Role of C5a in multiorgan failure during sepsis

Journal of Immunology

Volumn 166, Issue 2, 2001, Pages 1193-1199

  Huber Lang, M ^a   Sarma, V J ^a   Lu, K T ^a   McGuire, S R ^a   Padgaonkar, V A ^a   Guo, R F ^a   Younkin, E M ^a   Kunkel, R G ^a   Ding, J ^a   Erickson, R ^a   Curnutte, J T ^a   Ward, P A ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOTAXIN; COMPLEMENT COMPONENT C5A; FORMYLMETHIONYLLEUCYLPHENYLALANINE; LACTIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPLEMENT FIXATION; CONTROLLED STUDY; LACTATE BLOOD LEVEL; LACTIC ACIDOSIS; LIVER DYSFUNCTION; LUNG DISEASE; MALE; METABOLIC ACIDOSIS; MULTIPLE ORGAN FAILURE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; RAT; RESPIRATORY ALKALOSIS; SEPSIS;

EID: 0035863922     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.2.1193     Document Type: Article

References (28)

1. Multiple organ failure: Pathophysiology and potential future therapy
2. Systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), multiple organ failure (MOF): Are we winning the battle?
3. Immunopathologic responses to non-lethal sepsis
4. Immunology in the severely injured
5. Inhibition of interleukin-6 synthesis in an animal model of septic shock by anti-C5a monoclonal antibodies
6. Anaphylatoxin formation of sepsis
7. Chronological changes in the complement system in sepsis
8. Altered anaphylatoxin activity during induced hypoperfusion in acute and elective abdominal surgery
9. The chemotactic receptor for human C5a anaphylatoxin
10. Immunologic assessment of host defense impairment in patients with septic multiple organ failure: Relationship between complement activation and changes in neutrophil function
11. Neutrophil dysfunction in sepsis. II. Evidence for the role of complement activation products in cellular deactivation
12. A new small molecule C5a receptor antagonists inhibits the reverse-passive Arthus reaction and endotoxic shock in rats
13. Selection of a C5a receptor antagonist from phage libraries attenuating the inflammatory response in immune complex disease and ischemia/reperfusion injury
14. Protective effects of C5a blockade in sepsis
15. Oxygen-dependent and oxygen independent mechanisms of microbiological activity of neutrophils
16. Iodination of chemokines for use in receptor binding analysis
17. Demonstration of specific C5a receptor on intact human polymorphonuclear leukocytes
18. Impaired mast cell-dependant natural immunity in complement C3-deficient mice
19. Increased susceptibility to endotoxin shock in complement C3- and C4-deficient mice is corrected by C1 inhibitor replacement
20. Anaphylatoxin-induced shock and two patterns of anaphylactic shock: Hemodynamics and mediators
21. Effects of anti-C5a monoclonal antibodies on oxygen use in a porcine model of severe sepsis
22. Effects of anti-C5a antibodies on the adult respiratory distress syndrome in septic primates
23. Complement levels in septic primates treated with anti-C5a antibodies
24. Cellular injury score for multiple organ failure severity scoring system
25. The pro-inflammatory seven-transmembrane segment receptors of the leukocytes
26. Complement anaphylatoxins (C3a, C4a, C5a) and their receptors (C3aR, C5aR/CD 88) as therapeutic targets in inflammation
27. The formylpeptide receptor of the neutrophil: A search and conserve operation
28. Complement activation and clearance in acute illness and injury: Evidence for C5a as a cell-directed mediator of the adult respiratory distress syndrome in man