempa J, Travis J, D'Andrea MR, Andrade-Gordon P, Santulli R, Mackie EJ, Pike RN: Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion. Infect Immun 2001, 69:5121-5130
34. Molino M, Barnathan ES, Numerof R, Clark J, Dreyer M, Cumashi A, Hoxie JA, Schechter N, Woolkalis M, Brass LF: Interactions of mast cell tryptase with thrombin receptors and PAR-2. J Biol Chem 1997, 272:4043-4049
35. Keith IM, Jin J, Saban R: Nerve-mast cell interaction in normal guinea pig urinary bladder. J Comp Neurol 1995, 363:28-36
36. Tani K, Ogushi F, Shimizu T, Sone S: Protease-induced leukocyte chemotaxis and activation: roles in host defense and inflammation. J Med Invest 2001, 48:133-141
37. Erman A, Jeyernik K: Mouse urothelial cells in early postnatal development - proliferation and apical plasma membrane specialization. Pfluegers Arch 2000, 440:R183-R184
38. Li B, Kanamaru H, Saikawa S, Fukuda M, Okada K: Increased cell proliferation of urothelium in rat bladder following unilateral nephrectomy. J Urol 1997, 158:265-268
39. Romih R, Koprivec D, Martincic DS, Jezernik K: Restoration of the rat urothelium after cyclophosphamide treatment. Cell Biol Int 2001, 25:531-537
40. Nakanishi K, Kawai T, Aida S, Kasamatsu H, Aurues T, Ikeda T: Expression of p27(Kip1) protein in transitional cell carcinoma of the upper urinary tract. Mod Pathol 2001, 14:371-376
41. Coughlin S: Thrombin receptor function and cardiovascular disease. Trends Cardiovasc Med 1994, 4:77-83
42. Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, Moff S, Farese Jr. RV, Tam C, Coughlin SR: A dual thrombin receptor system for platelet activation. Nature 1998, 394:690-694
43. Steinhoff M, Vergnolle N, Young SH, Tognetto M, Amadesi S, Ennes HS, Trevisani M, Hollenberg MD, Wallace JL, Caughey GH, Mitchell SE, Williams LM, Geppetti P, Mayer EA, Bunnett NW: Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat Med 2000, 6:151-158
44. McLean PG, Aston D, Sarkar D, Ahluwalia A: Protease-activated receptor-2 activation causes EDHF-like coronary vasodilation: selective preservation in ischemia/reperfusion injury: involvement of lipoxygenase products, VR1 receptors, and C-fibers. Circ Res 2002, 90:465-472
45. Bell J: Inflammation: dousing the flames. Nat Rev Immunol 2001, 1:173
46. Lemack GE, Zimmern PE: Interstitial cystitis: reevaluation of patients who do no respond to standard treatments. Prog Urol 2001, 11:239-244
47. Messing E: Interstitial cystitis and related syndromes. Campbell's Urology. Edited by P Walsh, A Retik, T Stamey, JE Vaughan. Philadelphia, W. B. Saunders Co., 1992, p 982
48. Buckley CD, Pilling D, Lord JM, Akbar AN, Scheel-Toellner D, Salmon M: Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation. Trends Immunol 2001, 22:199-204
49. Bohm SK, Kong W, Bromme D, Smeekens SP, Anderson DC, Connolly A, Kahn M, Nelken NA, Coughlin SR, Payan DG, Bunnett NW: Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem J 1996, 314:1009-1016
50. Paing MM, Stutts AB, Kohout TA, Lefkowitz RJ, Trejo J: Beta-arrestins regulate protease-activated receptor-1 desensitization but not internalization or down-regulation. J Biol Chem 2002, 277:1292-1300
51. Trejo J, Altschuler Y, Fu HW, Mostov KE, Coughlin SR: Protease-activated receptor-1 down-regulation: a mutant HeLa cell line suggests novel requirements for PAR1 phosphorylation and recruitment to clathrin-coated pits. J Biol Chem 2000, 275:31255-31265
52. Dery O, Corvera CU, Steinhoff M, Bunnett NW: Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. Am J Physiol 1998, 274: C1429-C1452
53. Bohm SK, Khitin LM, Grady EF, Aponte G, Payan DG, Bunnett NW: Mechanisms of desensitization and resensitization of proteinase-activated receptor-2. J Biol Chem 1996, 271:22003-22016
54. Fiorucci S, Distrutti E: Role of PAR2 in pain and inflammation. Trends Pharmacol Sci 2002, 23:153-155
55. Fiorucci S, Mencarelli A, Palazzetti B, Distrutti E, Vergnolle N, Hollenberg MD, Wallace JL, Morelli A, Cirino G: Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis. Proc Natl Acad Sci USA 2001, 98:13936-13941
56. Saban R, Undem BJ, Keith IM, Saban MR, Tengowski MW, Graziano FM, Bjorling DE: Differential release of prostaglandins and leukotrienes by sensitized guinea pig urinary bladder layers upon antigen challenge. J Urol 1994, 152:544-549
57. Hollenberg M: Protease-mediated signaling: new paradigms for cell regulation and drug development. Trends Pharmacol Sci 1996, 17:3-6
58. Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W: Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science 2002, 296:1880-1882
59. Tomaszewski J, Landis J, Russack V, Williams T, Wang L, Hardy C, Brensinger C, Matthews Y, Abele S, Kusek J, Nyberg L: The Interstitial Cystitis Database Study Group. Biopsy features are associated with primary symptoms in interstitial cystitis: results from the interstitial cystitis database study. Urology 2001, 57:67-81