Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis

Critical Care

Volumn 13, Issue 1, 2009, Pages

  Flierl, Michael A ^a   Stahel, Philip F ^a   Rittirsch, Daniel ^b,e   Huber Lang, Markus ^c   Niederbichler, Andreas D ^d   Marco, L Marco ^e   Touban, Basel M ^a   Morgan, Steven J ^a   Smith, Wade R ^a   Ward, Peter A ^e   Ipaktchi, Kyros ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY HOSPITAL ULM   (Germany)

^d HANNOVER MEDICAL SCHOOL   (Germany)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C5A; COMPLEMENT COMPONENT C5A ANTIBODY; COMPLEMENT COMPONENT C5A RECEPTOR; CYTOKINE; GROWTH HORMONE; IMMUNOGLOBULIN G; NEUTRALIZING ANTIBODY; PLACEBO; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; BRAIN DISEASE; CONTROLLED STUDY; DISEASE SEVERITY; HYPOPHYSIS DISEASE; LIGATION; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; PUNCTURE; RAT; RECEPTOR UPREGULATION; SEPSIS; SHAM PROCEDURE; SPRAGUE DAWLEY RAT; ANIMAL; BIOSYNTHESIS; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; IMMUNOLOGY; METABOLISM;

ANIMALS; BLOOD-BRAIN BARRIER; COMPLEMENT C5A; IMMUNOGLOBULIN G; MALE; PITUITARY DISEASES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ANAPHYLATOXIN C5A; SEPSIS;

EID: 61649087203     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc7710     Document Type: Article

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