Activation of urothelial transient receptor potential vanilloid 4 by 4α-phorbol 12,13-didecanoate contributes to altered bladder reflexes in the rat

Journal of Pharmacology and Experimental Therapeutics

Volumn 323, Issue 1, 2007, Pages 227-235

  Birder, Lori A ^a   Kullmann, F Aura ^a   Lee, Hyosang ^b   Barrick, Stacey ^a   De Groat, William ^a   Kanai, Anthony ^a   Caterina, Michael ^b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4ALPHA PHORBOL DIDECANOATE; 5 [[(3 PHENOXYBENZYL) 1,2,3,4 TETRAHYDRO 1 NAPHTHALENYL]AMINO]CARBONYL] 1,2,3,4 BENZENETRICARBOXYLIC ACID; A 317491; ADENOSINE TRIPHOSPHATE; CALCIUM ION; CAPSAICIN; COMPLEMENTARY DNA; EGTAZIC ACID; IONOMYCIN; MUSCARINE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C ACTIVATOR; PURINE P2X3 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; RECOMBINANT PROTEIN; RNA; TRANSIENT RECEPTOR POTENTIAL CHANNEL; UNCLASSIFIED DRUG; URETHAN; VANILLOID RECEPTOR; VANILLOID RECEPTOR 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLADDER; BLADDER CONTRACTION; BLADDER DYSFUNCTION; BLADDER FUNCTION; CELL CULTURE; CONTINUOUS INFUSION; CONTROLLED STUDY; CYSTOMETRY; DETRUSOR MUSCLE; DRUG EFFECT; ELECTROSTIMULATION; FEMALE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; KIDNEY PELVIS; MALE; MICTURITION; MICTURITION REFLEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR DOWN REGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; URETER; URETHRA; UROTHELIUM;

ANIMALS; FEMALE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PHORBOL ESTERS; RATS; RATS, SPRAGUE-DAWLEY; REFLEX; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRPV CATION CHANNELS; URINARY BLADDER; URINATION; UROTHELIUM;

EID: 34548853751     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.125435     Document Type: Article

References (40)

1. Abelli L, Conte B, Somma V, Maggi CA, Giuliani S, Geppetti P, Alessan M, Theodorsson E, and Meli A (1988) The contribution of capsaicin-sensitive sensory nerves to xylene-induced visceral pain in conscious, freely moving rats. Naunyn Schmiedebergs Arch Pharmacol 337:545-551.
2. Alessandri-Haber N, Dina OA, Yeh JJ, Parada CA, Reichling DB, and Levine JD (2004) Transient receptor potential vanilloid 4 is essential in chemotherapy induced neuropathic pain in the rat. J Neurosci 24:4444-4452.
3. Al-Shahrani M and Lovatsis D (2005) Do subjective symptoms of obstructive voiding correlate with post-void residual urine volume in women? Int Urogynecol J Pelvic Floor Dysfunct 16:12-14.
4. Andersson K-E (2002) Bladder activation: afferent mechanisms. Urology 59:43-50.
5. Barbanti G, Maggi CA, Beneforti P, Baroldi P, and Turini D (1993) Relief of pain following intravesical capsaicin in patients with hypersensitive disorders of the lower urinary tract. Br J Urol 71:686-691.
6. Birder LA, Barrick S, Roppolo JR, Kanai AJ, de Groat WC, Kiss S, and Buffington CA (2003) Feline interstitial cystitis results in mechanical hypersensitivity and altered ATP release from bladder urothelium. Am J Physiol Renal Physiol 285:F423-F425.
7. Birder LA and de Groat WC (2007) Mechanisms of disease: involvement of the urothelium in bladder dysfunction. Nat Clin Pract Urol 4:46-54.
8. Birder LA, Kanai AJ, de Groat WC, Kiss S, Nealen ML, Burke NE, Dineley KE, Watkins S, Reynolds IJ, and Caterina MJ (2001) Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells. Proc Natl Acad Sci U S A 98:13396-13401.
9. Birder LA, Nakamura Y, Kiss S, Nealen ML, Barrick S, Kanai AJ, Wang E, Ruiz G, de Groat WC, Apodaca G, et al. (2002) Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nature Neurosci 5:856-860.
10. Burnstock G (2007) Physiology and pathophysiology of purinergic neurotransmission. Physiol Rev 87:659-797.
11. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, and Julius D (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816-824.
12. Chancellor MB and de Groat WC (1999) Intravesical capsaicin and resiniferatoxin therapy: spicing up the ways to treat overactive bladder. J Urol 162:3-11.
13. Cheng C-L, Chai C-Y, and de Groat WC (1997) Detrusor-sphincter dyssynergia induced by cold stimulation of the urinary bladder of rats. Am J Physiol 272: R1271-R1282.
14. Cheng CL, Liu JC, Chang SY, Ma CY, and de Groat WC (1999) Effect of capsaicin on the micturition reflex in normal and chronic spinal cord injured rats. Am J Physiol 277:R786-R794.
15. Chuang YC, Fraser MO, Yu Y, Beckel JM, Seki S, Nakanishi Y, Yokoyama H, Chancellor M, Yoshimura N, and de Groat WC (2001) Analysis of the afferent limb of the vesicovascular reflex using neurotoxins, resiniferatoxin and capsaicin. Am J Physiol Regul Integr Comp Physiol 281:R1302-R1310.
16. Chung M-K, Lee H, and Caterina MJ (2003) Warm temperatures activate TRPV4 in mouse 308 keratinocytes. J Biol Chem 278:32037-32046.
17. Chute CG, Panser LA, Girman CJ, Oesterling JE, Buess HA, Jacobsen SJ, and Lieber MM (1993) The prevalence of prostatism: a population-based survey of urinary symptoms. J Urol 150:85-89.
18. Clapham DE, Runnels LW, and Strubing C (2001) The TRP ion channel family. Nat Rev 2:387-395.
19. Cockayne DA, Hamilton SG, Zhu QM, Dunn PM, Zhong Y, Novakovic S, Malmberg AB, Cain G, Berson A, Kassotakis L, et al. (2000) Urinary bladder hyporeflexia and reduced pain-related behavior in P2X3-deficient mice. Nature 407:1011-1015.
20. de Groat WC (1993) Anatomy and physiology of the lower urinary tract. Urol Clin North Am 20:383-401.
21. Downie JW and Karmazyn M (1984) Mechanical trauma to bladder epithelium liberates prostanoids which modulate neurotransmission in rabbit detrusor muscle. J Pharmacol Exp Ther 230:445-449.
22. Durufle A, Petrilli S, Nicolas B, Robineau S, Guille F, Edan G, and Gallien P (2006) Effects of pregnancy and child birth on urinary symptoms and urodynamics in women with multiple sclerosis. Int Urogynecol J Pelvic Floor Dysfunct 17:352-355.
23. Ferguson DR, Kennedy I, and Burton TJ (1997) ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes: a possible sensory mechanism? J Physiol 505:503-511.
24. Fowler C (2000) Intravesical treatment of overactive bladder. Urology 55:60-64.
25. Gevaert T, Vandepitte J, Hutchings G, Vriens J, Nilius B, and De Ridder D (2007) TRPV1 is involved in stretch-evoked contractile changes in the rat autonomous bladder model: A study with piperine, a new TRPV1 agonist. Neurourol Urodyn 26:440-450.
26. Guler AD, Lee H, Iida T, Shimizu I, Tominaga M, and Caterina MJ (2002) Heat-evoked activation of the ion channel, TRPV4. J Neurosci 22:6408-6414.
27. Lee H, Iida T, Mizuno A, Suzuki M, and Caterina MJ (2005) Altered thermal selection behavior in mice lacking transient receptor potential vanilloid 4. J Neurosci 25:1304-1310.
28. Liedtke W, Choe Y, Marti-Renom MA, Bell AM, Denis CS, Sali A, Hudspeth A, Friedman JM, and Heller S (2000) Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 103:525-535.
29. Liedtke W and Friedman JM (2003) Abnormal osmotic regulation in trpv4-/- mice. Proc Natl Acad Sci U S A 100:13698-13703.
30. Liedtke W, Tobin DM, Bargmann CI, and Friedman JM (2003) Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans. Proc Natl Acad Sci U S A 100:14531-14536.
31. Maggi CA, Santicioli P, and Meli A (1984) The effects of topical capsaicin on rat urinary bladder motility in vivo. Eur J Pharmacol 103:41-50.
32. Nishiguchi J, Hayashi Y, Chancellor MB, de Miguel F, de Groat WC, Kumon H, and Yoshimura N (2005) Detrusor overactivity induced by intravesical application of adenosine 5′-triphosphate under different delivery conditions in rats. Urology 66:1332-1337.
33. Nilius B, Watanabe H, and Vriens J (2003) The TRPV4 channel: structure-function relationship and promiscuous gating behaviour. Pflugers Arch 446:298-303.
34. Sun Y, Keay S, DeDeyne PG, and Chai TC (2001) Augmented stretch activated adenosine triphosphate release from bladder uroepithelial cells in patients with interstitial cystitis. J Urol 166:1951-1956.
35. Tian W, Salanova M, Xu H, Lindsley JN, Oyama TT, Anderson S, Bachmann S, and Cohen DM (2004) Renal expression of osmotically responsive cation channel TRPV4 restricted to water-impermeant nephron segments. Am J Physiol Renal Physiol 287:F17-F24.
36. Tominaga M, Caterina MJ, Malmberg AB, Rosen TA, Gilbert H, Skinner S, Raumann BE, Basbaum AI, and Julius D (1998) The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21:531-543.
37. Watanabe H, Davis JB, Smart D, Jerman JC, Smith GD, Hayes P, Vriens J, Cairns W, Wissenbach U, Prenen J, et al. (2002) Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem 277:13569- 13577.
38. Watanabe H, Vriens J, Prenen J, Droogmans G, Voets T, and Nilius B (2003) Anandamide and arachidonic acid use epoxyeicosatrienoic acids activate TRPV4 channels. Nature 424:434-438.
39. Xu H, Zhao H, Tian W, Yoshida K, Roullet JB, and Cohen DM (2003) Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates it response to hypotonic stress. J Biol Chem 278:11520-11527.
40. Zhang X, Igawa Y, Ishizuka O, Nishizawa O, and Andersson K-E (2003) Effects of resiniferatoxin desensitization of capsaicin-sensitive afferents on detrusor overactivity induced by intravesical capsaicin, acetic acid or ATP in conscious rats. Naunyn Schmiedebergs Arch Pharmacol 367:473-479.