Protease-activated receptor-2 activation causes EDHF-like coronary vasodilation: Selective preservation in ischemia/reperfusion injury: Involvement of lipoxygenase products, VR1 receptors, and C-fibers

Circulation Research

Volumn 90, Issue 4, 2002, Pages 465-472

  McLean, Peter G ^a,b   Aston, Daniel ^a   Sarkar, David ^a   Ahluwalia, Amrita ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Endothelium derived hyperpolarizing factor; Ischemia reperfusion injury; Nitric oxide; Prostanoid; Protease activated receptors

Indexed keywords

ACETYLCHOLINE; APAMIN; BAICALEIN; CAPSAICIN; CAPSAZEPINE; CHARYBDOTOXIN; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; ICOSATETRAENOIC ACID; INDOMETACIN; LIPOXYGENASE INHIBITOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NORDIHYDROGUAIARETIC ACID; OXYHEMOGLOBIN; PINACIDIL; PROSTANOID; PROTEINASE ACTIVATED RECEPTOR 2; TETRYLAMMONIUM; TRYPSIN; VANILLOID RECEPTOR;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DRUG EFFECT; HEART FUNCTION; HEMODYNAMIC PARAMETERS; ISCHEMIC HEART DISEASE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; VASODILATATION;

ACETYLCHOLINE; ANIMALS; BIOLOGICAL FACTORS; CAPSAICIN; CORONARY VESSELS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; LIPOXYGENASE; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; NERVE FIBERS; OLIGOPEPTIDES; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; RATS; RATS, WISTAR; RECEPTOR, PAR-2; RECEPTORS, DRUG; RECEPTORS, THROMBIN; TRYPSIN; VASODILATION;

EID: 0037040862     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/hh0402.105372     Document Type: Article

References (54)

1. Proteinase-activated receptors
2. Increased expression of protease-activated receptor-2 (PAR2) and PAR4 in human coronary artery by inflammatory stimuli unveils endothelium-dependent relaxations to PAR2 and PAR4 agonists
3. Protease-activated receptors: Sentries for inflammation?
4. Proteinase-activated receptors: Novel mechanisms of signaling by serine proteases
5. Molecular cloning of a potential proteinase activated receptor
6. Interactions of mast cell tryptase with thrombin receptors and PAR-2
7. Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2
8. Coagulation factor Xa induces endothelium-dependent relaxations in rat aorta
9. Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa
10. Evidence for the presence of a proteinase-activated receptor distinct from the thrombin receptor in vascular endothelial cells
11. Vascular effects of proteinase-activated receptor 2 agonist peptide
12. Atypical protease-activated receptor mediates endothelium-dependent relaxation of human coronary arteries
13. Characterization of protease-activated receptor-2 immunoreactivity in normal human tissues
14. Differential expression of functional protease-activated receptor-2 (PAR-2) in human vascular smooth muscle cells
15. Protease-activated receptor-2 involvement in hypotension in normal and endotoxemic rats in vivo
16. Activation of protease-activated receptor-2 (PAR-2) elicits nitric oxide-dependent dilatation of the basilar artery in vivo
17. The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells
18. Increased expression of protease activated receptor-2 (PAR-2) in balloon-injured rat carotid artery
19. Protease-activated receptor-2 modulates myocardial ischemia-reperfusion injury in the rat heart
20. Increased vascular permeability by a specific agonist of protease-activated receptor-2 in rat hindpaw
21. Characterization of the inflammatory response to proteinase-activated receptor-2 (PAR2)-activating peptides in the rat paw
22. Proteinase-activated receptor-2-activating peptides induce leukocyte rolling, adhesion, and extravasation in vivo
23. Evidence for selective effects of chronic hypertension on cerebral artery vasodilatation to protease-activated receptor-2 activation
24. Inducible expression of the kinin BI receptor in the endotoxemic heart: Mechanisms of des-Arg9bradykinin-induced coronary vasodilation
25. Perfusion-induced changes in cardiac contractility and oxygen consumption are not endothelium-dependent
26. Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors
27. Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances
28. Role of lipoxygenase metabolites in ischemic preconditioning
29. Lipoxygenase metabolism of arachidonic acid in ischemic preconditioning and PKC-induced protection in heart
30. Leukocyte-type 12-lipoxygenase-deficient mice show impaired ischemic preconditioning-induced cardioprotection
31. Tachykinins and calcitonin gene-related peptide (CGRP) as cotransmitters released from peripheral endings of sensory nerves
32. A comparison of capsazepine and ruthenium red as capsaicin antagonists in the rat isolated urinary bladder and vas deferens
33. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
34. Capsaicin-sensitive sensory-motor neurotransmission in the peripheral control of cardiovascular function
35. Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1
36. Dual endothelium-dependent vascular activities of proteinase-activated receptor-2-activating peptides: Evidence for receptor heterogeneity
37. Bioregulation of kinins: Kallikreins, kininogens, and kininases
38. Coronary vascular reactivity after acute myocardial ischemia
39. Functional coronary microvascular injury evident as increased permeability due to brief ischemia and reperfusion
40. Reperfusion after acute coronary occlusion in dogs impairs endothelium-dependent relaxation to acetylcholine and augments contractile reactivity in vitro
41. Ischemic preconditioning protects against coronary endothelial dysfunction induced by ischemia and reperfusion
42. The effect of ischaemia on endothelium-dependent vasodilatation and adrenoceptor-mediated vasoconstriction in rat isolated hearts
43. Role of kinins in the endothelial protective effect of ischaemic preconditioning
44. The importance of the hyperpolarizing mechanism increases as the vessel size decreases in endothelium-dependent relaxations in rat mesenteric circulation
45. Endothelium-dependent hyperpolarization: A role in the control of vascular tone
46. + channels in the vasodilator response to bradykinin in the rat heart
47. Endothelium-derived relaxing, contracting and hyperpolarizing factors of mesenteric arteries of hypertensive and normotensive rats
48. Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium
49. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism
50. Nonadrenergic noncholinergic nerves regulate basal coronary flow via release of capsaicin-sensitive neuropeptides in the rat heart
51. The ligand that came from within
52. Aggravation of myocardial infarction in the porcine heart by capsaicin-induced depletion of calcitonin generelated peptide (CGRP)
53. Protection of calcitonin gene-related peptide-mediated preconditioning against coronary endothelial dysfunction induced by reperfusion in the isolated rat heart