-
1
-
-
0037588986
-
The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome
-
Aird, W. C. (2003). The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood 101, 3765-3777.
-
(2003)
Blood
, vol.101
, pp. 3765-3777
-
-
Aird, W.C.1
-
2
-
-
78149477844
-
Molecular intercommunication between the complement and coagulation systems
-
Amara, U., Flierl, M. A., Rittirsch, D., Klos, A., Chen, H., Acker, B., et al. (2010). Molecular intercommunication between the complement and coagulation systems. J. Immunol. 185,5628-5636.
-
(2010)
J. Immunol.
, vol.185
, pp. 5628-5636
-
-
Amara, U.1
Flierl, M.A.2
Rittirsch, D.3
Klos, A.4
Chen, H.5
Acker, B.6
-
3
-
-
79960196840
-
Complement dependency of cardiomyocyte release of mediators during sepsis
-
Atefi, G., Zetoune, F. S., Herron, T. J., Jalife, J., Bosmann, M., Al-Aref, R., et al. (2011). Complement dependency of cardiomyocyte release of mediators during sepsis. FASEB J. 25, 2500-2508.
-
(2011)
FASEB J
, vol.25
, pp. 2500-2508
-
-
Atefi, G.1
Zetoune, F.S.2
Herron, T.J.3
Jalife, J.4
Bosmann, M.5
Al-Aref, R.6
-
4
-
-
0022459082
-
Altered anaphylatoxin activity during induced hypoperfusion in acute and elective abdominal aortic surgery
-
Bengtson, A., and Heideman, M. (1986). Altered anaphylatoxin activity during induced hypoperfusion in acute and elective abdominal aortic surgery. J. Trauma 26, 631-637.
-
(1986)
J. Trauma
, vol.26
, pp. 631-637
-
-
Bengtson, A.1
Heideman, M.2
-
5
-
-
0023925627
-
Anaphylatoxin formation in sepsis
-
Bengtson, A., and Heideman, M. (1988). Anaphylatoxin formation in sepsis. Arch. Surg. 123, 645-649.
-
(1988)
Arch. Surg.
, vol.123
, pp. 645-649
-
-
Bengtson, A.1
Heideman, M.2
-
6
-
-
12444255105
-
Opposing and hierarchical roles of leukotrienes in local innate immune versus vascular responses in a model of sepsis
-
Benjamim, C. F., Canetti, C., Cunha, F. Q., Kunkel, S. L., and Peters-Golden, M. (2005). Opposing and hierarchical roles of leukotrienes in local innate immune versus vascular responses in a model of sepsis. J. Immunol. 174, 1616-1620.
-
(2005)
J. Immunol.
, vol.174
, pp. 1616-1620
-
-
Benjamim, C.F.1
Canetti, C.2
Cunha, F.Q.3
Kunkel, S.L.4
Peters-Golden, M.5
-
7
-
-
82655173731
-
-
Bosmann, M., Patel, V. R., Russkamp, N. F., Pache, F., Zetoune, F. S., Sarma, J. V., et al. (2011a). MyD88-dependent production of IL-17F is modulated by the anaphylatoxin C5a via the Akt signaling pathway. FASEB I 25,4222-4232.
-
(2011)
MyD88-dependent production of IL-17F is modulated by the anaphylatoxin C5a via the Akt signaling pathway. FASEB I
, vol.25
, pp. 4222-4232
-
-
Bosmann, M.1
Patel, V.R.2
Russkamp, N.F.3
Pache, F.4
Zetoune, F.S.5
Sarma, J.V.6
-
8
-
-
80052967619
-
The outcome of polymicrobial sepsis is independent of T and B cells
-
Bosmann, M., Russkamp, N. F., Patel, V. R., Zetoune, F. S., Sarma, J. V., and Ward, P. A. (2011b). The outcome of polymicrobial sepsis is independent of T and B cells. Shock 36, 396-401.
-
(2011)
Shock
, vol.36
, pp. 396-401
-
-
Bosmann, M.1
Russkamp, N.F.2
Patel, V.R.3
Zetoune, F.S.4
Sarma, J.V.5
Ward, P.A.6
-
9
-
-
84860902599
-
Evidence for anti-inflammatory effects of C5a on the innate IL-17A/IL-23 axis
-
Bosmann, M., Sarma, J. V., Atefi, G., Zetoune, F. S., and Ward, P. A. (2012). Evidence for anti-inflammatory effects of C5a on the innate IL-17A/IL-23 axis. FASEB J. 26, 1640-1651.
-
(2012)
FASEB J
, vol.26
, pp. 1640-1651
-
-
Bosmann, M.1
Sarma, J.V.2
Atefi, G.3
Zetoune, F.S.4
Ward, P.A.5
-
10
-
-
11244316320
-
Inhibition of C5 or absence of C6 protects from sepsis mortality
-
Buras, J. A., Rice, L., Orlow, D., Pavlides, S., Reenstra, W R., Ceonzo, K., et al. (2004). Inhibition of C5 or absence of C6 protects from sepsis mortality. Immunobiology 209, 629-635.
-
(2004)
Immunobiology
, vol.209
, pp. 629-635
-
-
Buras, J.A.1
Rice, L.2
Orlow, D.3
Pavlides, S.4
Reenstra, W.R.5
Ceonzo, K.6
-
11
-
-
0032805207
-
Tumor necrosis factor-alpha and interleukin-1beta synergistically depress human myocardial function
-
Cain, B. S., Meldrum, D. R., Dinarello, C. A., Meng, X., Joo, K. S., Banerjee, A., et al. (1999). Tumor necrosis factor-alpha and interleukin-1beta synergistically depress human myocardial function. Crit. Care Med.27, 1309-1318.
-
(1999)
Crit. Care Med. 27
, pp. 1309-1318
-
-
Cain, B.S.1
Meldrum, D.R.2
Dinarello, C.A.3
Meng, X.4
Joo, K.S.5
Banerjee, A.6
-
12
-
-
0025092009
-
Recombinant C5a enhances inter-leukin 1 and tumor necrosis factor release by lipopolysaccharide-stimulated monocytes and macrophages
-
Cavaillon, J. M., Fitting, C., and Haeffner-Cavaillon, N. (1990). Recombinant C5a enhances inter-leukin 1 and tumor necrosis factor release by lipopolysaccharide-stimulated monocytes and macrophages. Eur. J. Immunol. 20, 253-257.
-
(1990)
Eur. J. Immunol.
, vol.20
, pp. 253-257
-
-
Cavaillon, J.M.1
Fitting, C.2
Haeffner-Cavaillon, N.3
-
13
-
-
0035184254
-
Role of the classical pathway of complement activation in experimentally induced polymicrobial peritonitis
-
Celik, I., Stover, C., Botto, M., Thiel, S., Tzima, S., Kunkel, D., et al. (2001). Role of the classical pathway of complement activation in experimentally induced polymicrobial peritonitis. Infect. Immun. 69, 7304-7309.
-
(2001)
Infect. Immun.
, vol.69
, pp. 7304-7309
-
-
Celik, I.1
Stover, C.2
Botto, M.3
Thiel, S.4
Tzima, S.5
Kunkel, D.6
-
14
-
-
79952081601
-
Blockade of complement activation product C5a activity using specific antibody attenuates intestinal damage in trinitrobenzene sulfonic acid induced model of colitis
-
Chen, G., Yang, Y., Gao, X., Dou, Y., Wang, H., Han, G., et al. (2011). Blockade of complement activation product C5a activity using specific antibody attenuates intestinal damage in trinitrobenzene sulfonic acid induced model of colitis. Lab. Invest. 91,472-483.
-
(2011)
Lab. Invest.
, vol.91
, pp. 472-483
-
-
Chen, G.1
Yang, Y.2
Gao, X.3
Dou, Y.4
Wang, H.5
Han, G.6
-
15
-
-
33947110020
-
C5L2 is critical for the biological activities of the anaphyla-toxins C5a and C3a
-
Chen, N. J., Mirtsos, C., Suh, D., Lu, Y C, Lin, W J., McKerlie, C., et al. (2007). C5L2 is critical for the biological activities of the anaphyla-toxins C5a and C3a. Nature 446, 203-207.
-
(2007)
Nature
, vol.446
, pp. 203-207
-
-
Chen, N.J.1
Mirtsos, C.2
Suh, D.3
Lu, Y.C.4
Lin, W.J.5
McKerlie, C.6
-
16
-
-
0033052453
-
Protective effects of C5a blockade in sepsis
-
Czermak, B. J., Sarma, V., Pierson, C. L., Warner, R. L., Huber-Lang, M., Bless, N. M., et al. (1999). Protective effects of C5a blockade in sepsis. Nat. Med. 5, 788-792.
-
(1999)
Nat. Med.
, vol.5
, pp. 788-792
-
-
Czermak, B.J.1
Sarma, V.2
Pierson, C.L.3
Warner, R.L.4
Huber-Lang, M.5
Bless, N.M.6
-
17
-
-
79952743025
-
Distinct different contributions of the alternative and classical complement activation pathway for the innate host response during sepsis
-
Dahlke, K., Wrann, C. D., Sommerfeld, O., Sossdorf, M., Recknagel, P., Sachse, S., et al. (2011). Distinct different contributions of the alternative and classical complement activation pathway for the innate host response during sepsis. J. Immunol. 186, 3066-3075.
-
(2011)
J. Immunol.
, vol.186
, pp. 3066-3075
-
-
Dahlke, K.1
Wrann, C.D.2
Sommerfeld, O.3
Sossdorf, M.4
Recknagel, P.5
Sachse, S.6
-
18
-
-
0027451566
-
Activation of the complement system in baboons challenged with live Escherichia coli: correlation with mortality and evidence for a biphasic activation pattern
-
de Boer, J. P., Creasey, A. A., Chang, A., Roem, D., Eerenberg, A. J., Hack, C. E., et al. (1993). Activation of the complement system in baboons challenged with live Escherichia coli: correlation with mortality and evidence for a biphasic activation pattern. Infect. Immun. 61, 4293-4301.
-
(1993)
Infect. Immun.
, vol.61
, pp. 4293-4301
-
-
de Boer, J.P.1
Creasey, A.A.2
Chang, A.3
Roem, D.4
Eerenberg, A.J.5
Hack, C.E.6
-
19
-
-
80052927518
-
Akt regulates IL-10 mediated suppression of TNFalpha-induced cardiomyocyte apoptosis by upregulating Stat3 phosphory-lation
-
doi: 10.1371/journal.pone.0025009
-
Dhingra, S., Bagchi, A. K., Ludke, A. L., Sharma, A. K., and Singal, P. K. (2011). Akt regulates IL-10 mediated suppression of TNFalpha-induced cardiomyocyte apoptosis by upregulating Stat3 phosphory-lation. PLoS ONE 6:e25009. doi: 10.1371/journal.pone.0025009
-
(2011)
PLoS ONE
, vol.6
-
-
Dhingra, S.1
Bagchi, A.K.2
Ludke, A.L.3
Sharma, A.K.4
Singal, P.K.5
-
20
-
-
0035253577
-
Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma
-
Drouin, S. M., Kildsgaard, J., Haviland, J., Zabner, J., Jia, H. P., McCray, P. B. Jr., et al. (2001). Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma. J. Immunol. 166, 2025-2032.
-
(2001)
J. Immunol.
, vol.166
, pp. 2025-2032
-
-
Drouin, S.M.1
Kildsgaard, J.2
Haviland, J.3
Zabner, J.4
Jia, H.P.5
McCray Jr., P.B.6
-
21
-
-
0033978132
-
The C5a receptor is expressed in normal renal proximal tubular but not in normal pulmonary or hepatic epithelial cells
-
Fayyazi, A., Scheel, O., Werfel, T., Schweyer, S., Oppermann, M., Gotze, O., et al. (2000). The C5a receptor is expressed in normal renal proximal tubular but not in normal pulmonary or hepatic epithelial cells. Immunology 99, 38-45.
-
(2000)
Immunology
, vol.99
, pp. 38-45
-
-
Fayyazi, A.1
Scheel, O.2
Werfel, T.3
Schweyer, S.4
Oppermann, M.5
Gotze, O.6
-
22
-
-
50149117225
-
The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis
-
doi: 10.1371/journal.pone.0002560
-
Flierl, M. A., Rittirsch, D., Chen, A. J., Nadeau, B. A., Day, D. E., Sarma, J. V., et al. (2008a). The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis. PLoS ONE 3:e2560. doi: 10.1371/journal.pone.0002560
-
(2008)
PLoS ONE
, vol.3
-
-
Flierl, M.A.1
Rittirsch, D.2
Chen, A.J.3
Nadeau, B.A.4
Day, D.E.5
Sarma, J.V.6
-
23
-
-
46749158250
-
Adverse functions of IL-17A in experimental sepsis
-
Flierl, M. A., Rittirsch, D., Gao, H., Hoesel, L. M., Nadeau, B. A., Day, D. E., et al. (2008b). Adverse functions of IL-17A in experimental sepsis. FASEB J. 22, 2198-2205.
-
(2008)
FASEB J
, vol.22
, pp. 2198-2205
-
-
Flierl, M.A.1
Rittirsch, D.2
Gao, H.3
Hoesel, L.M.4
Nadeau, B.A.5
Day, D.E.6
-
24
-
-
33746294701
-
The role of complement
-
Flierl, M. A., Schreiber, H., and Huber-Lang, M. S. (2006). The role of complement, C5a and its receptors in sepsis and multiorgan dysfunction syndrome. J. Invest. Surg. 19, 255-265.
-
(2006)
C5a and its receptors in sepsis and multiorgan dysfunction syndrome. J. Invest. Surg.
, vol.19
, pp. 255-265
-
-
Flierl, M.A.1
Schreiber, H.2
Huber-Lang, M.S.3
-
25
-
-
61649087203
-
Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis
-
Flierl, M. A., Stahel, P. F., Rittirsch, D., Huber-Lang, M., Niederbichler, A. D., Hoesel, L. M., et al. (2009). Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis. Crit. Care 13, R12.
-
(2009)
Crit. Care
, vol.13
-
-
Flierl, M.A.1
Stahel, P.F.2
Rittirsch, D.3
Huber-Lang, M.4
Niederbichler, A.D.5
Hoesel, L.M.6
-
26
-
-
82755190055
-
C5a regulates NKT and NK cell functions in sepsis
-
Fusakio, M. E., Mohammed, J. P., Laumonnier, Y., Hoebe, K., Kohl, J., and Mattner, J. (2011). C5a regulates NKT and NK cell functions in sepsis.J. Immunol. 187, 5805-5812.
-
(2011)
J. Immunol.
, vol.187
, pp. 5805-5812
-
-
Fusakio, M.E.1
Mohammed, J.P.2
Laumonnier, Y.3
Hoebe, K.4
Kohl, J.5
Mattner, J.6
-
27
-
-
20444460795
-
Evidence for a functional role of the second C5a receptor C5L2
-
Gao, H., Neff, T. A., Guo, R. F., Speyer, C. L., Sarma, J. V., Tomlins, S., et al. (2005). Evidence for a functional role of the second C5a receptor C5L2. FASEB J. 19, 1003-1005.
-
(2005)
FASEB J
, vol.19
, pp. 1003-1005
-
-
Gao, H.1
Neff, T.A.2
Guo, R.F.3
Speyer, C.L.4
Sarma, J.V.5
Tomlins, S.6
-
28
-
-
0028863749
-
Identification and characterization of the complement C5a anaphylatoxin receptor on human astrocytes
-
Gasque, P., Chan, P., Fontaine, M., Ischenko, A., Lamacz, M., Gotze, O., et al. (1995). Identification and characterization of the complement C5a anaphylatoxin receptor on human astrocytes. J. Immunol. 155,4882-4889.
-
(1995)
J. Immunol.
, vol.155
, pp. 4882-4889
-
-
Gasque, P.1
Chan, P.2
Fontaine, M.3
Ischenko, A.4
Lamacz, M.5
Gotze, O.6
-
29
-
-
0024534975
-
Characterization of a receptor for C5a anaphylatoxin on human eosinophils
-
Gerard, N. P., Hodges, M. K., Drazen, J. M., Weller, P. F., and Gerard, C. (1989). Characterization of a receptor for C5a anaphylatoxin on human eosinophils. J. Biol. Chem. 264, 1760-1766.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 1760-1766
-
-
Gerard, N.P.1
Hodges, M.K.2
Drazen, J.M.3
Weller, P.F.4
Gerard, C.5
-
30
-
-
28844434626
-
An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein
-
Gerard, N. P., Lu, B., Liu, P., Craig, S., Fujiwara, Y., Okinaga, S., et al. (2005). An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2. J. Biol. Chem. 280, 39677-39680.
-
(2005)
C5L2. J. Biol. Chem.
, vol.280
, pp. 39677-39680
-
-
Gerard, N.P.1
Lu, B.2
Liu, P.3
Craig, S.4
Fujiwara, Y.5
Okinaga, S.6
-
31
-
-
0035957235
-
Internalization of the human N-formyl peptide and C5a chemoattractant receptors occurs via clathrin-independent mechanisms
-
Gilbert, T. L., Bennett, T. A., Maestas, D C., Cimino, D. F., and Prossnitz, E R. (2001). Internalization of the human N-formyl peptide and C5a chemoattractant receptors occurs via clathrin-independent mechanisms. Biochemistry 40, 3467-3475.
-
(2001)
Biochemistry
, vol.40
, pp. 3467-3475
-
-
Gilbert, T.L.1
Bennett, T.A.2
Maestas, D.C.3
Cimino, D.F.4
Prossnitz, E.R.5
-
32
-
-
0028082347
-
Immunologic assessment of host defense impairment in patients with septic multiple organ failure: relationship between complement activation and changes in neutrophil function
-
Goya, T., Morisaki, T., and Torisu, M. (1994). Immunologic assessment of host defense impairment in patients with septic multiple organ failure: relationship between complement activation and changes in neutrophil function. Surgery 115, 145-155.
-
(1994)
Surgery
, vol.115
, pp. 145-155
-
-
Goya, T.1
Morisaki, T.2
Torisu, M.3
-
33
-
-
0033692759
-
Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis
-
Guo, R. F., Huber-Lang, M., Wang, X., Sarma, V., Padgaonkar, V. A., Craig, R. A., et al. (2000). Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis. J. Clin. Invest. 106, 1271-1280.
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 1271-1280
-
-
Guo, R.F.1
Huber-Lang, M.2
Wang, X.3
Sarma, V.4
Padgaonkar, V.A.5
Craig, R.A.6
-
34
-
-
1142292743
-
Neutrophil C5a receptor and the outcome in a rat model of sepsis
-
Guo, R. F., Riedemann, N. C., Bernacki, K. D., Sarma, V. J., Laudes, I. J., Reuben, J. S., et al. (2003). Neutrophil C5a receptor and the outcome in a rat model of sepsis. FASEBJ. 17, 1889-1891.
-
(2003)
FASEBJ
, vol.17
, pp. 1889-1891
-
-
Guo, R.F.1
Riedemann, N.C.2
Bernacki, K.D.3
Sarma, V.J.4
Laudes, I.J.5
Reuben, J.S.6
-
35
-
-
11844295677
-
Role of C5a-C5aR interaction in sepsis
-
Guo, R. F., Riedemann, N. C., and Ward, P. A. (2004). Role of C5a-C5aR interaction in sepsis. Shock 21, 1-7.
-
(2004)
Shock
, vol.21
, pp. 1-7
-
-
Guo, R.F.1
Riedemann, N.C.2
Ward, P.A.3
-
36
-
-
33845462462
-
In vivo regulation of neutrophil apoptosis by C5a during sepsis
-
Guo, R. F., Sun, L., Gao, H., Shi, K. X., Rittirsch, D., Sarma, V. J., et al. (2006). In vivo regulation of neutrophil apoptosis by C5a during sepsis. J. Leukoc. Biol. 80, 1575-1583.
-
(2006)
J. Leukoc. Biol.
, vol.80
, pp. 1575-1583
-
-
Guo, R.F.1
Sun, L.2
Gao, H.3
Shi, K.X.4
Rittirsch, D.5
Sarma, V.J.6
-
37
-
-
17644388462
-
Role of C5a in inflammatory responses
-
Guo, R. F., and Ward, P. A. (2005). Role of C5a in inflammatory responses. Annu. Rev. Immunol. 23, 821-852.
-
(2005)
Annu. Rev. Immunol.
, vol.23
, pp. 821-852
-
-
Guo, R.F.1
Ward, P.A.2
-
38
-
-
79957829468
-
gammadeltaT-cell function in sepsis is modulated by C5a receptor signalling
-
Han, G., Geng, S., Li, Y., Chen, G., Wang, R., Li, X., et al. (2011). gammadeltaT-cell function in sepsis is modulated by C5a receptor signalling. Immunology 133, 340-349.
-
(2011)
Immunology
, vol.133
, pp. 340-349
-
-
Han, G.1
Geng, S.2
Li, Y.3
Chen, G.4
Wang, R.5
Li, X.6
-
39
-
-
0023136585
-
Adult respiratory distress syndrome
-
Hangen, D. H., Bloom, R. J., Stevens, J. H., O'Hanley, P., Ranchod, M., Collins, J., et al. (1987). Adult respiratory distress syndrome. A live E coli septic primate model. Am. J. Pathol. 126, 396-400.
-
(1987)
A live E coli septic primate model. Am. J. Pathol.
, vol.126
, pp. 396-400
-
-
Hangen, D.H.1
Bloom, R.J.2
Stevens, J.H.3
O'Hanley, P.4
Ranchod, M.5
Collins, J.6
-
40
-
-
0028850938
-
Cellular expression of the C5a anaphylatoxin receptor (C5aR): demonstration of C5aR on non-myeloid cells of the liver and lung
-
Haviland, D. L., McCoy, R. L., Whitehead, W T., Akama, H., Molmenti, E. P., Brown, A., et al. (1995). Cellular expression of the C5a anaphylatoxin receptor (C5aR): demonstration of C5aR on non-myeloid cells of the liver and lung. J. Immunol. 154, 1861-1869.
-
(1995)
J. Immunol.
, vol.154
, pp. 1861-1869
-
-
Haviland, D.L.1
McCoy, R.L.2
Whitehead, W.T.3
Akama, H.4
Molmenti, E.P.5
Brown, A.6
-
41
-
-
33745683792
-
New insights into cellular mechanisms during sepsis
-
Hoesel, L. M., Gao, H., and Ward, P. A. (2006). New insights into cellular mechanisms during sepsis. Immunol. Res. 34, 133-141.
-
(2006)
Immunol. Res.
, vol.34
, pp. 133-141
-
-
Hoesel, L.M.1
Gao, H.2
Ward, P.A.3
-
42
-
-
39149091052
-
Disruption of the C5a receptor gene increases resistance to acute Gram-negative bacteremia and endotoxic shock: opposing roles of C3a and C5a
-
Hollmann, T. J., Mueller-Ortiz, S. L., Braun, M. C., and Wetsel, R. A. (2008). Disruption of the C5a receptor gene increases resistance to acute Gram-negative bacteremia and endotoxic shock: opposing roles of C3a and C5a. Mol. Immunol. 45, 1907-1915.
-
(2008)
Mol. Immunol.
, vol.45
, pp. 1907-1915
-
-
Hollmann, T.J.1
Mueller-Ortiz, S.L.2
Braun, M.C.3
Wetsel, R.A.4
-
43
-
-
0029980816
-
Inhibition of interleukin-6 synthesis in an animal model of septic shock by anti-C5a monoclonal antibodies
-
Hopken, U., Mohr, M., Struber, A., Montz, H., Burchardi, H., Gotze, O., et al. (1996). Inhibition of interleukin-6 synthesis in an animal model of septic shock by anti-C5a monoclonal antibodies. Eur. I Immunol. 26, 1103-1109.
-
(1996)
Eur. I Immunol.
, vol.26
, pp. 1103-1109
-
-
Hopken, U.1
Mohr, M.2
Struber, A.3
Montz, H.4
Burchardi, H.5
Gotze, O.6
-
44
-
-
5944251623
-
Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte
-
Hotchkiss, R. S., Chang, K. C., Swanson, P. E., Tinsley, K. W., Hui, J. J., Klender, P., et al. (2000). Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte. Nat. Immunol. 1, 496-501.
-
(2000)
Nat. Immunol.
, vol.1
, pp. 496-501
-
-
Hotchkiss, R.S.1
Chang, K.C.2
Swanson, P.E.3
Tinsley, K.W.4
Hui, J.J.5
Klender, P.6
-
45
-
-
33750288937
-
Apoptosis and caspases regulate death and inflammation in sepsis
-
Hotchkiss, R. S., and Nicholson, D. W. (2006). Apoptosis and caspases regulate death and inflammation in sepsis. Nat. Rev. Immunol. 6, 813-822.
-
(2006)
Nat. Rev. Immunol.
, vol.6
, pp. 813-822
-
-
Hotchkiss, R.S.1
Nicholson, D.W.2
-
46
-
-
0036793526
-
Protection of innate immunity by C5aR antagonist in septic mice
-
Huber-Lang, M. S., Riedeman, N. C., Sarma, J. V., Younkin, E. M., McGuire, S. R., Laudes, I. J., et al. (2002a). Protection of innate immunity by C5aR antagonist in septic mice. FASEB J. 16, 1567-1574.
-
(2002)
FASEB J
, vol.16
, pp. 1567-1574
-
-
Huber-Lang, M.S.1
Riedeman, N.C.2
Sarma, J.V.3
Younkin, E.M.4
McGuire, S.R.5
Laudes, I.J.6
-
47
-
-
0037105426
-
Complement-induced impairment of innate immunity during sepsis
-
Huber-Lang, M. S., Younkin, E. M., Sarma, J. V., McGuire, S. R., Lu, K. T., Guo, R. F., et al. (2002b). Complement-induced impairment of innate immunity during sepsis. J. Immunol. 169, 3223-3231.
-
(2002)
J. Immunol.
, vol.169
, pp. 3223-3231
-
-
Huber-Lang, M.S.1
Younkin, E.M.2
Sarma, J.V.3
McGuire, S.R.4
Lu, K.T.5
Guo, R.F.6
-
48
-
-
0036840236
-
Generation of C5a by phagocytic cells
-
Huber-Lang, M., Younkin, E. M., Sarma, J. V., Riedemann, N., McGuire, S. R., Lu, K. T., et al. (2002c). Generation of C5a by phagocytic cells. Am. J. Pathol. 161, 1849-1859.
-
(2002)
Am. J. Pathol.
, vol.161
, pp. 1849-1859
-
-
Huber-Lang, M.1
Younkin, E.M.2
Sarma, J.V.3
Riedemann, N.4
McGuire, S.R.5
Lu, K.T.6
-
49
-
-
0035863922
-
Role of C5a in multiorgan failure during sepsis
-
Huber-Lang, M., Sarma, V. J., Lu, K. T., McGuire, S. R., Padgaonkar, V. A., Guo, R. F., et al. (2001a). Role of C5a in multiorgan failure during sepsis. J. Immunol. 166, 1193-1199.
-
(2001)
J. Immunol.
, vol.166
, pp. 1193-1199
-
-
Huber-Lang, M.1
Sarma, V.J.2
Lu, K.T.3
McGuire, S.R.4
Padgaonkar, V.A.5
Guo, R.F.6
-
50
-
-
0035286776
-
Protective effects of anti-C5a peptide antibodies in experimental sepsis
-
Huber-Lang, M. S., Sarma, J. V., McGuire, S. R., Lu, K. T., Guo, R. R, Padgaonkar, V. A., et al. (2001b). Protective effects of anti-C5a peptide antibodies in experimental sepsis. FASEBJ. 15,568-570.
-
(2001)
FASEBJ
, vol.15
, pp. 568-570
-
-
Huber-Lang, M.S.1
Sarma, J.V.2
McGuire, S.R.3
Lu, K.T.4
Guo, R.5
Padgaonkar, R.V.A.6
-
51
-
-
33744987414
-
Generation of C5a in the absence of C3: a new complement activation pathway
-
Huber-Lang, M., Sarma, J. V., Zetoune, R S., Rittirsch, D., Neff, T. A., McGuire, S. R., et al. (2006). Generation of C5a in the absence of C3: a new complement activation pathway. Nat. Med. 12, 682-687.
-
(2006)
Nat. Med.
, vol.12
, pp. 682-687
-
-
Huber-Lang, M.1
Sarma, J.V.2
Zetoune, R.S.3
Rittirsch, D.4
Neff, T.A.5
McGuire, S.R.6
-
52
-
-
0031045303
-
C5a induces tissue factor activity on endothelial cells
-
Ikeda, K., Nagasawa, K., Horiuchi, T., Tsuru, T., Nishizaka, H., and Niho, Y. (1997). C5a induces tissue factor activity on endothelial cells. Thromb. Haemost. 77, 394-398.
-
(1997)
Thromb. Haemost.
, vol.77
, pp. 394-398
-
-
Ikeda, K.1
Nagasawa, K.2
Horiuchi, T.3
Tsuru, T.4
Nishizaka, H.5
Niho, Y.6
-
53
-
-
81255160569
-
C5a/CD88 signaling alters blood-brain barrier integrity in lupus through nuclear factor-kappaB
-
Jacob, A., Hack, B., Chen, P., Quigg, R. J., and Alexander, J. J. (2011). C5a/CD88 signaling alters blood-brain barrier integrity in lupus through nuclear factor-kappaB. J. Neurochem. 119, 1041-1051.
-
(2011)
J. Neurochem.
, vol.119
, pp. 1041-1051
-
-
Jacob, A.1
Hack, B.2
Chen, P.3
Quigg, R.J.4
Alexander, J.J.5
-
54
-
-
0033834379
-
Hypersusceptibility of A/J mice to tuberculosis is in part due to a deficiency of the fifth complement component (C5)
-
Jagannath, C., Hoffmann, H., Sepulveda, E., Actor, J. K., Wetsel, R. A., and Hunter, R. L. (2000). Hypersusceptibility of A/J mice to tuberculosis is in part due to a deficiency of the fifth complement component (C5). Scand. I Immunol. 52, 369-379.
-
(2000)
Scand. I Immunol.
, vol.52
, pp. 369-379
-
-
Jagannath, C.1
Hoffmann, H.2
Sepulveda, E.3
Actor, J.K.4
Wetsel, R.A.5
Hunter, R.L.6
-
55
-
-
33846027130
-
Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines
-
Johswich, K., Martin, M., Thalmann, J., Rheinheimer, C., Monk, P. N., Klos, A. (2006). Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines. J. Biol. Chem. 281, 39088-39095.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 39088-39095
-
-
Johswich, K.1
Martin, M.2
Thalmann, J.3
Rheinheimer, C.4
Monk, P.N.5
Klos, A.6
-
56
-
-
34547190160
-
Cytokine profile of human septic shock serum inducing cardiomy-ocyte contractile dysfunction
-
Joulin, O., Petillot, P., Labalette, M., Lancel, S., and Neviere, R. (2007). Cytokine profile of human septic shock serum inducing cardiomy-ocyte contractile dysfunction. Physiol.Res. 56,291-297.
-
(2007)
Physiol. Res.
, vol.56
, pp. 291-297
-
-
Joulin, O.1
Petillot, P.2
Labalette, M.3
Lancel, S.4
Neviere, R.5
-
57
-
-
21244438039
-
C5L2 is a functional receptor for acylation-stimulating protein
-
Kalant, D., MacLaren, R., Cui, W., Samanta, R., Monk, P. N., Laporte, S. A., et al. (2005). C5L2 is a functional receptor for acylation-stimulating protein. J. Biol. Chem. 280,23936-23944.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 23936-23944
-
-
Kalant, D.1
MacLaren, R.2
Cui, W.3
Samanta, R.4
Monk, P.N.5
Laporte, S.A.6
-
58
-
-
84857843035
-
Factor VII-Activating protease is activated in multiple trauma patients and generates anaphylatoxin C5a
-
Kanse, S. M., Gallenmueller, A., Zeerleder, S., Stephan, F., Rannou, O., Denk, S., et al. (2012). Factor VII-Activating protease is activated in multiple trauma patients and generates anaphylatoxin C5a. J. Immunol. 188, 2858-2865.
-
(2012)
J. Immunol.
, vol.188
, pp. 2858-2865
-
-
Kanse, S.M.1
Gallenmueller, A.2
Zeerleder, S.3
Stephan, F.4
Rannou, O.5
Denk, S.6
-
59
-
-
0024310030
-
Interleukin 3-dependent mediator release in basophils triggered by C5a
-
Kurimoto, Y., de Weck, A. L., and Dahinden, C. A. (1989). Interleukin 3-dependent mediator release in basophils triggered by C5a. J. Exp. Med. 170, 467-479.
-
(1989)
J. Exp. Med.
, vol.170
, pp. 467-479
-
-
Kurimoto, Y.1
de Weck, A.L.2
Dahinden, C.A.3
-
60
-
-
84864072977
-
Recombinant human activated protein C for severe sepsis in neonates
-
Kylat, R. I., and Ohlsson, A. (2012). Recombinant human activated protein C for severe sepsis in neonates. Cochrane Database Syst. Rev. 4, CD005385.
-
(2012)
Cochrane Database Syst. Rev.
, vol.4
-
-
Kylat, R.I.1
Ohlsson, A.2
-
61
-
-
0029119287
-
Expression of the receptors for the C5a anaphylatoxin, interleukin-8 and FMLP by human astrocytes and microglia
-
Lacy, M., Jones, J., Whittemore, S. R., Haviland, D. L., Wetsel, R. A., and Barnum, S. R. (1995). Expression of the receptors for the C5a anaphylatoxin, interleukin-8 and FMLP by human astrocytes and microglia. J. Neuroimmunol. 61, 71-78.
-
(1995)
J. Neuroimmunol.
, vol.61
, pp. 71-78
-
-
Lacy, M.1
Jones, J.2
Whittemore, S.R.3
Haviland, D.L.4
Wetsel, R.A.5
Barnum, S.R.6
-
62
-
-
77956955243
-
Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma
-
Lajoie, S., Lewkowich, I. P., Suzuki, Y., Clark, J. R., Sproles, A. A., Dienger, K., et al. (2010). Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma. Nat. Immunol. 11, 928-935.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 928-935
-
-
Lajoie, S.1
Lewkowich, I.P.2
Suzuki, Y.3
Clark, J.R.4
Sproles, A.A.5
Dienger, K.6
-
63
-
-
0037111535
-
Expression and function of C5a receptor in mouse microvascular endothelial cells
-
Laudes, I. J., Chu, J. C., Huber-Lang, M., Guo, R. F., Riedemann, N. C., Sarma, J. V., et al. (2002a). Expression and function of C5a receptor in mouse microvascular endothelial cells. J. Immunol. 169, 5962-5970.
-
(2002)
J. Immunol.
, vol.169
, pp. 5962-5970
-
-
Laudes, I.J.1
Chu, J.C.2
Huber-Lang, M.3
Guo, R.F.4
Riedemann, N.C.5
Sarma, J.V.6
-
64
-
-
0036092494
-
Anti-c5a ameliorates coagula-tion/fibrinolytic protein changes in a rat model of sepsis
-
Laudes, I. J., Chu, J. C., Sikranth, S., Huber-Lang, M., Guo, R. F., Riedemann, N., et al. (2002b). Anti-c5a ameliorates coagula-tion/fibrinolytic protein changes in a rat model of sepsis. Am. J. Pathol. 160, 1867-1875.
-
(2002)
Am. J. Pathol.
, vol.160
, pp. 1867-1875
-
-
Laudes, I.J.1
Chu, J.C.2
Sikranth, S.3
Huber-Lang, M.4
Guo, R.F.5
Riedemann, N.6
-
65
-
-
6444244641
-
Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome
-
Le Tulzo, Y., Pangault, C., Gacouin, A., Guilloux, V., Tribut, O., Amiot, L., et al. (2002). Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome. Shock 18,487-494.
-
(2002)
Shock
, vol.18
, pp. 487-494
-
-
Le Tulzo, Y.1
Pangault, C.2
Gacouin, A.3
Guilloux, V.4
Tribut, O.5
Amiot, L.6
-
66
-
-
84874131345
-
Human recombinant activated protein C for severe sepsis
-
doi: 10.1002/14651858.CD004388. pub5
-
Marti-Carvajal, A. J., Sola, I., Lathyris, D., and Cardona, A. R. (2012). Human recombinant activated protein C for severe sepsis. Cochrane Database Syst. Rev. 3:CD004388. doi: 10.1002/14651858.CD004388. pub5
-
(2012)
Cochrane Database Syst. Rev
, vol.3
-
-
Marti-Carvajal, A.J.1
Sola, I.2
Lathyris, D.3
Cardona, A.R.4
-
67
-
-
0037871469
-
Regulation by complement C3a and C5a ana-phylatoxins of cytokine production in human umbilical vein endothelial cells
-
Monsinjon, T., Gasque, P., Chan, P., Ischenko, A., Brady, J. J., and Fontaine, M. C. (2003). Regulation by complement C3a and C5a ana-phylatoxins of cytokine production in human umbilical vein endothelial cells. FASEB J. 17, 1003-1014.
-
(2003)
FASEB J
, vol.17
, pp. 1003-1014
-
-
Monsinjon, T.1
Gasque, P.2
Chan, P.3
Ischenko, A.4
Brady, J.J.5
Fontaine, M.C.6
-
68
-
-
34848867174
-
Complement C5a anaphylatoxin is an innate determinant of dendritic cell-induced Th1 immunity to Mycobacterium bovis BCG infection in mice
-
Moulton, R. A., Mashruwala, M. A., Smith, A. K., Lindsey, D. R., Wetsel, R. A., Haviland, D. L., et al. (2007). Complement C5a anaphylatoxin is an innate determinant of dendritic cell-induced Th1 immunity to Mycobacterium bovis BCG infection in mice.J. Leukoc. Biol. 82, 956-967.
-
(2007)
J. Leukoc. Biol.
, vol.82
, pp. 956-967
-
-
Moulton, R.A.1
Mashruwala, M.A.2
Smith, A.K.3
Lindsey, D.R.4
Wetsel, R.A.5
Haviland, D.L.6
-
69
-
-
0018411524
-
C5 chemo-tactic fragment induces leukocyte production of tissue factor activity: a link between complement and coagulation
-
Muhlfelder, T. W., Niemetz, J., Kreutzer, D., Beebe, D., Ward, P. A., and Rosenfeld, S. I. (1979). C5 chemo-tactic fragment induces leukocyte production of tissue factor activity: a link between complement and coagulation. J. Clin. Invest. 63, 147-150.
-
(1979)
J. Clin. Invest.
, vol.63
, pp. 147-150
-
-
Muhlfelder, T.W.1
Niemetz, J.2
Kreutzer, D.3
Beebe, D.4
Ward, P.A.5
Rosenfeld, S.I.6
-
70
-
-
0000693801
-
Internalization and recycling of the C5a anaphylatoxin receptor: evidence that the agonist-mediated internalization is modulated by phosphorylation of the C-terminal domain
-
Naik, N., Giannini, E., Brouchon, L., and Boulay, R. (1997). Internalization and recycling of the C5a anaphylatoxin receptor: evidence that the agonist-mediated internalization is modulated by phosphorylation of the C-terminal domain. J. Cell. Sci. 110(Pt 19), 2381-2390.
-
(1997)
J. Cell. Sci.
, vol.110
, Issue.PART 19
, pp. 2381-2390
-
-
Naik, N.1
Giannini, E.2
Brouchon, L.3
Boulay, R.4
-
71
-
-
0028177412
-
Serum complement levels and severity of sepsis
-
Nakae, H., Endo, S., Inada, K., Takakuwa, T., Kasai, T., and Yoshida, M. (1994). Serum complement levels and severity of sepsis. Res. Commun. Chem. Pathol. Pharmacol. 84, 189-195.
-
(1994)
Res. Commun. Chem. Pathol. Pharmacol.
, vol.84
, pp. 189-195
-
-
Nakae, H.1
Endo, S.2
Inada, K.3
Takakuwa, T.4
Kasai, T.5
Yoshida, M.6
-
72
-
-
0029912311
-
Chronological changes in the complement system in sepsis
-
Nakae, H., Endo, S., Inada, K., and Yoshida, M. (1996). Chronological changes in the complement system in sepsis. Surg. Today 26, 225-229.
-
(1996)
Surg. Today
, vol.26
, pp. 225-229
-
-
Nakae, H.1
Endo, S.2
Inada, K.3
Yoshida, M.4
-
73
-
-
31344464342
-
An essential role for complement C5a in the pathogenesis of septic cardiac dysfunction
-
Niederbichler, A. D., Hoesel, L. M., Westfall, M. V., Gao, H., Ipaktchi, K. R., Sun, L., et al. (2006). An essential role for complement C5a in the pathogenesis of septic cardiac dysfunction. J. Exp. Med. 203, 53-61.
-
(2006)
J. Exp. Med.
, vol.203
, pp. 53-61
-
-
Niederbichler, A.D.1
Hoesel, L.M.2
Westfall, M.V.3
Gao, H.4
Ipaktchi, K.R.5
Sun, L.6
-
74
-
-
0035949476
-
Targeted adenovirus-induced expression of IL-10 decreases thymic apoptosis and improves survival in murine sepsis
-
Oberholzer, C., Oberholzer, A., Bahjat, F. R., Minter, R. M., Tannahill, C. L., Abouhamze, A., et al. (2001). Targeted adenovirus-induced expression of IL-10 decreases thymic apoptosis and improves survival in murine sepsis. Proc. Natl. Acad Sci. U.S.A. 98, 11503-11508.
-
(2001)
Proc. Natl. Acad Sci. U. S. A.
, vol.98
, pp. 11503-11508
-
-
Oberholzer, C.1
Oberholzer, A.2
Bahjat, F.R.3
Minter, R.M.4
Tannahill, C.L.5
Abouhamze, A.6
-
75
-
-
0033709969
-
A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells
-
Ohno, M., Hirata, T., Enomoto, M., Araki, T., Ishimaru, H., and Takahashi, T. A. (2000). A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells. Mol. Immunol. 37, 407-412.
-
(2000)
Mol. Immunol.
, vol.37
, pp. 407-412
-
-
Ohno, M.1
Hirata, T.2
Enomoto, M.3
Araki, T.4
Ishimaru, H.5
Takahashi, T.A.6
-
76
-
-
0041571471
-
C5L2, a nonsignaling C5A binding protein
-
Okinaga, S., Slattery, D., Humbles, A., Zsengeller, Z., Morteau, O., Kinrade, M. B., et al. (2003). C5L2, a nonsignaling C5A binding protein. Biochemistry 42, 9406-9415.
-
(2003)
Biochemistry
, vol.42
, pp. 9406-9415
-
-
Okinaga, S.1
Slattery, D.2
Humbles, A.3
Zsengeller, Z.4
Morteau, O.5
Kinrade, M.B.6
-
77
-
-
0036151650
-
C5a delays apoptosis of human neutrophils by a phosphatidylinositol 3-kinase-signaling pathway
-
Perianayagam, M. C., Balakrishnan, V. S., King, A. J., Pereira, B. J., and Jaber, B. L. (2002). C5a delays apoptosis of human neutrophils by a phosphatidylinositol 3-kinase-signaling pathway. Kidney Int. 61, 456-463.
-
(2002)
Kidney Int
, vol.61
, pp. 456-463
-
-
Perianayagam, M.C.1
Balakrishnan, V.S.2
King, A.J.3
Pereira, B.J.4
Jaber, B.L.5
-
78
-
-
80052139678
-
TLR activation enhances C5a-induced pro-inflammatory responses by negatively modulating the second C5a receptor
-
Raby, A. C., Holst, B., Davies, J., Colmont, C., Laumonnier, Y., Coles, B., et al. (2011). TLR activation enhances C5a-induced pro-inflammatory responses by negatively modulating the second C5a receptor, C5L2. Eur. J. Immunol. 41,2741-2752.
-
(2011)
C5L2. Eur. J. Immunol.
, vol.41
, pp. 2741-2752
-
-
Raby, A.C.1
Holst, B.2
Davies, J.3
Colmont, C.4
Laumonnier, Y.5
Coles, B.6
-
79
-
-
0041931068
-
Regulation by C5a of neutrophil activation during sepsis
-
Riedemann, N. C., Guo, R. F., Bernacki, K. D., Reuben, J. S., Laudes, I. J., Neff, T. A., et al. (2003a). Regulation by C5a of neutrophil activation during sepsis. Immunity 19, 193-202.
-
(2003)
Immunity
, vol.19
, pp. 193-202
-
-
Riedemann, N.C.1
Guo, R.F.2
Bernacki, K.D.3
Reuben, J.S.4
Laudes, I.J.5
Neff, T.A.6
-
80
-
-
0038578608
-
Novel strategies for the treatment of sepsis
-
Riedemann, N. C., Guo, R. F., and Ward, P. A. (2003b). Novel strategies for the treatment of sepsis. Nat. Med. 9, 517-524.
-
(2003)
Nat. Med.
, vol.9
, pp. 517-524
-
-
Riedemann, N.C.1
Guo, R.F.2
Ward, P.A.3
-
81
-
-
0037218519
-
Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression
-
Riedemann, N. C., Neff, T. A., Guo, R. F., Bernacki, K. D., Laudes, I. J., Sarma, J. V., et al. (2003c). Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression. J. Immunol. 170, 503-507.
-
(2003)
J. Immunol.
, vol.170
, pp. 503-507
-
-
Riedemann, N.C.1
Neff, T.A.2
Guo, R.F.3
Bernacki, K.D.4
Laudes, I.J.5
Sarma, J.V.6
-
82
-
-
1442290129
-
Regulatory role of C5a in LPS-induced IL-6 production by neutrophils during sepsis
-
Riedemann, N. C., Guo, R. F., Hollmann, T. J., Gao, H., Neff, T. A., Reuben, J. S., et al. (2004). Regulatory role of C5a in LPS-induced IL-6 production by neutrophils during sepsis. FASEB J. 18, 370-372.
-
(2004)
FASEB J
, vol.18
, pp. 370-372
-
-
Riedemann, N.C.1
Guo, R.F.2
Hollmann, T.J.3
Gao, H.4
Neff, T.A.5
Reuben, J.S.6
-
83
-
-
0036615932
-
C5a receptor and thymocyte apoptosis in sepsis
-
Riedemann, N. C., Guo, R. F., Laudes, I. J., Keller, K., Sarma, V. J., Padgaonkar, V., et al. (2002a). C5a receptor and thymocyte apoptosis in sepsis. FASEB J. 16,887-888.
-
(2002)
FASEB J
, vol.16
, pp. 887-888
-
-
Riedemann, N.C.1
Guo, R.F.2
Laudes, I.J.3
Keller, K.4
Sarma, V.J.5
Padgaonkar, V.6
-
84
-
-
0036304968
-
Increased C5a receptor expression in sepsis
-
Riedemann, N. C., Guo, R. F., Neff, T. A., Laudes, I. J., Keller, K. A., Sarma, V. J., et al. (2002b). Increased C5a receptor expression in sepsis. J. Clin. Invest. 110, 101-108.
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 101-108
-
-
Riedemann, N.C.1
Guo, R.F.2
Neff, T.A.3
Laudes, I.J.4
Keller, K.A.5
Sarma, V.J.6
-
85
-
-
0037083361
-
Expression and function of the C5a receptor in rat alveolar epithelial cells
-
Riedemann, N. C., Guo, R. F., Sarma, V. J., Laudes, I. J., Huber-Lang, M., Warner, R. L., et al. (2002c). Expression and function of the C5a receptor in rat alveolar epithelial cells. J. Immunol. 168, 1919-1925.
-
(2002)
J. Immunol.
, vol.168
, pp. 1919-1925
-
-
Riedemann, N.C.1
Guo, R.F.2
Sarma, V.J.3
Laudes, I.J.4
Huber-Lang, M.5
Warner, R.L.6
-
86
-
-
43249098418
-
Functional roles for C5a receptors in sepsis
-
Rittirsch, D., Flierl, M. A., Nadeau, B. A., Day, D. E., Huber-Lang, M., Mackay, C. R., et al. (2008). Functional roles for C5a receptors in sepsis. Nat. Med. 14, 551-557.
-
(2008)
Nat. Med.
, vol.14
, pp. 551-557
-
-
Rittirsch, D.1
Flierl, M.A.2
Nadeau, B.A.3
Day, D.E.4
Huber-Lang, M.5
Mackay, C.R.6
-
87
-
-
0030941650
-
Anaphylatoxin C5a receptor mRNA is strongly expressed in Kupffer and stellate cells and weakly in sinusoidal endothelial cells but not in hepatocytes of normal rat liver
-
Schieferdecker, H. L., Rothermel, E., Timmermann, A., Gotze, O., and Jungermann, K. (1997). Anaphylatoxin C5a receptor mRNA is strongly expressed in Kupffer and stellate cells and weakly in sinusoidal endothelial cells but not in hepatocytes of normal rat liver. FEBSLett. 406, 305-309.
-
(1997)
FEBSLett
, vol.406
, pp. 305-309
-
-
Schieferdecker, H.L.1
Rothermel, E.2
Timmermann, A.3
Gotze, O.4
Jungermann, K.5
-
88
-
-
0025094641
-
Recombinant C5a stimulates transcription rather than translation of interleukin-1 (IL-1) and tumor necrosis factor: translational signal provided by lipopolysac-charide or IL-1 itself
-
Schindler, R., Gelfand, J. A., and Dinarello, C. A. (1990). Recombinant C5a stimulates transcription rather than translation of interleukin-1 (IL-1) and tumor necrosis factor: translational signal provided by lipopolysac-charide or IL-1 itself. Blood 76, 1631-1638.
-
(1990)
Blood
, vol.76
, pp. 1631-1638
-
-
Schindler, R.1
Gelfand, J.A.2
Dinarello, C.A.3
-
89
-
-
84857958645
-
M-ficolin concentrations in cord blood are related to circulating phagocytes and to early-onset sepsis
-
Schlapbach, L. J., Kjaer, T. R., Thiel, S., Mattmann, M., Nelle, M., Wagner, B. P., et al. (2012). M-ficolin concentrations in cord blood are related to circulating phagocytes and to early-onset sepsis. Pediatr. Res. 71, 368-374.
-
(2012)
Pediatr. Res.
, vol.71
, pp. 368-374
-
-
Schlapbach, L.J.1
Kjaer, T.R.2
Thiel, S.3
Mattmann, M.4
Nelle, M.5
Wagner, B.P.6
-
90
-
-
0025039008
-
C5a-mediated release of interleukin 6 by human monocytes
-
Scholz, W., McClurg, M. R., Cardenas, G. J., Smith, M., Noonan, D. J., Hugli, T. E., et al. (1990). C5a-mediated release of interleukin 6 by human monocytes. Clin. Immunol. Immunopathol. 57, 297-307.
-
(1990)
Clin. Immunol. Immunopathol.
, vol.57
, pp. 297-307
-
-
Scholz, W.1
McClurg, M.R.2
Cardenas, G.J.3
Smith, M.4
Noonan, D.J.5
Hugli, T.E.6
-
91
-
-
60949109793
-
The human complement fragment receptor, C5L2, is a recycling decoy receptor
-
Scola, A. M., Johswich, K. O., Morgan, B. P., Klos, A., and Monk, P. N. (2009). The human complement fragment receptor, C5L2, is a recycling decoy receptor. Mol. Immunol. 46, 1149-1162.
-
(2009)
Mol. Immunol.
, vol.46
, pp. 1149-1162
-
-
Scola, A.M.1
Johswich, K.O.2
Morgan, B.P.3
Klos, A.4
Monk, P.N.5
-
92
-
-
1042280926
-
Vaccinia virus complement control protein increases early bacterial clearance during experimental peritonitis
-
Scott, M. J., Burch, P. T., Jha, P., Peyton, J. C., Kotwal, G. J., and Cheadle, W. G. (2003). Vaccinia virus complement control protein increases early bacterial clearance during experimental peritonitis. Surg. Infect. (Larchmt) 4, 317-326.
-
(2003)
Surg. Infect. (Larchmt)
, vol.4
, pp. 317-326
-
-
Scott, M.J.1
Burch, P.T.2
Jha, P.3
Peyton, J.C.4
Kotwal, G.J.5
Cheadle, W.G.6
-
93
-
-
0038171416
-
Neutrophil apoptosis pathways and theirmodifications in inflammation
-
Simon, H. U. (2003). Neutrophil apoptosis pathways and theirmodifications in inflammation. Immunol. Rev. 193, 101-110.
-
(2003)
Immunol. Rev.
, vol.193
, pp. 101-110
-
-
Simon, H.U.1
-
94
-
-
0024450510
-
Endotoxin-induced shock in the rat
-
Smedegard, G., Cui, L. X., and Hugli, T. E. (1989). Endotoxin-induced shock in the rat. A role for C5a. Am. I Pathol. 135, 489-497.
-
(1989)
A role for C5a. Am. I Pathol.
, vol.135
, pp. 489-497
-
-
Smedegard, G.1
Cui, L.X.2
Hugli, T.E.3
-
95
-
-
0019446122
-
Neutrophil dysfunction in sepsis
-
Solomkin, J. S., Jenkins, M. K., Nelson, R. D., Chenoweth, D., and Simmons, R. L. (1981). Neutrophil dysfunction in sepsis. II. Evidence for the role of complement activation products in cellular deactivation. Surgery 90, 319-327.
-
(1981)
II. Evidence for the role of complement activation products in cellular deactivation. Surgery
, vol.90
, pp. 319-327
-
-
Solomkin, J.S.1
Jenkins, M.K.2
Nelson, R.D.3
Chenoweth, D.4
Simmons, R.L.5
-
96
-
-
0033853982
-
IL-4-induced activation of the Stat6 pathway contributes to the suppression of cell-mediated immunity and death in sepsis
-
Song, G. Y., Chung, C. S., Chaudry, I. H., and Ayala, A. (2000). IL-4-induced activation of the Stat6 pathway contributes to the suppression of cell-mediated immunity and death in sepsis. Surgery 128, 133-138.
-
(2000)
Surgery
, vol.128
, pp. 133-138
-
-
Song, G.Y.1
Chung, C.S.2
Chaudry, I.H.3
Ayala, A.4
-
97
-
-
0037443560
-
IL-4 down-regulates ana phylatoxin receptors in monocytes and dendritic cells and impairs anaphylatoxin-induced migra-tion in vivo
-
Soruri, A., Kiafard, Z., Dettmer, C., Riggert, J., Kohl, J., and Zwirner, J. (2003). IL-4 down-regulates ana phylatoxin receptors in monocytes and dendritic cells and impairs anaphylatoxin-induced migra-tion in vivo. J. Immunol. 170, 3306-3314.
-
(2003)
J. Immunol.
, vol.170
, pp. 3306-3314
-
-
Soruri, A.1
Kiafard, Z.2
Dettmer, C.3
Riggert, J.4
Kohl, J.5
Zwirner, J.6
-
98
-
-
70350678971
-
Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis
-
Spite, M., Norling, L. V., Summers, L., Yang, R., Cooper, D., Petasis, N. A., et al. (2009). Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature 461, 1287-1291.
-
(2009)
Nature
, vol.461
, pp. 1287-1291
-
-
Spite, M.1
Norling, L.V.2
Summers, L.3
Yang, R.4
Cooper, D.5
Petasis, N.A.6
-
99
-
-
0022453148
-
Effects of anti-C5a antibodies on the adult respiratory distress syndrome in septic primates
-
Stevens, J. H., O'Hanley, P., Shapiro, J. M., Mihm, F G., Satoh, P. S., Collins, J. A., et al. (1986). Effects of anti-C5a antibodies on the adult respiratory distress syndrome in septic primates. J. Clin. Invest. 77, 1812-1816.
-
(1986)
J. Clin. Invest.
, vol.77
, pp. 1812-1816
-
-
Stevens, J.H.1
O'Hanley, P.2
Shapiro, J.M.3
Mihm, F.G.4
Satoh, P.S.5
Collins, J.A.6
-
100
-
-
0026754770
-
Cytokine-induced neutrophil-derived interleukin-8
-
Strieter, R. M., Kasahara, K., Allen, R. M., Standiford, T. J., Rolfe, M. W., Becker, F S., et al. (1992). Cytokine-induced neutrophil-derived interleukin-8. Am. J. Pathol. 141, 397-407.
-
(1992)
Am. J. Pathol.
, vol.141
, pp. 397-407
-
-
Strieter, R.M.1
Kasahara, K.2
Allen, R.M.3
Standiford, T.J.4
Rolfe, M.W.5
Becker, F.S.6
-
101
-
-
0023893101
-
Pulmonary alveolar type II epithelial cells synthesize and secrete proteins of the classical and alternative complement pathways
-
Strunk, R. C., Eidlen, D. M., and Mason, R. J. (1988). Pulmonary alveolar type II epithelial cells synthesize and secrete proteins of the classical and alternative complement pathways. J. Clin. Invest. 81, 1419-1426.
-
(1988)
J. Clin. Invest.
, vol.81
, pp. 1419-1426
-
-
Strunk, R.C.1
Eidlen, D.M.2
Mason, R.J.3
-
102
-
-
70350544115
-
Attenuation of IgG immune complex-induced acute lung injury by silencing C5aR in lung epithelial cells
-
Sun, L., Guo, R. F., Gao, H., Sarma, J. V., Zetoune, F S., and Ward, P. A. (2009). Attenuation of IgG immune complex-induced acute lung injury by silencing C5aR in lung epithelial cells. FASEB J. 23, 3808-3818.
-
(2009)
FASEB J
, vol.23
, pp. 3808-3818
-
-
Sun, L.1
Guo, R.F.2
Gao, H.3
Sarma, J.V.4
Zetoune, F.S.5
Ward, P.A.6
-
103
-
-
43549115877
-
Role of the carboxyl terminal di-leucine in phosphorylation and internalization of C5a receptor
-
Suvorova, E. S., Gripentrog, J. M., Oppermann, M., and Miettinen, H. M. (2008). Role of the carboxyl terminal di-leucine in phosphorylation and internalization of C5a receptor. Biochim. Biophys. Acta 1783, 1261-1270.
-
(2008)
Biochim. Biophys. Acta
, vol.1783
, pp. 1261-1270
-
-
Suvorova, E.S.1
Gripentrog, J.M.2
Oppermann, M.3
Miettinen, H.M.4
-
104
-
-
0023122016
-
Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon
-
Taylor, F B. Jr., Chang, A., Esmon, C. T., D'Angelo, A., Vigano-D'Angelo, S., and Blick, K. E. (1987). Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon. J. Clin. Invest. 79,918-925.
-
(1987)
J. Clin. Invest.
, vol.79
, pp. 918-925
-
-
Taylor Jr, F.B.1
Chang, A.2
Esmon, C.T.3
D'Angelo, A.4
Vigano-D'Angelo, S.5
Blick, K.E.6
-
105
-
-
0032928083
-
Nitric oxide in septic shock
-
Titheradge, M. A. (1999). Nitric oxide in septic shock. Biochim. Biophys. Acta 1411,437-455.
-
(1999)
Biochim. Biophys. Acta
, vol.1411
, pp. 437-455
-
-
Titheradge, M.A.1
-
106
-
-
0025174372
-
Regulation of C5a and formyl pep-tide receptor expression on human polymorphonuclear leukocytes
-
Van Epps, D. E., Simpson, S., Bender, J. G., and Chenoweth, D. E. (1990). Regulation of C5a and formyl pep-tide receptor expression on human polymorphonuclear leukocytes. J. Immunol. 144, 1062-1068.
-
(1990)
J. Immunol.
, vol.144
, pp. 1062-1068
-
-
Van Epps, D.E.1
Simpson, S.2
Bender, J.G.3
Chenoweth, D.E.4
-
107
-
-
1142310879
-
The dark side of C5a in sepsis
-
Ward, P. A. (2004). The dark side of C5a in sepsis. Nat. Rev. Immunol. 4, 133-142.
-
(2004)
Nat. Rev. Immunol.
, vol.4
, pp. 133-142
-
-
Ward, P.A.1
-
108
-
-
55949084597
-
Sepsis, apoptosis and complement
-
Ward, P. A. (2008). Sepsis, apoptosis and complement. Biochem. Pharmacol. 76, 1383-1388.
-
(2008)
Biochem. Pharmacol.
, vol.76
, pp. 1383-1388
-
-
Ward, P.A.1
-
109
-
-
78650289203
-
Role of C5 activation products in sepsis
-
Ward, P. A. (2010). Role of C5 activation products in sepsis. ScientificWorldJournal 10, 2395-2402.
-
(2010)
ScientificWorldJournal
, vol.10
, pp. 2395-2402
-
-
Ward, P.A.1
-
110
-
-
0026604784
-
Binding of fluorescein-labeled anaphyla-toxin C5a to human peripheral blood, spleen, and bone marrow leukocytes
-
Werfel, T., Oppermann, M., Schulze, M., Krieger, G., Weber, M., and Gotze, O. (1992). Binding of fluorescein-labeled anaphyla-toxin C5a to human peripheral blood, spleen, and bone marrow leukocytes. Blood 79, 152-160.
-
(1992)
Blood
, vol.79
, pp. 152-160
-
-
Werfel, T.1
Oppermann, M.2
Schulze, M.3
Krieger, G.4
Weber, M.5
Gotze, O.6
-
111
-
-
0028930272
-
Expression of the complement C5a anaphylatoxin receptor (C5aR) on non-myeloid cells
-
Wetsel, R. A. (1995). Expression of the complement C5a anaphylatoxin receptor (C5aR) on non-myeloid cells. Immunol. Lett. 44, 183-187.
-
(1995)
Immunol. Lett.
, vol.44
, pp. 183-187
-
-
Wetsel, R.A.1
-
112
-
-
4544235126
-
Involvement of the lectin pathway of complement activation in antimicrobial immune defense during experimental septic peritonitis
-
Windbichler, M., Echtenacher, B., Hehlgans, T., Jensenius, J. C., Schwaeble, W., and Mannel, D. N. (2004). Involvement of the lectin pathway of complement activation in antimicrobial immune defense during experimental septic peritonitis. Infect. Immun. 72, 5247-5252.
-
(2004)
Infect. Immun.
, vol.72
, pp. 5247-5252
-
-
Windbichler, M.1
Echtenacher, B.2
Hehlgans, T.3
Jensenius, J.C.4
Schwaeble, W.5
Mannel, D.N.6
-
113
-
-
0033152662
-
C5a suppresses the production of IL-12 by IFN-gamma-primed and lipopolysaccharide-challenged human monocytes
-
Wittmann, M., Zwirner, J., Larsson, V A., Kirchhoff, K., Begemann, G., Kapp, A., et al. (1999). C5a suppresses the production of IL-12 by IFN-gamma-primed and lipopolysaccharide-challenged human monocytes. J. Immunol. 162, 6763-6769.
-
(1999)
J. Immunol.
, vol.162
, pp. 6763-6769
-
-
Wittmann, M.1
Zwirner, J.2
Larsson, V.A.3
Kirchhoff, K.4
Begemann, G.5
Kapp, A.6
-
114
-
-
0031895683
-
Involvement and dual effects of nitric oxide in septic shock
-
Wolkow, P. P. (1998). Involvement and dual effects of nitric oxide in septic shock. Inflamm. Res. 47, 152-166.
-
(1998)
Inflamm. Res.
, vol.47
, pp. 152-166
-
-
Wolkow, P.P.1
-
115
-
-
34247643153
-
The phosphatidylinositol 3-kinase signaling pathway exerts protective effects during sepsis by controlling C5a-mediated activation of innate immune functions
-
Wrann, C. D., Tabriz, N. A., Barkhausen, T., Klos, A., van Griensven, M., Pape, H. C., et al. (2007). The phosphatidylinositol 3-kinase signaling pathway exerts protective effects during sepsis by controlling C5a-mediated activation of innate immune functions. J. Immunol. 178, 5940-5948.
-
(2007)
J. Immunol.
, vol.178
, pp. 5940-5948
-
-
Wrann, C.D.1
Tabriz, N.A.2
Barkhausen, T.3
Klos, A.4
van Griensven, M.5
Pape, H.C.6
-
116
-
-
84856295957
-
C5a-regulated CCAAT/Enhancer-binding proteins beta and delta are essential in Fcgamma receptor-mediated inflammatory cytokine and chemokine production in macrophages
-
Yan, C., Zhu, M., Staiger, J., Johnson, P. F., and Gao, H. (2012). C5a-regulated CCAAT/Enhancer-binding proteins beta and delta are essential in Fcgamma receptor-mediated inflammatory cytokine and chemokine production in macrophages. J. Biol.Chem. 287, 3217-3230.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 3217-3230
-
-
Yan, C.1
Zhu, M.2
Staiger, J.3
Johnson, P.F.4
Gao, H.5
-
117
-
-
0033838665
-
The C5a receptor is expressed by human renal proximal tubular epithelialcells
-
Zahedi, R., Braun, M., Wetsel, R. A., Ault, B. H., Khan, A., Welch, T. R., et al. (2000). The C5a receptor is expressed by human renal proximal tubular epithelialcells. Clin. Exp. Immunol. 121, 226-233.
-
(2000)
Clin. Exp. Immunol.
, vol.121
, pp. 226-233
-
-
Zahedi, R.1
Braun, M.2
Wetsel, R.A.3
Ault, B.H.4
Khan, A.5
Welch, T.R.6
-
118
-
-
78650668602
-
A critical role for C5L2 in the pathogenesis of experimental allergic asthma
-
Zhang, X., Schmudde, I., Laumonnier, Y., Pandey, M. K., Clark, J. R., Konig, P., et al. (2010). A critical role for C5L2 in the pathogenesis of experimental allergic asthma. J. Immunol. 185, 6741-6752.
-
(2010)
J. Immunol.
, vol.185
, pp. 6741-6752
-
-
Zhang, X.1
Schmudde, I.2
Laumonnier, Y.3
Pandey, M.K.4
Clark, J.R.5
Konig, P.6
|