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Volumn 6, Issue 9, 2011, Pages

Akt regulates IL-10 mediated suppression of TNFα-induced cardiomyocyte apoptosis by upregulating stat3 phosphorylation

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; JANUS KINASE 1; PROTEIN KINASE B; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; CASPASE 3;

EID: 80052927518     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025009     Document Type: Article
Times cited : (54)

References (37)
  • 1
    • 0029871896 scopus 로고    scopus 로고
    • Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the Studies of Left Ventricular Dysfunction (SOLVD)
    • Torre-Amione G, Kapadia S, Benedict C, Oral H, Young JB, et al. (1996) Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the Studies of Left Ventricular Dysfunction (SOLVD). J Am Coll Cardiol 27: 1201-1206.
    • (1996) J Am Coll Cardiol , vol.27 , pp. 1201-1206
    • Torre-Amione, G.1    Kapadia, S.2    Benedict, C.3    Oral, H.4    Young, J.B.5
  • 2
    • 0025286817 scopus 로고
    • Elevated circulating levels of tumor necrosis factor in severe chronic heart failure
    • Levine B, Kalman J, Mayer L, Fillit HM, Packer M, (1990) Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med 323: 236-241.
    • (1990) N Engl J Med , vol.323 , pp. 236-241
    • Levine, B.1    Kalman, J.2    Mayer, L.3    Fillit, H.M.4    Packer, M.5
  • 3
    • 0029090919 scopus 로고
    • Is tumor necrosis factor an important neurohormonal mechanism in chronic heart failure?
    • Packer M, (1995) Is tumor necrosis factor an important neurohormonal mechanism in chronic heart failure? Circulation 92: 1379-1382.
    • (1995) Circulation , vol.92 , pp. 1379-1382
    • Packer, M.1
  • 4
    • 0028334555 scopus 로고
    • Normal and abnormal consequences of apoptosis in the human heart. From postnatal morphogenesis to paroxysmal arrhythmias
    • James TN, (1994) Normal and abnormal consequences of apoptosis in the human heart. From postnatal morphogenesis to paroxysmal arrhythmias. Circulation 90: 556-573.
    • (1994) Circulation , vol.90 , pp. 556-573
    • James, T.N.1
  • 5
    • 85047694494 scopus 로고    scopus 로고
    • A mechanistic role for cardiac myocyte apoptosis in heart failure
    • Wencker D, Chandra M, Nguyen K, Miao W, Garantziotis S, et al. (2003) A mechanistic role for cardiac myocyte apoptosis in heart failure. J Clin Invest 111: 1497-1504.
    • (2003) J Clin Invest , vol.111 , pp. 1497-1504
    • Wencker, D.1    Chandra, M.2    Nguyen, K.3    Miao, W.4    Garantziotis, S.5
  • 6
    • 0038755661 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled, pilot trial of infliximab, a chimeric monoclonal antibody to tumor necrosis factor-α, in patients with moderate-to-severe heart failure: results of the anti-TNF Therapy Against Congestive Heart Failure (ATTACH) trial
    • Chung ES, Packer M, Lo KH, Fasanmade AA, Willerson JT, (2003) Randomized, double-blind, placebo-controlled, pilot trial of infliximab, a chimeric monoclonal antibody to tumor necrosis factor-α, in patients with moderate-to-severe heart failure: results of the anti-TNF Therapy Against Congestive Heart Failure (ATTACH) trial. Circulation 107: 3133-3140.
    • (2003) Circulation , vol.107 , pp. 3133-3140
    • Chung, E.S.1    Packer, M.2    Lo, K.H.3    Fasanmade, A.A.4    Willerson, J.T.5
  • 7
    • 11144355760 scopus 로고    scopus 로고
    • Targeted anticytokine therapy in patients with chronic heart failure: results of the Randomized Etanercept Worldwide Evaluation (RENEWAL)
    • Mann DL, McMurray JJ, Packer M, Swedberg K, Borer JS, et al. (2004) Targeted anticytokine therapy in patients with chronic heart failure: results of the Randomized Etanercept Worldwide Evaluation (RENEWAL). Circulation 109: 1594-1602.
    • (2004) Circulation , vol.109 , pp. 1594-1602
    • Mann, D.L.1    McMurray, J.J.2    Packer, M.3    Swedberg, K.4    Borer, J.S.5
  • 8
    • 0037102274 scopus 로고    scopus 로고
    • Effect of interleukin-10 on the production of tumor necrosis factor-α by peripheral blood mononuclear cells from patients with chronic heart failure
    • Bolger AP, Sharma R, von Haehling S, Doehner W, Oliver B, et al. (2002) Effect of interleukin-10 on the production of tumor necrosis factor-α by peripheral blood mononuclear cells from patients with chronic heart failure. Am J Cardiol 90: 384-389.
    • (2002) Am J Cardiol , vol.90 , pp. 384-389
    • Bolger, A.P.1    Sharma, R.2    von Haehling, S.3    Doehner, W.4    Oliver, B.5
  • 9
    • 0028136767 scopus 로고
    • Interleukin-10 and its receptor
    • Ho AS, Moore KW, (1994) Interleukin-10 and its receptor. Ther Immunol 1: 173-185.
    • (1994) Ther Immunol , vol.1 , pp. 173-185
    • Ho, A.S.1    Moore, K.W.2
  • 10
    • 0029118395 scopus 로고
    • IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 α and STAT3 complexes in human T cells and monocytes
    • Finbloom DS, Winestock KD, (1995) IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 α and STAT3 complexes in human T cells and monocytes. J Immunol 155: 1079-1090.
    • (1995) J Immunol , vol.155 , pp. 1079-1090
    • Finbloom, D.S.1    Winestock, K.D.2
  • 11
    • 2142765855 scopus 로고    scopus 로고
    • Interleukin-10-induced CCR5 expression in macrophage like HL-60 cells: involvement of Erk1/2 and STAT-3
    • Makuta Y, Sonoda Y, Yamamoto D, Funakoshi-Tago M, Aizu-Yokota E, et al. (2003) Interleukin-10-induced CCR5 expression in macrophage like HL-60 cells: involvement of Erk1/2 and STAT-3. Biol Pharm Bull 26: 1076-1081.
    • (2003) Biol Pharm Bull , vol.26 , pp. 1076-1081
    • Makuta, Y.1    Sonoda, Y.2    Yamamoto, D.3    Funakoshi-Tago, M.4    Aizu-Yokota, E.5
  • 12
    • 62349108668 scopus 로고    scopus 로고
    • IL-10 attenuates TNF-alpha-induced NF κB pathway activation and cardiomyocyte apoptosis
    • Dhingra S, Sharma AK, Arora RC, Slezak J, Singal PK, (2009) IL-10 attenuates TNF-alpha-induced NF κB pathway activation and cardiomyocyte apoptosis. Cardiovasc Res 82: 59-66.
    • (2009) Cardiovasc Res , vol.82 , pp. 59-66
    • Dhingra, S.1    Sharma, A.K.2    Arora, R.C.3    Slezak, J.4    Singal, P.K.5
  • 13
    • 36849008272 scopus 로고    scopus 로고
    • p38 and ERK1/2 MAPKs mediate the interplay of TNF-α and IL-10 in regulating oxidative stress and cardiac myocyte apoptosis
    • Dhingra S, Sharma AK, Singla DK, Singal PK, (2007) p38 and ERK1/2 MAPKs mediate the interplay of TNF-α and IL-10 in regulating oxidative stress and cardiac myocyte apoptosis. Am J Physiol Heart Circ Physiol 293: H3524-3531.
    • (2007) Am J Physiol Heart Circ Physiol , vol.293 , pp. 3524-3531
    • Dhingra, S.1    Sharma, A.K.2    Singla, D.K.3    Singal, P.K.4
  • 14
    • 4143117818 scopus 로고    scopus 로고
    • Cardiac myocyte apoptosis provokes adverse cardiac remodeling in transgenic mice with targeted TNF overexpression
    • Engel D, Peshock R, Armstong RC, Sivasubramanian N, Mann DL, (2004) Cardiac myocyte apoptosis provokes adverse cardiac remodeling in transgenic mice with targeted TNF overexpression. Am J Physiol Heart Circ Physiol 287: H1303-1311.
    • (2004) Am J Physiol Heart Circ Physiol , vol.287 , pp. 1303-1311
    • Engel, D.1    Peshock, R.2    Armstong, R.C.3    Sivasubramanian, N.4    Mann, D.L.5
  • 15
    • 0033604585 scopus 로고    scopus 로고
    • The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB
    • Kandel ES, Hay N, (1999) The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp Cell Res 253: 210-229.
    • (1999) Exp Cell Res , vol.253 , pp. 210-229
    • Kandel, E.S.1    Hay, N.2
  • 16
    • 0034651983 scopus 로고    scopus 로고
    • Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart
    • Fujio Y, Nguyen T, Wencker D, Kitsis RN, Walsh K, (2000) Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation 101: 660-667.
    • (2000) Circulation , vol.101 , pp. 660-667
    • Fujio, Y.1    Nguyen, T.2    Wencker, D.3    Kitsis, R.N.4    Walsh, K.5
  • 17
    • 0033534088 scopus 로고    scopus 로고
    • Adenoviral gene transfer of activated phosphatidylinositol 3′-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro
    • Matsui T, Li L, del Monte F, Fukui Y, Franke TF, et al. (1999) Adenoviral gene transfer of activated phosphatidylinositol 3′-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. Circulation 100: 2373-2379.
    • (1999) Circulation , vol.100 , pp. 2373-2379
    • Matsui, T.1    Li, L.2    del Monte, F.3    Fukui, Y.4    Franke, T.F.5
  • 18
    • 0033595011 scopus 로고    scopus 로고
    • Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
    • Biggs WH 3rd, Meisenhelder J, Hunter T, Cavenee WK, Arden KC, (1999) Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci U S A 96: 7421-7426.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 7421-7426
    • Biggs 3rd, W.H.1    Meisenhelder, J.2    Hunter, T.3    Cavenee, W.K.4    Arden, K.C.5
  • 19
    • 0033582929 scopus 로고    scopus 로고
    • Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
    • Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, et al. (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857-868.
    • (1999) Cell , vol.96 , pp. 857-868
    • Brunet, A.1    Bonni, A.2    Zigmond, M.J.3    Lin, M.Z.4    Juo, P.5
  • 20
    • 0033915344 scopus 로고    scopus 로고
    • Interleukin-10 and interleukin-13 inhibit proinflammatory cytokine-induced ceramide production through the activation of phosphatidylinositol 3-kinase
    • Pahan K, Khan M, Singh I, (2000) Interleukin-10 and interleukin-13 inhibit proinflammatory cytokine-induced ceramide production through the activation of phosphatidylinositol 3-kinase. J Neurochem 75: 576-582.
    • (2000) J Neurochem , vol.75 , pp. 576-582
    • Pahan, K.1    Khan, M.2    Singh, I.3
  • 21
    • 0035887654 scopus 로고    scopus 로고
    • IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and phosphatidylinositol 3′-kinase
    • Zhou JH, Broussard SR, Strle K, Freund GG, Johnson RW, et al. (2001) IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and phosphatidylinositol 3′-kinase. J Immunol 167: 4436-4442.
    • (2001) J Immunol , vol.167 , pp. 4436-4442
    • Zhou, J.H.1    Broussard, S.R.2    Strle, K.3    Freund, G.G.4    Johnson, R.W.5
  • 22
    • 33751231104 scopus 로고    scopus 로고
    • Interplay of TNF-α and IL-10 in regulating oxidative stress in isolated adult cardiac myocytes
    • Kaur K, Sharma AK, Dhingra S, Singal PK, (2006) Interplay of TNF-α and IL-10 in regulating oxidative stress in isolated adult cardiac myocytes. J Mol Cell Cardiol 41: 1023-1030.
    • (2006) J Mol Cell Cardiol , vol.41 , pp. 1023-1030
    • Kaur, K.1    Sharma, A.K.2    Dhingra, S.3    Singal, P.K.4
  • 23
    • 0030886770 scopus 로고    scopus 로고
    • Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats
    • Aikawa R, Komuro I, Yamazaki T, Zou Y, Kudoh S, et al. (1997) Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats. J Clin Invest 100: 1813-1821.
    • (1997) J Clin Invest , vol.100 , pp. 1813-1821
    • Aikawa, R.1    Komuro, I.2    Yamazaki, T.3    Zou, Y.4    Kudoh, S.5
  • 24
    • 0030758075 scopus 로고    scopus 로고
    • Nephropathy in human immunodeficiency virus-1 transgenic mice is due to renal transgene expression
    • Bruggeman LA, Dikman S, Meng C, Quaggin SE, Coffman TM, et al. (1997) Nephropathy in human immunodeficiency virus-1 transgenic mice is due to renal transgene expression. J Clin Invest 100: 84-92.
    • (1997) J Clin Invest , vol.100 , pp. 84-92
    • Bruggeman, L.A.1    Dikman, S.2    Meng, C.3    Quaggin, S.E.4    Coffman, T.M.5
  • 25
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM, (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 26
    • 42549116145 scopus 로고    scopus 로고
    • JAK/STAT and PI3K/AKT pathways form a mutual transactivation loop and afford resistance to oxidative stress-induced apoptosis in cardiomyocytes
    • Lu Y, Zhou J, Xu C, Lin H, Xiao J, et al. (2008) JAK/STAT and PI3K/AKT pathways form a mutual transactivation loop and afford resistance to oxidative stress-induced apoptosis in cardiomyocytes. Cell Physiol Biochem 21: 305-314.
    • (2008) Cell Physiol Biochem , vol.21 , pp. 305-314
    • Lu, Y.1    Zhou, J.2    Xu, C.3    Lin, H.4    Xiao, J.5
  • 27
    • 0038153911 scopus 로고    scopus 로고
    • TNF-α neutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal epithelial cell apoptosis
    • Marini M, Bamias G, Rivera-Nieves J, Moskaluk CA, Hoang SB, et al. (2003) TNF-α neutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal epithelial cell apoptosis. Proc Natl Acad Sci U S A 100: 8366-8371.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8366-8371
    • Marini, M.1    Bamias, G.2    Rivera-Nieves, J.3    Moskaluk, C.A.4    Hoang, S.B.5
  • 28
    • 0031918203 scopus 로고    scopus 로고
    • Tumor necrosis factor in the heart
    • Meldrum DR, (1998) Tumor necrosis factor in the heart. Am J Physiol 274: R577-595.
    • (1998) Am J Physiol , vol.274 , pp. 577-595
    • Meldrum, D.R.1
  • 30
    • 77955896408 scopus 로고    scopus 로고
    • Targeting the vicious inflammation-oxidative stress cycle for the management of heart failure
    • Khaper N, Bryan S, Dhingra S, Singal R, Bajaj A, et al. (2010) Targeting the vicious inflammation-oxidative stress cycle for the management of heart failure. Antioxid Redox Signal 13: 1033-1049.
    • (2010) Antioxid Redox Signal , vol.13 , pp. 1033-1049
    • Khaper, N.1    Bryan, S.2    Dhingra, S.3    Singal, R.4    Bajaj, A.5
  • 31
    • 0038004788 scopus 로고    scopus 로고
    • Decrease of serum levels of the anti-inflammatory cytokine interleukin-10 in patients with advanced chronic heart failure
    • Stumpf C, Lehner C, Yilmaz A, Daniel WG, Garlichs CD, (2003) Decrease of serum levels of the anti-inflammatory cytokine interleukin-10 in patients with advanced chronic heart failure. Clin Sci (Lond) 105: 45-50.
    • (2003) Clin Sci (Lond) , vol.105 , pp. 45-50
    • Stumpf, C.1    Lehner, C.2    Yilmaz, A.3    Daniel, W.G.4    Garlichs, C.D.5
  • 32
    • 33745698667 scopus 로고    scopus 로고
    • Significance of changes in TNF-α and IL-10 levels in the progression of heart failure subsequent to myocardial infarction
    • Kaur K, Sharma AK, Singal PK, (2006) Significance of changes in TNF-α and IL-10 levels in the progression of heart failure subsequent to myocardial infarction. Am J Physiol Heart Circ Physiol 291: H106-113.
    • (2006) Am J Physiol Heart Circ Physiol , vol.291 , pp. 106-113
    • Kaur, K.1    Sharma, A.K.2    Singal, P.K.3
  • 33
    • 36749010252 scopus 로고    scopus 로고
    • Interleukin-10 modulates pro-apoptotic effects of TNF-α in human articular chondrocytes in vitro
    • John T, Muller RD, Oberholzer A, Zreiqat H, Kohl B, et al. (2007) Interleukin-10 modulates pro-apoptotic effects of TNF-α in human articular chondrocytes in vitro. Cytokine 40: 226-234.
    • (2007) Cytokine , vol.40 , pp. 226-234
    • John, T.1    Muller, R.D.2    Oberholzer, A.3    Zreiqat, H.4    Kohl, B.5
  • 34
    • 0034517548 scopus 로고    scopus 로고
    • Intracoronary, adenovirus-mediated Akt gene transfer in heart limits infarct size following ischemia-reperfusion injury in vivo
    • Miao W, Luo Z, Kitsis RN, Walsh K, (2000) Intracoronary, adenovirus-mediated Akt gene transfer in heart limits infarct size following ischemia-reperfusion injury in vivo. J Mol Cell Cardiol 32: 2397-2402.
    • (2000) J Mol Cell Cardiol , vol.32 , pp. 2397-2402
    • Miao, W.1    Luo, Z.2    Kitsis, R.N.3    Walsh, K.4
  • 35
    • 67649398797 scopus 로고    scopus 로고
    • Amlodipine inhibits TNF-α production and attenuates cardiac dysfunction induced by lipopolysaccharide involving PI3K/Akt pathway
    • Li XQ, Cao W, Li T, Zeng AG, Hao LL, et al. (2009) Amlodipine inhibits TNF-α production and attenuates cardiac dysfunction induced by lipopolysaccharide involving PI3K/Akt pathway. Int Immunopharmacol 9: 1032-1041.
    • (2009) Int Immunopharmacol , vol.9 , pp. 1032-1041
    • Li, X.Q.1    Cao, W.2    Li, T.3    Zeng, A.G.4    Hao, L.L.5
  • 36
    • 0035970041 scopus 로고    scopus 로고
    • Glycoprotein 130 regulates cardiac myocyte survival in doxorubicin-induced apoptosis through phosphatidylinositol 3-kinase/Akt phosphorylation and Bcl-xL/caspase-3 interaction
    • Negoro S, Oh H, Tone E, Kunisada K, Fujio Y, et al. (2001) Glycoprotein 130 regulates cardiac myocyte survival in doxorubicin-induced apoptosis through phosphatidylinositol 3-kinase/Akt phosphorylation and Bcl-xL/caspase-3 interaction. Circulation 103: 555-561.
    • (2001) Circulation , vol.103 , pp. 555-561
    • Negoro, S.1    Oh, H.2    Tone, E.3    Kunisada, K.4    Fujio, Y.5
  • 37
    • 36849095428 scopus 로고    scopus 로고
    • Substitutions of potentially phosphorylatable serine residues of Bax reveal how they may regulate its interaction with mitochondria
    • Arokium H, Ouerfelli H, Velours G, Camougrand N, Vallette FM, et al. (2007) Substitutions of potentially phosphorylatable serine residues of Bax reveal how they may regulate its interaction with mitochondria. J Biol Chem 282: 35104-35112.
    • (2007) J Biol Chem , vol.282 , pp. 35104-35112
    • Arokium, H.1    Ouerfelli, H.2    Velours, G.3    Camougrand, N.4    Vallette, F.M.5


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